Details zur Publikation |
| Kategorie | Textpublikation |
| Referenztyp | Zeitschriften |
| DOI | 10.1080/01902140290096809 |
| Titel (primär) | [15N2]Argenine as a first potential inhaled diagnostic agent to characterize respiratory diseases |
| Autor | Krumbiegel, P.; Denk, E.; Russow, R.; Rolle-Kampczyk, U.; Metzner, G.; Herbarth, O. |
| Quelle | Experimental Lung Research |
| Erscheinungsjahr | 2002 |
| Department | BOPHY; EXPOEPID |
| Band/Volume | 28 |
| Heft | 7 |
| Seite von | 535 |
| Seite bis | 542 |
| Sprache | englisch |
| Abstract | Conventional diagnosis of the pulmonary tract uses physical methods such as spirometry and oscillometry. However; the inhilation of a chemical diagnostic agent ought to provide novel ways of more specific diagnosis, for instance of inflammatory states of the bronchial and lung mucosa. The stable isotopic technique using a N-15-labeled substrate appears to be a suitable tool for this application. In a pilot study, defined amounts of the amino acid L-[guanidino-N-15(2)]arginine monohydrochloride (aqueous solution, 20 atom % N-15) were inhaled as a diagnostic agent by healthy volunteers and pulmonary patients suffering from asthma bronchiole. The amino acid is resorbed and partly metabolized to (NO)-N-15. The exhaled air was collected under defined conditions in 10-L breath bags and analyzed for NO using chemiluminescence. Under standardized test conditions, healthy persons (n = 6) exhaled 0.97+/-0.08mumol NO/m(3) and asthmatic patients (n=7) 1.17+/-0.14mumol NO/m(3). A better distinction was expected comparing the (NO)-N-15 exhalation. |
| dauerhafte UFZ-Verlinkung | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=5716 |
| Krumbiegel, P., Denk, E., Russow, R., Rolle-Kampczyk, U., Metzner, G., Herbarth, O. (2002): [15N2]Argenine as a first potential inhaled diagnostic agent to characterize respiratory diseases Exp. Lung Res. 28 (7), 535 - 542 10.1080/01902140290096809 |
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