Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1126/science.1233521
Title (Primary) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Author Markle, J.G.M.; Frank, D.N.; Mortin-Toth, S.; Robertson, C.E.; Feazel, L.M.; Rolle-Kampczyk, U.; von Bergen, M.; McCoy, C.D.; Macpherson, A.J.; Danska, J.S.
Source Titel Science
Year 2013
Department METABOX; PROTEOM
Volume 339
Issue 6123
Page From 1084
Page To 1088
Language englisch
UFZ wide themes RU3;
Abstract Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. We demonstrate that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D. Transfer of gut microbiota from adult males to immature females altered the recipient's microbiota, resulting in elevated testosterone and metabolomic changes, reduced islet inflammation and autoantibody production, and robust T1D protection. These effects were dependent on androgen receptor activity. Thus, the commensal microbial community alters sex hormone levels and regulates autoimmune disease fate in individuals with high genetic risk.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13487
Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M., Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S. (2013):
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Science 339 (6123 ), 1084 - 1088