The microbiome of the gastro-intestinal tract is a complex and varied community of microorganisms, whose main contingent consists of bacteria. It is the most densely populated ecosystem known. A human host carries 10 times as many enterobacteria then his or her own somatic cells. The interactions between host and microbiome are manifold. The major functions of the microbiome include metabolizing a number of substrates into metabolites which the host can absorb and utilize, the synthesis of some vitamins useful for the host and the maturation of the immune system.
My PhD-thesis is part of the research project titled “The effect of bariatric surgery on the microbiome of the gastro-intestinal tract in rats with diet induced obesity". This is a cooperation project within the Integrated Centre for Research and Treatment of Adiposities Disorders between the Department of Pediatric Surgery at the University Hospital Leipzig and the Department of Proteomics at the Helmholtz Centre for Environmental Research. Bariatric surgery is performed on obese patients to reduce and limit their nutrient uptake. This leads to a permanent reduction in body weight. The topic of my thesis is to investigate changes in the microbiome of the gastro-intestinal tract in rats after bariatric surgery. With the help of the Protein-stable isotope probing (Protein-Sip) method, developed by the Department of Proteomics at the Helmholtz Centre for Environmental Research, changes in the proteome and metabolic flux in the microbiota and between the host rat and microbiota can be analyzed.
You could use our publication index for further requests.