Functional Metabolomics group - Helmholtz-Centre for Environmental Research

Functional Metabolomics

The metabolome of an organism is influenced by many different genetic and environmental factors. Thus, it depicts a complex and dynamic picture of characteristic properties of the metabolism. Our team focuses on the analysis of metabolites from intestinal microbiome as well as the metabolome of the host (Human samples from cohorts and animal models). We are interested in changes in metabolites due to external stress factors (like diseases, environmental pollutants, chemicals, drugs, diet etc.). Targeted and untargeted metabolomics approaches in combination with other OMCIS-techniques established in our working group (16S rRNA gene profiling, Metatranskriptomics, isotopic tracer analysis) are used to investigate these research questions.

Overview

Team

Leader
Rolle-Kampczyk, Dr. Ulrike E.	0341/60251537	ulrike.rolle-kampczyk@ufz.de

Scientists
Engelmann, Dr. Beatrice	0341/60251099	beatrice.engelmann@ufz.de
Haange, Dr. Sven	0341/60251193	sven.haange@ufz.de
Nabhan Homsi, Prof. Dr. Masun		masun.homsi@ufz.de

PhD students
Neuheuser, Friederike	0341/60251541	friederike.neuheuser@ufz.de
Goerdeler, Cornelius	0341/60252713	cornelius.goerdeler@ufz.de

Technicians
Pleßow, Olivia	0341/60254677	olivia.plessow@ufz.de
Bock, Nicole	0341/60254676	nicole.bock@ufz.de

Publicationen

Equipment

Cooperation partners

Higher education institutes
University of Leipzig	SFB 1052 Mechanisms of Obesity
RWTH Aachen	SFB 1352 The Intestinal-Liver Axis - Functional Relationships and Therapeutic Strategies

Research institutions
Max Planck Institute for Human Cognitive and Brain Sciences	Microbiome-Gut-Brain-Axis
Helmholtz Institute for Metabolic, Obesety and Vascular Research, HI-MAG
Christian-Albrechts-University Kiel	Institute for Medical Systems Biology
University Hospital Bonn	Section of Endocrinology, Diabetology and Metabolic Medicine
Interdisciplinary Centre for Clinical Research IZKF Erlangen
Fraunhofer IZI / Coburg University of Applied Sciences
German Aerospace Centre
Julius Kühn Institute for Bee Research JKI Braunschweig

Economy
Novo Nordisk Foundation	MATOMIC - Mathematicical Modelling of Health and Disease

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Recent Publications

2025 (16)

Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Seitz, H., Mockly, S., Kamp, H., Haake, V., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2025):
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
Arch. Toxicol. 99 (1), 309 - 332 10.1007/s00204-024-03876-2
Castañeda-Monsalve, V., Haange, S.-B., Fröhlich, L.-F., Fu, Q., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2025):
Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system
ISME Commun. 5 (1), ycaf050 10.1093/ismeco/ycaf050
Ghosh, D., Shi, Y., Zimmermann, I.M., Holzhauser, K., von Bergen, M., Kaster, A.-K., Spielvogel, S., Dippold, M.A., Müller, J.A., Jehmlich, N. (2025):
Cover crop root channels promote bacterial adaptation to drought in the maize rhizosphere
bioRxiv 10.1101/2025.05.05.651044
Gómez-Olarte, S., Röder, S., Rolle-Kampczyk, U., Sack, U., von Bergen, M., Borte, M., Zenclussen, A.C., Herberth, G. (2025):
Prenatal exposure to mixtures of phthalates and bisphenol A and eczema risk: findings in atopic and non-atopic children from the LiNA birth cohort
Environ. Res. 278 , art. 121667 10.1016/j.envres.2025.121667
Gwak, J.-H., Olabisi, A., Lee, U.-J., Abiola, C., Lee, S., Do, H., Choi, Y.J., Lee, J.-J., Jung, M.-Y., Jehmlich, N., von Bergen, M., Wagner, M., Awala, S.I., Quan, Z.-X., Rhee, S.-K. (2025):
Hypoosmolarity inhibits archaeal ammonia oxidation
bioRxiv 10.1101/2025.07.07.663500
Hagemann, T., Rolle-Kampczyk, U., Schubert, K., Dietrich, A., von Bergen, M., Blüher, M., Hoffmann, A. (2025):
Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure
Environ. Adv. 21 , art. 100655 10.1016/j.envadv.2025.100655
Heyer, R., Wolf, M., Benndorf, D., Uzzau, S., Seifert, J., Grenga, L., Pabst, M., Schmitt, H., Mesuere, B., Van Den Bossche, T., Haange, S.-B., Jehmlich, N., Di Luca, M., Ferrer, M., Serrano-Villar, S., Armengaud, J., Bode, H.B., Hellwig, P., Masselot, C.R., Léonard, R., Wilmes, P. (2025):
Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes
Microbiome 13 , art. 134 10.1186/s40168-025-02119-5
Kakavas, D., Engelmann, B., Krauss, M., Rolle-Kampczyk, U.E., Rochfort, K.D., Grintzalis, K. (2025):
Excreted metabolite nanocoronas impact metabolic and toxicity responses of daphnids to silver nanoink
Environ. Res. 283 , art. 122131 10.1016/j.envres.2025.122131
Kronstein-Wiedemann, R., Thiel, J., Brändle, D., Sürün, D., Teichert, M., Künzel, S.R., Schubert, K., Friedrich, U., Dahl, A., Buchholz, F., Hölig, K., Tonn, T. (2025):
Restoration of actin network dynamics by scinderin knockout in immortalized erythroid cells plays a key role in effective blood pharming
Cytotherapy 27 (5), S97 10.1016/j.jcyt.2025.03.186
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306
Pieńkowska, A., Fleischmann, J., Drabesch, S., Merbach, I., Wang, G., Nunes da Rocha, U., Reitz, T., Muehe, E.M. (2025):
Long-term organic fertilization shields soil prokaryotes from metal stress while mineral fertilization exacerbates it
Environ. Pollut. 382 , art. 126747 10.1016/j.envpol.2025.126747
Reddy, L.R., Egerter, C., Jehmlich, N., Fiskal, A., Helmholz, L., Castronovo, S., Schweyen, P., Wulf, S.-E., Ternes, T., Wick, A., Meier, J. (2025):
New insights in the metabolic functions of freshwater sulfate reducing communities during steel corrosion by biophysicochemical, 16S rRNA gene sequence and metaproteomic analysis
Int. Biodeterior. Biodegrad. 198 , art. 105995 10.1016/j.ibiod.2024.105995
Schlößer, S., Ullrich, A.-L., Modares, N.F., Schmitz, M.A., Schöneich, J., Zhang, K., Richter, I., Robrahn, L., Schraven, S., Nagai, J.S., Haange, S.-B., Jennings, S.A.V., Clavel, T., Rolle-Kampczyk, U., Kiessling, F., Costa, I.G., Muncan, V., Repnik, U., von Bergen, M., Dupont, A., Hornef, M.W. (2025):
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
Proc. Natl. Acad. Sci. U.S.A. 122 (1), e2403344122 10.1073/pnas.2403344122
Tanca, A., Schallert, K., Grenga, L., Peters, S.L., Abbondio, M., De Diego, L., Deledda, M.A., Haange, S.-B., Miotello, G., Sáenz, J.S., Wolf, M., Bastida, F., Devos, S., Hernandez-Raquet, G., Seifert, J., Wilmes, P., Van Den Bossche, T., Kunath, B.J., Heyer, R., Jehmlich, N., Benndorf, D., Hettich, R.L., Armengaud, J., Uzzau, S. (2025):
Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
bioRxiv 10.1101/2025.01.31.635836
Van Den Bossche, T., Armengaud, J., Benndorf, D., Blakeley-Ruiz, J.A., Brauer, M., Cheng, K., Creskey, M., Figeys, D., Grenga, L., Griffin, T.J., Henry, C., Hettich, R.L., Holstein, T., Jagtap, P.D., Jehmlich, N., Kim, J., Kleiner, M., Kunath, B.J., Malliet, X., Martens, L., Mehta, S., Mesuere, B., Ning, Z., Tanca, A., Uzzau, S., Verschaffelt, P., Wang, J., Wilmes, P., Zhang, X., Zhang, X., Li, L., The Metaproteomics Initiative, (2025):
The microbiologist's guide to metaproteomics
iMeta 4 (3), e70031 10.1002/imt2.70031