Prof. Dr. Martin von Bergen

Head of Department of Molecular Systems Biology


Helmholtz Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: 0341 235 1211
Fax:0341 235 1786


Martin von Bergen, Bild

Research Interests in Environmental Health

  • Cellular response mechanisms towards environmental pollutants with a focus on molecular pathways
  • Systems Biology based approaches using proteomic and metabolomic techniques in cells, tissue and on the systemic level
  • Characterisation of environmental exposure scenarios
  • Development of methods for qualitative and quantitative and structural proteomics

Research Interests in Microbiome Biology

  • Analysis of structure and functions of microbial communities by proteomic and metabolomic techniques
  • Mechanistic insights into anoxic degradation of environmental pollutants
  • Development of mass spectrometry based methods for quantitative and qualitative meta-proteomics of bacteria

CV

  • Since 2016: Head of Department of Molecular Systems Biology (merger of Departments of Proteomics and Metabolomics)
  • Since 2015: Professor of Functional Proteomics at University of Leipzig, Faculty of Life Sciences
  • 2013-2015: Part-time Professor for Systems Microbiology at Aalborg University, Aalborg, Denmark
  • since 2009: Speaker of Metabolomics Department
  • since 2007: “Habilitation” in molecular biology and Assistent Professor at the faculty of Biochemstry, Biology and Psychology at the University of Leipzig
  • since 2006: Head of Department of Proteomics at Helmholtz Centre for Environmental Research, Leipzig
  • 2002-2006: Senior scientist at Max Planck-Research Group for Structural Molecular Biology, Hamburg und Assistant Professor in the faculty of Biology at the University of Hamburg
  • 2001-2002: Head of Department of Proteomics in Startup company mice and more GmbH & Co KG, Hamburg
  • 1998-2001: Postdoc at Max-Planck-Research Group for Structural Molecular Biology, Hamburg
  • 1998: PhD at the faculty of Biology, University of Hamburg
  • 1995-1998: PhD studies at the Max-Planck-Research Group for Structural Molecular Biology, Hamburg
  • 1990-1995: Diploma studies in Biology at the University of Hamburg

Publications

   

2020 (3)

2019 (25)

2018 (21)

2017 (22)

2016 (43)

2015 (31)

2014 (20)

2013 (30)

2012 (25)

2011 (21)

 

2010

  • Strauber, H., Hubschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M. , Harms, H., and Muller, S. (2010):
    NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene)--a novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
    Cytometry A 77, 113-120
    http://dx.doi.org/10.1002/cyto.a.20811
  • Selesi, D., Jehmlich, N., von Bergen, M. , Schmidt, F., Rattei, T., Tischler, P., Lueders, T., and Meckenstock, R. U. (2010):
    Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    J Bacteriol 192, 295-306
    http://dx.doi.org/10.1128/JB.00874-09
  • Schirmer, C., Klein, C., von Bergen, M. , Simon, J. C., and Saalbach, A. (2010):
    Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells
    Blood116,1715-1725
    http://dx.doi.org/10.1182/blood-2010-01-263509
  • Ohler, M., Georgieva, D., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
    The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities
    J Proteome Res 9, 2422-2437
    http://dx.doi.org/10.1021/pr901128x
  • Muller, S. A., Kohajda, T., Findeiss, S., Stadler, P. F., Washietl, S., Kellis, M., von Bergen, M. , and Kalkhof, S. (2010):
    Optimization of parameters for coverage of low molecular weight proteins
    Anal Bioanal Chem
    http://dx.doi.org/10.1007/s00216-010-4093-x
  • Leibeling, S., Schmidt, F., Jehmlich, N., von Bergen, M. , Muller, R. H., and Harms, H. (2010):
    Declining capacity of starving Delftia acidovorans MC1 to degrade phenoxypropionate herbicides correlates with oxidative modification of the initial enzyme
    Environ Sci Technol 44, 3793-3799
    http://dx.doi.org/10.1021/es903619j
  • Kung, J. W., Baumann, S., von Bergen, M. , Muller, M., Hagedoorn, P. L., Hagen, W. R., and Boll, M. (2010):
    Reversible biological Birch reduction at an extremely low redox potential
    J Am Chem Soc 132, 9850-9856
    http://dx.doi.org/10.1021/ja103448u
  • Jehmlich, N., Hubschmann, T., Gesell Salazar, M., Volker, U., Benndorf, D., Muller, S., von Bergen, M. , and Schmidt, F. (2010):
    Advanced tool for characterization of microbial cultures by combining cytomics and proteomics
    Appl Microbiol Biotechnol 88, 575-584
    http://dx.doi.org/10.1007/s00253-010-2753-6
  • Jehmlich, N., Fetzer, I., Seifert, J., Mattow, J., Vogt, C., Harms, H., Thiede, B., Richnow, H. H., von Bergen, M. , and Schmidt, F. (2010):
    Decimal place slope, a fast and precise method for quantifying 13C incorporation levels for detecting the metabolic activity of microbial species
    Mol Cell Proteomics 9, 1221-1227
    http://dx.doi.org/10.1074/mcp.M900407-MCP200
  • Georgieva, D., Redecke, L., von Bergen, M. , Genov, N., and Betzel, C. (2010):
    Interactions of ginkgolides A and B with a recombinant human prion protein
    Protein Pept Lett 17, 399-404
    http://www.benthamdirect.org/pages/b_viewarticle.php?3157685
  • Georgieva, D., Ohler, M., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
    Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities
    J Proteome Res 9, 2302-2316
    http://dx.doi.org/10.1021/pr901042p
  • Fetzer, I., Jehmlich, N., Vogt, C., Richnow, H. H., Seifert, J., Harms, H., von Bergen, M. , and Schmidt, F. (2010):
    Calculation of partial isotope incorporation into peptides measured by mass spectrometry
    BMC Res Notes 3, 178
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913921/?tool=pubmed
  • Feltens, R., Gorner, R., Kalkhof, S., Groger-Arndt, H., and von Bergen, M. (2010):
    Discrimination of different species from the genus Drosophila by intact protein profiling using matrix-assisted laser desorption ionization mass spectrometry
    BMC Evol Biol 10, 95
    http://dx.doi.org/10.1186/1471-2148-10-95
  • Bastida, F., Rosell, M., Franchini, A. G., Seifert, J., Finsterbusch, S., Jehmlich, N., Jechalke, S., von Bergen, M. , and Richnow, H. H. (2010):
    Elucidating MTBE degradation in a mixed consortium using a multidisciplinary approach
    FEMS Microbiol Ecol 73, 370-384
    http://dx.DOI.org/10.1111/j.1574-6941.2010.00889.x
  • 2009

  • Wischgoll, S., Taubert, M., Peters, F., Jehmlich, N., von Bergen, M. , and Boll, M. (2009):
    Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria
    J Bacteriol 191, 4401-4409
    http://dx.doi.org/10.1128/JB.00205-09
  • Schleinitz, K. M., Schmeling, S., Jehmlich, N., von Bergen, M. , Harms, H., Kleinsteuber, S., Vogt, C., and Fuchs, G. (2009):
    Phenol degradation in the strictly anaerobic iron-reducing bacterium Geobacter metallireducens GS-15
    Appl Environ Microbiol 75, 3912-3919
    http://dx.doi.org/10.1128/AEM.01525-08
  • Risch, M., Georgieva, D., von Bergen, M. , Jehmlich, N., Genov, N., Arni, R. K., and Betzel, C. (2009):
    Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) -- relation to pharmacological activities
    J Proteomics 72, 256-269
    http://dx.doi.org/10.1016/j.jprot.2009.01.006
  • Rehders, D., Claasen, B., Redecke, L., Buschke, A., Reibe, C., Jehmlich, N., von Bergen, M. , Betzel, C., and Meyer, B. (2009):
    Peptide NMHRYPNQ of the cellular prion protein (PrP(C)) inhibits aggregation and is a potential key for understanding prion-prion interactions
    J Mol Biol 392, 198-207
    http://dx.doi.org/ 10.1016/j.jmb.2009.07.014
  • Morbt, N., Mogel, I., Kalkhof, S., Feltens, R., Roder-Stolinski, C., Zheng, J., Vogt, C., Lehmann, I., and von Bergen, M. (2009):
    Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism
    Proteomics 9, 4920-4933
    http://dx.doi.org/10.1002/pmic.200800836
  • Junghanns, C., Pecyna, M. J., Bohm, D., Jehmlich, N., Martin, C., von Bergen, M. , Schauer, F., Hofrichter, M., and Schlosser, D. (2009):
    Biochemical and molecular genetic characterisation of a novel laccase produced by the aquatic ascomycete Phoma sp. UHH 5-1-03
    Appl Microbiol Biotechnol 84, 1095-1105
    http://dx.doi.org/10.1007/s00253-009-2028-2
  • Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., von Bergen, M. , Richnow, H. H., and Vogt, C. (2009):
    Comparison of methods for simultaneous identification of bacterial species and determination of metabolic activity by protein-based stable isotope probing (Protein-SIP) experiments
    Rapid Commun Mass Spectrom 23, 1871-1878
    http://dx.doi.org/10.1002/rcm.4084
  • Heine, F., Stahl, F., Strauber, H., Wiacek, C., Benndorf, D., Repenning, C., Schmidt, F., Scheper, T., von Bergen, M. , Harms, H., and Muller, S. (2009):
    Prediction of flocculation ability of brewing yeast inoculates by flow cytometry, proteome analysis, and mRNA profiling
    Cytometry A 75, 140-147
    http://dx.doi.org/10.1002/cyto.a.20661
  • Benndorf, D., Vogt, C., Jehmlich, N., Schmidt, Y., Thomas, H., Woffendin, G., Shevchenko, A., Richnow, H. H., and von Bergen, M. (2009):
    Improving protein extraction and separation methods for investigating the metaproteome of anaerobic benzene communities within sediments
    Biodegradation 20, 737-750
    http://dx.doi.org/10.1007/s10532-009-9261-3
  • 2008

  • Thiele, B., Rieder, O., Jehmlich, N., von Bergen, M. , Muller, M., and Boll, M. (2008):
    Aromatizing cyclohexa-1,5-diene-1-carbonyl-coenzyme A oxidase. Characterization and its role in anaerobic aromatic metabolism
    J Biol Chem 283, 20713-20721
    http://dx.doi.org/10.1074/jbc.M802841200
  • Roder-Stolinski, C., Fischader, G., Oostingh, G. J., Feltens, R., Kohse, F., von Bergen, M. , Morbt, N., Eder, K., Duschl, A., and Lehmann, I. (2008):
    Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activation
    Toxicol Appl Pharmacol 231, 241-247
    http://dx.doi.org/10.1016/j.taap.2008.04.010
  • Johannes, J., Bluschke, A., Jehmlich, N., von Bergen, M. , and Boll, M. (2008):
    Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens
    J Bacteriol 190, 6493-6500
    http://dx.doi.org/10.1128/JB.00790-08
  • Jehmlich, N., Schmidt, F., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
    Protein-based stable isotope probing (Protein-SIP) reveals active species within anoxic mixed cultures
    ISME J 2, 1122-1133
    http://dx.doi.org/10.1038/ismej.2008.64
  • Jehmlich, N., Schmidt, F., Hartwich, M., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
    Incorporation of carbon and nitrogen atoms into proteins measured by protein-based stable isotope probing (Protein-SIP)
    Rapid Commun Mass Spectrom 22, 2889-2897
    http://dx.doi.org/10.1002/rcm.3684
  • Jeganathan, S., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2008):
    The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
    Biochemistry 47, 10526-10539
    http://dx.doi.org/10.1021/bi800783d
  • Hehemann, J. H., Redecke, L., Murugaiyan, J., von Bergen, M. , Betzel, C., and Saborowski, R. (2008):
    Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus
    Biochem Biophys Res Commun 370, 566-571
    http://dx.doi.org/10.1016/j.bbrc.2008.03.128
  • Georgieva, D., Risch, M., Kardas, A., Buck, F., von Bergen, M. , and Betzel, C. (2008):
    Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis
    J Proteome Res 7, 866-886
    http://dx.doi.org/10.1021/pr070376c
  • Benndorf, D., Muller, A., Bock, K., Manuwald, O., Herbarth, O., and von Bergen, M. (2008):
    Identification of spore allergens from the indoor mould Aspergillus versicolor
    Allergy 63, 454-460
    http://dx.doi.org/10.1111/j.1398-9995.2007.01603.x
  • Andronesi, O. C., von Bergen, M. , Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008):
    Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy
    J Am Chem Soc 130, 5922-5928
    http://dx.doi.org/10.1021/ja7100517
  • 2007

  • Santos, P. M., Roma, V., Benndorf, D., von Bergen, M. , Harms, H., and Sa-Correia, I. (2007):
    Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1 revealed by quantitative proteomics
    OMICS 11, 233-251
    http://dx.doi.org/10.1089/omi.2007.0009
  • Redecke, L., von Bergen, M. , Clos, J., Konarev, P. V., Svergun, D. I., Fittschen, U. E., Broekaert, J. A., Bruns, O., Georgieva, D., Mandelkow, E., Genov, N., and Betzel, C. (2007):
    Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro
    J Struct Biol 157, 308-320
    http://dx.doi.org/10.1016/j.jsb.2006.06.013
  • Mukrasch, M. D., von Bergen, M. , Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
    The "jaws" of the tau-microtubule interaction
    J Biol Chem 282, 12230-12239
    http://dx.doi.org/10.1074/jbc.M607159200
  • Martin, C., Pecyna, M., Kellner, H., Jehmlich, N., Junghanns, C., Benndorf, D., von Bergen, M. , and Schlosser, D. (2007):
    Purification and biochemical characterization of a laccase from the aquatic fungus Myrioconium sp. UHH 1-13-18-4 and molecular analysis of the laccase-encoding gene
    Appl Microbiol Biotechnol 77, 613-624
    http://dx.doi.org/10.1007/s00253-007-1207-2
  • Mandelkow, E., von Bergen, M. , Biernat, J., and Mandelkow, E. M. (2007):
    Structural principles of tau and the paired helical filaments of Alzheimer's disease
    Brain Pathol 17, 83-90
    http://dx.doi.org/10.1111/j.1750-3639.2007.00053.x
  • Gundel, U., Benndorf, D., von Bergen, M. , Altenburger, R., and Kuster, E. (2007):
    Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach
    Proteomics 7, 4541-4554
    http://dx.doi.org/10.1002/pmic.200700381
  • Fischer, D., Mukrasch, M. D., von Bergen, M. , Klos-Witkowska, A., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
    Structural and microtubule binding properties of tau mutants of frontotemporal dementias
    Biochemistry 46, 2574-2582
    http://dx.doi.org/10.1021/bi061318s
  • Benndorf, D., Balcke, G. U., Harms, H., and von Bergen, M. (2007):
    Functional metaproteome analysis of protein extracts from contaminated soil and groundwater
    ISME J 1, 224-234
    http://dx.doi.org/10.1038/ismej.2007.39
  • 2006

  • von Bergen, M. , Barghorn, S., Muller, S. A., Pickhardt, M., Biernat, J., Mandelkow, E. M., Davies, P., Aebi, U., and Mandelkow, E. (2006):
    The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
    Biochemistry 45, 6446-6457
    http://dx.doi.org/10.1021/bi052530j
  • von Bergen, M. , Barghorn, S., Jeganathan, S., Mandelkow, E. M., and Mandelkow, E. (2006):
    Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments
    Neurodegener Dis 3, 197-206
    http://dx.doi.org/10.1159/000095257
  • Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen, M. , Gazova, Z., Mandelkow, E., and Mandelkow, E. M. (2006):
    Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
    J Biol Chem 281, 1205-1214
    http://dx.doi.org/10.1074/jbc.M507753200
  • Jeganathan, S., von Bergen, M. , Brutlach, H., Steinhoff, H. J., and Mandelkow, E. (2006):
    Global hairpin folding of tau in solution
    Biochemistry 45, 2283-2293
    http://dx.doi.org/10.1021/bi0521543
  • Georgieva, D., Schwark, D., von Bergen, M. , Redecke, L., Genov, N., and Betzel, C. (2006):
    Interactions of recombinant prions with compounds of therapeutical significance
    Biochem Biophys Res Commun 344, 463-470
    http://dx.doi.org/10.1016/j.bbrc.2006.03.135
  • von Bergen, M. , Li, L., and Mandelkow, E. (2005):
    Intrinsic fluorescent detection of tau conformation and aggregation
    Methods Mol Biol 299, 175-184
    http://www.mpasmb-hamburg.mpg.de/mandelkow2/publikationen/index.html
  • 1998-2005

  • von Bergen, M. , Barghorn, S., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
    Tau aggregation is driven by a transition from random coil to beta sheet structure
    Biochim Biophys Acta 1739, 158-166
    http://dx.doi.org/10.1016/j.bbadis.2004.09.010
  • Pickhardt, M., von Bergen, M. , Gazova, Z., Hascher, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
    Screening for inhibitors of tau polymerization
    Curr Alzheimer Res 2, 219-226
    http://dx.DOI.ORG/10.2174/1567205053585891
  • Pickhardt, M., Gazova, Z., von Bergen, M. , Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (2005):
    Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
    J Biol Chem 280, 3628-3635
    http://dx.doi.org/10.1074/jbc.M410984200
  • Mukrasch, M. D., Biernat, J., von Bergen, M. , Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2005):
    Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions
    J Biol Chem 280, 24978-24986
    http://dx.doi.org/10.1074/jbc.M501565200
  • Li, L., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2002):
    Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis
    J Biol Chem 277, 41390-41400
    http://dx.doi.org/10.1074/jbc.M206334200
  • von Bergen, M. , Barghorn, S., Li, L., Marx, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2001):
    Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
    J Biol Chem 276, 48165-48174
    http://dx.doi.org/10.1074/jbc.M105196200
  • von Bergen, M. , Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E. M., and Mandelkow, E. (2000):
    Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
    Proc Natl Acad Sci U S A 97, 5129-5134
    http://www.pnas.org/content/97/10/5129.abstract
  • Friedhoff, P., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
    Structure of tau protein and assembly into paired helical filaments
    Biochim Biophys Acta 1502, 122-132
    http://dx.doi.org/10.1016/S0925-4439(00)00038-7
  • Barghorn, S., Zheng-Fischhofer, Q., Ackmann, M., Biernat, J., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
    Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
    Biochemistry 39, 11714-11721
    http://dx.doi.org/bi000850r
  • Schneider, A., Biernat, J., von Bergen, M. , Mandelkow, E., and Mandelkow, E. M. (1999):
    Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
    Biochemistry 38, 3549-3558
    http://www.ncbi.nlm.nih.gov/pubmed/10995239
  • Friedhoff, P., von Bergen, M. , Mandelkow, E. M., Davies, P., and Mandelkow, E. (1998):
    A nucleated assembly mechanism of Alzheimer paired helical filaments
    Proc Natl Acad Sci U S A 95, 15712-15717
    http://dx.doi.org/10.1016/S0925-4439(00)00038-7