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Title (Primary) Serum amino acid concentrations in infants from Malawi are associated with linear growth
Author Ordiz, M.I.; Semba, R.D.; Moaddel, R.; Rolle-Kampczyk, U.; von Bergen, M.; Herberth, G. ORCID logo ; Khadeer, M.; Röder, S.; Manary, M.J.
Journal Current Developments in Nutrition
Year 2019
Department IMMU; MOLSYB
Volume 3
Issue 10
Page From nzz100
Language englisch
Keywords amino acids; stunting; linear growth; Africa; global health
Abstract Serum amino acid (AA) concentrations are correlated with childhood stunting, but their relationship to linear growth velocity has not been explored. This was a secondary analysis of a clinical trial where Malawian infants 6–12 mo. of age were given a legume supplement providing 8.2 g/d of protein; anthropometry was measured at multiple intervals, and fasted serum AAs concentrations were measured at 12 mo. of age. Lysine, proline, tryptophan, tyrosine and valine concentrations were higher in infants with linear growth velocity z-score > 0 than those <0. Corrected Spearman's correlation coefficients between individual AA concentrations and weight-for-height and length velocity from 6–12 months of age were positively correlated for glycine, isoleucine, proline, serine, threonine, tyrosine and valine. Additionally, weight-for-height was correlated with arginine, asparagine, glutamine, leucine, lysine, methionine and phenylalanine. The observed associations suggest that testing the hypothesis that essential AA provision will reduce linear growth faltering is warranted.
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Ordiz, M.I., Semba, R.D., Moaddel, R., Rolle-Kampczyk, U., von Bergen, M., Herberth, G., Khadeer, M., Röder, S., Manary, M.J. (2019):
Serum amino acid concentrations in infants from Malawi are associated with linear growth
Curr. Dev. Nutr. 3 (10), nzz100