Prof. Dr. Martin von Bergen
Head of Department of Molecular Systems Biology
Helmholtz Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany
Tel: 0341 235 1211
Fax:0341 235 1786
Research Interests in Environmental Health
- Cellular response mechanisms towards environmental pollutants with a focus on molecular pathways
- Systems Biology based approaches using proteomic and metabolomic techniques in cells, tissue and on the systemic level
- Characterisation of environmental exposure scenarios
- Development of methods for qualitative and quantitative and structural proteomics
Research Interests in Microbiome Biology
- Analysis of structure and functions of microbial communities by proteomic and metabolomic techniques
- Mechanistic insights into anoxic degradation of environmental pollutants
- Development of mass spectrometry based methods for quantitative and qualitative meta-proteomics of bacteria
CV
- Since 2016: Head of Department of Molecular Systems Biology (merger of Departments of Proteomics and Metabolomics)
- Since 2015: Professor of Functional Proteomics at University of Leipzig, Faculty of Life Sciences
- 2013-2015: Part-time Professor for Systems Microbiology at Aalborg University, Aalborg, Denmark
- since 2009: Speaker of Metabolomics Department
- since 2007: “Habilitation” in molecular biology and Assistent Professor at the faculty of Biochemstry, Biology and Psychology at the University of Leipzig
- since 2006: Head of Department of Proteomics at Helmholtz Centre for Environmental Research, Leipzig
- 2002-2006: Senior scientist at Max Planck-Research Group for Structural Molecular Biology, Hamburg und Assistant Professor in the faculty of Biology at the University of Hamburg
- 2001-2002: Head of Department of Proteomics in Startup company mice and more GmbH & Co KG, Hamburg
- 1998-2001: Postdoc at Max-Planck-Research Group for Structural Molecular Biology, Hamburg
- 1998: PhD at the faculty of Biology, University of Hamburg
- 1995-1998: PhD studies at the Max-Planck-Research Group for Structural Molecular Biology, Hamburg
- 1990-1995: Diploma studies in Biology at the University of Hamburg
Publications
2024 (27)
Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis
iScience 27 (6), art. 109711 10.1016/j.isci.2024.109711
Impact of the lung microbiota on development and progression of lung cancer
Cancers 16 (19), art. 3342 10.3390/cancers16193342
Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
Front. Toxicol. 6 , art. 1394396 10.3389/ftox.2024.1394396
Enhancing toxicological insights through multi-omics: a case study on direct and indirect thyroid toxicity
Toxicol. Lett. 399 (Suppl. 2), S61 - S62 10.1016/j.toxlet.2024.07.171
High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): A metaproteomic and metabolomic study
Front. Microbiol. 15 , art. 1349367 10.3389/fmicb.2024.1349367
Unveiling fungal strategies: mycoremediation in multi-metal pesticide environments using proteomics
Sci. Rep. 14 , art. 23171 10.1038/s41598-024-74517-y
Cocoa seeds and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA amplicon sequencing
Crit. Rev. Food Sci. Nutr. 64 (10), 3122 - 3138 10.1080/10408398.2022.2130159
An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures
Front. Immunol. 15 , art. 1298971 10.3389/fimmu.2024.1298971
Proteomic and transcriptomic analysis of selenium utilization in Methanococcus maripaludis
mSystems 9 (5), e01338-23 10.1128/msystems.01338-23
Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism
Environ. Res. 252 , art. 118847 10.1016/j.envres.2024.118847
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
J. Hazard. Mater. 474 , art. 134683 10.1016/j.jhazmat.2024.134683
Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns
Environ. Int. 191 , art. 108981 10.1016/j.envint.2024.108981
Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism
JHEP Rep. 6 (1), art. 100930 10.1016/j.jhepr.2023.100930
Microbiota modulation by dietary beta-glucan prevents steatotic liver disease progression
JHEP Rep. 6 (3), art. 100987 10.1016/j.jhepr.2023.100987
Response of innate immune cells and alveolar type 1 cell line to 4,4'-methylenediphenyl diisocyanate
Naunyn-Schmiedebergs Arch. Pharmacol. 397 (Suppl. 1), S73 - P231 10.1007/s00210-024-02974-3
Multi-omics analysis unravels the impact of stool sample logistics on metabolites and microbial composition
Microorganisms 12 (10), art. 1998 10.3390/microorganisms12101998
DSS treatment does not affect murine colonic microbiota in absence of the host
Gut Microbes 16 (1), art. 2297831 10.1080/19490976.2023.2297831
Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Gut 73 (2), 298 - 310 10.1136/gutjnl-2023-330365
Data report on gene expression after hepatic portal vein ligation (PVL) in rats
Front. Genet. 15 , art. 1421955 10.3389/fgene.2024.1421955
Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis
Nano Today 59 , art. 102466 10.1016/j.nantod.2024.102466
The food sources in western diets modulate obesity development, insulin sensitivity, and the plasma and cecal metabolome in mice
Mol. Nutr. Food Res. 68 (16), art. 2400246 10.1002/mnfr.202400246
Glycemic control contributes to the neuroprotective effects of Mediterranean and green Mediterranean diets on brain age: the DIRECT-PLUS brain-magnetic resonance imaging randomized controlled trial
Am. J. Clin. Nutr. 10.1016/j.ajcnut.2024.09.013
FGF21 reflects a responsive adipose tissue-liver axis in both cardiometabolic burden and following metabolic surgery
medRxiv 10.1101/2024.05.31.24307065
Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity
Front. Immunol. 15 , art. 1416543 10.3389/fimmu.2024.1416543
Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action
Sci. Total Environ. 941 , art. 169650 10.1016/j.scitotenv.2023.169650
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes
Sci. Signal. 17 (845), eadd8913 10.1126/scisignal.add8913
The human intestinal bacterium Eggerthella lenta influences gut metabolomes in gnotobiotic mice
Microbiome Research Reports 3 , art. 14 10.20517/mrr.2023.652023 (28)
Exploring the regulatory effects of lysine acetylation and phosphorylation in adipocyte differentiation and their exposure to emerging plastic additives
Toxicol. Lett. 384 (Suppl. 1), S133 - S133 10.1016/S0378-4274(23)00578-7
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
Front. Toxicol. 5 , art. 1212509 10.3389/ftox.2023.1212509
Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis
Sci. Total Environ. 905 , art. 167034 10.1016/j.scitotenv.2023.167034
Infant gut microbiota contributes to cognitive performance in mice
Cell Host Microbe 31 (12), 1974 - 1988.e4 10.1016/j.chom.2023.11.004
The use of omics in monitoring food gut microbiota interaction outcomes: a review of novel trends and technologies
Curr. Opin. Food Sci. 52 , art. 101064 10.1016/j.cofs.2023.101064
How do food and drugs interact with gut microbiota? Toward better or worse health outcomes. Editorial
J. Adv. Res. 52 , 1 - 1 10.1016/j.jare.2023.09.006
Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity
Arch. Toxicol. 97 (8), 2291 - 2302 10.1007/s00204-023-03522-3
Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
Hepatol. Int. 17 (3), 698 - 708 10.1007/s12072-022-10473-x
Metabolic versatility enables sulfur-oxidizers to dominate primary production in groundwater
Water Res. 244 , art. 120426 10.1016/j.watres.2023.120426
A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial
Metab.-Clin. Exp. 145 , art. 155594 10.1016/j.metabol.2023.155594
A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways
Toxicol. Appl. Pharmacol. 475 , art. 116650 10.1016/j.taap.2023.116650
Oxidation is an underappreciated post-translational modification in the regulation of immune responses associated with changes in phosphorylation
Front. Immunol. 14 , art. 1244431 10.3389/fimmu.2023.1244431
Mycelial nutrient transfer promotes bacterial co-metabolic organochlorine pesticide degradation in nutrient-deprived environments
ISME J. 17 (4), 570 - 578 10.1038/s41396-023-01371-7
A physiologically-based model of bile acid metabolism in mice
iScience 26 (10), art. 107922 10.1016/j.isci.2023.107922
Differential contribution of nitrifying prokaryotes to groundwater nitrification
ISME J. 17 (10), 1601 - 1611 10.1038/s41396-023-01471-4
The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial
BMC Med. 21 , art. 364 10.1186/s12916-023-03067-3
Human gut microbiome and metabolite dynamics under simulated microgravity
Gut Microbes 15 (2), art. 2259033 10.1080/19490976.2023.2259033
Serum proteomics in American adults with acute liver failure
J. Hepatol. 78 (Suppl. 1), S136 - S138 10.1016/S0168-8278(23)00638-4
Serum proteomics in adults with Acute Liver Failure
Z. Gastroent. 61 (08), e460 - e461 10.1055/s-0043-1771831
Identification of inulin-responsive bacteria in the gut microbiota via multi-modal activity-based sorting
Nat. Commun. 14 , art. 8210 10.1038/s41467-023-43448-z
Gut microbiota contributes to cognitive performance in infants
IBRO Neurosci. Rep. 15 (Suppl. 1), S821 - S822 10.1016/j.ibneur.2023.08.1703
New approach methodologies in human regulatory toxicology – Not if, but how and when!
Environ. Int. 178 , art. 108082 10.1016/j.envint.2023.108082
Anti-inflammatory metabolites and allergenic proteins from Green Lipped Mussel (Perna canaliculus)
Integr. J. Vet. Biosci. 7 (1), 1 - 3 10.31038/IJVB.2023711
M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch
Immunity 56 (6), 1220 - 1238 10.1016/j.immuni.2023.04.002
Acoustic and vibration monitoring of honeybee colonies for beekeeping-relevant aspects of presence of queen bee and swarming
Comput. Electron. Agric. 205 , art. 107589 10.1016/j.compag.2022.107589
Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in a rats
Metabolites 13 (7), art. 847 10.3390/metabo13070847
Artefactual source of 2-hydroxypyridine
Research Square 10.21203/rs.3.rs-1827631/v2
Bacterial dehydrogenases facilitate oxidative inactivation and bioremediation of chloramphenicol
ChemBioChem 24 (2), e202200632 10.1002/cbic.2022006322022 (30)
Effects of different formulations of glyphosate on rumen microbial metabolism and microbial community composition in the Rumen Simulation Technique system
Front. Microbiol. 13 , art. 873101 10.3389/fmicb.2022.873101
Glyphosate differentially affects the allergic immune response across generations in mice
Sci. Total Environ. 850 , art. 157973 10.1016/j.scitotenv.2022.157973
Insight to the molecular mechanisms underpinning the mycoremediation of multiple metals by proteomic technique
Front. Microbiol. 13 , art. 872576 10.3389/fmicb.2022.872576
Metabolic profile and metabolite analyses in extreme weight responders to gastric bypass surgery
Metabolites 12 (5), art. 417 10.3390/metabo12050417
Bacterial necromass is rapidly metabolized by heterotrophic bacteria and supports multiple trophic levels of the groundwater microbiome
Microbiol. Spectr. 10 (4), e00437 10.1128/spectrum.00437-22
Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases
Autophagy 18 (11), 2519 - 2536 10.1080/15548627.2022.2039994
Sulfur and methane oxidation by a single microorganism
Proc. Natl. Acad. Sci. U.S.A. 119 (32), e2114799119 10.1073/pnas.2114799119
Ring trial on quantitative assessment of bile acids reveals a method- and analyte-specific accuracy and reproducibility
Metabolites 12 (7), art. 583 10.3390/metabo12070583
Genes and enzymes involved in the biodegradation of the quaternary carbon compound pivalate in the denitrifying Thauera humireducens strain PIV-1
Environ. Microbiol. 24 (7), 3181 - 3194 10.1111/1462-2920.16021
Eggerthella lenta DSM 2243 alleviates bile acid stress response in Clostridium ramosum and Anaerostipes caccae by transformation of bile acids
Microorganisms 10 (10), art. 2025 10.3390/microorganisms10102025
Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study
Sci. Total Environ. 814 , art. 152676 10.1016/j.scitotenv.2021.152676
Identification of new potential allergens from green-lipped mussel (Perna canaliculus)
Iran. J. Allergy Asthma Immunol. 21 (6), 711 - 715 10.18502/ijaai.v21i6.11532
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Am. J. Clin. Nutr. 115 (5), 1270 - 1281 10.1093/ajcn/nqac001
MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Environ. Int. 158 , art. 106985 10.1016/j.envint.2021.106985
Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance
Gut 71 (11), 2179 - 2193 10.1136/gutjnl-2021-324603
Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses
Front. Immunol. 13 , art. 989247 10.3389/fimmu.2022.989247
Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)
Animal Microbiome 4 , art. 358 10.1186/s42523-022-00209-5
Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity
Microbiome 10 , art. 96 10.1186/s40168-022-01264-5
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
Cell Death Dis. 13 , art. 53 10.1038/s41419-022-04507-3
Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
Structure 30 (10), 1424 - 1431.e3 10.1016/j.str.2022.07.007
Adaptation and resistance: How Bacteroides thetaiotaomicron copes with the bisphenol A substitute bisphenol F
Microorganisms 10 (8), art. 1610 10.3390/microorganisms10081610
Evaluation of antioxidant activity and biotransformation of Opuntia ficus fruit: The effect of in vitro and ex vivo gut microbiota metabolism
Molecules 27 (21), art. 7568 10.3390/molecules27217568
Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes
Environ. Int. 164 , art. 107279 10.1016/j.envint.2022.107279
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386 10.1007/s00204-022-03313-2
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45 10.1002/etc.5242
Deconstructing Methanosarcina acetivorans into an acetogenic archaeon
Proc. Natl. Acad. Sci. U.S.A. 119 (2), e2113853119 10.1073/pnas.2113853119
Microbial community functioning during plant litter decomposition
Sci. Rep. 12 , art. 7451 10.1038/s41598-022-11485-1
Bolstering fitness via CO2 fixation and organic carbon uptake: mixotrophs in modern groundwater
ISME J. 16 (4), 1153 - 1162 10.1038/s41396-021-01163-x
Neonatal Peyer's patch cDC activation as a pacemaker of postnatal immune maturation
Eur. J. Immunol. 52 (S1), 52 - 52 10.1002/eji.202270100
The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial
BMC Med. 20 , art. 327 10.1186/s12916-022-02525-82021 (39)
A workflow to identify novel proteins based on the direct mapping of peptide-spectrum-matches to genomic locations
BMC Bioinformatics 22 , art. 277 10.1186/s12859-021-04159-8
Proteomics reveals sex-specific heat shock response of Baikal amphipod Eulimnogammarus cyaneus
Sci. Total Environ. 763 , art. 143008 10.1016/j.scitotenv.2020.143008
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk
Mol. Metab. 48 , art. 101214 10.1016/j.molmet.2021.101214
Differences in the sperm metabolomes of smoking and nonsmoking men
Biol. Reprod. 105 (6), 1484 - 1493 10.1093/biolre/ioab179
How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials
Trends Food Sci. Technol. 118 (Part B), 920 - 937 10.1016/j.tifs.2021.11.004
Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury
Hepatology 73 (5), 1836 - 1854 10.1002/hep.31494
Influence of formic acid treatment on the proteome of the ectoparasite Varroa destructor
PLOS One 16 (10), e0258845 10.1371/journal.pone.0258845
Changes of the proteome and acetylome during transition into the stationary phase in the organohalide-respiring Dehalococcoides mccartyi strain CBDB1
Microorganisms 9 (2), art. 365 10.3390/microorganisms9020365
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry
Biol. Chem. 402 (11), 1427 - 1440 10.1515/hsz-2021-0167
Non-genomic AhR-signaling modulates the immune response in endotoxin-activated macrophages after activation by the environmental stressor BaP
Front. Immunol. 12 , art. 620270 10.3389/fimmu.2021.620270
The contact allergen NiSO4 triggers a distinct molecular response in primary human dendritic cells compared to bacterial LPS
Front. Immunol. 12 , art. 644700 10.3389/fimmu.2021.644700
Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study
Environ. Int. 151 , art. 106449 10.1016/j.envint.2021.106449
Omics reveal different oxidative stress levels induced by nanomaterials in vitro and in vivo
Toxicol. Lett. 350 (Suppl.), S125 10.1016/S0378-4274(21)00541-5
Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects
Sci. Total Environ. 801 , art. 149538 10.1016/j.scitotenv.2021.149538
HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes
Nucleic Acids Res. 49 (D1), D743 - D750 10.1093/nar/gkaa1031
Interspecies metabolite transfer and aggregate formation in a co-culture of Dehalococcoides and Sulfurospirillum dehalogenating tetrachloroethene to ethene
ISME J. 15 (6), 1794 - 1809 10.1038/s41396-020-00887-6
Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity
Int. J. Obes. 45 (3), 565 - 576 10.1038/s41366-020-00716-y
Insights into autotrophic activities and carbon flow in iron-rRich pelagic aggregates (iron snow)
Microorganisms 9 (7), art. 1368 10.3390/microorganisms9071368
Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior
Transl. Psychiatr. 11 , art. 500 10.1038/s41398-021-01620-3
An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes
NanoImpact 22 , art. 100315 10.1016/j.impact.2021.100315
Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β
npj Regen. Med. 6 , art. 84 10.1038/s41536-021-00194-4
Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
Microbiome 9 , art. 55 10.1186/s40168-020-00981-z
Effect of gut microbiota biotransformation on dietary tannins and human health implications
Microorganisms 9 (5), art. 965 10.3390/microorganisms9050965
The emerging plasticizer alternative DINCH and its metabolite MINCH induce oxidative stress and enhance inflammatory responses in human THP-1 macrophages
Cells 10 (9), art. 2367 10.3390/cells10092367
Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation
Environ. Int. 156 , art. 106730 10.1016/j.envint.2021.106730
Emerging substitutes of BPA cause inflammation-like state and impaired insulin sensitivity in differentiating human adipocytes
Toxicol. Lett. 350 (Suppl.), S130 10.1016/S0378-4274(21)00552-X
A multi-omics analysis of mucosal-associated-invariant T cells reveals key drivers of distinct modes of activation
Front. Immunol. 12 , art. 616967 10.3389/fimmu.2021.616967
Pesticide-induced metabolic changes are amplified by food stress
Sci. Total Environ. 792 , art. 148350 10.1016/j.scitotenv.2021.148350
Impact d’une exposition alimentaire chronique au glyphosate à des doses de référence sur le microbiote intestinal et le métabolisme énergétique chez la souris
Nutr. Clin. Metab. 35 (1), 74 - 74 10.1016/j.nupar.2021.01.110
Protein stable isotope probing with H218O differentiated cold stress response at permissive temperatures from general growth at optimal conditions in Escherichia coli K12
Rapid Commun. Mass Spectrom. 35 (1), e8941 10.1002/rcm.8941
The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice
Gut Microbes 13 (1), 1 - 21 10.1080/19490976.2020.1854008
Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Allergy 76 (10), 3122 - 3132 10.1111/all.14890
The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial
Heart 107 (13), 1054 - 1061 10.1136/heartjnl-2020-317802
Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows
Nat. Commun. 12 , art. 7305 10.1038/s41467-021-27542-8
A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae
Embo J. 40 (24), e108542 10.15252/embj.2021108542
Proteomic characterization of the cellular effects of AhR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
Int. J. Environ. Res. Public Health 18 (19), 10336 10.3390/ijerph181910336
Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129 10.1016/S0378-4274(21)00550-6
Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells
New J. Phys. 23 (10), art. 103020 10.1088/1367-2630/ac254e
The metabolomic-gut-clinical axis of Mankai plant-derived dietary polyphenols
Nutrients 13 (6), art. 1866 10.3390/nu130618662020 (31)
A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages
Nanotoxicology 14 (2), 181 - 195 10.1080/17435390.2019.1684592
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388 10.1007/s00204-020-02656-y
Mechanistic insight to mycoremediation potential of a metal resistant fungal strain for removal of hazardous metals from multimetal pesticide matrix
Environ. Pollut. 262 , art. 114255 10.1016/j.envpol.2020.114255
Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model
J. Adv. Res. 23 , 47 - 59 10.1016/j.jare.2020.01.001
Quantification of glyphosate and AMPA from microbiome reactor fluids
Rapid Commun. Mass Spectrom. 34 (7), e8668 10.1002/rcm.8668
Multiplexed quantitative assessment of the fate of taurine and sulfoquinovose in the intestinal microbiome
Metabolites 10 (11), art. 430 10.3390/metabo10110430
Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss
Microbiome 8 , art. 13 10.1186/s40168-020-0788-1
Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH
Biomedicines 8 (9), art. 350 10.3390/biomedicines8090350
Channeling C1 metabolism toward S-adenosylmethionine-dependent conversion of estrogens to androgens in estrogen-degrading bacteria
mBio 11 (4), e01259-20 10.1128/mBio.01259-20
In depth quantitative proteomic and transcriptomic characterization of human adipocyte differentiation using the SGBS cell line
Proteomics 20 (15-16), art. 1900405 10.1002/pmic.201900405
Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Int. J. Mol. Sci. 21 (24), art. 9371 10.3390/ijms21249371
The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro
Sci. Total Environ. 745 , art. 140932 10.1016/j.scitotenv.2020.140932
Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use
Gut Microbes 11 (4), 1116 - 1129 10.1080/19490976.2019.1702431
The activation of mucosal-associated invariant T (MAIT) cells is affected by microbial diversity and riboflavin utilization in vitro
Front. Microbiol. 11 , art. 755 10.3389/fmicb.2020.00755
An MRM-based multiplexed quantification assay for human adipokines and apolipoproteins
Molecules 25 (4), art. 775 10.3390/molecules25040775
Maternal paraben exposure triggers childhood overweight development
Nat. Commun. 11 , art. 561 10.1038/s41467-019-14202-1
Seasonal patterns of dominant microbes involved in central nutrient cycles in the subsurface
Microorganisms 8 (11), art. 1694 10.3390/microorganisms8111694
Function is what counts: how microbial community complexity affects species, proteome and pathway coverage in metaproteomics
Expert Rev. Proteomics 17 (2), 163 - 173 10.1080/14789450.2020.1738931
Ethnomedicinal survey and in vitro confirmation of anti-inflammatory and antispasmodic properties of the termite strain Macrotermes bellicosus used in traditional medicine in the Republic of Benin
J. Ethnopharmacol. 254 , art. 112705 10.1016/j.jep.2020.112705
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes
Gut 69 (10), 1796 - 1806 10.1136/gutjnl-2019-320118
Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria
J. Immunotoxicol. 17 (1), 10 - 20 10.1080/1547691X.2019.1706672
MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Clin. Exp. Immunol. 200 (2), 199 - 213 10.1111/cei.13423
Benzylsuccinate synthase is post-transcriptionally regulated in the toluene-degrading denitrifier Magnetospirillum sp. strain 15-1
Microorganisms 8 (5), art. 681 10.3390/microorganisms8050681
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization
Nat. Commun. 11 , art. 5104 10.1038/s41467-020-18928-1
Enrichment and identification of small proteins in a simplified human gut microbiome
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Incorporation of carbon and nitrogen atoms into proteins measured by protein-based stable isotope probing (Protein-SIP)
Rapid Commun Mass Spectrom 22, 2889-2897
http://dx.doi.org/10.1002/rcm.3684 - Jeganathan, S., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2008):
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
Biochemistry 47, 10526-10539
http://dx.doi.org/10.1021/bi800783d - Hehemann, J. H., Redecke, L., Murugaiyan, J., von Bergen, M. , Betzel, C., and Saborowski, R. (2008):
Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus
Biochem Biophys Res Commun 370, 566-571
http://dx.doi.org/10.1016/j.bbrc.2008.03.128 - Georgieva, D., Risch, M., Kardas, A., Buck, F., von Bergen, M. , and Betzel, C. (2008):
Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis
J Proteome Res 7, 866-886
http://dx.doi.org/10.1021/pr070376c - Benndorf, D., Muller, A., Bock, K., Manuwald, O., Herbarth, O., and von Bergen, M. (2008):
Identification of spore allergens from the indoor mould Aspergillus versicolor
Allergy 63, 454-460
http://dx.doi.org/10.1111/j.1398-9995.2007.01603.x - Andronesi, O. C., von Bergen, M. , Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008):
Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy
J Am Chem Soc 130, 5922-5928
http://dx.doi.org/10.1021/ja7100517 - Santos, P. M., Roma, V., Benndorf, D., von Bergen, M. , Harms, H., and Sa-Correia, I. (2007):
Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1 revealed by quantitative proteomics
OMICS 11, 233-251
http://dx.doi.org/10.1089/omi.2007.0009 - Redecke, L., von Bergen, M. , Clos, J., Konarev, P. V., Svergun, D. I., Fittschen, U. E., Broekaert, J. A., Bruns, O., Georgieva, D., Mandelkow, E., Genov, N., and Betzel, C. (2007):
Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro
J Struct Biol 157, 308-320
http://dx.doi.org/10.1016/j.jsb.2006.06.013 - Mukrasch, M. D., von Bergen, M. , Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
The "jaws" of the tau-microtubule interaction
J Biol Chem 282, 12230-12239
http://dx.doi.org/10.1074/jbc.M607159200 - Martin, C., Pecyna, M., Kellner, H., Jehmlich, N., Junghanns, C., Benndorf, D., von Bergen, M. , and Schlosser, D. (2007):
Purification and biochemical characterization of a laccase from the aquatic fungus Myrioconium sp. UHH 1-13-18-4 and molecular analysis of the laccase-encoding gene
Appl Microbiol Biotechnol 77, 613-624
http://dx.doi.org/10.1007/s00253-007-1207-2 - Mandelkow, E., von Bergen, M. , Biernat, J., and Mandelkow, E. M. (2007):
Structural principles of tau and the paired helical filaments of Alzheimer's disease
Brain Pathol 17, 83-90
http://dx.doi.org/10.1111/j.1750-3639.2007.00053.x - Gundel, U., Benndorf, D., von Bergen, M. , Altenburger, R., and Kuster, E. (2007):
Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach
Proteomics 7, 4541-4554
http://dx.doi.org/10.1002/pmic.200700381 - Fischer, D., Mukrasch, M. D., von Bergen, M. , Klos-Witkowska, A., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
Structural and microtubule binding properties of tau mutants of frontotemporal dementias
Biochemistry 46, 2574-2582
http://dx.doi.org/10.1021/bi061318s - Benndorf, D., Balcke, G. U., Harms, H., and von Bergen, M. (2007):
Functional metaproteome analysis of protein extracts from contaminated soil and groundwater
ISME J 1, 224-234
http://dx.doi.org/10.1038/ismej.2007.39 - von Bergen, M. , Barghorn, S., Muller, S. A., Pickhardt, M., Biernat, J., Mandelkow, E. M., Davies, P., Aebi, U., and Mandelkow, E. (2006):
The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
Biochemistry 45, 6446-6457
http://dx.doi.org/10.1021/bi052530j - von Bergen, M. , Barghorn, S., Jeganathan, S., Mandelkow, E. M., and Mandelkow, E. (2006):
Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments
Neurodegener Dis 3, 197-206
http://dx.doi.org/10.1159/000095257 - Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen, M. , Gazova, Z., Mandelkow, E., and Mandelkow, E. M. (2006):
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
J Biol Chem 281, 1205-1214
http://dx.doi.org/10.1074/jbc.M507753200 - Jeganathan, S., von Bergen, M. , Brutlach, H., Steinhoff, H. J., and Mandelkow, E. (2006):
Global hairpin folding of tau in solution
Biochemistry 45, 2283-2293
http://dx.doi.org/10.1021/bi0521543 - Georgieva, D., Schwark, D., von Bergen, M. , Redecke, L., Genov, N., and Betzel, C. (2006):
Interactions of recombinant prions with compounds of therapeutical significance
Biochem Biophys Res Commun 344, 463-470
http://dx.doi.org/10.1016/j.bbrc.2006.03.135 - von Bergen, M. , Li, L., and Mandelkow, E. (2005):
Intrinsic fluorescent detection of tau conformation and aggregation
Methods Mol Biol 299, 175-184
http://www.mpasmb-hamburg.mpg.de/mandelkow2/publikationen/index.html - von Bergen, M. , Barghorn, S., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
Tau aggregation is driven by a transition from random coil to beta sheet structure
Biochim Biophys Acta 1739, 158-166
http://dx.doi.org/10.1016/j.bbadis.2004.09.010 - Pickhardt, M., von Bergen, M. , Gazova, Z., Hascher, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
Screening for inhibitors of tau polymerization
Curr Alzheimer Res 2, 219-226
http://dx.DOI.ORG/10.2174/1567205053585891 - Pickhardt, M., Gazova, Z., von Bergen, M. , Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (2005):
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
J Biol Chem 280, 3628-3635
http://dx.doi.org/10.1074/jbc.M410984200 - Mukrasch, M. D., Biernat, J., von Bergen, M. , Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2005):
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions
J Biol Chem 280, 24978-24986
http://dx.doi.org/10.1074/jbc.M501565200 - Li, L., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2002):
Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis
J Biol Chem 277, 41390-41400
http://dx.doi.org/10.1074/jbc.M206334200 - von Bergen, M. , Barghorn, S., Li, L., Marx, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2001):
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
J Biol Chem 276, 48165-48174
http://dx.doi.org/10.1074/jbc.M105196200 - von Bergen, M. , Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E. M., and Mandelkow, E. (2000):
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
Proc Natl Acad Sci U S A 97, 5129-5134
http://www.pnas.org/content/97/10/5129.abstract - Friedhoff, P., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
Structure of tau protein and assembly into paired helical filaments
Biochim Biophys Acta 1502, 122-132
http://dx.doi.org/10.1016/S0925-4439(00)00038-7 - Barghorn, S., Zheng-Fischhofer, Q., Ackmann, M., Biernat, J., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
Biochemistry 39, 11714-11721
http://dx.doi.org/bi000850r - Schneider, A., Biernat, J., von Bergen, M. , Mandelkow, E., and Mandelkow, E. M. (1999):
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
Biochemistry 38, 3549-3558
http://www.ncbi.nlm.nih.gov/pubmed/10995239 - Friedhoff, P., von Bergen, M. , Mandelkow, E. M., Davies, P., and Mandelkow, E. (1998):
A nucleated assembly mechanism of Alzheimer paired helical filaments
Proc Natl Acad Sci U S A 95, 15712-15717
http://dx.doi.org/10.1016/S0925-4439(00)00038-7