Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3390/microorganisms9050965
Licence creative commons licence
Title (Primary) Effect of gut microbiota biotransformation on dietary tannins and human health implications
Author Sallam, I.E.; Abdelwareth, A.; Attia, H.; Aziz, R.K.; Homsi, M.N.; von Bergen, M.; Farag, M.A.
Source Titel Microorganisms
Year 2021
Department MOLSYB
Volume 9
Issue 5
Page From art. 965
Language englisch
Topic T9 Healthy Planet
Keywords tannins; gut microbiota; mutual interaction; polyphenols; biotransformation; molecular motifs
Abstract Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits
Persistent UFZ Identifier
Sallam, I.E., Abdelwareth, A., Attia, H., Aziz, R.K., Homsi, M.N., von Bergen, M., Farag, M.A. (2021):
Effect of gut microbiota biotransformation on dietary tannins and human health implications
Microorganisms 9 (5), art. 965 10.3390/microorganisms9050965