Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1038/s41598-024-74517-y
Lizenz creative commons licence
Titel (primär) Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environments using proteomics
Autor Dey, P.; Malik, A.; Singh, D.K.; Haange, S.-B. ORCID logo ; von Bergen, M.; Jehmlich, N. ORCID logo
Quelle Scientific Reports
Erscheinungsjahr 2024
Department MOLTOX
Band/Volume 14
Seite von art. 23171
Sprache englisch
Topic T9 Healthy Planet
Supplements https://static-content.springer.com/esm/art%3A10.1038%2Fs41598-024-74517-y/MediaObjects/41598_2024_74517_MOESM1_ESM.docx
Keywords Multimetal; Lindane; Haloalkane dehalogenase; Homogentisate 1,2-dioxygenase
Abstract Micropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of the pesticide lindane and multiple metals (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in Aspergillus fumigatus PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 of which were consistently present under both stress conditions. Specifically, Cu-Zn superoxide dismutase and heat shock proteins were up-regulated to counter oxidative stress and protein misfolding. Proteins involved in intracellular trafficking, secretion, and vesicular transport; RNA processing and modification showed enhanced abundance and regulating stress response pathways. Additionally, haloalkane dehalogenase and homogentisate 1,2-dioxygenase played pivotal roles in lindane mineralization. Bioinformatics analysis highlighted enriched pathways such as Glyoxylate and dicarboxylate metabolism and Purine metabolism, that are crucial for combating adverse environments. We identified the hub protein 26 S proteasome regulatory subunit complex as potential biomarker and remedial targets for mycoremediation of wastewater, suggesting practical applications for environmental remediation.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29746
Dey, P., Malik, A., Singh, D.K., Haange, S.-B., von Bergen, M., Jehmlich, N. (2024):
Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environments using proteomics
Sci. Rep. 14 , art. 23171 10.1038/s41598-024-74517-y