Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1016/j.scitotenv.2021.148350 |
| Document | accepted manuscript |
| Title (Primary) | Pesticide-induced metabolic changes are amplified by food stress |
| Author | Shahid, N.; Rolle-Kampczyk, U.; Siddique, A.
; von Bergen, M.; Liess, M. |
| Source Titel | Science of the Total Environment |
| Year | 2021 |
| Department | OEKOTOX; MOLSYB |
| Volume | 792 |
| Page From | art. 148350 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Keywords | Metabolic changes; Daphnia magna; Pyrethroid; Interaction; Food stress |
| Abstract | In natural ecosystems, long-term detrimental effects of pesticides may occur at very low concentrations, below those considered safe by the governmental risk assessment. Mechanisms potentially responsible for this unexpected sensitivity include environmental stress-factors such as food deficiency. To understand this so called “effect-paradox”, we investigated how food stress interacts with insecticide-induced biochemical fingerprints. Therefore, we measured metabolomic perturbations in Daphnia magna following a 24 h exposure to esfenvalerate under high and low food conditions. In total, 160 metabolites covering the groups of amino acids, fatty acids, lipids, and sugars were analyzed. At 0.001 μg/L esfenvalerate – a factor of >200 below the acute lethal concentration (LC50) – the endogenous metabolome was significantly affected. Further, the effect under low food conditions was considerably stronger compared to high food conditions. Individual metabolites showed up to 7-fold stronger effects under low food conditions. In general, the metabolomic changes were largely dose-specific and increased over seven days after contamination. We conclude that the metabolic profiles are altered for at least seven days after a pulse exposure, and therefore might be a key process to understanding population level changes at ultra-low pesticide concentrations in the field. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=24839 |
| Shahid, N., Rolle-Kampczyk, U., Siddique, A., von Bergen, M., Liess, M. (2021): Pesticide-induced metabolic changes are amplified by food stress Sci. Total Environ. 792 , art. 148350 10.1016/j.scitotenv.2021.148350 |
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