Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1038/s41467-019-14202-1
Lizenz creative commons licence
Titel (primär) Maternal paraben exposure triggers childhood overweight development
Autor Leppert, B.; Strunz, S.; Seiwert, B.; Schlittenbauer, L.; Schlichting, R.; Pfeifer, C.; Röder, S. ORCID logo ; Bauer, M.; Borte, M.; Stangl, G.I.; Schöneberg, T.; Schulz, A.; Karkossa, I.; Rolle-Kampczyk, U.E.; Thürmann, L.; von Bergen, M.; Escher, B.I.; Junge, K.M.; Reemtsma, T.; Lehmann, I.; Polte, T.
Quelle Nature Communications
Erscheinungsjahr 2020
Band/Volume 11
Seite von art. 561
Sprache englisch
Abstract Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially in recent years. Here we investigate the effect of prenatal paraben exposure on childhood overweight by combining epidemiological data from a mother–child cohort with experimental approaches. Mothers reporting the use of paraben-containing cosmetic products have elevated urinary paraben concentrations. For butyl paraben (BuP) a positive association is observed to overweight within the first eight years of life with a stronger trend in girls. Consistently, maternal BuP exposure of mice induces a higher food intake and weight gain in female offspring. The effect is accompanied by an epigenetic modification in the neuronal Pro-opiomelanocortin (POMC) enhancer 1 leading to a reduced hypothalamic POMC expression. Here we report that maternal paraben exposure may contribute to childhood overweight development by altered POMC-mediated neuronal appetite regulation.
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Leppert, B., Strunz, S., Seiwert, B., Schlittenbauer, L., Schlichting, R., Pfeifer, C., Röder, S., Bauer, M., Borte, M., Stangl, G.I., Schöneberg, T., Schulz, A., Karkossa, I., Rolle-Kampczyk, U.E., Thürmann, L., von Bergen, M., Escher, B.I., Junge, K.M., Reemtsma, T., Lehmann, I., Polte, T. (2020):
Maternal paraben exposure triggers childhood overweight development
Nat. Commun. 11 , art. 561 10.1038/s41467-019-14202-1