Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Structural principles of tau and the paired helical filaments of Alzheimer's disease
Autor Mandelkow, E.; von Bergen, M.; Biernat, J.; Mandelkow, E.-M.;
Journal / Serie Brain Pathology
Erscheinungsjahr 2007
Department PROTEOM;
Band/Volume 17
Heft 1
Sprache englisch;
Abstract Tau, a major microtubule-associated protein in brain, forms abnormal fibers in Alzheimer's disease and several other neurodegenerative diseases. Tau is highly soluble and adopts a natively unfolded structure in solution. In the paired helical filaments of Alzheimer's disease, small segments of tau adopt a ß-conformation and interact with other tau molecules. In the filament core, the microtubule-binding repeat region of tau has a cross-ß structure, while the rest of the protein retains its largely unfolded structure and gives rise to the fuzzy coat of the filaments.
ID 2042
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2042
Mandelkow, E., von Bergen, M., Biernat, J., Mandelkow, E.-M. (2007):
Structural principles of tau and the paired helical filaments of Alzheimer's disease
Brain Pathol. 17 (1), 83 - 90