Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.chom.2023.11.004 |
| Titel (primär) | Infant gut microbiota contributes to cognitive performance in mice |
| Autor | Cerdó, T.; Ruiz-Rodríguez, A.; Acuña, I.; Torres-Espínola, F.J.; Menchén-Márquez, S.; Gámiz, F.; Gallo, M.; Jehmlich, N.
; Haange, S.-B.
; von Bergen, M.; Campoy, C.; Suárez, A. |
| Quelle | Cell Host & Microbe |
| Erscheinungsjahr | 2023 |
| Department | MOLSYB |
| Band/Volume | 31 |
| Heft | 12 |
| Seite von | 1974 |
| Seite bis | 1988.e4 |
| Sprache | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc1.pdf https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc2.xlsx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc3.xlsx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc4.docx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc5.docx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc6.docx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc7.xlsx https://ars.els-cdn.com/content/image/1-s2.0-S1931312823004547-mmc8.pdf |
| Keywords | cognition; gut; infant; microbiota; germ-free mice; histidine metabolome; metaproteomics |
| Abstract | Gut microbiota has been linked to infant neurodevelopment. Here, an
association between infant composite cognition and gut microbiota composition
is established as soon as 6 months. Higher diversity and evenness
characterize microbial communities of infants with composite cognition above
(Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and
metabolomic analyses establish an association between microbial histidine
ammonia lyase and infant histidine metabolome with cognition. Fecal
transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice
shows that memory, assessed by a novel object recognition test, is a
transmissible trait. Furthermore, Inf-aboveCC mice are enriched in species
belonging to Phocaeicola, as well as Bacteroides and Bifidobacterium,
previously linked to cognition. Finally, Inf-aboveCC mice show lower fecal
histidine and urocanate:histidine and urocanate:glutamate ratios in the perirhinal
cortex compared to Inf-belowCC mice. Overall, these findings reveal a causative
role of gut microbiota on infant cognition, pointing at the modulation of
histidine metabolite levels as a potential underlying mechanism.
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| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=28499 |
| Cerdó, T., Ruiz-Rodríguez, A., Acuña, I., Torres-Espínola, F.J., Menchén-Márquez, S., Gámiz, F., Gallo, M., Jehmlich, N., Haange, S.-B., von Bergen, M., Campoy, C., Suárez, A. (2023): Infant gut microbiota contributes to cognitive performance in mice Cell Host Microbe 31 (12), 1974 - 1988.e4 10.1016/j.chom.2023.11.004 |
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