Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1002/etc.5242
Lizenz creative commons licence
Titel (primär) The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Autor Scholz, S. ORCID logo ; Nichols, J.W.; Escher, B.I.; Ankley, G.T.; Altenburger, R.; Blackwell, B.; Brack, W.; Burkhard, L.; Collette, T.W.; Doering, J.A.; Ekman, D.; Fay, K.; Fischer, F.; Hackermüller, J. ORCID logo ; Hoffman, J.C.; Lai, C.; Leuthold, D.; Martinovic-Weigelt, D.; Reemtsma, T.; Pollesch, N.; Schroeder, A.; Schüürmann, G.; von Bergen, M.
Quelle Environmental Toxicology and Chemistry
Erscheinungsjahr 2022
Band/Volume 41
Heft 1
Seite von 30
Seite bis 45
Sprache englisch
Topic T9 Healthy Planet
Keywords Exposome; Adverse outcome pathways; suspect screening; biomonitoring; internal exposure; external exposure
Abstract Organisms are exposed to ever changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept in human toxicology. Whether this concept has utility in the context of environmental hazard and risk assessment has not been discussed in detail. In this paper, we propose – by analogy to the human exposome - to define the eco-exposome as the totality of the internal exposure (anthropogenic and natural chemicals, their biotransformation products or adducts, and endogenous signaling molecules that may be sensitive to an anthropogenic chemical exposure) over the life time of an ecologically relevant organism. We describe how targeted and non-targeted chemical analyses and bioassays can be employed to characterize this exposure and discuss how the adverse outcome pathway (AOP) concept could be used to link this exposure to adverse effects. Available methods, their limitations and/or requirement for improvements for practical application of the eco-exposome concept are discussed. Even though analysis of the eco-exposome can be resource-intensive and challenging, new approaches and technologies make this assessment increasingly feasible. Furthermore, an improved understanding of mechanistic relationships between external chemical exposure(s), internal chemical exposure(s), and biological effects could result in the development of proxies; that is, relatively simple chemical and biological measurements that could be used to complement internal exposure assessment or infer the internal exposure when it is difficult to measure.
dauerhafte UFZ-Verlinkung
Scholz, S., Nichols, J.W., Escher, B.I., Ankley, G.T., Altenburger, R., Blackwell, B., Brack, W., Burkhard, L., Collette, T.W., Doering, J.A., Ekman, D., Fay, K., Fischer, F., Hackermüller, J., Hoffman, J.C., Lai, C., Leuthold, D., Martinovic-Weigelt, D., Reemtsma, T., Pollesch, N., Schroeder, A., Schüürmann, G., von Bergen, M. (2022):
The eco‐exposome concept: Supporting an integrated assessment of mixtures of environmental chemicals
Environ. Toxicol. Chem. 41 (1), 30 - 45 10.1002/etc.5242