Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Interactions of ginkgolides A and B with a recombinant human prion protein
Autor Georgieva, D.; Redecke, L.; von Bergen, M.; Genov, N.; Betzel, C.;
Journal / Serie Protein and Peptide Letters
Erscheinungsjahr 2010
Department PROTEOM;
Band/Volume 17
Heft 3
Sprache englisch;
Keywords Three-dimensional structure; structural transformation; ginkgolide; prion protein; protein misfolding
Abstract In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.
ID 9989
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=9989
Georgieva, D., Redecke, L., von Bergen, M., Genov, N., Betzel, C. (2010):
Interactions of ginkgolides A and B with a recombinant human prion protein
Protein Pept. Lett. 17 (3), 399 - 404