Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1111/all.14890
Lizenz creative commons licence
Titel (primär) Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Autor Thürmann, L.; Herberth, G. ORCID logo ; Seiwert, B.; Schlittenbauer, L.; Rolle-Kampczyk, U.; Röder, S. ORCID logo ; Sack, U.; Borte, M.; von Bergen, M.; Trump, S.; Reemtsma, T.; Lehmann, I.
Quelle Allergy
Erscheinungsjahr 2021
Department ANA; IMMU; MOLSYB
Band/Volume 76
Heft 10
Seite von 3122
Seite bis 3132
Sprache englisch
Topic T9 Healthy Planet
Keywords allergy; atopic dermatitis; paraben; prenatal; sex


Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD).


261 mother-child pairs of the German mother-child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician-diagnosed AD from age 1 to 8 years, disease onset, and persistence, childhood AD was classified into four different phenotypes.


4.6% (n = 12) and 12.3% (n = 32) of the children were classified as having very early-onset AD (until age two) either with or without remission, 11.9% (n = 31) as early-onset (after age two), and 3.1% (n = 8) as childhood-onset AD (after age six). Exposure to ethylparaben and n-butylparaben was associated with an increased risk to develop very early-onset AD without remission (EtP: adj.OR/95% CI:1.44/1.04–2.00,nBuP:adj.OR/95% CI:1.95/1.22–3.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex.


Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure.

dauerhafte UFZ-Verlinkung
Thürmann, L., Herberth, G., Seiwert, B., Schlittenbauer, L., Rolle-Kampczyk, U., Röder, S., Sack, U., Borte, M., von Bergen, M., Trump, S., Reemtsma, T., Lehmann, I. (2021):
Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Allergy 76 (10), 3122 - 3132 10.1111/all.14890