Alix Aldehoff

PhD Student Functional Metabolomics Functional Genomics

Contact

Address:
Building 6.0
Permoserstr. 15
04318 Leipzig
Telephone: +49 341 235 1541
alix-sarah.aldehoff@ufz.de

Foto: Sebastian Wiedling/UFZ

ResearchGate

Research interests

Effects of xenobiotic expoure on function and differentiation of adipocytes using proteomics and metabolomics
Post-translational protein modifications and their role in differentiating adipocytes

CV

October 2021 - present	PhD student in the CRC1052, Project Z3, Helmholtz-Centre for Environmental Research, Leipzig Post-translational modifications in the context of adipocyte differentiation and their exposure to environmental contaminants
2018 - 2021	Master of Science Biotechnology Münster University Analysis of the impact of perfluoroalkyl substance exposure on a simplified human intestinal microbiota using proteomics and metabolomics
2015 - 2018	Bachelor of Science Biological Sciences Münster University Functional analysis of selected lysine residues on Rubisco activase activity in Arabidopsis thaliana

Publications

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2025 (11)

Aldehoff, A.S., Karkossa, I., Broghammer, H., Krupka, S., Weiner, J., Goerdeler, C., Nuwayhid, R., Langer, S., Wabitsch, M., Rolle-Kampczyk, U., Klöting, N., Blüher, M., Heiker, J.T., von Bergen, M., Schubert, K. (2025):
Advanced proteomics approaches hold potential for the risk assessment of metabolism-disrupting chemicals as omics-based NAM: A case study using the phthalate substitute DINCH
Environ. Sci. Technol. 59 (31), 16193 - 16216 10.1021/acs.est.5c01206
Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Goerdeler, C., Engelmann, B., Broghammer, H., Aldehoff, A.S., Wabitsch, M., Schubert, K., Blüher, M., Heiker, J.T., Rolle-Kampczyk, U., von Bergen, M. (2025):
¹³C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals
SSRN 10.2139/ssrn.5342656
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the acetylome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059390
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the phosphoproteome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059416
Schubert, K., Aldehoff, A.S. (2025):
Effects of DINCH and MINCH exposure on the proteome of differentiating primary human stromal vascular fraction cells
PRoteomics IDEntifications Database (PRIDE)
Schubert, K., Aldehoff, A.S. (2025):
Tissue proteome of visceral, subcutaneous and brown adipose as well as liver tissues in an obese mouse model after dietary exposure to the emerging phthalate substitute DINCH
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD054970
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the proteome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059428
Schubert, K., Aldehoff, A.S. (2025):
Effects of dietary DINCH exposure on the proteome, phosphoproteome and acetylome of adipose tissue of a murine diet induced model of obesity
PRoteomics IDEntifications Database (PRIDE)
Schubert, K., Aldehoff, A.S. (2025):
Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059386

to index

2024 (11)

Aldehoff, A.S., Karkossa, I., Goerdeler, C., Krieg, L., Schor, J., Engelmann, B., Wabitsch, M., Landgraf, K., Hackermüller, J., Körner, A., Rolle-Kampczyk, U., Schubert, K., von Bergen, M. (2024):
Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis
iScience 27 (6), art. 109711 10.1016/j.isci.2024.109711
Fischer, F., Pierzchalski, A., Riesbeck, S., Aldehoff, A.S., Castañeda-Monsalve, V., Haange, S.-B., von Bergen, M., Rolle-Kampczyk, U.E., Jehmlich, N., Zenclussen, A.C., Herberth, G. (2024):
An in vitro model system for testing chemical effects on microbiome-immune interactions - examples with BPX and PFAS mixtures
Front. Immunol. 15 , art. 1298971 10.3389/fimmu.2024.1298971
Goerdeler, C., Engelmann, B., Aldehoff, A.S., Schaffert, A., Blüher, M., Heiker, J.T., Wabitsch, M., Schubert, K., Rolle-Kampczyk, U., von Bergen, M. (2024):
Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism
Environ. Res. 252 , art. 118847 10.1016/j.envres.2024.118847
Haange, S.-B., Riesbeck, S., Aldehoff, A.S., Engelmann, B., Jensen Pedersen, K., Castañeda-Monsalve, V., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2024):
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations
J. Hazard. Mater. 474 , art. 134683 10.1016/j.jhazmat.2024.134683
Schubert, K., Aldehoff, A.S. (2024):
Phosphoproteome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045778
Schubert, K., Aldehoff, A.S. (2024):
Phosphoproteome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045770
Schubert, K., Aldehoff, A.S. (2024):
Effects of MINCH exposure on the acetylome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD047016
Schubert, K., Aldehoff, A.S. (2024):
Acetylome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045768
Schubert, K., Aldehoff, A.S. (2024):
Proteome dynamics during differentiation of SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045767
Schubert, K., Aldehoff, A.S. (2024):
Acetylome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045776
Schubert, K., Aldehoff, A.S. (2024):
Proteome dynamics during differentiation of 3T3-L1 adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD045772

to index

2023 (1)

Aldehoff, A.S., Karkossa, I., Engelmann, B., Rolle-Kampczyk, U., von Bergen, M., Schubert, K. (2023):
Exploring the regulatory effects of lysine acetylation and phosphorylation in adipocyte differentiation and their exposure to emerging plastic additives
Toxicol. Lett. 384 (Suppl. 1), S133 - S133 10.1016/S0378-4274(23)00578-7

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Recent Publications

2025 (33)

Aldehoff, A.S., Karkossa, I., Broghammer, H., Krupka, S., Weiner, J., Goerdeler, C., Nuwayhid, R., Langer, S., Wabitsch, M., Rolle-Kampczyk, U., Klöting, N., Blüher, M., Heiker, J.T., von Bergen, M., Schubert, K. (2025):
Advanced proteomics approaches hold potential for the risk assessment of metabolism-disrupting chemicals as omics-based NAM: A case study using the phthalate substitute DINCH
Environ. Sci. Technol. 59 (31), 16193 - 16216 10.1021/acs.est.5c01206
Aldehoff, A.S., Türkowsky, D., Lohmann, P., Homsi, M.N., Rolle-Kampczyk, U., Ueberham, E., Lehmann, J., von Bergen, M., Jehmlich, N., Haange, S.-B. (2025):
Revealing novel protein interaction partners of glyphosate in Escherichia coli
Environ. Int. 195 , art. 109243 10.1016/j.envint.2024.109243
Canzler, S., Schubert, K., Rolle-Kampczyk, U.E., Wang, Z., Schreiber, S., Seitz, H., Mockly, S., Kamp, H., Haake, V., Huisinga, M., von Bergen, M., Buesen, R., Hackermüller, J. (2025):
Evaluating the performance of multi-omics integration: a thyroid toxicity case study
Arch. Toxicol. 99 (1), 309 - 332 10.1007/s00204-024-03876-2
Castañeda-Monsalve, V., Haange, S.-B., Fröhlich, L.-F., Fu, Q., Rolle-Kampczyk, U., von Bergen, M., Jehmlich, N. (2025):
Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system
ISME Commun. 5 (1), ycaf050 10.1093/ismeco/ycaf050
Engelmann, B. (2025):
Comprehension of the age-dependent gut and brain interaction of honeybee workers by integration of multi omics approaches
UCSD Metabolomics Workbench 10.21228/M8SV5J
Ghosh, D., Shi, Y., Zimmermann, I.M., Holzhauser, K., von Bergen, M., Kaster, A.-K., Spielvogel, S., Dippold, M.A., Müller, J.A., Jehmlich, N. (2025):
Cover crop root channels promote bacterial adaptation to drought in the maize rhizosphere
bioRxiv 10.1101/2025.05.05.651044
Goerdeler, C., Engelmann, B., Broghammer, H., Aldehoff, A.S., Wabitsch, M., Schubert, K., Blüher, M., Heiker, J.T., Rolle-Kampczyk, U., von Bergen, M. (2025):
¹³C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals
SSRN 10.2139/ssrn.5342656
Gómez-Olarte, S., Röder, S., Rolle-Kampczyk, U., Sack, U., von Bergen, M., Borte, M., Zenclussen, A.C., Herberth, G. (2025):
Prenatal exposure to mixtures of phthalates and bisphenol A and eczema risk: findings in atopic and non-atopic children from the LiNA birth cohort
Environ. Res. 278 , art. 121667 10.1016/j.envres.2025.121667
Gwak, J.-H., Olabisi, A., Lee, U.-J., Abiola, C., Lee, S., Do, H., Choi, Y.J., Lee, J.-J., Jung, M.-Y., Jehmlich, N., von Bergen, M., Wagner, M., Awala, S.I., Quan, Z.-X., Rhee, S.-K. (2025):
Hypoosmolarity inhibits archaeal ammonia oxidation
bioRxiv 10.1101/2025.07.07.663500
Hagemann, T., Rolle-Kampczyk, U., Schubert, K., Dietrich, A., von Bergen, M., Blüher, M., Hoffmann, A. (2025):
Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure
Environ. Adv. 21 , art. 100655 10.1016/j.envadv.2025.100655
Heyer, R., Wolf, M., Benndorf, D., Uzzau, S., Seifert, J., Grenga, L., Pabst, M., Schmitt, H., Mesuere, B., Van Den Bossche, T., Haange, S.-B., Jehmlich, N., Di Luca, M., Ferrer, M., Serrano-Villar, S., Armengaud, J., Bode, H.B., Hellwig, P., Masselot, C.R., Léonard, R., Wilmes, P. (2025):
Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes
Microbiome 13 , art. 134 10.1186/s40168-025-02119-5
Jehmlich, N. (2025):
Abstracts of the 3rd International Electronic Conference on Microbiology
Biol. Life Sci. Forum 46 (1), art. 3 10.3390/blsf2025046003
Kakavas, D., Engelmann, B., Krauss, M., Rolle-Kampczyk, U.E., Rochfort, K.D., Grintzalis, K. (2025):
Excreted metabolite nanocoronas impact metabolic and toxicity responses of daphnids to silver nanoink
Environ. Res. 283 , art. 122131 10.1016/j.envres.2025.122131
Kronstein-Wiedemann, R., Thiel, J., Brändle, D., Sürün, D., Teichert, M., Künzel, S.R., Schubert, K., Friedrich, U., Dahl, A., Buchholz, F., Hölig, K., Tonn, T. (2025):
Restoration of actin network dynamics by scinderin knockout in immortalized erythroid cells plays a key role in effective blood pharming
Cytotherapy 27 (5), S97 10.1016/j.jcyt.2025.03.186
Krupka, S., Aldehoff, A.S., Goerdeler, C., Engelmann, B., Rolle-Kampczyk, U., Schubert, K., Klöting, N., von Bergen, M., Blüher, M. (2025):
Metabolic and molecular characterization, following dietary exposure to DINCH, reveals new implications for its role as a metabolism-disrupting chemical
Environ. Int. 196 , art. 109306 10.1016/j.envint.2025.109306
Lipaeva, P., Drozdova, P., Vereshchagina, K., Jakob, L., Schubert, K., Bedulina, D., Luckenbach, T. (2025):
How to reproduce in the Siberian winter: Proteome dynamics reveals the timing of reproduction-related processes in an amphipod species endemic to Lake Baikal
Ecol. Evol. 15 (7), e71675 10.1002/ece3.71675
Murad, M., Reuken, P.A., Schubert, K., Reißing, J., Ibidapo-Obe, O., Große, K., Frissen, M., Haedge, F., El-Hassani, M., von Bergen, M., Bruns, T. (2025):
The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis
Sci. Rep. 15 , art. 25714 10.1038/s41598-025-08238-1
Owen, R., de Macedo, G., Nerlich, J., Scharkin, I., Bartmann, K., Döbler, J., Engelmann, B., Rolle-Kampczyk, U.E., Leuthold, D., Gutsfeld, S., Schweiger, N., Tal, T. (2025):
Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models
Toxicol. Sci. , kfaf101 10.1093/toxsci/kfaf101
Pieńkowska, A., Fleischmann, J., Drabesch, S., Merbach, I., Wang, G., Nunes da Rocha, U., Reitz, T., Muehe, E.M. (2025):
Long-term organic fertilization shields soil prokaryotes from metal stress while mineral fertilization exacerbates it
Environ. Pollut. 382 , art. 126747 10.1016/j.envpol.2025.126747
Reddy, L.R., Egerter, C., Jehmlich, N., Fiskal, A., Helmholz, L., Castronovo, S., Schweyen, P., Wulf, S.-E., Ternes, T., Wick, A., Meier, J. (2025):
New insights in the metabolic functions of freshwater sulfate reducing communities during steel corrosion by biophysicochemical, 16S rRNA gene sequence and metaproteomic analysis
Int. Biodeterior. Biodegrad. 198 , art. 105995 10.1016/j.ibiod.2024.105995
Schlößer, S., Ullrich, A.-L., Modares, N.F., Schmitz, M.A., Schöneich, J., Zhang, K., Richter, I., Robrahn, L., Schraven, S., Nagai, J.S., Haange, S.-B., Jennings, S.A.V., Clavel, T., Rolle-Kampczyk, U., Kiessling, F., Costa, I.G., Muncan, V., Repnik, U., von Bergen, M., Dupont, A., Hornef, M.W. (2025):
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
Proc. Natl. Acad. Sci. U.S.A. 122 (1), e2403344122 10.1073/pnas.2403344122
Schubert, K., Aldehoff, A.S. (2025):
Effects of dietary DINCH exposure on the proteome, phosphoproteome and acetylome of adipose tissue of a murine diet induced model of obesity
PRoteomics IDEntifications Database (PRIDE)
Schubert, K., Aldehoff, A.S. (2025):
Tissue proteome of visceral, subcutaneous and brown adipose as well as liver tissues in an obese mouse model after dietary exposure to the emerging phthalate substitute DINCH
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD054970
Schubert, K., Aldehoff, A.S. (2025):
Identification of potential protein interaction candidates of MINCH in SGBS adipocytes using Thermal Proteome Profiling (TPP)
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059386
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the proteome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059428
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the acetylome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059390
Schubert, K., Aldehoff, A.S. (2025):
Effects of DINCH and MINCH exposure on the proteome of differentiating primary human stromal vascular fraction cells
PRoteomics IDEntifications Database (PRIDE)
Schubert, K., Aldehoff, A.S. (2025):
Effects of MINCH exposure on the phosphoproteome of differentiating human SGBS adipocytes
PRoteomics IDEntifications Database (PRIDE) 10.6019/PXD059416
Tanca, A., Schallert, K., Grenga, L., Peters, S.L., Abbondio, M., De Diego, L., Deledda, M.A., Haange, S.-B., Miotello, G., Sáenz, J.S., Wolf, M., Bastida, F., Devos, S., Hernandez-Raquet, G., Seifert, J., Wilmes, P., Van Den Bossche, T., Kunath, B.J., Heyer, R., Jehmlich, N., Benndorf, D., Hettich, R.L., Armengaud, J., Uzzau, S. (2025):
Critical Assessment of MetaProteome Investigation 2 (CAMPI-2): Multi-laboratory assessment of sample processing methods to stabilize fecal microbiome for functional analysis
bioRxiv 10.1101/2025.01.31.635836
Thiel, J., Sürün, D., Brändle, D.C., Teichert, M., Künzel, S.R., Friedrich, U., Dahl, A., Schubert, K., Rzagalinski, I., Shevchenko, A., Traikov, S., Mirtschink, P, Wagenführ, L., Buchholz, F., Hölig, K., Tonn, T., Kronstein-Wiedemann, R. (2025):
Knock out of miRNA-30a-5p and reconstitution of the actin network dynamics partly restores the impaired terminal erythroid differentiation during blood pharming
Stem Cell Rev. Rep. 10.1007/s12015-025-10957-x
Uthoff, C., Herold, N., Alkassab, A.T., Engelmann, B., Rolle-Kampczyk, U., Pistorius, J., Schweiger, N., Finckh, S., Krauss, M., Thum, A.S., Jehmlich, N., Tal, T., von Bergen, M. (2025):
Cross-taxa sublethal impacts of plant protection products on honeybee in-hive and zebrafish swimming behaviours at environmentally relevant concentrations
Environ. Int. , art. 109750 10.1016/j.envint.2025.109750
Uthoff, C., Yakovlyeva, Y., Engelmann, B., Rolle-Kampczyk, U., Haange, S.-B., Alkassab, A.T., Pistorius, J., Brix, F., Waschina, S., Thurn, A.S., Jehmlich, N., von Bergen, M. (2025):
Comprehension of the age-dependent gut and brain interaction of honey bee workers by integration of multi omics approaches
J. Adv. Res. 10.1016/j.jare.2025.07.045
Van Den Bossche, T., Armengaud, J., Benndorf, D., Blakeley-Ruiz, J.A., Brauer, M., Cheng, K., Creskey, M., Figeys, D., Grenga, L., Griffin, T.J., Henry, C., Hettich, R.L., Holstein, T., Jagtap, P.D., Jehmlich, N., Kim, J., Kleiner, M., Kunath, B.J., Malliet, X., Martens, L., Mehta, S., Mesuere, B., Ning, Z., Tanca, A., Uzzau, S., Verschaffelt, P., Wang, J., Wilmes, P., Zhang, X., Zhang, X., Li, L., The Metaproteomics Initiative, (2025):
The microbiologist's guide to metaproteomics
iMeta 4 (3), e70031 10.1002/imt2.70031

Alix Aldehoff

PhD Student Functional Metabolomics Functional Genomics

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CV

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2025 (11)

2024 (11)

2023 (1)