Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.jhazmat.2024.134683
Lizenz creative commons licence
Titel (primär) Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
Autor Haange, S.-B. ORCID logo ; Riesbeck, S.; Aldehoff, A.S.; Engelmann, B.; Castañeda-Monsalve, V. ORCID logo ; Jensen Pedersen, K.; Rolle-Kampczyk, U.; von Bergen, M.; Jehmlich, N. ORCID logo
Quelle Journal of Hazardous Materials
Erscheinungsjahr 2024
Department MOLTOX
Seite von art. 134683
Sprache englisch
Topic T9 Healthy Planet
Supplements https://ars.els-cdn.com/content/image/1-s2.0-S0304389424012627-mmc1.docx
Keywords PFAS; bisphenols; microbiota; metaproteomics; toxicity
Abstract The microbial community present in our intestines is pivotal for converting indigestible substances into vital nutrients and signaling molecules such as short-chain fatty acids (SCFAs). These compounds have considerable influence over our immune system and the development of diverse human diseases. However, ingested environmental contaminants, known as xenobiotics, can upset the delicate balance of the microbial gut community and enzymatic processes, consequently affecting the host organism. In our study, we employed an in vitro bioreactor model system based on the simplified human microbiome model (SIHUMIx) to investigate the direct effects of specific xenobiotics, such as perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA) and perfluorobutanoic acid (PFBA) or bisphenol S (BPS) and bisphenol F (BPF), either individually or in combination, on the microbiota. We observed increased SCFA production, particularly acetate and butyrate, with PFAS exposure. Metaproteomics revealed pathway alterations across treatments, including changes in vitamin synthesis and fatty acid metabolism with BPX. This study underscores the necessity of assessing the combined effects of xenobiotics to better safeguard public health. It emphasizes the significance of considering adverse effects on the microbiome in the risk assessment of environmental chemicals.
dauerhafte UFZ-Verlinkung https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29128
Haange, S.-B., Riesbeck, S., Aldehoff, A.S., Engelmann, B., Castañeda-Monsalve, V., Jensen Pedersen, K., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2024):
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
J. Hazard. Mater. , art. 134683 10.1016/j.jhazmat.2024.134683