Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Bile acids drive the newborn’s gut microbiota maturation
Autor van Best, N.; Rolle-Kampczyk, U.; Schaap, F.G.; Basic, M.; Olde Damink, S.W.M.; Bleich, A.; Savelkoul, P.H.M.; von Bergen, M.; Penders, J.; Hornef, M.W.;
Journal / Serie Nature Communications
Erscheinungsjahr 2020
Department MOLSYB;
Band/Volume 11
Sprache englisch;
POF III (gesamt) F11;
Abstract Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6–10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major age-dependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or β-tauro-murocholic acid to newborn mice (n = 7–14 per group) accelerated postnatal microbiota maturation.
ID 23540
dauerhafte UFZ-Verlinkung
van Best, N., Rolle-Kampczyk, U., Schaap, F.G., Basic, M., Olde Damink, S.W.M., Bleich, A., Savelkoul, P.H.M., von Bergen, M., Penders, J., Hornef, M.W. (2020):
Bile acids drive the newborn’s gut microbiota maturation
Nat. Commun. 11 , art. 3692