Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.clim.2014.02.013
Title (Primary) The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
Author Junge, K.M.; Hörnig, F.; Herberth, G. ORCID logo ; Röder, S. ORCID logo ; Kohajda, T.; Rolle-Kampczyk, U.; von Bergen, M.; Borte, M.; Simon, J.-C.; Heroux, D.; Denburg, J.A.; Lehmann, I.
Source Titel Clinical Immunology
Year 2014
Volume 152
Issue 1-2
Page From 68
Page To 76
Language englisch
Keywords Cord blood; Eosinophil/basophil progenitors; Wheezing; Bronchitis; Two year old children; LINA
UFZ wide themes RU3;


Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment.


In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation.


Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months.


The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.


  • Cb, cord blood;
  • CFU, colony forming units;
  • Eo/B, eosinophil/basophil;
  • ETS, environmental tobacco smoke;
  • FHA, family history of atopy;
  • GM-CSF, granulocyte macrophage colony-stimulating factor;
  • IL-3, IL-5, interleukin 3, interleukin 5;
  • IL-5Rα, interleukin 5 receptor alpha sub-unit;
  • VOC, volatile organic compounds;
  • OR, odds ratio;
  • Th2, T helper cell type 2.
Persistent UFZ Identifier
Junge, K.M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.-C., Heroux, D., Denburg, J.A., Lehmann, I. (2014):
The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
Clin. Immunol. 152 (1-2), 68 - 76 10.1016/j.clim.2014.02.013