Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1016/j.chom.2023.11.004 |
| Title (Primary) | Infant gut microbiota contributes to cognitive performance in mice |
| Author | Cerdó, T.; Ruiz-Rodríguez, A.; Acuña, I.; Torres-Espínola, F.J.; Menchén-Márquez, S.; Gámiz, F.; Gallo, M.; Jehmlich, N.
; Haange, S.-B.
; von Bergen, M.; Campoy, C.; Suárez, A. |
| Source Titel | Cell Host & Microbe |
| Year | 2023 |
| Department | MOLSYB |
| Volume | 31 |
| Issue | 12 |
| Page From | 1974 |
| Page To | 1988.e4 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Supplements | Supplement 1 Supplement 2 Supplement 3 Supplement 4 Supplement 5 Supplement 6 Supplement 7 Supplement 8 |
| Keywords | cognition; gut; infant; microbiota; germ-free mice; histidine metabolome; metaproteomics |
| Abstract | Gut microbiota has been linked to infant neurodevelopment. Here, an
association between infant composite cognition and gut microbiota composition
is established as soon as 6 months. Higher diversity and evenness
characterize microbial communities of infants with composite cognition above
(Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and
metabolomic analyses establish an association between microbial histidine
ammonia lyase and infant histidine metabolome with cognition. Fecal
transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice
shows that memory, assessed by a novel object recognition test, is a
transmissible trait. Furthermore, Inf-aboveCC mice are enriched in species
belonging to Phocaeicola, as well as Bacteroides and Bifidobacterium,
previously linked to cognition. Finally, Inf-aboveCC mice show lower fecal
histidine and urocanate:histidine and urocanate:glutamate ratios in the perirhinal
cortex compared to Inf-belowCC mice. Overall, these findings reveal a causative
role of gut microbiota on infant cognition, pointing at the modulation of
histidine metabolite levels as a potential underlying mechanism.
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| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=28499 |
| Cerdó, T., Ruiz-Rodríguez, A., Acuña, I., Torres-Espínola, F.J., Menchén-Márquez, S., Gámiz, F., Gallo, M., Jehmlich, N., Haange, S.-B., von Bergen, M., Campoy, C., Suárez, A. (2023): Infant gut microbiota contributes to cognitive performance in mice Cell Host Microbe 31 (12), 1974 - 1988.e4 10.1016/j.chom.2023.11.004 |
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