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Title (Primary) Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE
Author Hoeke, H.; Roeder, S.; Mueller, A.; Bertsche, T.; Borte, M.; Rolle-Kampczyk, U.; von Bergen, M.; Wissenbach, D.K.;
Journal Allergy
Year 2016
Department STUDIEN; MOLSYB;
Volume 71
Issue 6
Language englisch;
POF III (all) F11; T42;
Keywords Acetaminophen; prenatal exposure; IgE; SX1
UFZ wide themes RU3;
Abstract An association between prenatal acetaminophen or ibuprofen intake and an increased risk for asthma and increased IgE level in children is discussed in various epidemiological studies. Although the molecular mechanistic link is still unknown, the question whether or not acetaminophen and/or ibuprofen are safe pain medications during pregnancy arose. In this study, we associate maternal acetaminophen and ibuprofen intake during pregnancy and breast feeding to infantile asthma phenotypes and elevated IgE level. Therefore, we analysed questionnaires from a local mother-child cohort and monitored drug intake by LC-MS bio monitoring in urine. No association was found between drug intake and any analysed health outcome using questionnaire data. For the information obtained by bio monitoring no association was found for ibuprofen and acetaminophen intake during breast feeding. However, an association between prenatal acetaminophen intake and increased infantile IgEs related to aeroallergens was statistically detected, but not for asthma phenotypes.
ID 17284
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17284
Hoeke, H., Roeder, S., Mueller, A., Bertsche, T., Borte, M., Rolle-Kampczyk, U., von Bergen, M., Wissenbach, D.K. (2016):
Biomonitoring of prenatal analgesic intake and correlation with infantile anti-aeroallergens IgE
Allergy 71 (6), 901 - 906