Prof. Dr. Martin von Bergen

Head of Department of Molecular Systems Biology


Helmholtz Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany

Tel: 0341 235 1211
Fax:0341 235 1786


Martin von Bergen, Bild

Research Interests in Environmental Health

  • Cellular response mechanisms towards environmental pollutants with a focus on molecular pathways
  • Systems Biology based approaches using proteomic and metabolomic techniques in cells, tissue and on the systemic level
  • Characterisation of environmental exposure scenarios
  • Development of methods for qualitative and quantitative and structural proteomics

Research Interests in Microbiome Biology

  • Analysis of structure and functions of microbial communities by proteomic and metabolomic techniques
  • Mechanistic insights into anoxic degradation of environmental pollutants
  • Development of mass spectrometry based methods for quantitative and qualitative meta-proteomics of bacteria

CV

  • Since 2016: Head of Department of Molecular Systems Biology (merger of Departments of Proteomics and Metabolomics)
  • Since 2015: Professor of Functional Proteomics at University of Leipzig, Faculty of Life Sciences
  • 2013-2015: Part-time Professor for Systems Microbiology at Aalborg University, Aalborg, Denmark
  • since 2009: Speaker of Metabolomics Department
  • since 2007: “Habilitation” in molecular biology and Assistent Professor at the faculty of Biochemstry, Biology and Psychology at the University of Leipzig
  • since 2006: Head of Department of Proteomics at Helmholtz Centre for Environmental Research, Leipzig
  • 2002-2006: Senior scientist at Max Planck-Research Group for Structural Molecular Biology, Hamburg und Assistant Professor in the faculty of Biology at the University of Hamburg
  • 2001-2002: Head of Department of Proteomics in Startup company mice and more GmbH & Co KG, Hamburg
  • 1998-2001: Postdoc at Max-Planck-Research Group for Structural Molecular Biology, Hamburg
  • 1998: PhD at the faculty of Biology, University of Hamburg
  • 1995-1998: PhD studies at the Max-Planck-Research Group for Structural Molecular Biology, Hamburg
  • 1990-1995: Diploma studies in Biology at the University of Hamburg

Publications

   

2019 (24)

2018 (21)

2017 (22)

2016 (43)

2015 (31)

2014 (20)

2013 (30)

2012 (25)

2011 (21)

 

2010

  • Strauber, H., Hubschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M. , Harms, H., and Muller, S. (2010):
    NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene)--a novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
    Cytometry A 77, 113-120
    http://dx.doi.org/10.1002/cyto.a.20811
  • Selesi, D., Jehmlich, N., von Bergen, M. , Schmidt, F., Rattei, T., Tischler, P., Lueders, T., and Meckenstock, R. U. (2010):
    Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    J Bacteriol 192, 295-306
    http://dx.doi.org/10.1128/JB.00874-09
  • Schirmer, C., Klein, C., von Bergen, M. , Simon, J. C., and Saalbach, A. (2010):
    Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells
    Blood116,1715-1725
    http://dx.doi.org/10.1182/blood-2010-01-263509
  • Ohler, M., Georgieva, D., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
    The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities
    J Proteome Res 9, 2422-2437
    http://dx.doi.org/10.1021/pr901128x
  • Muller, S. A., Kohajda, T., Findeiss, S., Stadler, P. F., Washietl, S., Kellis, M., von Bergen, M. , and Kalkhof, S. (2010):
    Optimization of parameters for coverage of low molecular weight proteins
    Anal Bioanal Chem
    http://dx.doi.org/10.1007/s00216-010-4093-x
  • Leibeling, S., Schmidt, F., Jehmlich, N., von Bergen, M. , Muller, R. H., and Harms, H. (2010):
    Declining capacity of starving Delftia acidovorans MC1 to degrade phenoxypropionate herbicides correlates with oxidative modification of the initial enzyme
    Environ Sci Technol 44, 3793-3799
    http://dx.doi.org/10.1021/es903619j
  • Kung, J. W., Baumann, S., von Bergen, M. , Muller, M., Hagedoorn, P. L., Hagen, W. R., and Boll, M. (2010):
    Reversible biological Birch reduction at an extremely low redox potential
    J Am Chem Soc 132, 9850-9856
    http://dx.doi.org/10.1021/ja103448u
  • Jehmlich, N., Hubschmann, T., Gesell Salazar, M., Volker, U., Benndorf, D., Muller, S., von Bergen, M. , and Schmidt, F. (2010):
    Advanced tool for characterization of microbial cultures by combining cytomics and proteomics
    Appl Microbiol Biotechnol 88, 575-584
    http://dx.doi.org/10.1007/s00253-010-2753-6
  • Jehmlich, N., Fetzer, I., Seifert, J., Mattow, J., Vogt, C., Harms, H., Thiede, B., Richnow, H. H., von Bergen, M. , and Schmidt, F. (2010):
    Decimal place slope, a fast and precise method for quantifying 13C incorporation levels for detecting the metabolic activity of microbial species
    Mol Cell Proteomics 9, 1221-1227
    http://dx.doi.org/10.1074/mcp.M900407-MCP200
  • Georgieva, D., Redecke, L., von Bergen, M. , Genov, N., and Betzel, C. (2010):
    Interactions of ginkgolides A and B with a recombinant human prion protein
    Protein Pept Lett 17, 399-404
    http://www.benthamdirect.org/pages/b_viewarticle.php?3157685
  • Georgieva, D., Ohler, M., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
    Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities
    J Proteome Res 9, 2302-2316
    http://dx.doi.org/10.1021/pr901042p
  • Fetzer, I., Jehmlich, N., Vogt, C., Richnow, H. H., Seifert, J., Harms, H., von Bergen, M. , and Schmidt, F. (2010):
    Calculation of partial isotope incorporation into peptides measured by mass spectrometry
    BMC Res Notes 3, 178
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913921/?tool=pubmed
  • Feltens, R., Gorner, R., Kalkhof, S., Groger-Arndt, H., and von Bergen, M. (2010):
    Discrimination of different species from the genus Drosophila by intact protein profiling using matrix-assisted laser desorption ionization mass spectrometry
    BMC Evol Biol 10, 95
    http://dx.doi.org/10.1186/1471-2148-10-95
  • Bastida, F., Rosell, M., Franchini, A. G., Seifert, J., Finsterbusch, S., Jehmlich, N., Jechalke, S., von Bergen, M. , and Richnow, H. H. (2010):
    Elucidating MTBE degradation in a mixed consortium using a multidisciplinary approach
    FEMS Microbiol Ecol 73, 370-384
    http://dx.DOI.org/10.1111/j.1574-6941.2010.00889.x
  • 2009

  • Wischgoll, S., Taubert, M., Peters, F., Jehmlich, N., von Bergen, M. , and Boll, M. (2009):
    Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria
    J Bacteriol 191, 4401-4409
    http://dx.doi.org/10.1128/JB.00205-09
  • Schleinitz, K. M., Schmeling, S., Jehmlich, N., von Bergen, M. , Harms, H., Kleinsteuber, S., Vogt, C., and Fuchs, G. (2009):
    Phenol degradation in the strictly anaerobic iron-reducing bacterium Geobacter metallireducens GS-15
    Appl Environ Microbiol 75, 3912-3919
    http://dx.doi.org/10.1128/AEM.01525-08
  • Risch, M., Georgieva, D., von Bergen, M. , Jehmlich, N., Genov, N., Arni, R. K., and Betzel, C. (2009):
    Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) -- relation to pharmacological activities
    J Proteomics 72, 256-269
    http://dx.doi.org/10.1016/j.jprot.2009.01.006
  • Rehders, D., Claasen, B., Redecke, L., Buschke, A., Reibe, C., Jehmlich, N., von Bergen, M. , Betzel, C., and Meyer, B. (2009):
    Peptide NMHRYPNQ of the cellular prion protein (PrP(C)) inhibits aggregation and is a potential key for understanding prion-prion interactions
    J Mol Biol 392, 198-207
    http://dx.doi.org/ 10.1016/j.jmb.2009.07.014
  • Morbt, N., Mogel, I., Kalkhof, S., Feltens, R., Roder-Stolinski, C., Zheng, J., Vogt, C., Lehmann, I., and von Bergen, M. (2009):
    Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism
    Proteomics 9, 4920-4933
    http://dx.doi.org/10.1002/pmic.200800836
  • Junghanns, C., Pecyna, M. J., Bohm, D., Jehmlich, N., Martin, C., von Bergen, M. , Schauer, F., Hofrichter, M., and Schlosser, D. (2009):
    Biochemical and molecular genetic characterisation of a novel laccase produced by the aquatic ascomycete Phoma sp. UHH 5-1-03
    Appl Microbiol Biotechnol 84, 1095-1105
    http://dx.doi.org/10.1007/s00253-009-2028-2
  • Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., von Bergen, M. , Richnow, H. H., and Vogt, C. (2009):
    Comparison of methods for simultaneous identification of bacterial species and determination of metabolic activity by protein-based stable isotope probing (Protein-SIP) experiments
    Rapid Commun Mass Spectrom 23, 1871-1878
    http://dx.doi.org/10.1002/rcm.4084
  • Heine, F., Stahl, F., Strauber, H., Wiacek, C., Benndorf, D., Repenning, C., Schmidt, F., Scheper, T., von Bergen, M. , Harms, H., and Muller, S. (2009):
    Prediction of flocculation ability of brewing yeast inoculates by flow cytometry, proteome analysis, and mRNA profiling
    Cytometry A 75, 140-147
    http://dx.doi.org/10.1002/cyto.a.20661
  • Benndorf, D., Vogt, C., Jehmlich, N., Schmidt, Y., Thomas, H., Woffendin, G., Shevchenko, A., Richnow, H. H., and von Bergen, M. (2009):
    Improving protein extraction and separation methods for investigating the metaproteome of anaerobic benzene communities within sediments
    Biodegradation 20, 737-750
    http://dx.doi.org/10.1007/s10532-009-9261-3
  • 2008

  • Thiele, B., Rieder, O., Jehmlich, N., von Bergen, M. , Muller, M., and Boll, M. (2008):
    Aromatizing cyclohexa-1,5-diene-1-carbonyl-coenzyme A oxidase. Characterization and its role in anaerobic aromatic metabolism
    J Biol Chem 283, 20713-20721
    http://dx.doi.org/10.1074/jbc.M802841200
  • Roder-Stolinski, C., Fischader, G., Oostingh, G. J., Feltens, R., Kohse, F., von Bergen, M. , Morbt, N., Eder, K., Duschl, A., and Lehmann, I. (2008):
    Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activation
    Toxicol Appl Pharmacol 231, 241-247
    http://dx.doi.org/10.1016/j.taap.2008.04.010
  • Johannes, J., Bluschke, A., Jehmlich, N., von Bergen, M. , and Boll, M. (2008):
    Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens
    J Bacteriol 190, 6493-6500
    http://dx.doi.org/10.1128/JB.00790-08
  • Jehmlich, N., Schmidt, F., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
    Protein-based stable isotope probing (Protein-SIP) reveals active species within anoxic mixed cultures
    ISME J 2, 1122-1133
    http://dx.doi.org/10.1038/ismej.2008.64
  • Jehmlich, N., Schmidt, F., Hartwich, M., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
    Incorporation of carbon and nitrogen atoms into proteins measured by protein-based stable isotope probing (Protein-SIP)
    Rapid Commun Mass Spectrom 22, 2889-2897
    http://dx.doi.org/10.1002/rcm.3684
  • Jeganathan, S., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2008):
    The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
    Biochemistry 47, 10526-10539
    http://dx.doi.org/10.1021/bi800783d
  • Hehemann, J. H., Redecke, L., Murugaiyan, J., von Bergen, M. , Betzel, C., and Saborowski, R. (2008):
    Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus
    Biochem Biophys Res Commun 370, 566-571
    http://dx.doi.org/10.1016/j.bbrc.2008.03.128
  • Georgieva, D., Risch, M., Kardas, A., Buck, F., von Bergen, M. , and Betzel, C. (2008):
    Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis
    J Proteome Res 7, 866-886
    http://dx.doi.org/10.1021/pr070376c
  • Benndorf, D., Muller, A., Bock, K., Manuwald, O., Herbarth, O., and von Bergen, M. (2008):
    Identification of spore allergens from the indoor mould Aspergillus versicolor
    Allergy 63, 454-460
    http://dx.doi.org/10.1111/j.1398-9995.2007.01603.x
  • Andronesi, O. C., von Bergen, M. , Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008):
    Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy
    J Am Chem Soc 130, 5922-5928
    http://dx.doi.org/10.1021/ja7100517
  • 2007

  • Santos, P. M., Roma, V., Benndorf, D., von Bergen, M. , Harms, H., and Sa-Correia, I. (2007):
    Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1 revealed by quantitative proteomics
    OMICS 11, 233-251
    http://dx.doi.org/10.1089/omi.2007.0009
  • Redecke, L., von Bergen, M. , Clos, J., Konarev, P. V., Svergun, D. I., Fittschen, U. E., Broekaert, J. A., Bruns, O., Georgieva, D., Mandelkow, E., Genov, N., and Betzel, C. (2007):
    Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro
    J Struct Biol 157, 308-320
    http://dx.doi.org/10.1016/j.jsb.2006.06.013
  • Mukrasch, M. D., von Bergen, M. , Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
    The "jaws" of the tau-microtubule interaction
    J Biol Chem 282, 12230-12239
    http://dx.doi.org/10.1074/jbc.M607159200
  • Martin, C., Pecyna, M., Kellner, H., Jehmlich, N., Junghanns, C., Benndorf, D., von Bergen, M. , and Schlosser, D. (2007):
    Purification and biochemical characterization of a laccase from the aquatic fungus Myrioconium sp. UHH 1-13-18-4 and molecular analysis of the laccase-encoding gene
    Appl Microbiol Biotechnol 77, 613-624
    http://dx.doi.org/10.1007/s00253-007-1207-2
  • Mandelkow, E., von Bergen, M. , Biernat, J., and Mandelkow, E. M. (2007):
    Structural principles of tau and the paired helical filaments of Alzheimer's disease
    Brain Pathol 17, 83-90
    http://dx.doi.org/10.1111/j.1750-3639.2007.00053.x
  • Gundel, U., Benndorf, D., von Bergen, M. , Altenburger, R., and Kuster, E. (2007):
    Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach
    Proteomics 7, 4541-4554
    http://dx.doi.org/10.1002/pmic.200700381
  • Fischer, D., Mukrasch, M. D., von Bergen, M. , Klos-Witkowska, A., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
    Structural and microtubule binding properties of tau mutants of frontotemporal dementias
    Biochemistry 46, 2574-2582
    http://dx.doi.org/10.1021/bi061318s
  • Benndorf, D., Balcke, G. U., Harms, H., and von Bergen, M. (2007):
    Functional metaproteome analysis of protein extracts from contaminated soil and groundwater
    ISME J 1, 224-234
    http://dx.doi.org/10.1038/ismej.2007.39
  • 2006

  • von Bergen, M. , Barghorn, S., Muller, S. A., Pickhardt, M., Biernat, J., Mandelkow, E. M., Davies, P., Aebi, U., and Mandelkow, E. (2006):
    The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
    Biochemistry 45, 6446-6457
    http://dx.doi.org/10.1021/bi052530j
  • von Bergen, M. , Barghorn, S., Jeganathan, S., Mandelkow, E. M., and Mandelkow, E. (2006):
    Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments
    Neurodegener Dis 3, 197-206
    http://dx.doi.org/10.1159/000095257
  • Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen, M. , Gazova, Z., Mandelkow, E., and Mandelkow, E. M. (2006):
    Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
    J Biol Chem 281, 1205-1214
    http://dx.doi.org/10.1074/jbc.M507753200
  • Jeganathan, S., von Bergen, M. , Brutlach, H., Steinhoff, H. J., and Mandelkow, E. (2006):
    Global hairpin folding of tau in solution
    Biochemistry 45, 2283-2293
    http://dx.doi.org/10.1021/bi0521543
  • Georgieva, D., Schwark, D., von Bergen, M. , Redecke, L., Genov, N., and Betzel, C. (2006):
    Interactions of recombinant prions with compounds of therapeutical significance
    Biochem Biophys Res Commun 344, 463-470
    http://dx.doi.org/10.1016/j.bbrc.2006.03.135
  • von Bergen, M. , Li, L., and Mandelkow, E. (2005):
    Intrinsic fluorescent detection of tau conformation and aggregation
    Methods Mol Biol 299, 175-184
    http://www.mpasmb-hamburg.mpg.de/mandelkow2/publikationen/index.html
  • 1998-2005

  • von Bergen, M. , Barghorn, S., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
    Tau aggregation is driven by a transition from random coil to beta sheet structure
    Biochim Biophys Acta 1739, 158-166
    http://dx.doi.org/10.1016/j.bbadis.2004.09.010
  • Pickhardt, M., von Bergen, M. , Gazova, Z., Hascher, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2005):
    Screening for inhibitors of tau polymerization
    Curr Alzheimer Res 2, 219-226
    http://dx.DOI.ORG/10.2174/1567205053585891
  • Pickhardt, M., Gazova, Z., von Bergen, M. , Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (2005):
    Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
    J Biol Chem 280, 3628-3635
    http://dx.doi.org/10.1074/jbc.M410984200
  • Mukrasch, M. D., Biernat, J., von Bergen, M. , Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2005):
    Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions
    J Biol Chem 280, 24978-24986
    http://dx.doi.org/10.1074/jbc.M501565200
  • Li, L., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2002):
    Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis
    J Biol Chem 277, 41390-41400
    http://dx.doi.org/10.1074/jbc.M206334200
  • von Bergen, M. , Barghorn, S., Li, L., Marx, A., Biernat, J., Mandelkow, E. M., and Mandelkow, E. (2001):
    Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
    J Biol Chem 276, 48165-48174
    http://dx.doi.org/10.1074/jbc.M105196200
  • von Bergen, M. , Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E. M., and Mandelkow, E. (2000):
    Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
    Proc Natl Acad Sci U S A 97, 5129-5134
    http://www.pnas.org/content/97/10/5129.abstract
  • Friedhoff, P., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
    Structure of tau protein and assembly into paired helical filaments
    Biochim Biophys Acta 1502, 122-132
    http://dx.doi.org/10.1016/S0925-4439(00)00038-7
  • Barghorn, S., Zheng-Fischhofer, Q., Ackmann, M., Biernat, J., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2000):
    Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
    Biochemistry 39, 11714-11721
    http://dx.doi.org/bi000850r
  • Schneider, A., Biernat, J., von Bergen, M. , Mandelkow, E., and Mandelkow, E. M. (1999):
    Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
    Biochemistry 38, 3549-3558
    http://www.ncbi.nlm.nih.gov/pubmed/10995239
  • Friedhoff, P., von Bergen, M. , Mandelkow, E. M., Davies, P., and Mandelkow, E. (1998):
    A nucleated assembly mechanism of Alzheimer paired helical filaments
    Proc Natl Acad Sci U S A 95, 15712-15717
    http://dx.doi.org/10.1016/S0925-4439(00)00038-7