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Title (Primary) MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Author Mendler, A.; Pierzchalski, A.; Bauer, M.; Röder, S.; Sattler, A.; Standl, M.; Borte, M.; von Bergen, M.; Rolle-Kampczyk, U.; Herberth, G.;
Journal Clinical and Experimental Immunology
Year 2020
Department IMMU; MOLSYB;
Volume 200
Issue 2
Language englisch;
POF III (all) F11; T42;
Supplements https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fcei.13423&file=cei13423-sup-0001-FigE1.pdf
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https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fcei.13423&file=cei13423-sup-0003-TableE1-E4.docx
Keywords MAIT cells; Bile acids; Conjugated bile acids; Body weight; MAIT cell activation
Abstract Bile acids (BAs) are produced by liver hepatocytes and were recently shown to exert functions additionally to their well‐known role in lipid digestion. As yet it is not known whether the mucosal‐associated invariant T (MAIT) cells, which represent 10‐15 % of the hepatic T cell population, are affected by BAs. The focus of the present investigation was on the association of BA serum concentration with MAIT cell function and inflammatory parameters as well as on the relation of these parameters to body weight. Blood samples from 41 normal weight and 41 overweight children of the LISA (Life style Immune System Allergy) study were analyzed with respect to MAIT cell surface and activation markers (CD107a, CD137, CD69, IFN‐γ, TNF‐α) after E. coli stimulation, mRNA expression of PLZF and MR1, the inflammatory markers CRP, IL‐8 and MIP‐1α as well as the concentrations of 13 conjugated and unconjugated BAs. Higher body weight was associated with reduced MAIT cell activation and expression of NKp80 and CXCR3. BA concentrations were positively associated with the inflammatory parameters CRP, IL‐8 and MIP‐1α but were negatively associated with the number of activated MAIT cells and the MAIT cell transcription factor PLZF. These relationships were exclusively found with conjugated BAs. BA‐mediated inhibition of MAIT cell activation was confirmed in vitro. Thus, conjugated BAs have the capacity to modulate the balance between pro‐ and anti‐inflammatory immune responses.
ID 22750
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=22750
Mendler, A., Pierzchalski, A., Bauer, M., Röder, S., Sattler, A., Standl, M., Borte, M., von Bergen, M., Rolle-Kampczyk, U., Herberth, G. (2020):
MAIT cell activation in adolescents is impacted by bile acid concentrations and body weight
Clin. Exp. Immunol. 200 (2), 199 - 213