Dr. rer. nat. Ulrike E. Rolle-Kampczyk
Arbeitsgruppenleiterin AG "Funktionelle Metabolomik"
Fachchemikerin für Toxikologie & Umweltschutz,
Fachchemikerin für Analytik & Spektroskopie
Kontakt
Helmholtz-Zentrum für Umweltforschung - UFZ
Permoserstr. 15
04318 Leipzig, Germany
Tel: 0341 6025 1537
Wissenschaftsnetzwerk
Forschungsschwerpunkte
Zielgerichtete und nichtzielgerichtete Metabolomik
Metabolomik des intestinalen Microbioms und mikrobieller Gemeinschaften
Biomonitoring/Biotransormation
Lebenslauf
2024 -
2016 - 2023
2009 - 2015
Department Molekulare Toxikologie
Arbeitsgruppenleiterin der Gruppe "Functional Metabolomics" , Helmholtz-Zentrum für Umweltforschung, UFZ, Leipzig, Deutschland
Zielgerichtete und nichtzielgerichtete Metabolomik in verschiedenen biologischen Matrices gewonnen aus Kohorten und Modellsystemen, Fokus metabolomische Wechselwirkungen mikrobieller Gemeinschaft und Host - Wirts Interaktionen
Department Molekulare Systembiologie
Arbeitsgruppenleiterin der Gruppe "Functional Metabolomics" , Helmholtz-Zentrum für Umweltforschung, UFZ, Leipzig, Deutschland
Untersuchung von schadstoffbedingetn Effekten in Kohortenstudien und Untersuchung Wirkungen von Umwelteinflüssen, Erkrankungen und Lebensstil auf den endogenen Metabolismus in Kohorten und Modelsystemen
Wissenschaftliche Mitarbeiterin, Department Metabolomics, Helmholtz-Zentrum für Umweltforschung, UFZ, Leipzig, Deutschland
Thema: „Untersuchung von Zusammenhängen zwischen Lebensstilfaktoren auf die Schadstoffmetabolitenelimination und Metabolomänderungen auf die Gesundheit"
1996 - 2009
Wissenschaftliche Mitarbeiterin, Department Expositionsforschung und Epidemiologie, Helmholtz-Zentrum für Umweltforschung, UFZ, Leipzig, Deutschland
Thema: „Innere Belastung und Differentialdiagnose zur Anwendung in der Umweltmedizin“
1993-1995
Postdoc, Sektion Expositionsforschung und Epidemiologie, Helmholtz-Zentrum für Umweltforschung, UFZ, Leipzig, Deutschland
Thema: „Entwicklung und Erprobung von 15N Diagnostika zur Untersuchung von Störungen des enterohepatischen Kreislauf in Menschen“
Mitarbeit in epidemiologischen Studien unter Anwendung stabilisotoper Funktionstests
1991-1992
Wissenschaftliche Mitarbeiterin, Fakultät für Physik, Universität Leipzig, Deutschland
Thema: “PFG-NMR Messungen an Kieselgelen“
1988-1991
Industrieaspirantur Arzneimittelwerk Dresden, Dissertation (Dr. rer. nat.) Fakultät für Chemie, Universität Leipzig, Deutschland
Thema: “Synthese substitutierter 9-Azabicyclononane”
1988
Diplom Fakultät für Chemie, Universität Leipzig, Deutschland
Thema: "Synthese von 5-Acylamino-2-arylureido- und 2,5-Diacylaminophenolen und Untersuchung ihrer blaugrünen Indoanilinfarbstoffe"
Kooperationen / Projekte
Department Umweltimmunologie, UFZ Leipzig
Arbeitsgruppe Core Facility und Studien am Helmholtzzentrum für Umweltforschung (UFZ Leipzig)
Universität Leipzig, Fachbereich Medizin (SFB 1052 Adipositas)
RWTH Aachen (SFB 1382 Gut-Liver Axis)
Lehrkrankenhaus St. Georg Leipzig, Klinik für Kinder- und Jugendmedizin
Helmholtzzentrum München, Institut für Epidemiologie
DIfE Potsdam
DKFZ Heidelberg
University of Toronto, Faculty of Medicine, Canada
Universität Bern, Department Klinische Forschung, Schweiz
Universität Hohenheim
Max Planck Institut für Evolutionsbiologie, Plön,
Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke
Publikationen
2024 (17)
- Aldehoff, A.S., Karkossa, I., Goerdeler, C., Krieg, L., Schor, J., Engelmann, B., Wabitsch, M., Landgraf, K., Hackermüller, J., Körner, A., Rolle-Kampczyk, U., Schubert, K., von Bergen, M. (2024):
Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis
iScience 27 (6), art. 109711 10.1016/j.isci.2024.109711 - Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Pozhidaeva, M., Seitz, H., Kamp, H., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2024):
Enhancing toxicological insights through multi-omics: a case study on direct and indirect thyroid toxicity
Toxicol. Lett. 399 (Suppl. 2), S61 - S62 10.1016/j.toxlet.2024.07.171 - Castañeda-Monsalve, V., Fröhlich, L.-F., Haange, S.-B., Homsi, M.N., Rolle-Kampczyk, U., Fu, Q., von Bergen, M., Jehmlich, N. (2024):
High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): A metaproteomic and metabolomic study
Front. Microbiol. 15 , art. 1349367 10.3389/fmicb.2024.1349367 - Fischer, F., Pierzchalski, A., Riesbeck, S., Aldehoff, A.S., Castañeda-Monsalve, V., Haange, S.-B., von Bergen, M., Rolle-Kampczyk, U.E., Jehmlich, N., Zenclussen, A.C., Herberth, G. (2024):
An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures
Front. Immunol. 15 , art. 1298971 10.3389/fimmu.2024.1298971 - Goerdeler, C., Engelmann, B., Aldehoff, A.S., Schaffert, A., Blüher, M., Heiker, J.T., Wabitsch, M., Schubert, K., Rolle-Kampczyk, U., von Bergen, M. (2024):
Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism
Environ. Res. 252 , art. 118847 10.1016/j.envres.2024.118847 - Haange, S.-B., Riesbeck, S., Aldehoff, A.S., Engelmann, B., Jensen Pedersen, K., Castañeda-Monsalve, V., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2024):
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
J. Hazard. Mater. 474 , art. 134683 10.1016/j.jhazmat.2024.134683 - Huber, C., Brack, W., Röder, S., von Bergen, M., Rolle-Kampczyk, U., Zenclussen, A.C., Krauss, M., Herberth, G. (2024):
Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns
Environ. Int. 191 , art. 108981 10.1016/j.envint.2024.108981 - Huillet, M., Lasserre, F., Gratacap, M.-P., Engelmann, B., Bruse, J., Polizzi, A., Fougeray, T., Martin, C.M.P., Rives, C., Fougerat, A., Naylies, C., Lippi, Y., Garcia, G., Rousseau-Bacquie, E., Canlet, C., Debrauwer, L., Rolle-Kampczyk, U., von Bergen, M., Payrastre, B., Boutet-Robinet, E., Gamet-Payrastre, L., Guillou, H., Loiseau, N., Ellero-Simatos, S. (2024):
Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism
JHEP Rep. 6 (1), art. 100930 10.1016/j.jhepr.2023.100930 - Jaeger, J.W., Brandt, A., Gui, W., Yergaliyev, T., Hernández-Arriaga, A., Muthu, M.M., Edlund, K., Elashy, A., Molinaro, A., Möckel, D., Sarges, J, Halibasic, E., Trauner, M., Kahles, F., Rolle-Kampczyk, U., Hengstler, J., Schneider, C.V., Lammers, T., Marschall, H.-U., von Bergen, M., Camarinha-Silva, A., Bergheim, I., Trautwein, C., Schneider, K.M. (2024):
Microbiota modulation by dietary beta-glucan prevents steatotic liver disease progression
JHEP Rep. 6 (3), art. 100987 10.1016/j.jhepr.2023.100987 - Jax, M., Weßendorf, A., Lichter, J., Stief, L., Lobes, N., Egele, K., Rolle-Kampczyk, U., Engelmann, B., von Bergen, M., Bock, U., Blömeke, B. (2024):
Response of innate immune cells and alveolar type 1 cell line to 4,4'-methylenediphenyl diisocyanate
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S73 - P231 10.1007/s00210-024-02974-3 - Krause, J.L., Engelmann, B., Lallinger, D.J.D., Rolle-Kampczyk, U., von Bergen, M., Chang, H.-D. (2024):
Multi-omics analysis unravels the impact of stool sample logistics on metabolites and microbial composition
Microorganisms 12 (10), art. 1998 10.3390/microorganisms12101998 - Krause, J.L., Engelmann, B., Schaepe, S.S., Rolle-Kampczyk, U., Jehmlich, N., Chang, H.-D., Slanina, U., Hoffmann, M., Lehmann, J., Zenclussen, A.C., Herberth, G., von Bergen, M., Haange, S.-B. (2024):
DSS treatment does not affect murine colonic microbiota in absence of the host
Gut Microbes 16 (1), art. 2297831 10.1080/19490976.2023.2297831 - Medawar, E., Beyer, F., Thieleking, R., Haange, S.-B., Rolle-Kampczyk, U., Reinicke, M., Chakaroun, R., von Bergen, M., Stumvoll, M., Villringer, A., Witte, A.V. (2024):
Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Gut 73 (2), 298 - 310 10.1136/gutjnl-2023-330365 - Myrmel, L.S., Fjære, E., Han, M., Jensen, B.A.H., Rolle-Kampczyk, U., Danneskiold-Samsøe, N.B., Ho, Q.T., Smette, A., von Bergen, M., Xiao, L., Kristiansen, K., Madsen, L. (2024):
The food sources in western diets modulate obesity development, insulin sensitivity, and the plasma and cecal metabolome in mice
Mol. Nutr. Food Res. 68 (16), art. 2400246 10.1002/mnfr.202400246 - Radushev, V., Karkossa, I., Berg, J., von Bergen, M., Engelmann, B., Rolle-Kampczyk, U.E., Blüher, M., Wagner, U., Schubert, K., Rossol, M. (2024):
Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity
Front. Immunol. 15 , art. 1416543 10.3389/fimmu.2024.1416543 - Raulien, N., Friedrich, K., Strobel, S., Raps, S., Hecker, F., Pierer, M., Schilling, E., Lainka, E., Kallinich, T., Baumann, S., Fritz-Wallace, K., Rolle-Kampczyk, U., von Bergen, M., Aigner, A., Ewe, A., Schett, G., Cross, M., Rossol, M., Wagner, U. (2024):
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes
Sci. Signal. 17 (845), eadd8913 10.1126/scisignal.add8913 - Viehof, A., Haange, S.-B., Streidl, T., Schubert, K., Engelmann, B., Haller, D., Rolle-Kampczyk, U., von Bergen, M., Clavel, T. (2024):
The human intestinal bacterium Eggerthella lenta influences gut metabolomes in gnotobiotic mice
Microbiome Research Reports 3 , art. 14 10.20517/mrr.2023.65
2023 (9)
- Aldehoff, A.S., Karkossa, I., Engelmann, B., Rolle-Kampczyk, U., von Bergen, M., Schubert, K. (2023):
Exploring the regulatory effects of lysine acetylation and phosphorylation in adipocyte differentiation and their exposure to emerging plastic additives
Toxicol. Lett. 384 (Suppl. 1), S133 - S133 10.1016/S0378-4274(23)00578-7 - Buchenauer, L., Haange, S.-B., Bauer, M., Rolle-Kampczyk, U.E., Wagner, M., Stucke, J., Elter, E., Fink, B., Vass, M., von Bergen, M., Schulz, A., Zenclussen, A.C., Junge, K.M., Stangl, G.I., Polte, T. (2023):
Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis
Sci. Total Environ. 905 , art. 167034 10.1016/j.scitotenv.2023.167034 - Hoffmann, A., Meir, A.Y., Hagemann, T., Czechowski, P., Müller, L., Engelmann, B., Haange, S.-B., Rolle-Kampczyk, U., Tsaban, G., Zelicha, H., Rinott, E., Kaplan, A., Shelef, I., Stumvoll, M., Blüher, M., Liang, L., Ceglarek, U., Isermann, B., von Bergen, M., Kovacs, P., Keller, M., Shai, I. (2023):
A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial
Metab.-Clin. Exp. 145 , art. 155594 10.1016/j.metabol.2023.155594 - Kister, B., Viehof, A., Rolle-Kampczyk, U., Schwentker, A., Treichel, N.S., Jennings, S., Wirtz, T.H., Blank, L.M., Hornef, M.W., von Bergen, M., Clavel, T., Kuepfer, L. (2023):
A physiologically-based model of bile acid metabolism in mice
iScience 26 (10), art. 107922 10.1016/j.isci.2023.107922 - Meir, A.Y., Keller, M., Hoffmann, A., Rinott, E., Tsaban, G., Kaplan, A., Zelicha, H., Hagemann, T., Ceglarek, U., Isermann, B., Shelef, I., Blüher, M., Stumvoll, M., Li, J., Haange, S.-B., Engelmann, B., Rolle-Kampczyk, U., von Bergen, M., Hu, F.B., Stampfer, M.J., Kovacs, P., Liang, L., Shai, I. (2023):
The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial
BMC Med. 21 , art. 364 10.1186/s12916-023-03067-3 - O’Rourke, K., Engelmann, B., Altenburger, R., Rolle-Kampczyk, U., Grintzalis, K. (2023):
Molecular responses of daphnids to chronic exposures to pharmaceuticals
Int. J. Mol. Sci. 24 (4), art. 4100 10.3390/ijms24044100 - Panagiotidis, K., Engelmann, B., Krauss, M., Rolle-Kampczyk, U.E., Altenburger, R., Rochfort, K.D., Grintzalis, K. (2023):
The impact of amine and carboxyl functionalised microplastics on the physiology of daphnids
J. Hazard. Mater. 458 , art. 132023 10.1016/j.jhazmat.2023.132023 - Ramos-Nascimento, A., Grenga, L., Haange, S.-B., Himmelmann, A., Arndt, F.S., Ly, Y.-T., Miotello, G., Pible, O., Jehmlich, N., Engelmann, B., von Bergen, M., Mulder, E., Frings-Meuthen, P., Hellweg, C.E., Jordan, J., Rolle-Kampczyk, U., Armengaud, J., Moeller, R. (2023):
Human gut microbiome and metabolite dynamics under simulated microgravity
Gut Microbes 15 (2), art. 2259033 10.1080/19490976.2023.2259033 - Wang, Z., Haange, S.-B., Haake, V., Huisinga, M., Kamp, H., Buesen, R., Schubert, K., Canzler, S., Hackermüller, J., Rolle-Kampczyk, U., von Bergen, M. (2023):
Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in a rats
Metabolites 13 (7), art. 847 10.3390/metabo13070847
2022 (11)
- Brede, M., Haange, S.-B., Riede, S., Engelmann, B., Jehmlich, N., Rolle-Kampczyk, U.E., Rohn, K., Von Soosten, D., von Bergen, M., Breves, G. (2022):
Effects of different formulations of glyphosate on rumen microbial metabolism and microbial community composition in the Rumen Simulation Technique system
Front. Microbiol. 13 , art. 873101 10.3389/fmicb.2022.873101 - Fries, C.M., Haange, S.-B., Rolle-Kampczyk, U., Till, A., Lammert, M., Grasser, L., Medawar, E., Dietrich, A., Horstmann, A., von Bergen, M., Fenske, W.K. (2022):
Metabolic profile and metabolite analyses in extreme weight responders to gastric bypass surgery
Metabolites 12 (5), art. 417 10.3390/metabo12050417 - Haange, S.-B., Till, A., Bergh, P.-O., Fauler, G., Gigl, M., Löfgren-Sandblom, A., Schaap, F.G., Clavel, T., Trautwein, C., Fenske, W., Kleigrewe, K., Marschall, H.-U., Olde Damink, S.W.M., Moustafa, T., von Bergen, M., Rolle-Kampczyk, U. (2022):
Ring trial on quantitative assessment of bile acids reveals a method- and analyte-specific accuracy and reproducibility
Metabolites 12 (7), art. 583 10.3390/metabo12070583 - Jensen Pedersen, K., Haange, S.-B., Žížalová, K., Viehof, A., Clavel, T., Leniček, M., Engelmann, B., Wick, L.Y., Schaap, F.G., Jehmlich, N., Rolle-Kampczyk, U., von Bergen, M. (2022):
Eggerthella lenta DSM 2243 alleviates bile acid stress response in Clostridium ramosum and Anaerostipes caccae by transformation of bile acids
Microorganisms 10 (10), art. 2025 10.3390/microorganisms10102025 - Junge, K.M., Buchenauer, L., Strunz, S., Seiwert, B., Thürmann, L., Rolle-Kampczyk, U.E., Röder, S., Borte, M., Kiess, W., von Bergen, M., Simon, J.C., Zenclussen, A.C., Schöneberg, T., Stangl, G.I., Herberth, G., Lehmann, I., Reemtsma, T., Polte, T. (2022):
Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study
Sci. Total Environ. 814 , art. 152676 10.1016/j.scitotenv.2021.152676 - Krause, J.L., Engelmann, B., Nunes da Rocha, U., Pierzchalski, A., Chang, H.D., Zenclussen, A.C., von Bergen, M., Rolle-Kampczyk, U., Herberth, G. (2022):
MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Environ. Int. 158 , art. 106985 10.1016/j.envint.2021.106985 - Menanteau-Ledouble, S., Skov, J., Lukassen, M.B., Rolle-Kampczyk, U., Haange, S.-B., Dalsgaard, I., von Bergen, M., Nielsen, J.L. (2022):
Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)
Animal Microbiome 4 , art. 358 10.1186/s42523-022-00209-5 - Münzker, J., Haase, N., Till, A., Sucher, R., Haange, S.-B., Nemetschke, L., Gnad, T., Jäger, E., Chen, J., Riede, S.J., Chakaroun, R., Massier, L., Kovacs, P., Ost, M., Rolle-Kampczyk, U., Jehmlich, N., Weinert, J., Heiker, J.T., Klöting, N., Seeger, G., Morawski, M., Keitel, V., Pfeifer, A., von Bergen, M., Heeren, J., Krügel, U., Fenske, W.K. (2022):
Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity
Microbiome 10 , art. 96 10.1186/s40168-022-01264-5 - Riesbeck, S., Petruschke, H., Rolle-Kampczyk, U., Schori, C., Ahrens, C.H., Eberlein, C., Heipieper, H.J., von Bergen, M., Jehmlich, N. (2022):
Adaptation and resistance: How Bacteroides thetaiotaomicron copes with the bisphenol A substitute bisphenol F
Microorganisms 10 (8), art. 1610 10.3390/microorganisms10081610 - Sallam, I.E., Rolle-Kampczyk, U., Schäpe, S.S., Zaghloul, S.S., El Dine, R.S., Shao, P., von Bergen, M., Farag, M.A. (2022):
Evaluation of antioxidant activity and biotransformation of Opuntia ficus fruit: The effect of in vitro and ex vivo gut microbiota metabolism
Molecules 27 (21), art. 7568 10.3390/molecules27217568 - Zelicha, H., Kloting, N., Kaplan, A., Meir, A.Y., Rinott, E., Tsaban, G., Chassidim, Y., Bluher, M., Ceglarek, U., Isermann, B., Stumvoll, M., Quayson, R.N., von Bergen, M., Engelmann, B., Rolle-Kampczyk, U., Haange, S.-B., Tuohy, K.M., Diotallevi, C., Shelef, I., Hu, F.B., Stampfer, M.J., Shai, I. (2022):
The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial
BMC Med. 20 , art. 327 10.1186/s12916-022-02525-8
2021 (13)
- Engel, K.M., Baumann, S., Blaurock, J., Rolle-Kampczyk, U., Schiller, J., von Bergen, M., Grunewald, S. (2021):
Differences in the sperm metabolomes of smoking and nonsmoking men
Biol. Reprod. 105 (6), 1484 - 1493 10.1093/biolre/ioab179 - Frissen, M., Liao, L., Schneider, K.M., Djudjaj, S., Haybaeck, J., Wree, A., Rolle-Kampczyk, U., von Bergen, M., Latz, E., Boor, P., Trautwein, C. (2021):
Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury
Hepatology 73 (5), 1836 - 1854 10.1002/hep.31494 - Junge, K.M., Buchenauer, L., Elter, E., Butter, K., Kohajda, T., Herberth, G., Röder, S., Borte, M., Kiess, W., von Bergen, M., Simon, J.C., Rolle-Kampczyk, U.E., Lehmann, I., Gminski, R., Ohlmeyer, M., Polte, T. (2021):
Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study
Environ. Int. 151 , art. 106449 10.1016/j.envint.2021.106449 - Le Duc, D., Lin, C.-C., Popkova, Y., Yang, Z., Akhil, V., Çakir, M.V., Grunewald, S., Simon, J.-C., Dietz, A., Dannenberger, D., Garten, A., Lemke, J.R., Schiller, J., Blüher, M., Nono Nankam, P.A., Rolle-Kampczyk, U., von Bergen, M., Kelso, J., Schöneberg, T. (2021):
Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity
Int. J. Obes. 45 (3), 565 - 576 10.1038/s41366-020-00716-y - Medawar, E., Haange, S.-B., Rolle-Kampczyk, U., Engelmann, B., Dietrich, A., Thieleking, R., Wiegank, C., Fries, C., Horstmann, A., Villringer, A., von Bergen, M., Fenske, W., Witte, A.V. (2021):
Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior
Transl. Psychiatr. 11 , art. 500 10.1038/s41398-021-01620-3 - Müller-Deile, J., Sarau, G., Kotb, A.M., Jaremenko, C., Rolle-Kampczyk, U.E., Daniel, C., Kalkhof, S., Christiansen, S.H., Schiffer, M. (2021):
Novel diagnostic and therapeutic techniques reveal changed metabolic profiles in recurrent focal segmental glomerulosclerosis
Sci. Rep. 11 , art. 4577 10.1038/s41598-021-83883-w - Schubert, K., Karkossa, I., Schor, J., Engelmann, B., Steinheuer, L.M., Bruns, T., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M. (2021):
A multi-omics analysis of mucosal-associated-invariant T cells reveals key drivers of distinct modes of activation
Front. Immunol. 12 , art. 616967 10.3389/fimmu.2021.616967 - Shahid, N., Rolle-Kampczyk, U., Siddique, A., von Bergen, M., Liess, M. (2021):
Pesticide-induced metabolic changes are amplified by food stress
Sci. Total Environ. 792 , art. 148350 10.1016/j.scitotenv.2021.148350 - Smith, L., Martin, C., Lasserre, F., Engelmann, B., Klément, W., Fougerat, A., Polizzi, A., Canlet, C., Rolle-Kampczyk, U., von Bergen, M., Lippi, Y., Guillou, H., Loiseau, N., Payastre, L., Ellero-Simatos, S. (2021):
Impact d’une exposition alimentaire chronique au glyphosate à des doses de référence sur le microbiote intestinal et le métabolisme énergétique chez la souris
Nutr. Clin. Metab. 35 (1), 74 - 74 10.1016/j.nupar.2021.01.110 - Thürmann, L., Herberth, G., Seiwert, B., Schlittenbauer, L., Rolle-Kampczyk, U., Röder, S., Sack, U., Borte, M., von Bergen, M., Trump, S., Reemtsma, T., Lehmann, I. (2021):
Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Allergy 76 (10), 3122 - 3132 10.1111/all.14890 - Venkat, K., Hoyos, M., Haycocks, J.R.J., Cassidy, L., Engelmann, B., Rolle-Kampczyk, U., von Bergen, M., Tholey, A., Grainger, D.C., Papenfort, K. (2021):
A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae
Embo J. 40 (24), e108542 10.15252/embj.2021108542 - Wang, Z., Karkossa, I., Großkopf, H., Canzler, S., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2021):
Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129 10.1016/S0378-4274(21)00550-6 - Yaskolka Meir, A., Tuohy, K., von Bergen, M., Krajmalnik-Brown, R., Heinig, U., Zelicha, H., Tsaban, G., Rinott, E., Kaplan, A., Aharoni, A., Zeibich, L., Chang, D., Dirks, B., Diotallevi, C., Arapitsas, P., Vrhovsek, U., Ceglarek, U., Haange, S.-B., Rolle-Kampczyk, U., Engelmann, B., Lapidot, M., Colt, M., Sun, Q., Shai, I. (2021):
The metabolomic-gut-clinical axis of Mankai plant-derived dietary polyphenols
Nutrients 13 (6), art. 1866 10.3390/nu13061866
2020 (18)
- Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388 10.1007/s00204-020-02656-y - Ernst, J., Gert, K., Kraus, F.B., Rolle-Kampczyk, U.E., Wabitsch, M., Dehghani, F., Schaedlich, K. (2020):
Androstenedione changes steroidogenic activity of SGBS cells
Endocr. Connect. 9 (7), 587 - 598 10.1530/EC-19-0549 - Farag, M.A., Abdelwareth, A., Sallam, I.E., el Shorbagi, M., Jehmlich, N., Fritz, K., Schaepe, S., Rolle-Kampczyk, U., Ehrlich, A., Wessjohann, L.A., von Bergen, M. (2020):
Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model
J. Adv. Res. 23 , 47 - 59 10.1016/j.jare.2020.01.001 - Fritz-Wallace, K., Engelmann, B., Krause, J.L., Schäpe, S.S., Pöppe, J., Herberth, G., Rösler, U., Jehmlich, N., von Bergen, M., Rolle-Kampczyk, U. (2020):
Quantification of glyphosate and AMPA from microbiome reactor fluids
Rapid Commun. Mass Spectrom. 34 (7), e8668 10.1002/rcm.8668 - Haange, S.-B., Groeger, N., Froment, J., Rausch, T., Burkhardt, W., Gonnermann, S., Braune, A., Blaut, M., von Bergen, M., Rolle-Kampczyk, U. (2020):
Multiplexed quantitative assessment of the fate of taurine and sulfoquinovose in the intestinal microbiome
Metabolites 10 (11), art. 430 10.3390/metabo10110430 - Haange, S.-B., Jehmlich, N., Krügel, U., Hintschich, C., Wehrmann, D., Hankir, M., Seyfried, F., Froment, J., Hübschmann, T., Müller, S., Wissenbach, D.K., Kang, K.H., Buettner, C., Panagiotou, G., Noll, M., Rolle-Kampczyk, U., Fenske, W., von Bergen, M. (2020):
Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss
Microbiome 8 , art. 13 10.1186/s40168-020-0788-1 - Hsu, M.-J., Karkossa, I., Schäfer, I., Christ, M., Kühne, H., Schubert, K., Rolle-Kampczyk, U.E., Kalkhof, S., Nickel, S., Seibel, P., von Bergen, M., Christ, B. (2020):
Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH
Biomedicines 8 (9), art. 350 10.3390/biomedicines8090350 - Krause, J.L., Haange, S.-B., Schäpe, S.S., Engelmann, B., Rolle-Kampczyk, U., Fritz-Wallace, K., Wang, Z., Jehmlich, N., Türkowsky, D., Schubert, K., Pöppe, J., Bote, K., Rösler, U., Herberth, G., von Bergen, M. (2020):
The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro
Sci. Total Environ. 745 , art. 140932 10.1016/j.scitotenv.2020.140932 - Krause, J.L., Schaepe, S.S., Fritz-Wallace, K., Engelmann, B., Rolle-Kampczyk, U., Kleinsteuber, S., Schattenberg, F., Liu, Z., Müller, S., Jehmlich, N., von Bergen, M., Herberth, G. (2020):
Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use
Gut Microbes 11 (4), 1116 - 1129 10.1080/19490976.2019.1702431 - Krause, J.L., Schäpe, S.S., Schattenberg, F., Müller, S., Ackermann, G., Rolle-Kampczyk, U.E., Jehmlich, N., Pierzchalski, A., von Bergen, M., Herberth, G. (2020):
The activation of mucosal-associated invariant T (MAIT) cells is affected by microbial diversity and riboflavin utilization in vitro
Front. Microbiol. 11 , art. 755 10.3389/fmicb.2020.00755 - Leppert, B., Strunz, S., Seiwert, B., Schlittenbauer, L., Schlichting, R., Pfeifer, C., Röder, S., Bauer, M., Borte, M., Stangl, G.I., Schöneberg, T., Schulz, A., Karkossa, I., Rolle-Kampczyk, U.E., Thürmann, L., von Bergen, M., Escher, B.I., Junge, K.M., Reemtsma, T., Lehmann, I., Polte, T. (2020):
Maternal paraben exposure triggers childhood overweight development
Nat. Commun. 11 , art. 561 10.1038/s41467-019-14202-1 - Mendler, A., Geier, F., Haange, S.-B., Pierzchalski, A., Krause, J.L., Nijenhuis, I., Froment, J., Jehmlich, N., Berger, U., Ackermann, G., Rolle-Kampczyk, U., von Bergen, M., Herberth, G. (2020):
Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria
J. Immunotoxicol. 17 (1), 10 - 20 10.1080/1547691X.2019.1706672 - Mendler, A., Pierzchalski, A., Bauer, M., Röder, S., Sattler, A., Standl, M., Borte, M., von Bergen, M., Rolle-Kampczyk, U., Herberth, G. (2020):
MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Clin. Exp. Immunol. 200 (2), 199 - 213 10.1111/cei.13423 - Riba, A., Hassani, K., Walker, A., van Best, N., von Zeschwitz, D., Anslinger, T., Sillner, N., Rosenhain, S., Eibach, D., Maiga-Ascofaré, O., Rolle-Kampczyk, U., Basic, M., Binz, A., Mocek, S., Sodeik, B., Bauerfeind, R., Mohs, A., Trautwein, C., Kiessling, F., May, J., Klingenspor, M., Gremse, F., Schmitt-Kopplin, P., Bleich, A., Torow, N., von Bergen, M., Hornef, M.W. (2020):
Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Sci. Transl. Med. 12 (565), eaay7019 10.1126/scitranslmed.aay7019 - Rolle-Kampczyk, U., Gebauer, S., Haange, S.-B., Schubert, K., Kern, M., Moulla, Y., Dietrich, A., Schön, M.R., Klöting, N., von Bergen, M., Blüher, M. (2020):
Accumulation of distinct persistent organic pollutants is associated with adipose tissue inflammation
Sci. Total Environ. 748 , art. 142458 10.1016/j.scitotenv.2020.142458 - Schäpe, S.S., Krause, J.L., Masanetz, R.K., Riesbeck, S., Starke, R., Rolle-Kampczyk, U., Eberlein, C., Heipieper, H.J., Herberth, G., von Bergen, M., Jehmlich, N. (2020):
Environmentally relevant concentration of bisphenol S shows slight effects on SIHUMIx
Microorganisms 8 (9), art. 1436 10.3390/microorganisms8091436 - van Best, N., Rolle-Kampczyk, U., Schaap, F.G., Basic, M., Olde Damink, S.W.M., Bleich, A., Savelkoul, P.H.M., von Bergen, M., Penders, J., Hornef, M.W. (2020):
Bile acids drive the newborn’s gut microbiota maturation
Nat. Commun. 11 , art. 3692 10.1038/s41467-020-17183-8 - Wang, Z., Karkossa, I., Großkopf, H., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2020):
Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP
Toxicology 448 , art. 152652 10.1016/j.tox.2020.152652
2019 (6)
- Engel, K.M., Baumann, S., Rolle-Kampczyk, U., Schiller, J., von Bergen, M., Grunewald, S. (2019):
Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma
PLOS One 14 (2), e0211679 10.1371/journal.pone.0211679 - Mandić, A.D., Woting, A., Jaenicke, T., Sander, A., Sabrowski, W., Rolle-Kampczyk, U., von Bergen, M., Blaut, M. (2019):
Clostridium ramosum regulates enterochromaffin cell development and serotonin release
Sci. Rep. 9 , art. 1177 10.1038/s41598-018-38018-z - Mueller, A., Ulrich, N., Hollmann, J., Zapata Sanchez, C.E., Rolle-Kampczyk, U.E., von Bergen, M. (2019):
Characterization of a multianalyte GC-MS/MS procedure for detecting and quantifying polycyclic aromatic hydrocarbons (PAHs) and PAH derivatives from air particulate matter for an improved risk assessment
Environ. Pollut. 255 (Part 2), art. 112967 10.1016/j.envpol.2019.112967 - Ordiz, M.I., Semba, R.D., Moaddel, R., Rolle-Kampczyk, U., von Bergen, M., Herberth, G., Khadeer, M., Röder, S., Manary, M.J. (2019):
Serum amino acid concentrations in infants from Malawi are associated with linear growth
Curr. Dev. Nutr. 3 (10), nzz100 10.1093/cdn/nzz100 - Schäpe, S.S., Krause, J.L., Engelmann, B., Fritz-Wallace, K., Schattenberg, F., Liu, Z., Müller, S., Jehmlich, N., Rolle-Kampczyk, U., Herberth, G., von Bergen, M. (2019):
The simplified human intestinal microbiota (SIHUMIx) shows high structural and functional resistance against changing transit times in in vitro bioreactors
Microorganisms 7 (12), art. 641 10.3390/microorganisms7120641 - Thürmann, L., Herberth, G., Rolle-Kampczyk, U., Röder, S., Borte, M., von Bergen, M., Lehmann, I., Trump, S. (2019):
Elevated gestational IL-13 during fetal development is associated with hyperactivity and inattention in eight-year-old children
Front. Immunol. 10 , art. 1658 10.3389/fimmu.2019.01658
2018 (2)
- Floegel, A., Kühn, T., Sookthai, D., Johnson, T., Prehn, C., Rolle-Kampczyk, U., Otto, W., Weikert, C., Illig, T., von Bergen, M., Adamski, J., Boeing, H., Kaaks, R., Pischon, T. (2018):
Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts
Eur. J. Epidemiol. 33 (1), 55 - 66 10.1007/s10654-017-0333-0 - Russo, R., Haange, S.-B., Rolle-Kampczyk, U., von Bergen, M., Becker, J.M., Liess, M. (2018):
Identification of pesticide exposure-induced metabolic changes in mosquito larvae
Sci. Total Environ. 643 , 1533 - 1541 10.1016/j.scitotenv.2018.06.282
2017 (2)
- Englich, B., Herberth, G., Rolle-Kampczyk, U., Trump, S., Röder, S., Borte, M., Stangl, G.I., von Bergen, M., Lehmann, I., Junge, K.M. (2017):
Maternal cytokine status may prime the metabolic profile and increase risk of obesity in children
Int. J. Obes. 41 (9), 1440 - 1446 10.1038/ijo.2017.113 - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106 10.1016/j.envint.2016.11.029
2016 (11)
- Bauer, T., Trump, S., Ishaque, N., Thürmann, L., Gu, L., Bauer, M., Bieg, M., Gu, Z., Weichenhan, D., Mallm, J.-P., Röder, S., Herberth, G., Takada, E., Mücke, O., Winter, M., Junge, K.M., Grützmann, K., Rolle-Kampczyk, U., Wang, Q., Lawerenz, C., Borte, M., Polte, T., Schlesner, M., Schanne, M., Wiemann, S., Geörg, C., Stunnenberg, H.G., Plass, C., Rippe, K., Mizuguchi, J., Herrmann, C., Eils, R., Lehmann, I. (2016):
Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children
Mol. Syst. Biol. 12 (3), art. 861 10.15252/msb.20156520 - Gjesing Welinder, K., Hansen, R., Toft Overgaard, M., Brohus, M., Sønderkær, M., von Bergen, M., Rolle-Kampczyk, U., Otto, W., Lindahl, T.L., Arinell, K., Evans, A.L., Swenson, J.E., Revsbech, I.G., Frøbert, O. (2016):
Biochemical foundations of health and energy conservation in hibernating free-ranging subadult brown bear Ursus arctos
J. Biol. Chem. 291 , 22509 - 22523 10.1074/jbc.M116.742916 - Hoeke, H., Roeder, S., Mueller, A., Bertsche, T., Borte, M., Rolle-Kampczyk, U., von Bergen, M., Wissenbach, D.K. (2016):
Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE
Allergy 71 (6), 901 - 906 10.1111/all.12897 - Hörnig, F., Kohajda, T., Röder, S., Herberth, G., von Bergen, M., Borte, M., Diez, U., Rolle-Kampczyk, U., Simon, J.-C., Denburg, J.A., Lehmann, I., Junge, K.M. (2016):
The LINA study: higher sensitivity of infant compared to maternal eosinophil/basophil progenitors to indoor chemical exposures
J. Environ. Public Health 2016 , art. 5293932 10.1155/2016/5293932 - Huber, K., Dänicke, S., Rehage, J., Sauerwein, H., Otto, W., Rolle-Kampczyk, U., von Bergen, M. (2016):
Metabotypes with properly functioning mitochondria and antiinflammation predict extended productive life span in dairy cows
Sci. Rep. 6 , art. 24642 10.1038/srep24642 - Kenéz, Á., Dänicke, S., Rolle-Kampczyk, U., von Bergen, M., Huber, K. (2016):
A metabolomics approach to characterize phenotypes of metabolic transition from late pregnancy to early lactation in dairy cows
Metabolomics 12 (11), art. 165 10.1007/s11306-016-1112-8 - Kühn, T., Floegel, A., Sookthai, D., Johnson, T., Rolle-Kampczyk, U., Otto, W., von Bergen, M., Boeing, H., Kaaks, R. (2016):
Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study
BMC Med. 14 , art. 13 10.1186/s12916-016-0552-3 - Kühn, T., Sookthai, D., Rolle-Kampczyk, U., Otto, W., Otto, W., von Bergen, M., Kaaks, R., Johnson, T. (2016):
Mid- and long-term correlations of plasma metabolite concentrations measured by a targeted metabolomics approach
Metabolomics 12 (12), art. 184 10.1007/s11306-016-1133-3 - Pham, H.T., Arnhard, K., Asad, Y.J., Deng, L., Felder, T.K., St. John-Williams, L., Kaever, V., Leadley, M., Mitro, N., Muccio, S., Prehn, C., Rauh, M., Rolle-Kampczyk, U., Thompson, J.W., Uhl, O., Ulaszewska, M., Vogeser, M., Wishart, D.S., Koal, T. (2016):
Inter-laboratory robustness of next-generation bile acid study in mice and humans: international ring trial involving 12 laboratories
J. Appl. Lab. Med. 1 (2), 129 - 142 10.1373/jalm.2016.020537 - Rolle-Kampczyk, U.E., Krumsiek, J., Otto, W., Röder, S.W., Kohajda, T., Borte, M., Theis, F., Lehmann, I., von Bergen, M. (2016):
Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns
Metabolomics 12 (4), art. 76 10.1007/s11306-016-0983-z - Wissenbach, D.K., Oliphant, K., Rolle-Kampczyk, U., Yen, S., Höke, H., Baumann, S., Haange, S.B., Verdu, E.F., Allen-Vercoe, E., von Bergen, M. (2016):
Optimization of metabolomics of defined in vitro gut microbial ecosystems
Int. J. Med. Microbiol. 306 (5), 280 - 289 10.1016/j.ijmm.2016.03.007
2015 (2)
- Herberth, G., Offenberg, K., Rolle-Kampczyk, U., Bauer, M., Otto, W., Röder, S., Grützmann, K., Sack, E., Simon, J.-C., Borte, M., von Bergen, M., Lehmann, I. (2015):
Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases
J. Allergy Clin. Immunol. 136 (2), 495 - 497 10.1016/j.jaci.2015.01.022 - Klöting, N., Hesselbarth, N., Gericke, M., Kunath, A., Biemann, R., Chakaroun, R., Kosacka, J., Kovacs, P., Kern, M., Stumvoll, M., Fischer, B., Rolle-Kampczyk, U., Feltens, R., Otto, W., Wissenbach, D.K., von Bergen, M., Blüher, M. (2015):
Di-(2-ethylhexyl)-phthalate (DEHP) causes impaired adipocyte function and alters serum metabolites
PLOS One 10 (12), e0143190 10.1371/journal.pone.0143190
2014 (4)
- Franck, U., Weller, A., Röder, S.W., Herberth, G., Junge, K.M., Kohajda, T., von Bergen, M., Rolle-Kampczyk, U., Diez, U., Borte, M., Lehmann, I. (2014):
Prenatal VOC exposure and redecoration are related to wheezing in early infancy
Environ. Int. 73 , 393 - 401 10.1016/j.envint.2014.08.013 - Herberth, G., Bauer, M., Gasch, M., Hinz, D., Röder, S., Olek, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Sack, U., Borte, M., Lehmann, I. (2014):
Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers
J. Allergy Clin. Immunol. 133 (2), 543 - 550.e4 10.1016/j.jaci.2013.06.036 - Hoffmann, A., Krumbiegel, P., Richter, T., Richter, M., Röder, S., Rolle-Kampczyk, U., Herbarth, O. (2014):
Helicobacter pylori prevalence in children influenced by non-specific antibiotic treatments
Cent. Eur. J. Public Health 22 (1), 48 - 53 10.21101/cejph.a3890 - Junge, K.M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.-C., Heroux, D., Denburg, J.A., Lehmann, I. (2014):
The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
Clin. Immunol. 152 (1-2), 68 - 76 10.1016/j.clim.2014.02.013
2013 (4)
- Baumann, S., Kalkhof, S., Hackermüller, J., Otto, W., Tomm, J.M., Wissenbach, D.K., Rolle-Kampczyk, U., von Bergen, M. (2013):
Requirements and perspectives for integrating metabolomics with other omics data
Current Metabolomics 1 (1), 15 - 27 10.2174/2213235X11301010015 - Herberth, G., Bauer, M., Gasch, M., Hinz, D., Röder, S., Olek, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen-Tomm, M., Sack, U., Borte, M., Lehmann, I. (2013):
Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and with low Treg numbers
Allergy 68 (Suppl. 97), 628 - 628 10.1111/all.12252 - Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M., Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S. (2013):
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Science 339 (6123 ), 1084 - 1088 10.1126/science.1233521 - Weisse, K., Winkler, S., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen, M., Olek, S., Richter, T., Diez, U., Borte, M., Stangl, G.I., Lehmann, I. (2013):
Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
Allergy 68 (2), 220 - 228 10.1111/all.12081
2012 (1)
- Weisse, K., Winkler, S., Stangl, G.I., Hirche, F., Herberth, G., Hinz, D., Bauer, M., Röder, S., Rolle-Kampczyk, U., von Bergen-Tomm, M., Olek, S., Sack, U., Borte, M., Richter, T., Lehmann, I. (2012):
Maternal and newborn vitamin D status and its impact on fetal regulatory T cell development and children's atopy risk in the German LINA cohort study
J. Reprod. Immunol. 94 (1), 53 - 54 10.1016/j.jri.2012.03.335
2011 (2)
- Bauer, S., Krumbiegel, P., Richter, M., Richter, T., Röder, S., Rolle-Kampczyk, U., Herbarth, P. (2011):
Influence of sociodemographic factors on Helicobacter pylori prevalence variability among schoolchildren in Leipzig, Germany. A long-term follow-up study
Cent. Eur. J. Public Health 19 (1), 42 - 45 10.21101/cejph.a3643 - Oberbach, A., Blüher, M., Wirth, H., Till, H., Kovacs, P., Kullnick, Y., Schlichting, N., Tomm, J.M., Rolle-Kampczyk, U., Murugaiyan, J., Binder, H., Dietrich, A., von Bergen, M. (2011):
Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes
J. Proteome Res. 10 (10), 4769 - 4788 10.1021/pr2005555
2010 (1)
- Strebel, K., Rolle-Kampczyk, U., Richter, M., Kindler, A., Richter, T., Schlink, U. (2010):
A rigorous small area modelling-study for the helicobacter pylori epidemiology
Sci. Total Environ. 408 (18), 3931 - 3942 10.1016/j.scitotenv.2010.03.045
2008 (1)
- Rolle-Kampczyk, U.E., Greef, M.L., Manuwald, O., Rehwagen, M., Herbarth, O., Röder, S., Müller, A. (2008):
Lung function parameters and MVOC
In: Kungolos, A., Brebbia, C.A., Zamorano, M. (eds.)
Environmental toxicology II
WIT Transactions on Biomedicine and Health 110
WIT Press, Southampton, p. 235 - 239 10.2495/ETOX080251
2007 (1)
- Herbarth, O., Bauer, M., Fritz, G.J., Herbarth, P., Rolle-Kampczyk, U., Krumbiegel, P., Richter, M., Richter, T. (2007):
Helicobacter pylori colonisation and eczema
J. Epidemiol. Community Health 61 (7), 638 - 640 10.1136/jech.2006.046706
2006 (5)
- Herbarth, O., Krumbiegel, P., Rolle-Kampczyk, U., Richter, T. (2006):
Risk factors and exposure pathways of Helicobacter pylori colonization
Epidemiology 17 (6), S236 - S237 10.1097/00001648-200611001-00609 - Köller, G., Wichmann, G., Rolle-Kampczyk, U., Popp, P., Herbarth, O. (2006):
Comparison of ELISA and capillary electrophoresis with laser-induced fluorescence detection in the analysis of Ochratoxin A in low volumes of human blood serum
J. Chromatogr. B 840 (2), 94 - 98 10.1016/j.jchromb.2006.04.048 - Röder, S., Rolle-Kampczyk, U., Herbarth, O. (2006):
Visualization of depending patterns in metabonomics
In: King, I., Wang, J., Chan, L.-W., Wang, D.L. (eds.)
Neural Information Processing. 13th International Conference, ICONIP 2006, Hong Kong, China, October 3-6, 2006. Proceedings, Part III
Lect. Notes Comput. Sci. 4234
Springer, Berlin, Heidelberg, New York, p. 278 - 284 10.1007/11893295_32 - Rolle-Kampczyk, U.E., Rehwagen, M., Franck, U., Weiß, H., Krumbiegel, P., Herbarth, O. (2006):
Bio-effect monitoring using a [15N]methacetin test as diagnostic tool to monitor remediation effects in an industrially polluted region
Toxicol. Lett. 162 (2-3), 234 - 238 10.1016/j.toxlet.2005.09.017 - Strebel, K., Schlink, U., Rolle-Kampczyk, U., Kindler, A., Herbarth, O. (2006):
Spatially modelling and ranking the risks of Helicobacter pylori infection
Epidemiology 17 (6), S523
2005 (4)
- Diez, U., Rolle-Kampczyk, U., Borte, M., Herbarth, O. (2005):
Umweltmedizinische Aspekte bei der Diagnostik allergischer Erkrankungen im Kindesalter
Arzneimittel-, Therapie-Kritik & Medizin und Umwelt 37 (1), 89 - 97 - Diez, U., Rolle-Kampczyk, U., Borte, M., Herbarth, O. (2005):
Umweltmedizinische Aspekte bei der Diagnostik allergischer Erkrankungen im Kindesalter
Internistische Praxis 45 (1), 221 - 229 - Herbarth, O., Bauer, M., Franck, U., Krumbiegel, P., Rehwagen, M., Rolle-Kampczyk, U., Weiß, H. (2005):
Effect of remediation measures on exposure and liver detoxification capacity of children
In: Aral, M.M., Brebbia, C.A., Maslia, M.L., Sinks, T. (eds.)
Environmental exposure and health
WIT Transactions on Ecology and the Environment 85
WIT Press, Southampton, p. 429 - 437 10.2495/EEH050441 - Rolle-Kampczyk, U., Diez, U., Rehwagen, M., Richter, M., Borte, M., Herbarth, O. (2005):
Biomonitoring in environmental medicine - results of LARS
In: Brebbia, C.A., Popov, V., Fayzieva, D. (eds.)
Environmental health risk III
WIT Transactions on Biomedicine and Health 9
WIT Press, Southampton, p. 41 - 49 10.2495/EHR050051
2004 (6)
- Herbarth, O., Franck, U., Krumbiegel, P., Rehwagen, M., Rolle-Kampczyk, U., Weiß, H. (2004):
Noninvasive assessment of liver detoxification capacity of children, observed in children from heavily polluted industrial and clean control areas, together with assessments of air pollution and chloro-organic body burden
Environ.Toxicol. 19 (2), 103 - 108 10.1002/tox.20001 - Herbarth, O., Rolle-Kampczyk, U., Franck, U., Rehwagen, M., Weiß, H., Krumbiegel, P. (2004):
Detecting exposure-dependent changes of liver detoxification capacity of children in a formerly high-loaded industrial area with a 15N-labelled diagnostic tool
Isot. Environ. Health Stud. 40 (1), 69 - 74 10.1080/10256010310001646545 - Köller, G., Rolle-Kampczyk, U., Lehmann, I., Popp, P., Herbarth, O. (2004):
Determination of Ochratoxin A in small volumes of human blood serum
J. Chromatogr. B 804 (2), 313 - 317 10.1016/j.jchromb.2004.01.025 - Krumbiegel, P., Lehmann, I., Alfreider, A., Fritz, G.J., Boeckler, D., Rolle-Kampczyk, U., Richter, M., Jorks, S., Müller, L., Richter, M.W., Herbarth, O. (2004):
Helicobacter pylori determination in non-municipal drinking water and epidemiological findings
Isot. Environ. Health Stud. 40 (1), 75 - 80 10.1080/10256010310001639868 - Rolle-Kampczyk, U.E., Fritz, G.J., Diez, U., Lehmann, I., Richter, M., Herbarth, O. (2004):
Well water - one source of Helicobacter pylori colonization
Int. J. Hyg. Environ. Health. 207 (4), 363 - 368 10.1078/1438-4639-00301 - Rolle-Kampczyk, U.E., Fritz, G.J., Diez, U., Lehmann, I., Richter, M., Herbarth, O. (2004):
Contaminated well water: a risk factor for Heliobacter pylori infection
In: Brebbia, C.A. (ed.)
Risk analysis IV : papers from the 4th international conference on computer simulation in risk analysis and hazard mitigation : 27-29 September 2004, Rhodes, Greece
Management Information Systems 9
WIT Press, Southampton, p. 445 - 454
2003 (5)
- Diez, U., Rehwagen, M., Rolle-Kampczyk, U., Wetzig, H., Schulz, R., Richter, M., Lehmann, I., Borte, M., Herbarth, O. (2003):
Redecoration of apartments promotes obstructive bronchitis in atopy risk infants - results of the LARS study
Int. J. Hyg. Environ. Health. 206 (3), 173 - 179 10.1078/1438-4639-00218 - Herbarth, O., Diez, U., Borte, M., Fritz, G.J., Rehwagen, M., Rolle-Kampczyk, U., Krumbiegel, P. (2003):
Epidemiologie umweltbeeinflusster Erkrankungen
Päd: praktische Pädiatrie 9 (2), 140 - 143 - Köller, G., Rolle-Kampczyk, U., Popp, P., Herbarth, O. (2003):
A new method for the sensitive analysis of ochratoxin A in house dust
Chromatographia 58 (11/12), 763 - 767 10.1365/s10337-003-0112-9 - Rolle-Kampczyk, U., Diez, U. (2003):
Gesundheitliche Beeinträchtigung durch häusliche Schimmelpilzbelastungen
Internistische Praxis 43 , 211 - 219 - Rolle-Kampczyk, U., Diez, U. (2003):
Gesundheitliche Beeinträchtigung durch häusliche Schimmelpilzbelastungen
Arzneimittel-, Therapie-Kritik & Medizin und Umwelt 35 , 91 - 99
2002 (9)
- Diez, U., Rehwagen, M., Rolle-Kampczyk, U., Wetzig, H., Schulz, R., Richter, M., Lehmann, I., Borte, M., Herbarth, O. (2002):
Redecoration of the dwelling and obstructive bronchitis in atopy-risk children
Allergy 57 (Suppl. 73), 117 - 118 10.1034/j.1398-9995.57.s73.85.x - Franck, U., Herbarth, O., Rolle-Kampczyk, U., Krumbiegel, P., Müller, A., Rehwagen, M., Schilde, M., Stärk, H.-J. (2002):
Heavy metal, pentachlorophenol, pyrethroids, and allergens in dust from children's dwellings
Exposure of children to substances used as ingredients of pesticides: Workshop on Exposure of Children to Substances used as Ingredients in Pesticides, Berlin, 27–29 September 2001
German Federal Institute for Health Protection of Consumers and Veterinary Medicine, 14 - 19 - Herbarth, O., Diez, U., Franck, U., Krumbiegel, P., Rehwagen, M., Rolle-Kampczyk, U. (2002):
Exposure dependent change of liver detoxification capacity of children in former high loaded industrial areas
Epidemiology 13 (4), S162 - S163 - Herbarth, O., Diez, U., Lehmann, I., Müller, A., Rolle-Kampczyk, U., Wichmann, G. (2002):
Umweltmedizinische Untersuchungen beim Vorliegen einer Schimmelpilzbelastung und Erfassung immunmodulatorischer Effekte
In: Keller, R., Senkpiel, K., Samson, R.A., Hoekstra, E.S. (Hrsg.)
Umgebungsanalyse bei gesundheitlichen Beschwerden durch mikrobielle Belastungen im Innenraum : 6. Lübecker Fachtagung für Umwelthygiene
Schriftenreihe des Instituts für Medizinische Mikrobiologie und Hygiene der Universität zu Lübeck 6
Schmidt-Römhild, Lübeck, S. 35 - 60 - Herbarth, O., Fritz, G.J., Diez, U., Krumbiegel, P., Rehwagen, M., Richter, M., Rolle-Kampczyk, U., Wildführ, W., Kroeßner, T., Borte, M. (2002):
Umwelt und Gesundheit
Acta Academiae Scientiarum 6 , 197 - 213 - Krumbiegel, P., Denk, E., Russow, R., Rolle-Kampczyk, U., Metzner, G., Herbarth, O. (2002):
[15N2]Argenine as a first potential inhaled diagnostic agent to characterize respiratory diseases
Exp. Lung Res. 28 (7), 535 - 542 10.1080/01902140290096809 - Krumbiegel, P., Rolle-Kampczyk, U., Liebergeld, P., Herbarth, O., Köbrich, R. (2002):
Towards an inhalative 13C Breath test method
Isot. Environ. Health Stud. 38 (2), 65 - 70 10.1080/10256010208033313 - Lehmann, I., Thoelke, A., Rehwagen, M., Rolle-Kampczyk, U., Schlink, U., Schulz, R., Borte, M., Diez, U., Herbarth, O. (2002):
The influence of maternal exposure to volatile organic compounds on the cytokine secretion profile of neonatal T cells
Environ.Toxicol. 17 (3), 203 - 210 10.1002/tox.10055 - Rolle-Kampczyk, U.E., Rehwagen, M., Diez, U., Richter, M., Herbarth, O., Borte, M. (2002):
Passive smoking, excretion of metabolites, and health effects: results of the Leipzig's Allergy Risk Study (LARS)
Arch. Environ. Health 57 (4), 326 - 331 10.1080/00039890209601416
2001 (11)
- Diez, U., Borte, M., Fritzsch, C., Herbarth, O., Lehmann, I., Metzner, G., Müller, A., Rehwagen, M., Richter, M., Rolle-Kampczyk, U., Schuster, V., Schwenke, A., Thomas, A. (2001):
Kooperation in der Umweltmedizin in Leipzig - Vorstellung des LEIPI-Programms zur Untersuchung von Patienten mit Schimmelpilzbelastung. Cooperation in environmental medicine - the "LEIPI" program
Umweltmed. Forsch. Prax. 6 (2), 97 - 100 10.1065/ufp2001.02.001 - Diez, U., Feyer, A., Wetzig, H., Rehwagen, M., Rolle-Kampczyk, U., Lehmann, I., Schlink, U., Borte, M., Herbarth, O. (2001):
The effect of redecoration on obstructive bronchitis in 4-year-old atopy risk children - results of the Leipzig allergy risk children study (LARS). Abstracts GHU/ISEM conference, Garmisch-Partenkirchen, September 6–8, 2001
Int. J. Hyg. Environ. Health. 204 (4), 280 10.1078/1438-4639-00147 - Herbarth, O., Diez, U., Borte, M., Fritz, G.J., Rehwagen, M., Rolle-Kampczyk, U., Krumbiegel, P. (2001):
Epidemiologie umweltbeeinflußter Erkrankungen
Forum HNO 3 (3), 60 - 64 - Herbarth, O., Diez, U., Fritz, G.J., Kroessner, T., Krumbiegel, P., Lehmann, I., Metzner, G., Müller, A., Rehwagen, M., Richter, M., Rolle-Kampczyk, U., Schlink, U., Schulz, R., Wetzig, H., Borte, M. (2001):
Allergieentwicklung im frühen Kindesalter
In: Ring, J., Darsow, U. (Hrsg.)
Allergie 2000: Probleme, Strategien und praktische Konsequenzen. 21. Tagung der DGAI Oktober 1999
Fortschritte der Allergologie und Immunologie 21
Dustri-Verlag Dr. Karl Feistle, München, S. 30 - 39 - Lehmann, I., Rehwagen, M., Diez, U., Seiffart, A., Rolle-Kampczyk, U., Richter, M., Wetzig, H., Borte, M., Herbarth, O. (2001):
Indoor exposure to volatile organic compounds (VOC) is associated with T cell polarization toward the type 2 phenotype and allergic sensitization to food allergens: results of the LARS study
Immunobiology 204 (1-2), 281 - 282 10.1078/0171-2985-00077 - Lehmann, I., Rehwagen, M., Diez, U., Seiffart, A., Rolle-Kampczyk, U., Richter, M., Wetzig, H., Borte, M., Herbarth, O. (2001):
Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: results of the LARS study
Int. J. Hyg. Environ. Health. 204 (4), 211 - 221 10.1078/1438-4639-00100 - Rehwagen, M., Krumbiegel, P., Koschny, I., Rolle-Kampczyk, U., Richter, M., Herbarth, O. (2001):
The [15N]methacetin liver function test characterizes multicomponent exposure of children in industrially polluted regions
Isot. Environ. Health Stud. 37 (2), 167 - 174 10.1080/10256010108033291 - Rolle-Kampczyk, U., Denk, E., Metzner, G., Diez, U., Herbarth, O., Krumbiegel, P. (2001):
Is inhaled L-[15N]Arginin suitable to reflect environmental related changes in the NO metabolism of airways' first results
Int. J. Hyg. Environ. Health. 204 (4), 278 10.1078/1438-4639-00147 - Rolle-Kampczyk, U., Denk, E., Metzner, G., Diez, U., Herbarth, O., Krumbiegel, P. (2001):
L-[15N]Arginin als Inhalationsdiagnostikum
Pneumologie 55 (1), 47 - Rolle-Kampczyk, U., Müller, A., Diez, U., Rehwagen, M., Schwenke, A., Metzner, G., Herbarth, O. (2001):
Hausstaub als Quelle für eine potenzielle Belastung mit Mykotoxinen - ein Fallbeispiel
Umweltmed. Forsch. Prax. 6 (1), 42 - 46 - Wichmann, G., Herbarth, O., Müller, A., Rolle-Kampczyk, U., Lehmann, I. (2001):
The mycotoxins citrinin, gliotoxin and patulin affect TH1 rather than TH2 cytokine production in vitro
10th International Symposium on Toxicity Assessment, ISTA, Quebec, Canada, August 26-31, 2001
2000 (9)
- Borte, M., Diez, U., Herbarth, O., Meusel, S., Müller, A., Müller, D., Rehwagen, M., Lehmann, I., Rolle-Kampczyk, U., Schilde, M., Sierig, G., Springer, A., Wetzig, H. (Hrsg., 2000):
LARS - Leipziger Allergierisiko-Kinder-Studie. Abschlussbericht für das SMWK zum Projekt 4-7531.50-03-UFZ/701
Sächsisches Staatsministerium für Wissenschaft und Kunst, Dresden, 222 S. - Lehmann, I., Rehwagen, M., Diez, U., Seiffart, A., Rolle-Kampczyk, U., Richter, M., Wetzig, H., Borte, M., Herbarth, O. (2000):
Enhanced in vivo IgE production and TH2 reactivity resulting from indoor exposure to VOC: results of the LARS study
4th Annual Meeting of the International Society of Environmental Medicine (ISEM), Hannover, 1.-4.10.2000 - Lehmann, I., Rehwagen, M., Diez, U., Seiffart, A., Rolle-Kampczyk, U., Richter, M., Wetzig, H., Borte, M., Herbarth, O. (2000):
Indoor exposure (VOC) dependent in vivo IgE production and TH2 reactivity in young children - LARS study
International Symposium New Trends in Allergy V, Davos, 15.-17.9.2000 - Rehwagen, M., Krumbiegel, P., Koschny, I., Rolle-Kampczyk, U., Herbarth, O. (2000):
The [15N]methacetin liver function test characterizes multicomponent exposure of children in industrially polluted regions
Isot. Environ. Health Stud. 36 (4), 339 10.1080/10256010008055156 - Rehwagen, M., Rolle-Kampczyk, U., Diez, U., Borte, M., Herbarth, O. (2000):
Untersuchung von Hausstaub aus Leipziger Wohnungen auf den Gehalt ausgewählter Pyrethroide. Determination of pyrethroids in house dust from Leipzig dwellings
Gefahrst. Reinhalt. Luft 60 (7-8), 305 - 307 - Rolle-Kampczyk, U., Müller, A., Diez, U., Rehwagen, M., Schwenke, A., Metzner, G., Herbarth, O. (2000):
Mycotoxins in house dust - an underestimated problem?
Mycotoxin Research 16 (1 Suppl.), 100 - 104 10.1007/BF02942993 - Rolle-Kampczyk, U., Rehwagen, M., Diez, U., Borte, M., Herbarth, O. (2000):
Cotinin als Biomarker für die Passivrauchbelastung von Kleinkindern
Umweltmed. Forsch. Prax. 5 (4), 213 - 217 - Rolle-Kampczyk, U., Voigt, K., Liebergeld, G., Krumbiegel, P. (2000):
A simple 15N method to detect urease (and Heliobacter pylori) in human saliva
Isot. Environ. Health Stud. 36 (4), 338 10.1080/10256010008055156 - Wichmann, G., Müller, A., Rolle-Kampczyk, U., Herbarth, O., Lehmann, I. (2000):
Mycotoxins affect Th1 rather than Th2 cytokine production in vitro
Immunobiology 203 (1-3), 580 10.1016/S0171-2985(00)80027-3
1999 (7)
- Diez, U., Borte, M., Fink, B., Herbarth, O., Kroessner, T., Krumbiegel, P., Lehmann, I., Metzner, G., Müller, A., Nagl, G., Rehwagen, M., Richter, M., Rolle-Kampczyk, U., Schlink, U., Schulz, R., Sierig, G., Seiffart, A., Stärk, H.-J., Wetzig, H. (1999):
Projekt "Neugeborene-Umwelt": Elterninformation zu Ergebnissen der LARS-Studie
UFZ Leipzig-Halle GmbH, Leipzig, - Herbarth, O., Diez, U., Borte, M., Fritz, G., Rehwagen, M., Rolle-Kampczyk, U., Krumbiegel, P. (1999):
Epidemiologie umweltbeeinflußter Erkrankungen
Derm 5 (6), 367 - 371 - Krumbiegel, P., Herbarth, O., Müller, A., Arndt, K., Rehwagen, M., Rolle-Kampczyk, U. (1999):
Biomarkers of the effect to VOC exposure: recent developments
In: Brebbia, C.A., Jacobson, M., Power, H. (eds.)
Air Pollution VII
WIT Transactions on Ecology and the Environment 37
WIT Press, Southampton, p. 581 - 588 10.2495/AIR990561 - Rehwagen, M., Rolle-Kampczyk, U., Herbarth, O., Schlink, U., Krumbiegel, P. (1999):
Pentachlorphenol in Hausstäuben und im Urin ostdeutscher Kinder. Pentachlorphenol in house dusts and urine of Eastern German children
Gefahrst. Reinhalt. Luft 59 (1-2), 43 - 47 - Rolle-Kampczyk, U., Herbarth, O., Rehwagen, M. (1999):
Noninvasive methods in environmental medicine - biomonitoring
J. Environ. Med. 1 (2), 65 - 70 10.1002/(SICI)1099-1301(199904/06)1:2<65::AID-JEM19>3.0.CO;2-S - Rolle-Kampczyk, U., Rehwagen, M., Herbarth, O. (1999):
Belastungen durch Benzol und Toluol aus der Innenraumluft und ihr nichtinvasiver Nachweis durch spezifische Metaboliten im Urin
7. Kongress der Gesellschaft für Hygiene und Umweltmedizin, Leipzig, 7.-9.3.1999 - Rolle-Kampczyk, U., Rehwagen, M., Herbarth, O. (1999):
Is the internal burden in human beings reflected by air pollution measurements?
In: Brebbia, C.A., Jacobson, M., Power, H. (eds.)
Air pollution VII
WIT Transactions on Ecology and the Environment 37
WIT Press, Southampton, p. 447 - 456 10.2495/AIR990431
1998 (5)
- Diez, U., Rehwagen, M., Rolle-Kampczyk, U., Müller, A., Richter, M., Herbarth, O., Borte, M., Raue, W. (1998):
Umweltmedizin in der Kinderheilkunde - das Leipziger Modell
Zbl. Hyg. u. Umweltmed. 201 , 47 - 47 - Herbarth, O., Rolle-Kampczyk, U., Rehwagen, M. (1998):
Importance of specifity of metabolites in assessing exposure to benzene and toluene in indoor air
Epidemiology 9 (4), S94 - Krumbiegel, P., Miethe, S., Herbarth, O., Rehwagen, M., Rolle-Kampczyk, U., Franck, U., Stärk, H.-J., Fritz, G., Kalteich, W.E., Ettrich, C. (1998):
Longitudinal assessment of exposure and health effects in kindergarten children from Saxony-Anhalt, Germany
In: Brebbia, C.A., Power, H. (eds.)
Air pollution VI
WIT Transactions on Ecology and the Environment 28
WIT Press, Southampton, p. 629 - 636 10.2495/AIR980611 - Miethe, S., Krumbiegel, P., Ettrich, C., Stärk, H.-J., Rehwagen, M., Franck, U., Rolle-Kampczyk, U., Kalteich, W.E., Wege, F., Herbarth, O. (1998):
Longitudinal-Verfolgung von Umwelteinflüssen auf die Gesundheit von Kindergarten-Kindern Sachsen-Anhalts
Proceedings ASI '98, Oktober 1998, Düsseldorf, P 6 - Rolle-Kampczyk, U., Rehwagen, M., Herbarth, O. (1998):
Merkaptursäuren im Urin als Index für Innenraum-Expositionen von Benzol und Toluol
Umweltmed. Forsch. Prax. 3 (5), 287 - 290
1996 (2)
- Arndt, K., Krumbiegel, P., Rolle-Kampczyk, U., Herbarth, O. (1996):
15N investigations on effects of air pollutants on the nitrogen metabolism of Tetrahymena pyriformis as a model for environmental medicine
Isot. Environ. Health Stud. 32 (2-3), 252 - 253 10.1080/10256019608036317 - Rolle-Kampczyk, U.E., Krumbiegel, P. (1996):
Routine determination of 15N amounts in urine samples: Emission spectroscopy coupled with Kjeldahl digestion or with dry combustion?
Isot. Environ. Health Stud. 32 (1), 111 - 115 10.1080/10256019608036299