Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1136/gutjnl-2023-330365
Licence creative commons licence
Title (Primary) Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Author Medawar, E.; Beyer, F.; Thieleking, R.; Haange, S.-B. ORCID logo ; Rolle-Kampczyk, U.; Reinicke, M.; Chakaroun, R.; von Bergen, M.; Stumvoll, M.; Villringer, A.; Witte, A.V.
Source Titel Gut
Year 2024
Department MOLTOX
Volume 73
Issue 2
Page From 298
Page To 310
Language englisch
Topic T9 Healthy Planet
Data and Software links https://doi.org/10.17605/OSF.IO/FC2G4
Supplements https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/0/gutjnl-2023-330365supp001_data_supplement.pdf
https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/1/gutjnl-2023-330365supp002_data_supplement.pdf
https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/2/gutjnl-2023-330365supp003_data_supplement.pdf
https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/3/gutjnl-2023-330365supp004_data_supplement.pdf
https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/4/gutjnl-2023-330365supp005_data_supplement.pdf
https://gut.bmj.com/highwire/filestream/257456/field_highwire_adjunct_files/5/gutjnl-2023-330365supp006_data_supplement.pdf
Abstract

Objective Animal studies suggest that prebiotic, plant-derived nutrients could improve homoeostatic and hedonic brain functions through improvements in microbiome–gut–brain communication. However, little is known if these results are applicable to humans. Therefore, we tested the effects of high-dosed prebiotic fibre on reward-related food decision-making in a randomised controlled within-subject cross-over study and assayed potential microbial and metabolic markers.

Design 59 overweight young adults (19 females, 18–42 years, body mass index 25–30 kg/m2) underwent functional task MRI before and after 14 days of supplementary intake of 30 g/day of inulin (prebiotics) and equicaloric placebo, respectively. Short chain fatty acids (SCFA), gastrointestinal hormones, glucose/lipid and inflammatory markers were assayed in fasting blood. Gut microbiota and SCFA were measured in stool.

Results Compared with placebo, participants showed decreased brain activation towards high-caloric wanted food stimuli in the ventral tegmental area and right orbitofrontal cortex after prebiotics (preregistered, family wise error-corrected p <0.05). While fasting blood levels remained largely unchanged, 16S-rRNA sequencing showed significant shifts in the microbiome towards increased occurrence of, among others, SCFA-producing Bifidobacteriaceae, and changes in >60 predicted functional signalling pathways after prebiotic intake. Changes in brain activation correlated with changes in Actinobacteria microbial abundance and associated activity previously linked with SCFA production, such as ABC transporter metabolism.

Conclusions In this proof-of-concept study, a prebiotic intervention attenuated reward-related brain activation during food decision-making, paralleled by shifts in gut microbiota.

Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=27563
Medawar, E., Beyer, F., Thieleking, R., Haange, S.-B., Rolle-Kampczyk, U., Reinicke, M., Chakaroun, R., von Bergen, M., Stumvoll, M., Villringer, A., Witte, A.V. (2024):
Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Gut 73 (2), 298 - 310