Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1111/all.14890
Licence creative commons licence
Title (Primary) Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Author Thürmann, L.; Herberth, G. ORCID logo ; Seiwert, B.; Schlittenbauer, L.; Rolle-Kampczyk, U.; Röder, S. ORCID logo ; Sack, U.; Borte, M.; von Bergen, M.; Trump, S.; Reemtsma, T.; Lehmann, I.
Source Titel Allergy
Year 2021
Department ANA; IMMU; MOLSYB
Volume 76
Issue 10
Page From 3122
Page To 3132
Language englisch
Topic T9 Healthy Planet
Keywords allergy; atopic dermatitis; paraben; prenatal; sex


Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD).


261 mother-child pairs of the German mother-child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician-diagnosed AD from age 1 to 8 years, disease onset, and persistence, childhood AD was classified into four different phenotypes.


4.6% (n = 12) and 12.3% (n = 32) of the children were classified as having very early-onset AD (until age two) either with or without remission, 11.9% (n = 31) as early-onset (after age two), and 3.1% (n = 8) as childhood-onset AD (after age six). Exposure to ethylparaben and n-butylparaben was associated with an increased risk to develop very early-onset AD without remission (EtP: adj.OR/95% CI:1.44/1.04–2.00,nBuP:adj.OR/95% CI:1.95/1.22–3.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex.


Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure.

Persistent UFZ Identifier
Thürmann, L., Herberth, G., Seiwert, B., Schlittenbauer, L., Rolle-Kampczyk, U., Röder, S., Sack, U., Borte, M., von Bergen, M., Trump, S., Reemtsma, T., Lehmann, I. (2021):
Prenatal paraben exposure and atopic dermatitis-related outcomes among children
Allergy 76 (10), 3122 - 3132 10.1111/all.14890