Publication Details |
Category | Text Publication |
Reference Category | Journals |
DOI | 10.1111/j.1750-3639.2007.00053.x |
Title (Primary) | Structural principles of tau and the paired helical filaments of Alzheimer's disease |
Author | Mandelkow, E.; von Bergen, M.; Biernat, J.; Mandelkow, E.-M. |
Source Titel | Brain Pathology |
Year | 2007 |
Department | PROTEOM |
Volume | 17 |
Issue | 1 |
Page From | 83 |
Page To | 90 |
Language | englisch |
Abstract | Tau, a major microtubule-associated protein in brain, forms abnormal fibers in Alzheimer's disease and several other neurodegenerative diseases. Tau is highly soluble and adopts a natively unfolded structure in solution. In the paired helical filaments of Alzheimer's disease, small segments of tau adopt a ß-conformation and interact with other tau molecules. In the filament core, the microtubule-binding repeat region of tau has a cross-ß structure, while the rest of the protein retains its largely unfolded structure and gives rise to the fuzzy coat of the filaments. |
Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2042 |
Mandelkow, E., von Bergen, M., Biernat, J., Mandelkow, E.-M. (2007): Structural principles of tau and the paired helical filaments of Alzheimer's disease Brain Pathol. 17 (1), 83 - 90 10.1111/j.1750-3639.2007.00053.x |