Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Autor Markle, J.G.M.; Frank, D.N.; Mortin-Toth, S.; Robertson, C.E.; Feazel, L.M.; Rolle-Kampczyk, U.; von Bergen, M.; McCoy, C.D.; Macpherson, A.J.; Danska, J.S.;
Journal / Serie Science
Erscheinungsjahr 2013
Department METABOX; PROTEOM;
Band/Volume 339
Heft 6123
Sprache englisch;
POF III (gesamt) F11;
UFZ Querschnittsthemen RU3;
Abstract Microbial exposures and sex hormones exert potent effects on autoimmune diseases, many of which are more prevalent in women. We demonstrate that early-life microbial exposures determine sex hormone levels and modify progression to autoimmunity in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D). Colonization by commensal microbes elevated serum testosterone and protected NOD males from T1D. Transfer of gut microbiota from adult males to immature females altered the recipient's microbiota, resulting in elevated testosterone and metabolomic changes, reduced islet inflammation and autoantibody production, and robust T1D protection. These effects were dependent on androgen receptor activity. Thus, the commensal microbial community alters sex hormone levels and regulates autoimmune disease fate in individuals with high genetic risk.
ID 13487
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=13487
Markle, J.G.M., Frank, D.N., Mortin-Toth, S., Robertson, C.E., Feazel, L.M., Rolle-Kampczyk, U., von Bergen, M., McCoy, C.D., Macpherson, A.J., Danska, J.S. (2013):
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Science 339 (6123 ), 1084 - 1088