Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.3390/ijms21249371
Lizenz creative commons licence
Titel (primär) Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Autor Karkossa, I.; Raps, S.; von Bergen, M.; Schubert, K.
Quelle International Journal of Molecular Sciences
Erscheinungsjahr 2020
Department MOLSYB
Band/Volume 21
Heft 24
Seite von art. 9371
Sprache englisch
Keywords multi-omics; macrophages; toxicology; xenobiotics
Abstract Insights into the modes of action (MoAs) of xenobiotics are of utmost importance for the definition of adverse outcome pathways (AOPs), which are essential for a mechanism-based risk assessment. A well-established strategy to reveal MoAs of xenobiotics is the use of omics. However, often an even more comprehensive approach is needed, which can be achieved using multi-omics. Since the immune system plays a central role in the defense against foreign substances and pathogens, with the innate immune system building a first barrier, we systematically reviewed multi-omics studies investigating the effects of xenobiotics on macrophages. Surprisingly, only nine publications were identified, combining proteomics with transcriptomics or metabolomics. We summarized pathways and single proteins, transcripts, or metabolites, which were described to be affected upon treatment with xenobiotics in the reviewed studies, thus revealing a broad range of effects. In summary, we show that macrophages are a relevant model system to investigate the toxicological effects induced by xenobiotics. Furthermore, the multi-omics approaches led to a more comprehensive overview compared to only one omics layer with slight advantages for combinations that complement each other directly, e.g., proteome and metabolome.
dauerhafte UFZ-Verlinkung
Karkossa, I., Raps, S., von Bergen, M., Schubert, K. (2020):
Systematic review of multi-omics approaches to investigate toxicological effects in macrophages
Int. J. Mol. Sci. 21 (24), art. 9371 10.3390/ijms21249371