Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Autor Riba, A.; Hassani, K.; Walker, A.; van Best, N.; von Zeschwitz, D.; Anslinger, T.; Sillner, N.; Rosenhain, S.; Eibach, D.; Maiga-Ascofaré, O.; Rolle-Kampczyk, U.; Basic, M.; Binz, A.; Mocek, S.; Sodeik, B.; Bauerfeind, R.; Mohs, A.; Trautwein, C.; Kiessling, F.; May, J.; Klingenspor, M.; Gremse, F.; Schmitt-Kopplin, P.; Bleich, A.; Torow, N.; von Bergen, M.; Hornef, M.W.;
Journal / Serie Science Translational Medicine
Erscheinungsjahr 2020
Department MOLSYB;
Band/Volume 12
Heft 565
Sprache englisch;
POF III (gesamt) F11;
Supplements http://stm.sciencemag.org/cgi/content/full/12/565/eaay7019/DC1
UFZ Querschnittsthemen Exposom
Abstract Although infection with the human enteropathogen Giardia lamblia causes self-limited diarrhea in adults, infant populations in endemic areas experience persistent pathogen carriage in the absence of diarrhea. The persistence of this protozoan parasite in infants has been associated with reduced weight gain and linear growth (height-for-age). The mechanisms that support persistent infection and determine the different disease outcomes in the infant host are incompletely understood. Using a neonatal mouse model of persistent G. lamblia infection, we demonstrate that G. lamblia induced bile secretion and used the bile constituent phosphatidylcholine as a substrate for parasite growth. In addition, we show that G. lamblia infection altered the enteric microbiota composition, leading to enhanced bile acid deconjugation and increased expression of fibroblast growth factor 15. This resulted in elevated energy expenditure and dysregulated lipid metabolism with reduced adipose tissue, body weight gain, and growth in the infected mice. Our results indicate that this enteropathogen’s modulation of bile acid metabolism and lipid metabolism in the neonatal mouse host led to an altered body composition, suggesting how G. lamblia infection could contribute to growth restriction in infants in endemic areas.
ID 23761
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=23761
Riba, A., Hassani, K., Walker, A., van Best, N., von Zeschwitz, D., Anslinger, T., Sillner, N., Rosenhain, S., Eibach, D., Maiga-Ascofaré, O., Rolle-Kampczyk, U., Basic, M., Binz, A., Mocek, S., Sodeik, B., Bauerfeind, R., Mohs, A., Trautwein, C., Kiessling, F., May, J., Klingenspor, M., Gremse, F., Schmitt-Kopplin, P., Bleich, A., Torow, N., von Bergen, M., Hornef, M.W. (2020):
Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment
Sci. Transl. Med. 12 (565), eaay7019