Dr. Kristin Schubert
Kontakt / Adressen
Dr. rer. nat. Kristin Schubert
Arbeitsgruppenleitung 'Functional Genomics'
Department für Molekulare Systembiologie
Helmholtz Zentrum für Umweltforschung - UFZ
Permoserstraße 15 | 04318 Leipzig
Phone: +49 341 235 1819
kristin.schubert@ufz.de
kristin.schubert@kennedy.ox.ac.uk
Forschungsschwerpunkte
- Systembiologische Analyse der Funktion von MAIT-Zellen und Makrophagen
- Mode of Action von Schadstoffen
- Immunoproteomics
- Immunometabolismus
Lebenslauf
| seit 2017 |
Arbeitsgruppenleitung 'Functional Genomics' Department für Molekulare Systembiologie Helmholtz Zentrum für Umweltforschung - UFZ |
| seit 2016 |
Associated Postdoctoral Researcher Kennedy Institute of Rheumatology, University of Oxford, UK |
| 2014 - 2016 |
Postdoctoral Researcher Kennedy Institute of Rheumatology, University of Oxford, UK |
| 2010 - 2013 |
PhD Student Experimentelle Rheumatologie, Universität Leipzig |
| 2003 - 2009 |
Biologie Studium (Diplom) Martin-Luther-Universität Halle-Wittenberg |
Publikationen
Inhalt:
Weiterführende Recherchen können Sie in unserem Publikationsverzeichnis durchführen.
2023 (3)
- Gerhards, M., Böhme, A., Schubert, K., Kodritsch, B., Ulrich, N. (2023):
DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene
Curr. Res. Toxicol. 4 , art. 100097
Volltext (DOI) - Gurbuz, B., Guldiken, N., Reuken, P., Fu, L., Remih, K., Preisinger, C., Brůha, R., Leníček, M., Petrtýl, J., Reissing, J., Aly, M., Fromme, M., Zhou, B., Karkossa, I., Schubert, K., von Bergen, M., Stallmach, A., Bruns, T., Strnad, P. (2023):
Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
Hepatol. Int. 17 (3), 698 - 708
Volltext (DOI) - Lipaeva, P., Karkossa, I., Bedulina, D., Schubert, K., Luckenbach, T. (2023):
Cold-adapted amphipod species upon heat stress: Proteomic responses and their correlation with transcriptomic responses
Comp. Biochem. Physiol. D-Genomics Proteomics 45 , art. 101048
Volltext (DOI)
2022 (5)
- Kage, P., Schubert, K., Treudler, R., Simon, J.-C., von Bergen, M., Tomm, J. (2022):
Identification of new potential allergens from green-lipped mussel (Perna canaliculus)
Iran. J. Allergy Asthma Immunol. 21 (6), 711 - 715
Volltext (DOI) - Krieg, L., Didt, K., Karkossa, I., Bernhart, S.H., Kehr, S., Subramanian, N., Lindhorst, A., Schaudinn, A., Tabei, S., Keller, M., Stumvoll, M., Dietrich, A., von Bergen, M., Stadler, P.F., Laurencikiene, J., Krüger, M., Blüher, M., Gericke, M., Schubert, K., Kovacs, P., Chakaroun, R., Massier, L. (2022):
Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance
Gut 71 (11), 2179 - 2193
Volltext (DOI) - Lentz, L.S., Stutz, A.J., Meyer, N., Schubert, K., Karkossa, I., von Bergen, M., Zenclussen, A.C., Schumacher, A. (2022):
Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses
Front. Immunol. 13 , art. 989247
Volltext (DOI) - Murthy, S., Karkossa, I., Schmidt, C., Hoffmann, A., Hagemann, T., Rothe, K., Seifert, O., Anderegg, U., von Bergen, M., Schubert, K., Rossol, M. (2022):
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
Cell Death Dis. 13 , art. 53
Volltext (DOI) - Schaffert, A., Karkossa, I., Ueberham, E., Schlichting, R., Walter, K., Arnold, J., Blüher, M., Heiker, J.T., Lehmann, J., Wabitsch, M., Escher, B.I., von Bergen, M., Schubert, K. (2022):
Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes
Environ. Int. 164 , art. 107279
Volltext (DOI)
2021 (14)
- Großkopf, H., Vogel, S., Müller, C.D., Köhling, S., Dürig, J.-N., Möller, S., Schnabelrauch, M., Rademann, J., Hempel, U., von Bergen, M., Schubert, K. (2021):
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry
Biol. Chem. 402 (11), 1427 - 1440
Volltext (DOI) - Großkopf, H., Walter, K., Karkossa, I., von Bergen, M., Schubert, K. (2021):
Non-genomic AhR-signaling modulates the immune response in endotoxin-activated macrophages after activation by the environmental stressor BaP
Front. Immunol. 12 , art. 620270
Volltext (DOI) - Höper, T., Siewert, K., Dumit, V.I., von Bergen, M., Schubert, K., Haase, A. (2021):
The contact allergen NiSO4 triggers a distinct molecular response in primary human dendritic cells compared to bacterial LPS
Front. Immunol. 12 , art. 644700
Volltext (DOI) - Karkossa, I., Bannuscher, A., Hellack, B., Wohlleben, W., Laloy, J., Stan, M.S., Dinischiotu, A., Wiemann, M., Luch, A., Haase, A., von Bergen, M., Schubert, K. (2021):
Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects
Sci. Total Environ. 801 , art. 149538
Volltext (DOI) - Karkossa, I., Bannuscher, A., Hellack, B., Wohlleben, W., Laloy, J., Stan, M.S., Dinischiotu, A., Wiemann, M., Luch, A., Haase, A., von Bergen, M., Schubert, K. (2021):
Omics reveal different oxidative stress levels induced by nanomaterials in vitro and in vivo
Toxicol. Lett. 350 (Suppl.), S125
Volltext (DOI) - Monikh, F.A., Chupani, L., Karkossa, I., Gardian, Z., Arenas-Logo, D., von Bergen, M., Schubert, K., Piackova, V., Zuskova, E., Jiskoot, W., Vijver, M.G., Peijnenburg, W.J.G.M. (2021):
An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes
NanoImpact 22 , art. 100315
Volltext (DOI) - Nickel, S., Vlaic, S., Christ, M., Schubert, K., Henschler, R., Tautenhahn, F., Burger, C., Kühne, H., Erler, S., Roth, A., Wild, C., Brach, J., Hammad, S., Gittel, C., Baunack, M., Lange, U., Broschewitz, J., Stock, P., Metelmann, I., Bartels, M., Pietsch, U.-C., Krämer, S., Eichfeld, U., von Bergen, M., Dooley, S., Tautenhahn, H.-M., Christ, B. (2021):
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β
npj Regen. Med. 6 , art. 84
Volltext (DOI) - Schaffert, A., Arnold, J., Karkossa, I., Blüher, M., von Bergen, M., Schubert, K. (2021):
The emerging plasticizer alternative DINCH and its metabolite MINCH induce oxidative stress and enhance inflammatory responses in human THP-1 macrophages
Cells 10 (9), art. 2367
Volltext (DOI) - Schaffert, A., Krieg, L., Weiner, J., Schlichting, R., Ueberham, E., Karkossa, I., Bauer, M., Landgraf, K., Junge, K.M., Wabitsch, M., Lehmann, J., Escher, B.I., Zenclussen, A.C., Körner, A., Blüher, M., Heiker, J.T., von Bergen, M., Schubert, K. (2021):
Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation
Environ. Int. 156 , art. 106730
Volltext (DOI) - Schaffert, A., Krieg, L., Weinert, J., Schlichting, R., Ueberham, E., Karkossa, I., Bauer, M., Junge, K., Wabitsch, M., Lehmann, J., Escher, B.I., Zenclussen, A.C., Körner, A., Blüher, M., Heiker, J.T., von Bergen, M., Schubert, K. (2021):
Emerging substitutes of BPA cause inflammation-like state and impaired insulin sensitivity in differentiating human adipocytes
Toxicol. Lett. 350 (Suppl.), S130
Volltext (DOI) - Schubert, K., Karkossa, I., Schor, J., Engelmann, B., Steinheuer, L.M., Bruns, T., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M. (2021):
A multi-omics analysis of mucosal-associated-invariant T cells reveals key drivers of distinct modes of activation
Front. Immunol. 12 , art. 616967
Volltext (DOI) - Streidl, T., Karkossa, I., Segura Muñoz, R.R., Eberl, C., Zaufel, A., Plagge, J., Schmaltz, R., Schubert, K., Basic, M., Schneider, K.M., Afify, M., Trautwein, C., Tolba, R., Stecher, B., Doden, H.L., Ridlon, J.M., Ecker, J., Moustafa, T., von Bergen, M., Ramer-Tait, A.E., Clavel, T. (2021):
The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice
Gut Microbes 13 (1), 1 - 21
Volltext (DOI) - Walter, K., Grosskopf, H., Karkossa, I., von Bergen, M., Schubert, K. (2021):
Proteomic characterization of the cellular effects of AhR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
Int. J. Environ. Res. Public Health 18 (19), 10336
Volltext (DOI) - Wang, Z., Karkossa, I., Großkopf, H., Canzler, S., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2021):
Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129
Volltext (DOI)
2020 (9)
- Bannuscher, A., Karkossa, I., Buhs, S., Nollau, P., Kettler, K., Balas, M., Dinischiotu, A., Hellack, B., Wiemann, M., Luch, A., von Bergen, M., Haase, A., Schubert, K. (2020):
A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages
Nanotoxicology 14 (2), 181 - 195
Volltext (DOI) - Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388
Volltext (DOI) - Hsu, M.-J., Karkossa, I., Schäfer, I., Christ, M., Kühne, H., Schubert, K., Rolle-Kampczyk, U.E., Kalkhof, S., Nickel, S., Seibel, P., von Bergen, M., Christ, B. (2020):
Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH
Biomedicines 8 (9), art. 350
Volltext (DOI) - Kalkhof, S., Krieg, L., Büttner, P., Wabitsch, M., Küntzel, C., Friebe, D., Landgraf, K., Hanschkow, M., Schubert, K., Kiess, W., Krohn, K., Blüher, M., von Bergen, M., Körner, A. (2020):
In depth quantitative proteomic and transcriptomic characterization of human adipocyte differentiation using the SGBS cell line
Proteomics 20 (15-16), art. 1900405
Volltext (DOI) - Karkossa, I., Raps, S., von Bergen, M., Schubert, K. (2020):
Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Int. J. Mol. Sci. 21 (24), art. 9371
Volltext (DOI) - Krause, J.L., Haange, S.-B., Schäpe, S.S., Engelmann, B., Rolle-Kampczyk, U., Fritz-Wallace, K., Wang, Z., Jehmlich, N., Türkowsky, D., Schubert, K., Pöppe, J., Bote, K., Rösler, U., Herberth, G., von Bergen, M. (2020):
The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro
Sci. Total Environ. 745 , art. 140932
Volltext (DOI) - Krieg, L., Schaffert, A., Kern, M., Landgraf, K., Wabitsch, M., Beck-Sickinger, A.G., Koerner, A., Blüher, M., von Bergen, M., Schubert, K. (2020):
An MRM-based multiplexed quantification assay for human adipokines and apolipoproteins
Molecules 25 (4), art. 775
Volltext (DOI) - Rolle-Kampczyk, U., Gebauer, S., Haange, S.-B., Schubert, K., Kern, M., Moulla, Y., Dietrich, A., Schön, M.R., Klöting, N., von Bergen, M., Blüher, M. (2020):
Accumulation of distinct persistent organic pollutants is associated with adipose tissue inflammation
Sci. Total Environ. 748 , art. 142458
Volltext (DOI) - Wang, Z., Karkossa, I., Großkopf, H., Rolle-Kampczyk, U., Hackermüller, J., von Bergen, M., Schubert, K. (2020):
Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP
Toxicology 448 , art. 152652
Volltext (DOI)
2019 (7)
- Großkopf, H., Schubert, K., von Bergen, M. (2019):
AhR-dependent non-genomic signaling in macrophages - A multi-PTM-omics and proteomics study
Eur. J. Immunol. 49 (Suppl. 1), 137
Volltext (DOI) - Karkossa, I., Bannuscher, A., Hellack, B., Bahl, A., Buhs, S., Nollau, P., Luch, A., Schubert, K., von Bergen, M., Haase, A. (2019):
An in-depth multi-omics analysis in RLE-6TN rat alveolar epithelial cells allows for nanomaterial categorization
Part. Fibre Toxicol. 16 (1), art. 38
Volltext (DOI) - Kratochvil, I., Bannuscher, A., Hellack, B., von Bergen, M., Haase, A., Schubert, K. (2019):
Nanomaterials affect oxidative phosphorylation and phagocytosis in alveolar macrophages
Eur. J. Immunol. 49 (Suppl. 1), 232
Volltext (DOI) - Schmidt, J.R., Geurtzen, K., von Bergen, M., Schubert, K., Knopf, F. (2019):
Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins
Front. Endocrinol. 10 , art. 674
Volltext (DOI) - Schmidt, J.R., Vogel, S., Moeller, S., Kalkhof, S., Schubert, K., von Bergen, M., Hempel, U. (2019):
Sulfated hyaluronic acid and dexamethasone possess a synergistic potential in the differentiation of osteoblasts from human bone marrow stromal cells
J. Cell. Biochem. 120 (5), 8706 - 8722
Volltext (DOI) - Schubert, K., Collins, L.E., Green, P., Nagase, H., Troeberg, L. (2019):
LRP1 controls TNF release via the TIMP-3/ADAM17 axis in endotoxin-activated macrophages
J. Immunol. 202 (4), 1501 - 1509
Volltext (DOI) - Schubert, K., Schor, J., Kratochvil, I., Hackermüller, J., von Bergen, M. (2019):
Multi-omics profiling of MAIT cells reveals specific patterns of antigen-dependent and -independent activation
Eur. J. Immunol. 49 (Suppl. 1), 141
Volltext (DOI)
2018 (2)
- Firacative, C., Gressler, A.E., Schubert, K., Schulze, B., Müller, U., Brombacher, F., von Bergen, M., Alber, G. (2018):
Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection
Sci. Rep. 8 , art. 2681
Volltext (DOI) - Schmidt, J.R., Rücker-Braun, E., Heidrich, K., von Bonin, M., Stölzel, F., Thiede, C., Middeke, J.M., Ehninger, G., Bornhäuser, M., Schetelig, J., Schubert, K., von Bergen, M., Heidenreich, F. (2018):
Pilot study on mass spectrometry–based analysis of the proteome of CD34+CD123+ progenitor cells for the identification of potential targets for immunotherapy in acute myeloid leukemia
Proteomes 6 (1), art. 11
Volltext (DOI)
2017 (1)
- Schubert, K., Olde Damink, S.W.M., von Bergen, M., Schaap, F.G. (2017):
Interactions between bile salts, gut microbiota, and hepatic innate immunity
Immunol. Rev. 279 (1), 23 - 35
Volltext (DOI)
Schmidt, J. R., E. Rucker-Braun, K. Heidrich, M. von Bonin, F. Stolzel, C. Thiede, J. M. Middeke, et al. "Pilot Study on Mass Spectrometry-Based Analysis of the Proteome of Cd34(+)Cd123(+) Progenitor Cells for the Identification of Potential Targets for Immunotherapy in Acute Myeloid Leukemia." Proteomes 6, no. 1 (Feb 12 2018).
Firacative, C., A. E. Gressler, K. Schubert, B. Schulze, U. Muller, F. Brombacher, M. von Bergen, and G. Alber. "Identification of T Helper (Th)1- and Th2-Associated Antigens of Cryptococcus Neoformans in a Murine Model of Pulmonary Infection." Sci Rep 8, no. 1 (Feb 8 2018): 2681.
Schubert, K., S. W. M. Olde Damink, M. von Bergen, and F. G. Schaap. "Interactions between Bile Salts, Gut Microbiota, and Hepatic Innate Immunity." Immunol Rev 279, no. 1 (Sep 2017): 23-35.
Rothe, K., D. Quandt, K. Schubert, M. Rossol, M. Klingner, S. Jasinski-Bergner, R. Scholz, et al. "Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic Lir-1+Cd8+ T Cells." Arthritis Rheumatol 68, no. 2 (Feb 2016): 337-46.
Schubert, K., U. Meusch, R. Scholz, M. Rossol, and U. Wagner. "To Which Lineage Do Tumor Necrosis Factor Receptor Type I-Positive Proinflammatory Cells Belong? " Arthritis Rheumatol 66, no. 7 (Jul 2014): 1961-2.
Rossol, M.*, K. Schubert*, U. Meusch, A. Schulz, B. Biedermann, J. Grosche, M. Pierer, et al. "Tumor Necrosis Factor Receptor Type I Expression of Cd4+ T Cells in Rheumatoid Arthritis Enables Them to Follow Tumor Necrosis Factor Gradients into the Rheumatoid Synovium." Arthritis Rheum 65, no. 6 (Jun 2013): 1468-76. *shared authorship
Annibal, A., K. Schubert, U. Wagner, R. Hoffmann, J. Schiller, and M. Fedorova. "New Covalent Modifications of Phosphatidylethanolamine by Alkanals: Mass Spectrometry Based Structural Characterization and Biological Effects." J Mass Spectrom 49, no. 7 (Jul 2014): 557-69.
Rossol, M., M. Pierer, N. Raulien, D. Quandt, U. Meusch, K. Rothe, K. Schubert, et al. "Extracellular Ca2+ Is a Danger Signal Activating the Nlrp3 Inflammasome through G Protein-Coupled Calcium Sensing Receptors." Nat Commun 3 (2012): 1329.