Details zur Publikation |
Kategorie | Textpublikation |
Referenztyp | Zeitschriften |
DOI | 10.1111/j.1750-3639.2007.00053.x |
Titel (primär) | Structural principles of tau and the paired helical filaments of Alzheimer's disease |
Autor | Mandelkow, E.; von Bergen, M.; Biernat, J.; Mandelkow, E.-M. |
Quelle | Brain Pathology |
Erscheinungsjahr | 2007 |
Department | PROTEOM |
Band/Volume | 17 |
Heft | 1 |
Seite von | 83 |
Seite bis | 90 |
Sprache | englisch |
Abstract | Tau, a major microtubule-associated protein in brain, forms abnormal fibers in Alzheimer's disease and several other neurodegenerative diseases. Tau is highly soluble and adopts a natively unfolded structure in solution. In the paired helical filaments of Alzheimer's disease, small segments of tau adopt a ß-conformation and interact with other tau molecules. In the filament core, the microtubule-binding repeat region of tau has a cross-ß structure, while the rest of the protein retains its largely unfolded structure and gives rise to the fuzzy coat of the filaments. |
dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2042 |
Mandelkow, E., von Bergen, M., Biernat, J., Mandelkow, E.-M. (2007): Structural principles of tau and the paired helical filaments of Alzheimer's disease Brain Pathol. 17 (1), 83 - 90 10.1111/j.1750-3639.2007.00053.x |