Prof. Dr. Martin von Bergen
Head of Department of Molecular Systems Biology
Helmholtz Centre for Environmental Research - UFZ
Permoserstr. 15
04318 Leipzig, Germany
Tel: 0341 235 1211
Fax:0341 235 1786

Research Interests in Environmental Health
- Cellular response mechanisms towards environmental pollutants with a focus on molecular pathways
- Systems Biology based approaches using proteomic and metabolomic techniques in cells, tissue and on the systemic level
- Characterisation of environmental exposure scenarios
- Development of methods for qualitative and quantitative and structural proteomics
Research Interests in Microbiome Biology
- Analysis of structure and functions of microbial communities by proteomic and metabolomic techniques
- Mechanistic insights into anoxic degradation of environmental pollutants
- Development of mass spectrometry based methods for quantitative and qualitative meta-proteomics of bacteria
CV
- Since 2016: Head of Department of Molecular Systems Biology (merger of Departments of Proteomics and Metabolomics)
- Since 2015: Professor of Functional Proteomics at University of Leipzig, Faculty of Life Sciences
- 2013-2015: Part-time Professor for Systems Microbiology at Aalborg University, Aalborg, Denmark
- since 2009: Speaker of Metabolomics Department
- since 2007: “Habilitation” in molecular biology and Assistent Professor at the faculty of Biochemstry, Biology and Psychology at the University of Leipzig
- since 2006: Head of Department of Proteomics at Helmholtz Centre for Environmental Research, Leipzig
- 2002-2006: Senior scientist at Max Planck-Research Group for Structural Molecular Biology, Hamburg und Assistant Professor in the faculty of Biology at the University of Hamburg
- 2001-2002: Head of Department of Proteomics in Startup company mice and more GmbH & Co KG, Hamburg
- 1998-2001: Postdoc at Max-Planck-Research Group for Structural Molecular Biology, Hamburg
- 1998: PhD at the faculty of Biology, University of Hamburg
- 1995-1998: PhD studies at the Max-Planck-Research Group for Structural Molecular Biology, Hamburg
- 1990-1995: Diploma studies in Biology at the University of Hamburg
Publications
2023 (18)
Exploring the regulatory effects of lysine acetylation and phosphorylation in adipocyte differentiation and their exposure to emerging plastic additives
Toxicol. Lett. 384 (Suppl. 1), S133 - S133
Volltext (DOI)
Maternal exposure of mice to glyphosate induces depression- and anxiety-like behavior in the offspring via alterations of the gut-brain axis
Sci. Total Environ. 905 , art. 167034
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The use of omics in monitoring food gut microbiota interaction outcomes: a review of novel trends and technologies
Curr. Opin. Food Sci. 52 , art. 101064
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity
Arch. Toxicol. 97 (8), 2291 - 2302
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Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
Hepatol. Int. 17 (3), 698 - 708
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Metabolic versatility enables sulfur-oxidizers to dominate primary production in groundwater
Water Res. 244 , art. 120426
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A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial
Metab.-Clin. Exp. 145 , art. 155594
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A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways
Toxicol. Appl. Pharmacol. 475 , art. 116650
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Oxidation is an underappreciated post-translational modification in the regulation of immune responses associated with changes in phosphorylation
Front. Immunol. 14 , art. 1244431
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Mycelial nutrient transfer promotes bacterial co-metabolic organochlorine pesticide degradation in nutrient-deprived environments
ISME J. 17 , 570 - 578
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A physiologically-based model of bile acid metabolism in mice
iScience
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Differential contribution of nitrifying prokaryotes to groundwater nitrification
ISME J. 17 (10), 1601 - 1611
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A prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomized controlled within-subject cross-over trial
medRxiv 10.1101/2023.05.30.23290707
New approach methodologies in human regulatory toxicology – Not if, but how and when!
Environ. Int. 178 , art. 108082
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M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer’s patch
Immunity
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Acoustic and vibration monitoring of honeybee colonies for beekeeping-relevant aspects of presence of queen bee and swarming
Comput. Electron. Agric. 205 , art. 107589
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Assessing the influence of propylthiouracil and phenytoin on the metabolomes of the thyroid, liver, and plasma in a rats
Metabolites 13 (7), art. 847
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Bacterial dehydrogenases facilitate oxidative inactivation and bioremediation of chloramphenicol
ChemBioChem 24 (2), e202200632
Volltext (DOI)2022 (30)
Effects of different formulations of glyphosate on rumen microbial metabolism and microbial community composition in the Rumen Simulation Technique system
Front. Microbiol. 13 , art. 873101
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Glyphosate differentially affects the allergic immune response across generations in mice
Sci. Total Environ. 850 , art. 157973
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Insight to the molecular mechanisms underpinning the mycoremediation of multiple metals by proteomic technique
Front. Microbiol. 13 , art. 872576
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Cocoa seeds and chocolate products interaction with gut microbiota; mining microbial and functional biomarkers from mechanistic studies, clinical trials and 16S rRNA amplicon sequencing
Crit. Rev. Food Sci. Nutr.
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Metabolic profile and metabolite analyses in extreme weight responders to gastric bypass surgery
Metabolites 12 (5), art. 417
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Bacterial necromass is rapidly metabolized by heterotrophic bacteria and supports multiple trophic levels of the groundwater microbiome
Microbiol. Spectr. 10 (4), e00437
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Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases
Autophagy 18 (11), 2519 - 2536
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Sulfur and methane oxidation by a single microorganism
Proc. Natl. Acad. Sci. U.S.A. 119 (32), e2114799119
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Ring trial on quantitative assessment of bile acids reveals a method- and analyte-specific accuracy and reproducibility
Metabolites 12 (7), art. 583
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Genes and enzymes involved in the biodegradation of the quaternary carbon compound pivalate in the denitrifying Thauera humireducens strain PIV-1
Environ. Microbiol. 24 (7), 3181 - 3194
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Eggerthella lenta DSM 2243 alleviates bile acid stress response in Clostridium ramosum and Anaerostipes caccae by transformation of bile acids
Microorganisms 10 (10), art. 2025
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Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study
Sci. Total Environ. 814 , art. 152676
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Identification of new potential allergens from green-lipped mussel (Perna canaliculus)
Iran. J. Allergy Asthma Immunol. 21 (6), 711 - 715
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The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Am. J. Clin. Nutr. 115 (5), 1270 - 1281
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MAIT cell activation is reduced by direct and microbiota-mediated exposure to bisphenols
Environ. Int. 158 , art. 106985
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Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance
Gut 71 (11), 2179 - 2193
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Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses
Front. Immunol. 13 , art. 989247
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Modulation of gut microbiota, blood metabolites, and disease resistance by dietary β-glucan in rainbow trout (Oncorhynchus mykiss)
Animal Microbiome 4 , art. 358
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Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity
Microbiome 10 , art. 96
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Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
Cell Death Dis. 13 , art. 53
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Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
Structure 30 (10), 1424 - 1431.e3
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Adaptation and resistance: How Bacteroides thetaiotaomicron copes with the bisphenol A substitute bisphenol F
Microorganisms 10 (8), art. 1610
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Evaluation of antioxidant activity and biotransformation of Opuntia ficus fruit: The effect of in vitro and ex vivo gut microbiota metabolism
Molecules 27 (21), art. 7568
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Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes
Environ. Int. 164 , art. 107279
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The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Arch. Toxicol. 96 (8), 2381 - 2386
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The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45
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Deconstructing Methanosarcina acetivorans into an acetogenic archaeon
Proc. Natl. Acad. Sci. U.S.A. 119 (2), e2113853119
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Microbial community functioning during plant litter decomposition
Sci. Rep. 12 , art. 7451
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Bolstering fitness via CO2 fixation and organic carbon uptake: mixotrophs in modern groundwater
ISME J. 16 (4), 1153 - 1162
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Neonatal Peyer's patch cDC activation as a pacemaker of postnatal immune maturation
Eur. J. Immunol. 52 (S1), 52 - 52
Volltext (DOI)2021 (39)
A workflow to identify novel proteins based on the direct mapping of peptide-spectrum-matches to genomic locations
BMC Bioinformatics 22 , art. 277
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Proteomics reveals sex-specific heat shock response of Baikal amphipod Eulimnogammarus cyaneus
Sci. Total Environ. 763 , art. 143008
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Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk
Mol. Metab. 48 , art. 101214
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Differences in the sperm metabolomes of smoking and nonsmoking men
Biol. Reprod. 105 (6), 1484 - 1493
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How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials
Trends Food Sci. Technol. 118 (Part B), 920 - 937
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Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury
Hepatology 73 (5), 1836 - 1854
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Influence of formic acid treatment on the proteome of the ectoparasite Varroa destructor
PLOS One 16 (10), e0258845
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Changes of the proteome and acetylome during transition into the stationary phase in the organohalide-respiring Dehalococcoides mccartyi strain CBDB1
Microorganisms 9 (2), art. 365
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Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry
Biol. Chem. 402 (11), 1427 - 1440
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Non-genomic AhR-signaling modulates the immune response in endotoxin-activated macrophages after activation by the environmental stressor BaP
Front. Immunol. 12 , art. 620270
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The contact allergen NiSO4 triggers a distinct molecular response in primary human dendritic cells compared to bacterial LPS
Front. Immunol. 12 , art. 644700
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Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study
Environ. Int. 151 , art. 106449
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Omics reveal different oxidative stress levels induced by nanomaterials in vitro and in vivo
Toxicol. Lett. 350 (Suppl.), S125
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Nanomaterials induce different levels of oxidative stress, depending on the used model system: Comparison of in vitro and in vivo effects
Sci. Total Environ. 801 , art. 149538
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HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes
Nucleic Acids Res. 49 (D1), D743 - D750
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Interspecies metabolite transfer and aggregate formation in a co-culture of Dehalococcoides and Sulfurospirillum dehalogenating tetrachloroethene to ethene
ISME J. 15 (6), 1794 - 1809
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Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity
Int. J. Obes. 45 (3), 565 - 576
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Insights into autotrophic activities and carbon flow in iron-rRich pelagic aggregates (iron snow)
Microorganisms 9 (7), art. 1368
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Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior
Transl. Psychiatr. 11 , art. 500
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An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes
NanoImpact 22 , art. 100315
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Mesenchymal stromal cells mitigate liver damage after extended resection in the pig by modulating thrombospondin-1/TGF-β
npj Regen. Med. 6 , art. 84
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Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome
Microbiome 9 , art. 55
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Effect of gut microbiota biotransformation on dietary tannins and human health implications
Microorganisms 9 (5), art. 965
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The emerging plasticizer alternative DINCH and its metabolite MINCH induce oxidative stress and enhance inflammatory responses in human THP-1 macrophages
Cells 10 (9), art. 2367
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Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation
Environ. Int. 156 , art. 106730
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Emerging substitutes of BPA cause inflammation-like state and impaired insulin sensitivity in differentiating human adipocytes
Toxicol. Lett. 350 (Suppl.), S130
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A multi-omics analysis of mucosal-associated-invariant T cells reveals key drivers of distinct modes of activation
Front. Immunol. 12 , art. 616967
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Pesticide-induced metabolic changes are amplified by food stress
Sci. Total Environ. 792 , art. 148350
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Impact d’une exposition alimentaire chronique au glyphosate à des doses de référence sur le microbiote intestinal et le métabolisme énergétique chez la souris
Nutr. Clin. Metab. 35 (1), 74 - 74
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Protein stable isotope probing with H218O differentiated cold stress response at permissive temperatures from general growth at optimal conditions in Escherichia coli K12
Rapid Commun. Mass Spectrom. 35 (1), e8941
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The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice
Gut Microbes 13 (1), 1 - 21
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Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Allergy 76 (10), 3122 - 3132
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The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial
Heart 107 (13), 1054 - 1061
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Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows
Nat. Commun. 12 , art. 7305
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A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae
Embo J. 40 (24), e108542
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Proteomic characterization of the cellular effects of AhR activation by microbial tryptophan catabolites in endotoxin-activated human macrophages
Int. J. Environ. Res. Public Health 18 (19), 10336
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Quantitative proteomics reveal mechanistic insights into direct and indirect drug-induced thyroid toxicity in rats
Toxicol. Lett. 350 (Suppl.), S129
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Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells
New J. Phys. 23 (10), art. 103020
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The metabolomic-gut-clinical axis of Mankai plant-derived dietary polyphenols
Nutrients 13 (6), art. 1866
Volltext (DOI)2020 (31)
A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages
Nanotoxicology 14 (2), 181 - 195
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Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388
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Mechanistic insight to mycoremediation potential of a metal resistant fungal strain for removal of hazardous metals from multimetal pesticide matrix
Environ. Pollut. 262 , art. 114255
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Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model
J. Adv. Res. 23 , 47 - 59
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Quantification of glyphosate and AMPA from microbiome reactor fluids
Rapid Commun. Mass Spectrom. 34 (7), e8668
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Multiplexed quantitative assessment of the fate of taurine and sulfoquinovose in the intestinal microbiome
Metabolites 10 (11), art. 430
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Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss
Microbiome 8 , art. 13
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Mitochondrial transfer by human mesenchymal stromal cells ameliorates hepatocyte lipid load in a mouse model of NASH
Biomedicines 8 (9), art. 350
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Channeling C1 metabolism toward S-adenosylmethionine-dependent conversion of estrogens to androgens in estrogen-degrading bacteria
mBio 11 (4), e01259-20
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In depth quantitative proteomic and transcriptomic characterization of human adipocyte differentiation using the SGBS cell line
Proteomics 20 (15-16), art. 1900405
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Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Int. J. Mol. Sci. 21 (24), art. 9371
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The glyphosate formulation Roundup® LB plus influences the global metabolome of pig gut microbiota in vitro
Sci. Total Environ. 745 , art. 140932
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Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use
Gut Microbes 11 (4), 1116 - 1129
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The activation of mucosal-associated invariant T (MAIT) cells is affected by microbial diversity and riboflavin utilization in vitro
Front. Microbiol. 11 , art. 755
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An MRM-based multiplexed quantification assay for human adipokines and apolipoproteins
Molecules 25 (4), art. 775
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Maternal paraben exposure triggers childhood overweight development
Nat. Commun. 11 , art. 561
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Seasonal patterns of dominant microbes involved in central nutrient cycles in the subsurface
Microorganisms 8 (11), art. 1694
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Function is what counts: how microbial community complexity affects species, proteome and pathway coverage in metaproteomics
Expert Rev. Proteomics 17 (2), 163 - 173
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Ethnomedicinal survey and in vitro confirmation of anti-inflammatory and antispasmodic properties of the termite strain Macrotermes bellicosus used in traditional medicine in the Republic of Benin
J. Ethnopharmacol. 254 , art. 112705
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Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes
Gut 69 (10), 1796 - 1806
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Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria
J. Immunotoxicol. 17 (1), 10 - 20
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MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Clin. Exp. Immunol. 200 (2), 199 - 213
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Benzylsuccinate synthase is post-transcriptionally regulated in the toluene-degrading denitrifier Magnetospirillum sp. strain 15-1
Microorganisms 8 (5), art. 681
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Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization
Nat. Commun. 11 , art. 5104
Volltext (DOI)
Enrichment and identification of small proteins in a simplified human gut microbiome
J. Proteomics 213 , art. 103604
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Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Sci. Transl. Med. 12 (565), eaay7019
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Accumulation of distinct persistent organic pollutants is associated with adipose tissue inflammation
Sci. Total Environ. 748 , art. 142458
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Environmentally relevant concentration of bisphenol S shows slight effects on SIHUMIx
Microorganisms 8 (9), art. 1436
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Tracing incorporation of heavy water into proteins for species-specific metabolic activity in complex communities
J. Proteomics 222 , art. 103791
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Bile acids drive the newborn’s gut microbiota maturation
Nat. Commun. 11 , art. 3692
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Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP
Toxicology 448 , art. 152652
Volltext (DOI)2019 (25)
The class II benzoyl‐coenzyme A reductase complex from the sulfate‐reducing Desulfosarcina cetonica
Environ. Microbiol. 21 (11), 4241 - 4252
Volltext (DOI)
Pseudomonas spp. are key players in agricultural biogas substrate degradation
Sci. Rep. 9 , 12871
Volltext (DOI)
Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma
PLOS One 14 (2), e0211679
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Enzymes involved in phthalate degradation in sulphate‐reducing bacteria
Environ. Microbiol. 21 (10), 3601 - 3612
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AhR-dependent non-genomic signaling in macrophages - A multi-PTM-omics and proteomics study
Eur. J. Immunol. 49 (Suppl. 1), 137
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Disease development is accompanied by changes in bacterial protein abundance and functions in a refined model of dextran sulfate sodium (DSS)-induced colitis
J. Proteome Res. 18 (4), 1774 - 1786
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Chancen und Risiken von Metaproteomik in der Mikrobiomforschung. Opportunities and pitfalls of metaproteomics in microbiome research
Adipositas - Ursachen, Folgeerkrankungen, Therapie 13 (4), 205 - 213
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One-megadalton metalloenzyme complex in Geobacter metallireducens involved in benzene ring reduction beyond the biological redox window
Proc. Natl. Acad. Sci. U.S.A. 116 (6), 2259 - 2264
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An in-depth multi-omics analysis in RLE-6TN rat alveolar epithelial cells allows for nanomaterial categorization
Part. Fibre Toxicol. 16 (1), art. 38
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Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice
Mol. Metab. 22 , 96 - 109
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Nanomaterials affect oxidative phosphorylation and phagocytosis in alveolar macrophages
Eur. J. Immunol. 49 (Suppl. 1), 232
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Mono(2‐ethylhexyl) phthalate (MEHP) and mono(2‐ethyl‐5‐oxohexyl) phthalate (MEOHP) but not di(2‐ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator‐activated receptor γ
Rapid Commun. Mass Spectrom. 33 (S1), 75 - 85
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Effects of five substances with different modes of action on cathepsin H, C and L activities in zebrafish embryos
Int. J. Environ. Res. Public Health 16 (20), art. 3956
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Clostridium ramosum regulates enterochromaffin cell development and serotonin release
Sci. Rep. 9 , art. 1177
Volltext (DOI)
Characterization of a multianalyte GC-MS/MS procedure for detecting and quantifying polycyclic aromatic hydrocarbons (PAHs) and PAH derivatives from air particulate matter for an improved risk assessment
Environ. Pollut. 255 (Part 2), art. 112967
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Serum amino acid concentrations in infants from Malawi are associated with linear growth
Curr. Dev. Nutr. 3 (10), nzz100
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The simplified human intestinal microbiota (SIHUMIx) shows high structural and functional resistance against changing transit times in in vitro bioreactors
Microorganisms 7 (12), art. 641
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Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins
Front. Endocrinol. 10 , art. 674
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Sulfated hyaluronic acid and dexamethasone possess a synergistic potential in the differentiation of osteoblasts from human bone marrow stromal cells
J. Cell. Biochem. 120 (5), 8706 - 8722
Volltext (DOI)
Multi-omics profiling of MAIT cells reveals specific patterns of antigen-dependent and -independent activation
Eur. J. Immunol. 49 (Suppl. 1), 141
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Communal metabolism by Methylococcaceae and Methylophilaceae is driving rapid aerobic methane oxidation in sediments of a shallow seep near Elba, Italy
Environ. Microbiol. 21 (10), 3780 - 3795
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Elevated gestational IL-13 during fetal development is associated with hyperactivity and inattention in eight-year-old children
Front. Immunol. 10 , art. 1658
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Thermal proteome profiling allows quantitative assessment of interactions between tetrachloroethene reductive dehalogenase and trichloroethene
J. Proteomics 192 , 10 - 17
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Widespread soil bacterium that oxidizes atmospheric methane
Proc. Natl. Acad. Sci. U.S.A. 116 (17), 8515 - 8524
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Ecological functions of agricultural soil bacteria and microeukaryotes in chitin degradation: A case study
Front. Microbiol. 10 , art. 1293
Volltext (DOI)2018 (21)
Proteomic definition of human mucosal‐associated invariant T cells determines their unique molecular effector phenotype
Eur. J. Immunol. 48 (8), 1336 - 1349
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Maternal pre-pregnancy body mass index imprints a gut microbial community composition with a specific functionality
Ann. Nutr. Metab. 73 (Suppl. 2), 55
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Gut microbial functional maturation and succession during human early life
Environ. Microbiol. 20 (6), 2160 - 2177
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Insight into the modulation of intestinal proteome of juvenile common carp (Cyprinus carpio L.) after dietary exposure to ZnO nanoparticles
Sci. Total Environ. 613-614 , 62 - 71
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Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection
Sci. Rep. 8 , art. 2681
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Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts
Eur. J. Epidemiol. 33 (1), 55 - 66
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Sulfur-34S and 36S stable isotope labeling of amino acids for quantification (SULAQ34/36) of proteome analyses
In: Becher, D. (ed.)
Microbial proteomics : methods and protocols
Methods in Molecular Biology 1841
Springer Nature, p. 163 - 174
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Glycosaminoglycan derivatives - functional nanostructures modulating healing processes in bone and skin
FEBS Open Bio 8 (S1), 50 - 50
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Comparison of metabolite networks from four German population-based studies
Int. J. Epidemiol. 47 (6), 2070 - 2081
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Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications
J. Allergy Clin. Immunol. 141 (2), 741 - 753
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MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development
Clin. Epigenetics 10 , art. 58
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Proteome and phosphoproteome analysis of commensally induced dendritic cell maturation states
J. Proteomics 180 , 11 - 24
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Desulfitobacterium contributes to the microbial transformation of 2,4,5‐T by methanogenic enrichment cultures from a Vietnamese active landfill
Microb. Biotechnol. 11 (6), 1137 - 1156
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Identification of pesticide exposure-induced metabolic changes in mosquito larvae
Sci. Total Environ. 643 , 1533 - 1541
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Pilot study on mass spectrometry–based analysis of the proteome of CD34+CD123+ progenitor cells for the identification of potential targets for immunotherapy in acute myeloid leukemia
Proteomes 6 (1), art. 11
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Tracking active groundwater microbes with D2O labelling to understand their ecosystem function
Environ. Microbiol. 20 (1), 369 - 384
Volltext (DOI)
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2010
- Strauber, H., Hubschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M. , Harms, H., and Muller, S. (2010):
NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene)--a novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
Cytometry A 77, 113-120
http://dx.doi.org/10.1002/cyto.a.20811 - Selesi, D., Jehmlich, N., von Bergen, M. , Schmidt, F., Rattei, T., Tischler, P., Lueders, T., and Meckenstock, R. U. (2010):
Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
J Bacteriol 192, 295-306
http://dx.doi.org/10.1128/JB.00874-09 - Schirmer, C., Klein, C., von Bergen, M. , Simon, J. C., and Saalbach, A. (2010):
Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells
Blood116,1715-1725
http://dx.doi.org/10.1182/blood-2010-01-263509 - Ohler, M., Georgieva, D., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities
J Proteome Res 9, 2422-2437
http://dx.doi.org/10.1021/pr901128x - Muller, S. A., Kohajda, T., Findeiss, S., Stadler, P. F., Washietl, S., Kellis, M., von Bergen, M. , and Kalkhof, S. (2010):
Optimization of parameters for coverage of low molecular weight proteins
Anal Bioanal Chem
http://dx.doi.org/10.1007/s00216-010-4093-x - Leibeling, S., Schmidt, F., Jehmlich, N., von Bergen, M. , Muller, R. H., and Harms, H. (2010):
Declining capacity of starving Delftia acidovorans MC1 to degrade phenoxypropionate herbicides correlates with oxidative modification of the initial enzyme
Environ Sci Technol 44, 3793-3799
http://dx.doi.org/10.1021/es903619j - Kung, J. W., Baumann, S., von Bergen, M. , Muller, M., Hagedoorn, P. L., Hagen, W. R., and Boll, M. (2010):
Reversible biological Birch reduction at an extremely low redox potential
J Am Chem Soc 132, 9850-9856
http://dx.doi.org/10.1021/ja103448u - Jehmlich, N., Hubschmann, T., Gesell Salazar, M., Volker, U., Benndorf, D., Muller, S., von Bergen, M. , and Schmidt, F. (2010):
Advanced tool for characterization of microbial cultures by combining cytomics and proteomics
Appl Microbiol Biotechnol 88, 575-584
http://dx.doi.org/10.1007/s00253-010-2753-6 - Jehmlich, N., Fetzer, I., Seifert, J., Mattow, J., Vogt, C., Harms, H., Thiede, B., Richnow, H. H., von Bergen, M. , and Schmidt, F. (2010):
Decimal place slope, a fast and precise method for quantifying 13C incorporation levels for detecting the metabolic activity of microbial species
Mol Cell Proteomics 9, 1221-1227
http://dx.doi.org/10.1074/mcp.M900407-MCP200 - Georgieva, D., Redecke, L., von Bergen, M. , Genov, N., and Betzel, C. (2010):
Interactions of ginkgolides A and B with a recombinant human prion protein
Protein Pept Lett 17, 399-404
http://www.benthamdirect.org/pages/b_viewarticle.php?3157685 - Georgieva, D., Ohler, M., Seifert, J., von Bergen, M. , Arni, R. K., Genov, N., and Betzel, C. (2010):
Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities
J Proteome Res 9, 2302-2316
http://dx.doi.org/10.1021/pr901042p - Fetzer, I., Jehmlich, N., Vogt, C., Richnow, H. H., Seifert, J., Harms, H., von Bergen, M. , and Schmidt, F. (2010):
Calculation of partial isotope incorporation into peptides measured by mass spectrometry
BMC Res Notes 3, 178
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Discrimination of different species from the genus Drosophila by intact protein profiling using matrix-assisted laser desorption ionization mass spectrometry
BMC Evol Biol 10, 95
http://dx.doi.org/10.1186/1471-2148-10-95 - Bastida, F., Rosell, M., Franchini, A. G., Seifert, J., Finsterbusch, S., Jehmlich, N., Jechalke, S., von Bergen, M. , and Richnow, H. H. (2010):
Elucidating MTBE degradation in a mixed consortium using a multidisciplinary approach
FEMS Microbiol Ecol 73, 370-384
http://dx.DOI.org/10.1111/j.1574-6941.2010.00889.x - Wischgoll, S., Taubert, M., Peters, F., Jehmlich, N., von Bergen, M. , and Boll, M. (2009):
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria
J Bacteriol 191, 4401-4409
http://dx.doi.org/10.1128/JB.00205-09 - Schleinitz, K. M., Schmeling, S., Jehmlich, N., von Bergen, M. , Harms, H., Kleinsteuber, S., Vogt, C., and Fuchs, G. (2009):
Phenol degradation in the strictly anaerobic iron-reducing bacterium Geobacter metallireducens GS-15
Appl Environ Microbiol 75, 3912-3919
http://dx.doi.org/10.1128/AEM.01525-08 - Risch, M., Georgieva, D., von Bergen, M. , Jehmlich, N., Genov, N., Arni, R. K., and Betzel, C. (2009):
Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) -- relation to pharmacological activities
J Proteomics 72, 256-269
http://dx.doi.org/10.1016/j.jprot.2009.01.006 - Rehders, D., Claasen, B., Redecke, L., Buschke, A., Reibe, C., Jehmlich, N., von Bergen, M. , Betzel, C., and Meyer, B. (2009):
Peptide NMHRYPNQ of the cellular prion protein (PrP(C)) inhibits aggregation and is a potential key for understanding prion-prion interactions
J Mol Biol 392, 198-207
http://dx.doi.org/ 10.1016/j.jmb.2009.07.014 - Morbt, N., Mogel, I., Kalkhof, S., Feltens, R., Roder-Stolinski, C., Zheng, J., Vogt, C., Lehmann, I., and von Bergen, M. (2009):
Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism
Proteomics 9, 4920-4933
http://dx.doi.org/10.1002/pmic.200800836 - Junghanns, C., Pecyna, M. J., Bohm, D., Jehmlich, N., Martin, C., von Bergen, M. , Schauer, F., Hofrichter, M., and Schlosser, D. (2009):
Biochemical and molecular genetic characterisation of a novel laccase produced by the aquatic ascomycete Phoma sp. UHH 5-1-03
Appl Microbiol Biotechnol 84, 1095-1105
http://dx.doi.org/10.1007/s00253-009-2028-2 - Jehmlich, N., Schmidt, F., Taubert, M., Seifert, J., von Bergen, M. , Richnow, H. H., and Vogt, C. (2009):
Comparison of methods for simultaneous identification of bacterial species and determination of metabolic activity by protein-based stable isotope probing (Protein-SIP) experiments
Rapid Commun Mass Spectrom 23, 1871-1878
http://dx.doi.org/10.1002/rcm.4084 - Heine, F., Stahl, F., Strauber, H., Wiacek, C., Benndorf, D., Repenning, C., Schmidt, F., Scheper, T., von Bergen, M. , Harms, H., and Muller, S. (2009):
Prediction of flocculation ability of brewing yeast inoculates by flow cytometry, proteome analysis, and mRNA profiling
Cytometry A 75, 140-147
http://dx.doi.org/10.1002/cyto.a.20661 - Benndorf, D., Vogt, C., Jehmlich, N., Schmidt, Y., Thomas, H., Woffendin, G., Shevchenko, A., Richnow, H. H., and von Bergen, M. (2009):
Improving protein extraction and separation methods for investigating the metaproteome of anaerobic benzene communities within sediments
Biodegradation 20, 737-750
http://dx.doi.org/10.1007/s10532-009-9261-3 - Thiele, B., Rieder, O., Jehmlich, N., von Bergen, M. , Muller, M., and Boll, M. (2008):
Aromatizing cyclohexa-1,5-diene-1-carbonyl-coenzyme A oxidase. Characterization and its role in anaerobic aromatic metabolism
J Biol Chem 283, 20713-20721
http://dx.doi.org/10.1074/jbc.M802841200 - Roder-Stolinski, C., Fischader, G., Oostingh, G. J., Feltens, R., Kohse, F., von Bergen, M. , Morbt, N., Eder, K., Duschl, A., and Lehmann, I. (2008):
Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activation
Toxicol Appl Pharmacol 231, 241-247
http://dx.doi.org/10.1016/j.taap.2008.04.010 - Johannes, J., Bluschke, A., Jehmlich, N., von Bergen, M. , and Boll, M. (2008):
Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens
J Bacteriol 190, 6493-6500
http://dx.doi.org/10.1128/JB.00790-08 - Jehmlich, N., Schmidt, F., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
Protein-based stable isotope probing (Protein-SIP) reveals active species within anoxic mixed cultures
ISME J 2, 1122-1133
http://dx.doi.org/10.1038/ismej.2008.64 - Jehmlich, N., Schmidt, F., Hartwich, M., von Bergen, M. , Richnow, H. H., and Vogt, C. (2008):
Incorporation of carbon and nitrogen atoms into proteins measured by protein-based stable isotope probing (Protein-SIP)
Rapid Commun Mass Spectrom 22, 2889-2897
http://dx.doi.org/10.1002/rcm.3684 - Jeganathan, S., von Bergen, M. , Mandelkow, E. M., and Mandelkow, E. (2008):
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
Biochemistry 47, 10526-10539
http://dx.doi.org/10.1021/bi800783d - Hehemann, J. H., Redecke, L., Murugaiyan, J., von Bergen, M. , Betzel, C., and Saborowski, R. (2008):
Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus
Biochem Biophys Res Commun 370, 566-571
http://dx.doi.org/10.1016/j.bbrc.2008.03.128 - Georgieva, D., Risch, M., Kardas, A., Buck, F., von Bergen, M. , and Betzel, C. (2008):
Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis
J Proteome Res 7, 866-886
http://dx.doi.org/10.1021/pr070376c - Benndorf, D., Muller, A., Bock, K., Manuwald, O., Herbarth, O., and von Bergen, M. (2008):
Identification of spore allergens from the indoor mould Aspergillus versicolor
Allergy 63, 454-460
http://dx.doi.org/10.1111/j.1398-9995.2007.01603.x - Andronesi, O. C., von Bergen, M. , Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008):
Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy
J Am Chem Soc 130, 5922-5928
http://dx.doi.org/10.1021/ja7100517 - Santos, P. M., Roma, V., Benndorf, D., von Bergen, M. , Harms, H., and Sa-Correia, I. (2007):
Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1 revealed by quantitative proteomics
OMICS 11, 233-251
http://dx.doi.org/10.1089/omi.2007.0009 - Redecke, L., von Bergen, M. , Clos, J., Konarev, P. V., Svergun, D. I., Fittschen, U. E., Broekaert, J. A., Bruns, O., Georgieva, D., Mandelkow, E., Genov, N., and Betzel, C. (2007):
Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro
J Struct Biol 157, 308-320
http://dx.doi.org/10.1016/j.jsb.2006.06.013 - Mukrasch, M. D., von Bergen, M. , Biernat, J., Fischer, D., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
The "jaws" of the tau-microtubule interaction
J Biol Chem 282, 12230-12239
http://dx.doi.org/10.1074/jbc.M607159200 - Martin, C., Pecyna, M., Kellner, H., Jehmlich, N., Junghanns, C., Benndorf, D., von Bergen, M. , and Schlosser, D. (2007):
Purification and biochemical characterization of a laccase from the aquatic fungus Myrioconium sp. UHH 1-13-18-4 and molecular analysis of the laccase-encoding gene
Appl Microbiol Biotechnol 77, 613-624
http://dx.doi.org/10.1007/s00253-007-1207-2 - Mandelkow, E., von Bergen, M. , Biernat, J., and Mandelkow, E. M. (2007):
Structural principles of tau and the paired helical filaments of Alzheimer's disease
Brain Pathol 17, 83-90
http://dx.doi.org/10.1111/j.1750-3639.2007.00053.x - Gundel, U., Benndorf, D., von Bergen, M. , Altenburger, R., and Kuster, E. (2007):
Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach
Proteomics 7, 4541-4554
http://dx.doi.org/10.1002/pmic.200700381 - Fischer, D., Mukrasch, M. D., von Bergen, M. , Klos-Witkowska, A., Biernat, J., Griesinger, C., Mandelkow, E., and Zweckstetter, M. (2007):
Structural and microtubule binding properties of tau mutants of frontotemporal dementias
Biochemistry 46, 2574-2582
http://dx.doi.org/10.1021/bi061318s - Benndorf, D., Balcke, G. U., Harms, H., and von Bergen, M. (2007):
Functional metaproteome analysis of protein extracts from contaminated soil and groundwater
ISME J 1, 224-234
http://dx.doi.org/10.1038/ismej.2007.39 - von Bergen, M. , Barghorn, S., Muller, S. A., Pickhardt, M., Biernat, J., Mandelkow, E. M., Davies, P., Aebi, U., and Mandelkow, E. (2006):
The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis
Biochemistry 45, 6446-6457
http://dx.doi.org/10.1021/bi052530j - von Bergen, M. , Barghorn, S., Jeganathan, S., Mandelkow, E. M., and Mandelkow, E. (2006):
Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments
Neurodegener Dis 3, 197-206
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Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs
J Biol Chem 281, 1205-1214
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Global hairpin folding of tau in solution
Biochemistry 45, 2283-2293
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Interactions of recombinant prions with compounds of therapeutical significance
Biochem Biophys Res Commun 344, 463-470
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Intrinsic fluorescent detection of tau conformation and aggregation
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Tau aggregation is driven by a transition from random coil to beta sheet structure
Biochim Biophys Acta 1739, 158-166
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Screening for inhibitors of tau polymerization
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Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
J Biol Chem 280, 3628-3635
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Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions
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Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis
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Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
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