Alix Aldehoff

PhD Student Functional Metabolomics Functional Genomics

Contact

Address:
Building 6.0
Permoserstr. 15
04318 Leipzig
Telephone: +49 341 235 1541
alix-sarah.aldehoff@ufz.de

Foto: Sebastian Wiedling/UFZ

ResearchGate

Research interests

Effects of xenobiotic expoure on function and differentiation of adipocytes using proteomics and metabolomics
Post-translational protein modifications and their role in differentiating adipocytes

CV

October 2021 - present	PhD student in the CRC1052, Project Z3, Helmholtz-Centre for Environmental Research, Leipzig Post-translational modifications in the context of adipocyte differentiation and their exposure to environmental contaminants
2018 - 2021	Master of Science Biotechnology Münster University Analysis of the impact of perfluoroalkyl substance exposure on a simplified human intestinal microbiota using proteomics and metabolomics
2015 - 2018	Bachelor of Science Biological Sciences Münster University Functional analysis of selected lysine residues on Rubisco activase activity in Arabidopsis thaliana

Publications

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2025 (2)

Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306

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2024 (10)

Aldehoff, A.S., Karkossa, I., Goerdeler, C., Krieg, L., Schor, J., Engelmann, B., Wabitsch, M., Landgraf, K., Hackermüller, J., Körner, A., Rolle-Kampczyk, U., Schubert, K., von Bergen, M. (2024):
Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis
iScience 27 (6), art. 109711 10.1016/j.isci.2024.109711
Fischer, F., Pierzchalski, A., Riesbeck, S., Aldehoff, A.S., Castañeda-Monsalve, V., Haange, S.-B., von Bergen, M., Rolle-Kampczyk, U.E., Jehmlich, N., Zenclussen, A.C., Herberth, G. (2024):
An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures
Front. Immunol. 15 , art. 1298971 10.3389/fimmu.2024.1298971
Goerdeler, C., Engelmann, B., Aldehoff, A.S., Schaffert, A., Blüher, M., Heiker, J.T., Wabitsch, M., Schubert, K., Rolle-Kampczyk, U., von Bergen, M. (2024):
Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism
Environ. Res. 252 , art. 118847 10.1016/j.envres.2024.118847
Haange, S.-B., Riesbeck, S., Aldehoff, A.S., Engelmann, B., Jensen Pedersen, K., Castañeda-Monsalve, V., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2024):
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
J. Hazard. Mater. 474 , art. 134683 10.1016/j.jhazmat.2024.134683
Schubert, K., Aldehoff, A.S. (2024):
Phosphoproteome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045770
Schubert, K., Aldehoff, A.S. (2024):
Phosphoproteome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045778
Schubert, K., Aldehoff, A.S. (2024):
Acetylome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045768
Schubert, K., Aldehoff, A.S. (2024):
Proteome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045767
Schubert, K., Aldehoff, A.S. (2024):
Acetylome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045776
Schubert, K., Aldehoff, A.S. (2024):
Proteome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045772

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2023 (1)

Aldehoff, A.S., Karkossa, I., Engelmann, B., Rolle-Kampczyk, U., von Bergen, M., Schubert, K. (2023):
Exploring the regulatory effects of lysine acetylation and phosphorylation in adipocyte differentiation and their exposure to emerging plastic additives
Toxicol. Lett. 384 (Suppl. 1), S133 - S133 10.1016/S0378-4274(23)00578-7

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Recent Publications

2025 (7)

Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Seitz, H., Mockly, S., Kamp, H., Haake, V., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2025):
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
Arch. Toxicol. 99 (1), 309 - 332 10.1007/s00204-024-03876-2
Castañeda-Monsalve, V., Haange, S.-B., Fröhlich, L.-F., Fu, Q., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2025):
Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system
ISME Commun. 5 (1), ycaf050 10.1093/ismeco/ycaf050
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306
Reddy, L.R., Egerter, C., Jehmlich, N., Fiskal, A., Helmholz, L., Castronovo, S., Schweyen, P., Wulf, S.-E., Ternes, T., Wick, A., Meier, J. (2025):
New insights in the metabolic functions of freshwater sulfate reducing communities during steel corrosion by biophysicochemical, 16S rRNA gene sequence and metaproteomic analysis
Int. Biodeterior. Biodegrad. 198 , art. 105995 10.1016/j.ibiod.2024.105995
Schlößer, S., Ullrich, A.-L., Modares, N.F., Schmitz, M.A., Schöneich, J., Zhang, K., Richter, I., Robrahn, L., Schraven, S., Nagai, J.S., Haange, S.-B., Jennings, S.A.V., Clavel, T., Rolle-Kampczyk, U., Kiessling, F., Costa, I.G., Muncan, V., Repnik, U., von Bergen, M., Dupont, A., Hornef, M.W. (2025):
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
Proc. Natl. Acad. Sci. U.S.A. 122 (1), e2403344122 10.1073/pnas.2403344122
Tanca, A., Schallert, K., Grenga, L., Peters, S.L., Abbondio, M., De Diego, L., Deledda, M.A., Haange, S.-B., Miotello, G., Sáenz, J.S., Wolf, M., Bastida, F., Devos, S., Hernandez-Raquet, G., Seifert, J., Wilmes, P., Van Den Bossche, T., Kunath, B.J., Heyer, R., Jehmlich, N., Benndorf, D., Hettich, R.L., Armengaud, J., Uzzau, S. (2025):
Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
bioRxiv 10.1101/2025.01.31.635836

Alix Aldehoff

PhD Student Functional Metabolomics Functional Genomics

Contact

Scientific network

Research interests

CV

Publications

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2025 (2)

2024 (10)

2023 (1)