Sven-Bastiaan Haange

Sven-Bastiaan Haange
PhD student

Department of Molecular Systems Biology
Helmholtz Centre
for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: 0341 235 1355
Fax:0341 2351786

sven.haange@ufz.de

sven

Research field

The microbiome of the gastro-intestinal tract is a complex and varied community of microorganisms, whose main contingent consists of bacteria. It is the most densely populated ecosystem known. A human host carries 10 times as many enterobacteria then his or her own somatic cells. The interactions between host and microbiome are manifold. The major functions of the microbiome include metabolizing a number of substrates into metabolites which the host can absorb and utilize, the synthesis of some vitamins useful for the host and the maturation of the immune system.
My PhD-thesis is part of the research project titled “The effect of bariatric surgery on the microbiome of the gastro-intestinal tract in rats with diet induced obesity". This is a cooperation project within the Integrated Centre for Research and Treatment of Adiposities Disorders between the Department of Pediatric Surgery at the University Hospital Leipzig and the Department of Proteomics at the Helmholtz Centre for Environmental Research. Bariatric surgery is performed on obese patients to reduce and limit their nutrient uptake. This leads to a permanent reduction in body weight. The topic of my thesis is to investigate changes in the microbiome of the gastro-intestinal tract in rats after bariatric surgery. With the help of the Protein-stable isotope probing (Protein-Sip) method, developed by the Department of Proteomics at the Helmholtz Centre for Environmental Research, changes in the proteome and metabolic flux in the microbiota and between the host rat and microbiota can be analyzed.


Curriculum vitae

from 2011

PhD student in the Department of Molecular Systems Biology at the Helmholtz Centre for Environment Research and in the Department of Pediatric Surgery at the University Hospital Leipzig

2009 - 2010

Diploma thesis titled “Analysis of nitrogen metabolism in Ralstonia eutropha” at the Institute of Microbiology, Division of Microbial Physiology and Molecular Biology, University of Greifswald.

2006 - 2010

Studied biochemistry at the Institut for Biochemistry, Ernst-Moritz Arndt University of Greifswald


Publications

Index:

2018 (1)
2017 (2)
2016 (3)
2015 (2)
2013 (1)
2012 (1)

You could use our publication index for further requests.

2018 (1)

  • Chupani, L., Niksirat, H., Lünsmann, V., Haange, S.-B., von Bergen, M., Jehmlich, N., Zuskova, E., (2018):
    Insight into the modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles
    Sci. Total Environ. 613-614 , 62 - 71
    full text (url)
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2017 (2)

  • Chupani, L., Zusková, É., Niksirat, H., Panáček, A., Lünsmann, V., Haange, S.-B., von Bergen, M., Jehmlich, N., (2017):
    Effects of chronic dietary exposure of zinc oxide nanoparticles on the serum protein profile of juvenile common carp (Cyprinus carpio L.)
    Sci. Total Environ. 579 , 1504 - 1511
    full text (url)
  • Oberbach, A., Haange, S.-B., Schlichting, N., Heinrich, M., Lehmann, S., Till, H., Hugenholtz, F., Kullnick, Y., Smidt, H., Frank, K., Seifert, J., Jehmlich, N., von Bergen, M., (2017):
    Metabolic in vivo labeling highlights differences of metabolically active microbes from the mucosal gastrointestinal microbiome between high-fat and normal chow diet
    J. Proteome Res. 16 (4), 1593 - 1604
    full text (url)
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2016 (3)

  • Haange, S.-B., Jehmlich, N., (2016):
    Proteomic interrogation of the gut microbiota: potential clinical impact
    Expert Rev. Proteomics 13 (6), 535 - 537
    full text (url)
  • Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S.B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., von Bergen, M., Bleich, A., Haller, D., (2016):
    Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
    Gut 65 , 225 - 237
    full text (url)
  • Wissenbach, D.K., Oliphant, K., Rolle-Kampczyk, U., Yen, S., Höke, H., Baumann, S., Haange, S.B., Verdu, E.F., Allen-Vercoe, E., von Bergen, M., (2016):
    Optimization of metabolomics of defined in vitro gut microbial ecosystems
    Int. J. Med. Microbiol. 306 (5), 280 - 289
    full text (url)
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2015 (2)

  • Müller, S.A., Pernitzsch, S.R., Haange, S.-B., Uetz, P., von Bergen, M., Sharma, C.M., Kalkhof, S., (2015):
    Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori
    J. Proteomics 126 , 34 - 45
    full text (url)
  • Schaubeck, M., Clavel, T., Lagkouvardos, M., Calasan, J., Haange, S.B., Jehmlich, N., von Bergen, M., Basic, M., Bleich, A., Haller, D., (2015):
    Transmissive Crohn's disease-like ileitis is caused by functional dysbiosis in the intestinal microbiota independent of inflammation-driven Paneth cell failure
    J. Crohns Colitis 9 (Suppl. 1), S1 - S1
    full text (url)
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2013 (1)

  • Ferrer, M., Ruiz, A., Lanza, F., Haange, S.-B., Oberbach, A., Till, H., Bargiela, R., Campoy, C., Segura, M.T., Richter, M., von Bergen, M., Seifert, J., Suarez, A., (2013):
    Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure
    Environ. Microbiol. 15 (1), 211 - 226
    full text (url)
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2012 (1)

  • Haange, S.-B., Oberbach, A., Schlichting, N., Hugenholtz, F., Smidt, H., von Bergen, M., Till, H., Seifert, J., (2012):
    Metaproteome analysis and molecular genetics of rat intestinal microbiota reveals section and localisation resolved species distribution and enzymatic functionalities
    J. Proteome Res. 11 (11), 5406 - 5417
    full text (url)
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