Details zur Publikation |
Kategorie | Textpublikation |
Referenztyp | Zeitschriften |
DOI | 10.1016/j.ajcnut.2024.09.013 |
Lizenz ![]() |
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Titel (primär) | Glycemic control contributes to the neuroprotective effects of Mediterranean and green Mediterranean diets on brain age: the DIRECT-PLUS brain-magnetic resonance imaging randomized controlled trial |
Autor | Pachter, D.; Kaplan, A.; Tsaban, G.; Zelicha, H.; Meir, A.Y.; Rinott, E.; Levakov, G.; Salti, M.; Yovell, Y.; Huhn, S.; Beyer, F.; Witte, V.; Kovacs, P.; von Bergen, M.; Ceglarek, U.; Blüher, M.; Stumvoll, M.; Hu, F.B.; Stampfer, M.J.; Friedman, A.; Shelef, I.; Avidan, G.; Shai, I. |
Quelle | American Journal of Clinical Nutrition |
Erscheinungsjahr | 2024 |
Department | ETOX; MOLTOX |
Band/Volume | 120 |
Heft | 5 |
Seite von | 1029 |
Seite bis | 1036 |
Sprache | englisch |
Topic | T9 Healthy Planet |
Supplements | https://ars.els-cdn.com/content/image/1-s2.0-S0002916524007457-mmc1.docx |
Keywords | aging; brain age; dietary intervention; glycemic control; green-Mediterranean; hippocampal occupancy score; polyphenols |
Abstract | Background We recently reported that Mediterranean (MED) and green-MED diets significantly attenuated age-related brain atrophy by ∼50% within 18 mo. Objective The objective of this study was to explore the contribution of specific diet-induced parameters to brain-volume deviation from chronologic age. Methods A post hoc analysis of the 18-mo DIRECT-PLUS trial, where participants were randomly assigned to the following groups: 1) healthy dietary guidelines, 2) MED diet, or 3) green-MED diet, high in polyphenols, and low in red meat. Both MED groups consumed 28 g walnuts/d (+440 mg/d polyphenols). The green-MED group further consumed green tea (3–4 cups/d) and Mankai green shake (Wolffia globosa aquatic plant) (+800 mg/d polyphenols). We collected blood samples through the intervention and followed brain structure volumes by magnetic resonance imaging (MRI). We used hippocampal occupancy (HOC) score (hippocampal and inferior lateral-ventricle volumes ratio) as a neurodegeneration marker and brain-age proxy. We applied multivariate linear regression models. Results Of 284 participants [88% male; age = 51.1 y; body mass index = 31.2 kg/m2; hemoglobin A1c (HbA1c) = 5.48%; APOE-ε4 genotype = 15.7%], 224 completed the trial with eligible whole-brain MRIs. Individuals with higher HOC deviations (i.e., younger brain age) presented lower body weight [r = –0.204; 95% confidence interval (CI): –0.298, –0.101], waist circumference (r = –0.207; 95% CI: –0.310, –0.103), diastolic (r = –0.186; 95% CI: –0.304, –0.072), systolic blood pressure (r = –0.189; 95% CI: –0.308, –0.061), insulin (r = –0.099; 95% CI: –0.194, –0.004), and HbA1c (r = –0.164; 95% CI: –0.337, –0.006) concentrations. After 18 mo, greater changes in HOC deviations (i.e., brain-age decline attenuation) were independently associated with improved HbA1c (β = –0.254; 95% CI: –0.392, –0.117), HOMA-IR (β = –0.200; 95% CI: –0.346, –0.055), fasting glucose (β = –0.155; 95% CI: –0.293, –0.016), and s-reactive protein (β = –0.153; 95% CI: –0.296, –0.010). Improvement in diabetes status was associated with greater HOC deviation changes than either no change in diabetes status (0.010; 95% CI: 0.002, 0.019) or with an unfavorable change (0.012; 95% CI: 0.002, 0.023). A decline in HbA1c is further associated with greater deviation changes in the thalamus, caudate nucleus, and cerebellum (P < 0.05). Greater consumption of Mankai and green tea (green-MED diet components) were associated with greater HOC deviation changes beyond weight loss. Conclusions Glycemic control contributes to the neuroprotective effects of the MED and green-MED diets on brain age. Polyphenols-rich diet components as Mankai and green tea may contribute to a more youthful brain age. |
dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29735 |
Pachter, D., Kaplan, A., Tsaban, G., Zelicha, H., Meir, A.Y., Rinott, E., Levakov, G., Salti, M., Yovell, Y., Huhn, S., Beyer, F., Witte, V., Kovacs, P., von Bergen, M., Ceglarek, U., Blüher, M., Stumvoll, M., Hu, F.B., Stampfer, M.J., Friedman, A., Shelef, I., Avidan, G., Shai, I. (2024): Glycemic control contributes to the neuroprotective effects of Mediterranean and green Mediterranean diets on brain age: the DIRECT-PLUS brain-magnetic resonance imaging randomized controlled trial Am. J. Clin. Nutr. 120 (5), 1029 - 1036 10.1016/j.ajcnut.2024.09.013 |