Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1016/j.scitotenv.2010.03.045 |
| Titel (primär) | A rigorous small area modelling-study for the helicobacter pylori epidemiology |
| Autor | Strebel, K.; Rolle-Kampczyk, U.; Richter, M.; Kindler, A.; Richter, T.; Schlink, U.
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| Quelle | Science of the Total Environment |
| Erscheinungsjahr | 2010 |
| Department | SUSOZ; METABOX; STUDIEN |
| Band/Volume | 408 |
| Heft | 18 |
| Seite von | 3931 |
| Seite bis | 3942 |
| Sprache | englisch |
| Keywords | CAR model; Explained deviance; Helicobacter pylori; Over-dispersion; Spatial autocorrelation; Spatial/individual heterogeneity; Spatial risk |
| Abstract | This paper presents an investigation into spatial risk differences over small distances for the Helicobacter pylori infection in the city of Leipzig, Germany and two rural districts. A model, using Bayesian inference, was developed that adjusts the risk for individual-specific factors, and for spatial or individual over-dispersion, respectively. Additionally, the model takes into account conditional spatial autocorrelation. We found a significant positive association to the H. pylori infection risk for: "more than three children live in the household" (OR = 2.4, p = 0.001), "more persons live per sq.m than average" (OR = 1.4, p = 0.03), "home situated at main road" (OR = 1.4, p = 0.04) and "using well water" (OR = 2.3, p = 0.05). A protective effect was identified for "travelled to low prevalence region" (OR = 0.4, p < 0.0001) and "born in Germany" (OR = 0.2, p < 0.0001). Three administrative areas with significantly increased spatial risk were identified: one in the rural district and two in the city of Leipzig. The model explained 24.9% of the total deviance. Contrary to expectations, the largest part of deviance of the data was not explained by the identified significant risk factors, but by individual-specific heterogeneities. We conclude that further - so far not discussed - factors influence the risk and the spatial variation of the H. pylori infection. Furthermore, from the results we speculate about a possible impact of long-time air pollution and surface water. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=10561 |
| Strebel, K., Rolle-Kampczyk, U., Richter, M., Kindler, A., Richter, T., Schlink, U. (2010): A rigorous small area modelling-study for the helicobacter pylori epidemiology Sci. Total Environ. 408 (18), 3931 - 3942 10.1016/j.scitotenv.2010.03.045 |
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