Publication Details |
Category | Text Publication |
Reference Category | Journals |
DOI | 10.1016/j.clim.2014.02.013 |
Title (Primary) | The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy |
Author | Junge, K.M.; Hörnig, F.; Herberth, G.
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Source Titel | Clinical Immunology |
Year | 2014 |
Department | IMMU; METABOX; PROTEOM; STUDIEN |
Volume | 152 |
Issue | 1-2 |
Page From | 68 |
Page To | 76 |
Language | englisch |
Keywords | Cord blood; Eosinophil/basophil progenitors; Wheezing; Bronchitis; Two year old children; LINA |
UFZ wide themes | RU3; |
Abstract | RationaleCord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. MethodsIn a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. ResultsCord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. ConclusionsThe association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment. Abbreviations
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Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14679 |
Junge, K.M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.-C., Heroux, D., Denburg, J.A., Lehmann, I. (2014): The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy Clin. Immunol. 152 (1-2), 68 - 76 10.1016/j.clim.2014.02.013 |