Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.3389/fimmu.2024.1416543 |
Licence  |
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| Title (Primary) | Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity |
| Author | Radushev, V.; Karkossa, I.; Berg, J.; von Bergen, M.; Engelmann, B.; Rolle-Kampczyk, U.E.; Blüher, M.; Wagner, U.; Schubert, K.; Rossol, M. |
| Source Titel | Frontiers in Immunology |
| Year | 2024 |
| Department | iDiv; MOLTOX |
| Volume | 15 |
| Page From | art. 1416543 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1416543/full#supplementary-material |
| Keywords | monocytes; immunometabolism; respiratory burst, obesity; IL-8 |
| Abstract | Introduction: Obesity is associated with a plethora of health
complications, including increased susceptibility to infections or
decreased vaccine efficacy, partly due to dysregulated immune responses.
Monocytes play a crucial role in innate immunity, yet their functional
alterations in obesity remain poorly understood. Methods: Here, we employed proteomic and metabolomic analyses to investigate monocyte characteristics in individuals with overweight, obesity, impaired glucose tolerance (IGT), and type 2 diabetes (T2D), compared to lean donors. Results and discussion: Our results revealed distinct molecular signatures in monocytes from individuals with obesity, with significant alterations in pathways related to metabolism, cellular migration, and phagocytosis. Moreover, LPS-induced activation of monocytes unveiled heightened metabolic reprogramming towards glycolysis in subjects with obesity accompanied by dysregulated cytokine responses and elevated oxidative stress. Additionally, monocytes from donors with obesity exhibited increased lipid droplet accumulation. These findings shed light on the immunometabolic dysregulation underlying obesity-associated immune dysfunction, highlighting potential targets for therapeutic intervention. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29298 |
| Radushev, V., Karkossa, I., Berg, J., von Bergen, M., Engelmann, B., Rolle-Kampczyk, U.E., Blüher, M., Wagner, U., Schubert, K., Rossol, M. (2024): Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity Front. Immunol. 15 , art. 1416543 10.3389/fimmu.2024.1416543 |
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