Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1186/s12916-022-02525-8 |
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| Title (Primary) | The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial |
| Author | Zelicha, H.; Kloting, N.; Kaplan, A.; Meir, A.Y.; Rinott, E.; Tsaban, G.; Chassidim, Y.; Bluher, M.; Ceglarek, U.; Isermann, B.; Stumvoll, M.; Quayson, R.N.; von Bergen, M.; Engelmann, B.; Rolle-Kampczyk, U.; Haange, S.-B.
; Tuohy, K.M.; Diotallevi, C.; Shelef, I.; Hu, F.B.; Stampfer, M.J.; Shai, I. |
| Source Titel | BMC Medicine |
| Year | 2022 |
| Department | MOLSYB |
| Volume | 20 |
| Page From | art. 327 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://static-content.springer.com/esm/art%3A10.1186%2Fs12916-022-02525-8/MediaObjects/12916_2022_2525_MOESM1_ESM.docx |
| Keywords | Mediterranean; Obesity; Plant-based diet; Polyphenols; Visceral adipose tissue |
| Abstract | Background Mediterranean (MED) diet is a rich source of polyphenols, which benefit adiposity by several mechanisms. We explored the effect of the green-MED diet, twice fortified in dietary polyphenols and lower in red/processed meat, on visceral adipose tissue (VAT). Methods In the 18-month Dietary Intervention Randomized Controlled Trial PoLyphenols UnproceSsed (DIRECT-PLUS) weight-loss trial, 294 participants were randomized to (A) healthy dietary guidelines (HDG), (B) MED, or (C) green-MED diets, all combined with physical activity. Both isocaloric MED groups consumed 28 g/day of walnuts (+ 440 mg/day polyphenols). The green-MED group further consumed green tea (3–4 cups/day) and Wolffia globosa (duckweed strain) plant green shake (100 g frozen cubes/day) (+ 800mg/day polyphenols) and reduced red meat intake. We used magnetic resonance imaging (MRI) to quantify the abdominal adipose tissues. Results Participants (age = 51 years; 88% men; body mass index = 31.2 kg/m2; 29% VAT) had an 89.8% retention rate and 79.3% completed eligible MRIs. While both MED diets reached similar moderate weight (MED: − 2.7%, green-MED: − 3.9%) and waist circumference (MED: − 4.7%, green-MED: − 5.7%) loss, the green-MED dieters doubled the VAT loss (HDG: − 4.2%, MED: − 6.0%, green-MED: − 14.1%; p < 0.05, independent of age, sex, waist circumference, or weight loss). Higher dietary consumption of green tea, walnuts, and Wolffia globosa; lower red meat intake; higher total plasma polyphenols (mainly hippuric acid), and elevated urine urolithin A polyphenol were significantly related to greater VAT loss (p < 0.05, multivariate models). Conclusions A green-MED diet, enriched with plant-based polyphenols and lower in red/processed meat, may be a potent intervention to promote visceral adiposity regression. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29583 |
| Zelicha, H., Kloting, N., Kaplan, A., Meir, A.Y., Rinott, E., Tsaban, G., Chassidim, Y., Bluher, M., Ceglarek, U., Isermann, B., Stumvoll, M., Quayson, R.N., von Bergen, M., Engelmann, B., Rolle-Kampczyk, U., Haange, S.-B., Tuohy, K.M., Diotallevi, C., Shelef, I., Hu, F.B., Stampfer, M.J., Shai, I. (2022): The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial BMC Med. 20 , art. 327 10.1186/s12916-022-02525-8 |
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