Publication Details

Category Text Publication
Reference Category Journals
DOI 10.2174/092986610790780314
Title (Primary) Interactions of ginkgolides A and B with a recombinant human prion protein
Author Georgieva, D.; Redecke, L.; von Bergen, M.; Genov, N.; Betzel, C.
Source Titel Protein and Peptide Letters
Year 2010
Department PROTEOM
Volume 17
Issue 3
Page From 399
Page To 404
Language englisch
Keywords Three-dimensional structure; structural transformation; ginkgolide; prion protein; protein misfolding
Abstract In the presence of ginkgolides A and B a recombinant human prion protein (90-231) is more susceptible to proteolysis, which is characteristic for the non-infective form of prion proteins and more thermostable than in the absence of ginkgolides. Probably, ginkgolides exert a neuroprotective effect through a rearrangement of the prion structure.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=9989
Georgieva, D., Redecke, L., von Bergen, M., Genov, N., Betzel, C. (2010):
Interactions of ginkgolides A and B with a recombinant human prion protein
Protein Pept. Lett. 17 (3), 399 - 404