Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1080/19490976.2023.2259033
Licence creative commons licence
Title (Primary) Human gut microbiome and metabolite dynamics under simulated microgravity
Author Ramos-Nascimento, A.; Grenga, L.; Haange, S.-B. ORCID logo ; Himmelmann, A.; Arndt, F.S.; Ly, Y.-T.; Miotello, G.; Pible, O.; Jehmlich, N. ORCID logo ; Engelmann, B.; von Bergen, M.; Mulder, E.; Frings-Meuthen, P.; Hellweg, C.E.; Jordan, J.; Rolle-Kampczyk, U.; Armengaud, J.; Moeller, R.
Source Titel Gut Microbes
Year 2023
Department MOLSYB
Volume 15
Issue 2
Page From art. 2259033
Language englisch
Topic T9 Healthy Planet
Abstract The Artificial Gravity Bed Rest – European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of artificial gravity as a countermeasure in an analog of long-duration spaceflight. In this study, we investigated the impact of simulated microgravity on the gut microbiome of 12 participants during a 60-day head-down tilt bed rest at the :envihab facilities. Over 60 days of simulated microgravity resulted in a mild change in the gut microbiome, with distinct microbial patterns and pathway expression in the feces of the countermeasure group compared to the microgravity simulation-only group. Additionally, we found that the countermeasure protocols selectively increased the abundance of beneficial short-chain fatty acids in the gut, such as acetate, butyrate, and propionate. Some physiological signatures also included the modulation of taxa reported to be either beneficial or opportunistic, indicating a mild adaptation in the microbiome network balance. Our results suggest that monitoring the gut microbial catalog along with pathway clustering and metabolite profiling is an informative synergistic strategy to determine health disturbances and the outcome of countermeasure protocols for future space missions.
Persistent UFZ Identifier
Ramos-Nascimento, A., Grenga, L., Haange, S.-B., Himmelmann, A., Arndt, F.S., Ly, Y.-T., Miotello, G., Pible, O., Jehmlich, N., Engelmann, B., von Bergen, M., Mulder, E., Frings-Meuthen, P., Hellweg, C.E., Jordan, J., Rolle-Kampczyk, U., Armengaud, J., Moeller, R. (2023):
Human gut microbiome and metabolite dynamics under simulated microgravity
Gut Microbes 15 (2), art. 2259033 10.1080/19490976.2023.2259033