||Infantile eosinophil/basophil progenitors are more sensitive to indoor chemical exposures compared to their mothers
||Hörnig, F.; Weisse, K.; Röder, S.
; Kohajda, T.; von Bergen-Tomm, M.; Borte, M.; Diez, U.; Simon, J.; Denburg, J.; Lehmann, I.
||IMMU; PROTEOM; STUDIEN
Background: Enhanced eosinophil/basophil (Eo/B) progenitor levels are
known to contribute to allergic inflammation and associated with atopic risk. So
far, less data exist about the responsiveness of Eo/B progenitor cells to
environmental pollutants. Therefore, the aim of the present study was to
investigate the influence of different indoor exposures on the recruitment and
differentiation of Eo/B progenitors in mother-child pairs.
Analyses of Eo/B progenitors were performed in a sub cohort of 68
mother-child-pairs at children's age of two within the LINA cohort study
(Lifestyle and environmental factors and their Influence on Newborns Allergy
risk). PBMCs were used for methylcellulose assays to assess colony formation
(CFU) in presence of IL-3, IL-5 or GM-CSF. Standardized questionnaires answered
by parents were used to collect information about atopic outcomes and indoor
exposures to tobacco smoke as well as disinfectants during the second year of
life. Concentrations of volatile organic compounds (VOC) were measured around
the first birthday in the home.
Result: A positive correlation was
found between maternal and infantile circulating IL-3 (p<0.001) and GM-CSF
(p<0.05) stimulated Eo/B CFUs at children's age of two. In children,
increased numbers of IL-3, IL-5 or GM-CSF stimulated Eo/B CFUs were seen in
response to indoor VOC exposures, tobacco smoke and usage of disinfectants. In
contrast, maternal Eo/B CFUs were not significantly affected by most of these
exposures. Further, children's enhanced numbers of IL-3 and GM-CSF stimulated
Eo/B CFUs, raw or adjusted for known confounders, were associated with treated
wheezing during the second year of life (p<0.05).
study demonstrates that the recruitment and differentiation of Eo/B progenitors
in infants is much more sensitive to indoor air pollutants compared to their
corresponding mothers. Resulting enhanced numbers of Eo/B CFUs may contribute to
the development of respiratory diseases in early infancy.
|Persistent UFZ Identifier
|Hörnig, F., Weisse, K., Röder, S., Kohajda, T., von Bergen-Tomm, M., Borte, M., Diez, U., Simon, J., Denburg, J., Lehmann, I. (2012):
Infantile eosinophil/basophil progenitors are more sensitive to indoor chemical exposures compared to their mothers
Allergy 67 (Suppl. 96), 574 - 574