Publication Details

Reference Category Journals
DOI / URL link
Title (Primary) Allergen-induced IL-6 regulates IL-9/IL-17A balance in CD4+ T cells in allergic airway inflammation
Author Schütze, N.; Trojandt, S.; Kuhn, S.; Tomm, J.M.; von Bergen, M.; Simon, J.C.; Polte, T.;
Journal Journal of Immunology
Year 2016
Department IMMU; MOLSYB;
Volume 197
Issue 7
Language englisch;
POF III (all) F11; T42;
UFZ wide themes RU3;
Abstract IL-9–secreting Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases. To what extent IL-9–producing cells are induced or regulated by sensitization with naturally occurring allergens is not yet clear. Naturally occurring allergens are capable of inducing IL-6 production in dendritic cells (DCs). Whether allergen-induced IL-6 supports a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 differentiation is not finally resolved. Therefore, in the present study we have investigated the impact of IL-6 on the Th9/Th17 balance depending on the predominant cytokine milieu and, additionally, in vivo using a DC-driven murine asthma model. In vitro, IL-6 increases Th9 cells under strong IL-4 and TGF-β activation, whereas under moderate IL-4 and TGF-β activation the presence of IL-6 shifts naive CD4+ cells to Th17 cells. To induce allergic airway inflammation, OVA-pulsed DCs from IL-6–deficient or wild-type donors were adoptively transferred into BALB/c mice. Recipients receiving IL-6–producing wild-type DCs showed a significant decrease of Th9- and IL-4–producing Th2 cells but an increase of Th17 cells in lung tissue in comparison with recipients sensitized with IL-6–deficient DCs. Our data suggest that the IL-6–mediated reduction of Th2-related IL-4 leads to a decline of the Th9 immune response and allows Th17 differentiation
ID 17852
Persistent UFZ Identifier
Schütze, N., Trojandt, S., Kuhn, S., Tomm, J.M., von Bergen, M., Simon, J.C., Polte, T. (2016):
Allergen-induced IL-6 regulates IL-9/IL-17A balance in CD4+ T cells in allergic airway inflammation
J. Immunol. 197 (7), 2653 - 2664