Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1038/s41598-025-08238-1 |
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| Title (Primary) | The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis |
| Author | Murad, M.; Reuken, P.A.; Schubert, K.; Reißing, J.; Ibidapo-Obe, O.; Große, K.; Frissen, M.; Haedge, F.; El-Hassani, M.; von Bergen, M.; Bruns, T. |
| Source Titel | Scientific Reports |
| Year | 2025 |
| Department | MOLTOX |
| Volume | 15 |
| Page From | art. 25714 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Keywords | Cirrhosis; Ascites; HDL; Apolipoprotein A-II; Apolipoprotein A-I |
| Abstract | Apolipoproteins (Apo) A-I and A-II are major components of high-density lipoproteins (HDL) with immunomodulatory functions. Low serum apoA-I levels indicate complications of cirrhosis. We hypothesized that HDL-associated apolipoproteins in ascitic fluid (AF) are differentially abundant during spontaneous bacterial peritonitis (SBP). Serum and non-infected AF samples from 18 patients with cirrhosis (cohort 1) were analyzed using LC–MS/MS to identify differentially regulated apolipoproteins. In cohort 2, samples from 59 patients with SBP and 59 without were analyzed for AF apoA-II and apoA-I concentrations using ELISA, and cumulative 90-day transplant-free survival was analyzed. Proteomic analysis indicated depletion of AF apoA-II in the absence of SBP. Lower AF apoA-II and apoA-I correlated with lower AF protein and albumin, higher serum bilirubin, and lower platelets. During SBP, AF apoA-II levels significantly increased, leading to higher apoA-II/apoA-I ratios. AF apoA-II, but not apoA-I, correlated with peritoneal IL-6 concentrations. AF apoA-II > 45 µg/ml during SBP indicated an increased risk of death or transplantation within 90 days and remained a predictor of transplant or death after adjustment for age and MELD (adjusted hazard ratio, 2.59; 95% CI, 1.08–5.91; P = 0.032). In summary, the composition of HDL-associated apolipoproteins in ascites is altered during SBP and correlates with disease course. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=31136 |
| Murad, M., Reuken, P.A., Schubert, K., Reißing, J., Ibidapo-Obe, O., Große, K., Frissen, M., Haedge, F., El-Hassani, M., von Bergen, M., Bruns, T. (2025): The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis Sci. Rep. 15 , art. 25714 10.1038/s41598-025-08238-1 |
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