|Title (Primary)||The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy|
|Author||Junge, K.M.; Hörnig, F.; Herberth, G. ; Röder, S. ; Kohajda, T.; Rolle-Kampczyk, U.; von Bergen, M.; Borte, M.; Simon, J.-C.; Heroux, D.; Denburg, J.A.; Lehmann, I.|
|Department||IMMU; METABOX; PROTEOM; STUDIEN|
|Keywords||Cord blood; Eosinophil/basophil progenitors; Wheezing; Bronchitis; Two year old children; LINA|
|UFZ wide themes||RU3;|
Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment.
In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation.
Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months.
The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.
|Persistent UFZ Identifier||https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=14679|
|Junge, K.M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., von Bergen, M., Borte, M., Simon, J.-C., Heroux, D., Denburg, J.A., Lehmann, I. (2014):
The LINA cohort: cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
Clin. Immunol. 152 (1-2), 68 - 76