Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.chom.2023.11.004
Title (Primary) Infant gut microbiota contributes to cognitive performance in mice
Author Cerdó, T.; Ruiz-Rodríguez, A.; Acuña, I.; Torres-Espínola, F.J.; Menchén-Márquez, S.; Gámiz, F.; Gallo, M.; Jehmlich, N. ORCID logo ; Haange, S.-B. ORCID logo ; von Bergen, M.; Campoy, C.; Suárez, A.
Source Titel Cell Host & Microbe
Year 2023
Department MOLSYB
Volume 31
Issue 12
Page From 1974
Page To 1988.e4
Language englisch
Topic T9 Healthy Planet
Keywords cognition; gut; infant; microbiota; germ-free mice; histidine metabolome; metaproteomics
Abstract Gut microbiota has been linked to infant neurodevelopment. Here, an association between infant composite cognition and gut microbiota composition is established as soon as 6 months. Higher diversity and evenness characterize microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses establish an association between microbial histidine ammonia lyase and infant histidine metabolome with cognition. Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice shows that memory, assessed by a novel object recognition test, is a transmissible trait. Furthermore, Inf-aboveCC mice are enriched in species belonging to Phocaeicola, as well as Bacteroides and Bifidobacterium, previously linked to cognition. Finally, Inf-aboveCC mice show lower fecal histidine and urocanate:histidine and urocanate:glutamate ratios in the perirhinal cortex compared to Inf-belowCC mice. Overall, these findings reveal a causative role of gut microbiota on infant cognition, pointing at the modulation of histidine metabolite levels as a potential underlying mechanism.


Persistent UFZ Identifier
Cerdó, T., Ruiz-Rodríguez, A., Acuña, I., Torres-Espínola, F.J., Menchén-Márquez, S., Gámiz, F., Gallo, M., Jehmlich, N., Haange, S.-B., von Bergen, M., Campoy, C., Suárez, A. (2023):
Infant gut microbiota contributes to cognitive performance in mice
Cell Host Microbe 31 (12), 1974 - 1988.e4 10.1016/j.chom.2023.11.004