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Title (Primary) Metabotypes with properly functioning mitochondria and antiinflammation predict extended productive life span in dairy cows
Author Huber, K.; Dänicke, S.; Rehage, J.; Sauerwein, H.; Otto, W.; Rolle-Kampczyk, U.; von Bergen, M.;
Journal Scientific Reports
Year 2016
Department IMMU; MOLSYB;
Volume 6
Language englisch;
POF III (all) F11; T42;
UFZ wide themes RU3;
Abstract The failure to adapt metabolism to the homeorhetic demands of lactation is considered as a main factor in reducing the productive life span of dairy cows. The so far defined markers of production performance and metabolic health in dairy cows do not predict the length of productive life span satisfyingly. This study aimed to identify novel pathways and biomarkers related to productive life in dairy cows by means of (targeted) metabolomics. In a longitudinal study from 42 days before up to 100 days after parturition, we identified metabolites such as long-chain acylcarnitines and biogenic amines associated with extended productive life spans. These metabolites are mainly secreted by the liver and depend on the functionality of hepatic mitochondria. The concentrations of biogenic amines and some acylcarnitines differed already before the onset of lactation thus indicating their predictive potential for continuation or early ending of productive life.
ID 17349
Persistent UFZ Identifier http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17349
Huber, K., Dänicke, S., Rehage, J., Sauerwein, H., Otto, W., Rolle-Kampczyk, U., von Bergen, M. (2016):
Metabotypes with properly functioning mitochondria and antiinflammation predict extended productive life span in dairy cows
Sci. Rep. 6 , art. 24642