Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1111/all.12897
Volltext Shareable Link
Titel (primär) Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE
Autor Hoeke, H.; Roeder, S. ORCID logo ; Mueller, A.; Bertsche, T.; Borte, M.; Rolle-Kampczyk, U.; von Bergen, M.; Wissenbach, D.K.
Journal / Serie Allergy
Erscheinungsjahr 2016
Department STUDIEN; MOLSYB
Band/Volume 71
Heft 6
Seite von 901
Seite bis 906
Sprache englisch
Keywords Acetaminophen; prenatal exposure; IgE; SX1
UFZ Querschnittsthemen RU3;
Abstract An association between prenatal acetaminophen or ibuprofen intake and an increased risk for asthma and increased IgE level in children is discussed in various epidemiological studies. Although the molecular mechanistic link is still unknown, the question whether or not acetaminophen and/or ibuprofen are safe pain medications during pregnancy arose. In this study, we associate maternal acetaminophen and ibuprofen intake during pregnancy and breast feeding to infantile asthma phenotypes and elevated IgE level. Therefore, we analysed questionnaires from a local mother-child cohort and monitored drug intake by LC-MS bio monitoring in urine. No association was found between drug intake and any analysed health outcome using questionnaire data. For the information obtained by bio monitoring no association was found for ibuprofen and acetaminophen intake during breast feeding. However, an association between prenatal acetaminophen intake and increased infantile IgEs related to aeroallergens was statistically detected, but not for asthma phenotypes.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17284
Hoeke, H., Roeder, S., Mueller, A., Bertsche, T., Borte, M., Rolle-Kampczyk, U., von Bergen, M., Wissenbach, D.K. (2016):
Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE
Allergy 71 (6), 901 - 906