Research Topics

Toxicoproteomics group

Analysis of the cellular transcriptome, proteome and metabolome of immune cells and adipocytes in health and disease with a focus on the effects of environmental contaminants.

The degradation efficiency of bacteria in different environmental compartments depends on the complex interactions in the microbial communities. In addition, processes mediated by the endogenous microbiome play an important role in metabolic diseases.

Influence on the metabolome

Microbiome

Microbiome – taxonomic community and functional structure and its metabolic crosstalk with the host

Human cohort studies

Metabolic screening in human cohort studies

Analytical methods

working group logo

Link to guest editorship at the journal Metabolites for the special issue entitled "Bile Acid Metabolism and Gut Microbiota"

Methods development

Development of new proteomic and metabolomic technics

Department News

Final Thesis

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Recent Publications

2025 (11)

Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Seitz, H., Mockly, S., Kamp, H., Haake, V., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2025):
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
Arch. Toxicol. 99 (1), 309 - 332 10.1007/s00204-024-03876-2
Castañeda-Monsalve, V., Haange, S.-B., Fröhlich, L.-F., Fu, Q., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2025):
Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system
ISME Commun. 5 (1), ycaf050 10.1093/ismeco/ycaf050
Ghosh, D., Shi, Y., Zimmermann, I.M., Holzhauser, K., von Bergen, M., Kaster, A.-K., Spielvogel, S., Dippold, M.A., Müller, J.A., Jehmlich, N. (2025):
Cover crop root channels promote bacterial adaptation to drought in the maize rhizosphere
bioRxiv 10.1101/2025.05.05.651044
Gómez-Olarte, S., Röder, S., Rolle-Kampczyk, U., Sack, U., von Bergen, M., Borte, M., Zenclussen, A.C., Herberth, G. (2025):
Prenatal exposure to mixtures of phthalates and bisphenol A and eczema risk: findings in atopic and non-atopic children from the LiNA birth cohort
Environ. Res. 278 , art. 121667 10.1016/j.envres.2025.121667
Kronstein-Wiedemann, R., Thiel, J., Brändle, D., Sürün, D., Teichert, M., Künzel, S.R., Schubert, K., Friedrich, U., Dahl, A., Buchholz, F., Hölig, K., Tonn, T. (2025):
Restoration of actin network dynamics by scinderin knockout in immortalized erythroid cells plays a key role in effective blood pharming
Cytotherapy 27 (5), S97 10.1016/j.jcyt.2025.03.186
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306
Reddy, L.R., Egerter, C., Jehmlich, N., Fiskal, A., Helmholz, L., Castronovo, S., Schweyen, P., Wulf, S.-E., Ternes, T., Wick, A., Meier, J. (2025):
New insights in the metabolic functions of freshwater sulfate reducing communities during steel corrosion by biophysicochemical, 16S rRNA gene sequence and metaproteomic analysis
Int. Biodeterior. Biodegrad. 198 , art. 105995 10.1016/j.ibiod.2024.105995
Schlößer, S., Ullrich, A.-L., Modares, N.F., Schmitz, M.A., Schöneich, J., Zhang, K., Richter, I., Robrahn, L., Schraven, S., Nagai, J.S., Haange, S.-B., Jennings, S.A.V., Clavel, T., Rolle-Kampczyk, U., Kiessling, F., Costa, I.G., Muncan, V., Repnik, U., von Bergen, M., Dupont, A., Hornef, M.W. (2025):
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
Proc. Natl. Acad. Sci. U.S.A. 122 (1), e2403344122 10.1073/pnas.2403344122
Tanca, A., Schallert, K., Grenga, L., Peters, S.L., Abbondio, M., De Diego, L., Deledda, M.A., Haange, S.-B., Miotello, G., Sáenz, J.S., Wolf, M., Bastida, F., Devos, S., Hernandez-Raquet, G., Seifert, J., Wilmes, P., Van Den Bossche, T., Kunath, B.J., Heyer, R., Jehmlich, N., Benndorf, D., Hettich, R.L., Armengaud, J., Uzzau, S. (2025):
Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
bioRxiv 10.1101/2025.01.31.635836
Van Den Bossche, T., Armengaud, J., Benndorf, D., Blakeley-Ruiz, J.A., Brauer, M., Cheng, K., Creskey, M., Figeys, D., Grenga, L., Griffin, T.J., Henry, C., Hettich, R.L., Holstein, T., Jagtap, P.D., Jehmlich, N., Kim, J., Kleiner, M., Kunath, B.J., Malliet, X., Martens, L., Mehta, S., Mesuere, B., Ning, Z., Tanca, A., Uzzau, S., Verschaffelt, P., Wang, J., Wilmes, P., Zhang, X., Zhang, X., Li, L., The Metaproteomics Initiative, (2025):
The microbiologist's guide to metaproteomics
iMeta 10.1002/imt2.70031