Prof. Dr. Susann Müller

Contact

Prof. Dr. Susann Müller
Group Leader Flow Cytometry

Department of Environmental Microbiology
Working Group Flow Cytometry
Helmholtz Centre for
Environmental Research - UFZ
Permoserstr. 15, 04318 Leipzig, Germany

Phone +49 341 235-1318
susann.mueller@ufz.de

Web of Science ResearcherID: K-1293-2013

Susann Müller

CV / Scientific Career

1985

Diploma in Biochemistry, Martin-Luther-University Halle-Wittenberg

1985-1991

Scientific assistant at the Institute of Biotechnology of the Academy of Science of the GDR, Leipzig

1992

PhD, University of Halle-Wittenberg, subject: 'Population dynamics of S. cerevisiae'

1992-1993

Scientific assistant in the Scientist Integration Programme of the Coordination and Development Initiative for institutes of the former Academy of Sciences of the GDR

1994-1997

Scientific assistant at the University of Leipzig; Faculty of Biosciences, Pharmacy and Psychology; Department Biotechnology

1997-2000

Grant for habilitation of the Saxon Ministry of Science and Art (SMWK), Dresden

since 2001

Senior scientist at the Department of Environmental Microbiology, UFZ Centre for Environmental Research Leipzig-Halle

2003

Habilitation at the Technical University Dresden, Faculty of Natural Science and Mathematics; subject: 'Multiparametric Cytometry'

2011

apl. Professor for Microbiology at the Leipzig University, Faculty of Life Sciences


Research interests

The process control of bioreactor grown microbial communities must handle a niche with certain boundaries and also with fast growth and assembly dynamics of the community members. In order to probe, monitor, and eventually control artificial or natural communities in managed systems, rapid detection and evaluation methods are required. We apply microbial community flow cytometry, which provides single cell-based high-dimensional data. To interpret the resulting time series data, we draw inspiration from macroecology, in which a rich set of concepts has been developed for describing population dynamics. We focused, for example, on stability concepts and developed a workflow to monitor and compute the stability properties resistance, resilience, displacement speed, and elasticity. In addition, metacommunity paradigms are studied on the single cell level. We use various diversity indices and interaction profiles to describe community assembly strategies and functional dependencies of community members.
In addition, we are working in projects connected to a future bio-based circular economy. The carboxylate platform is one of these proposals and a promising technology for substituting fossil resources for the provision of platform chemicals and liquid fuels. We also aim to develop a biological system for phosphate recovery from wastewater thus using waste streams as raw materials.



Current research

Deutsche Bundestiftung Umwelt (DBU), Aktenzeichen:33960/01-32
On-demand Produktion von Phosphatdünger aus Reststoffen von Brauerei und Kläranlage (Bio-P2)
(responsible: Susann Müller),
1.2.2018 - 31.1.2021

Total: 692.516 €

Zentrales Innovationsprogramm Mittelstand (ZIM) des BMWi – Kooperationsnetzwerke
Aktenzeichen: 16KN043226, INAR - BioPRec
BioP-Rec - Die Entwicklung eines automatisierten, rein biologischen, chemiefreien Phosphorrückgewinnungsverfahrens (im Zuge einer klassischen Abwasserreinigungsanlage) zur Herstellung eines hocheffizienten schwermetallfreien, organischen Phosphordüngers'
Responsible: Susann Müller
01.03.2019 – 28.02.2022
Total: 187.919 €

Zentrales Innovationsprogramm Mittelstand (ZIM) des BMWi – Kooperationsnetzwerke
Aktenzeichen: 16KN074623 INET - BitCa
Entwicklung einer Bioinformatischen Community Analyse zur Regelung von komplexen mikrobiellen biotechnischen Prozessen – BitCA
Responsible: Susann Müller
01.01.2019 – 31.12.2021
Total: 181.071 €

Chinese Scholarship Council (CSC)
China, Ministery of Education
‘Harnessing microbial community assembly and plasticity for resiliencing heterogeneous cell systems’
(responsible: Susann Müller)
01.03.2019-31.10.2022
Total: Scholarship

Bundesministerium für Bildung und Forschung BMBF
Aktenzeichen: 031L0192B
Culture Challenge - Geltropfenbasierte Hochdurchsatz-Isolation und -Kultivierung von Bakterien unter Verwendung von
Helferstämmen (Association)
Sondierungsphase (plus U Tübingen, EMBL Heidelberg)
01.01.20120-31.08.2020
Total: 200.000 €



Current classes

Modul: Mikrobielle Ökologie natürlicher und technischer Systeme 11-BIO-204
Master of Science Integrative Biology, Focus Biodiversity, Ecology, and Evolution (BEE)
Vorlesung (2SWS), Seminar (2SWS), Praktikum (5SWS)
Zusammenarbeit mit Prof. Dr. Chatzinotas
Masterstudiengang Biologie, 1. Semester

Modul: Quantitative Biologie und Biotechnologie 11-BCH-0822
Mitarbeit im Rahmen der Vorlesung
Masterstudiengang Biochemie, 1. Semester

Modul: Mikrobielle Ökologie und Umweltbiotechnologie 11-BCH-0707
Mitarbeit im Rahmen des Seminars und Praktikums
Masterstudiengang Biochemie, 1. Semester

Modul: Interaktionen in aquatischen und terrestrischen Ökosystemen
Mitarbeit im Rahmen der Vorlesung
Masterstudiengang Biologie, 1. Semester


Other Professional Activities

  • President of the German Society of Cytometry (DGfZ, 2008 -2010)
  • Associate Editor for Microbiology for CYTOMETRY Part A
  • Member of the Educational Committee of ISAC (2011 - 2012)
  • Board member of ISAC Scholars Program Committee (ISPC, 2013-2015)


Selected Publications

Haange SB, Jehmlich N, Krügel U, Hintschich C, Wehrmann D, Hankir M, Seyfried F, Froment J, Hübschmann T, Müller S, Wissenbach DK, Kang K, Buettner C, Panagiotou G, Noll M, Rolle-Kampczyk U, Fenske W, von Bergen M.
Gastric bypass surgery alters the community structure and functional composition of the intestinal microbiota independently of weight loss.
Microbiomes (2020) accepted

Krause JL, Schaepe SS, Fritz-Wallace K, Engelmann B, Rolle-Kampczyk U, Kleinsteuber S, Schattenberg F, Liu Z, Mueller S, Jehmlich N,Von Bergen M, and Herberth G.
Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use.
Gut Microbes (2020) accepted

Liu Z, Müller S.
Bacterial community diversity dynamics highlight degrees of nestedness and turnover patterns.
Cytometry Part A (2020) accepted

Lambrecht J, Cichocki N, Schattenberg F, Kleinsteuber S, Harms H, Müller S, Sträuber, H
Key sub-community dynamics of medium-cain carboxylate production
Microbial Cell Factory (2019) 18:92.

Ludwig J, Höner zu Siederdissen C, Liu Z, Stadler PF, Müller S
flowEMMi: An automated model-based clustering tool for microbial cytometric data.
BMC Bioinformatics (2019), 20:643

Liu Z, Cichocki N, Hübschmann T, Süring C, Ofiţeru ID, Sloan WT, Grimm V, Müller S
Neutral mechanisms and niche differentiation in steady-state insular microbial communities revealed by single cell analysis.
Environmental Microbiology (2019), 21/1, 164-181.

Liu Z, Cichocki N, Bonk F, Günther S, Schattenberg F, Harms H, Centler F, Müller S. Ecological stability properties of microbial communities assessed by flow cytometry.
mSphere (2018), 3/1, e00564-17

Koch C, Müller S.
Personalized microbiome dynamics – Cytometric fingerprints for routine diagnostics.
Molecular Aspects of Medicine (2018), 59, 123-134


Günther S, Faust K, Schumann, J, Harms H, Raes, J, Müller S.
Species-sorting and mass-transfer paradigms control managed natural metacommunities.
Environmental Microbiology (2016); 18(12):4862-4877.

Zimmermann J, Hübschmann T, Schattenberg F, Schumann J, Durek P, Riedel R, Friedrich M, Glauben R, Siegmund B, Radbruch A, Müller S, Dong HD
High-resolution Microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition.
European Journal of Immunology (2016) 46, 1300-1303

Jahn M, Günther S, Müller S
Non-random distribution of macromolecules as driving forces for phenotypic variation
Current Opinion Microbiology (2015) 25, 49-55.

Koch C, Harnisch F, Schröder U and Müller S
Cytometric fingerprints: evaluation of new tools for analyzing microbial community dynamics
Frontiers in Microbiology Section Systems Microbiology 2014, Vol. 5 Article 273, 1-11.

Jahn M, Vorpahl C, Türkowsky D, Lindmeyer M, Bühler B, Harms H, Müller S
Accurate Determination of Plasmid Copy Number of Flow-Sorted Cells using Droplet Digital PCR
Analytical Chemistry (2014) 86 5969-5976.

Koch C, Harms H, Müller S
Dynamics in the microbial cytome – single cell analytics in natural systems
Current Opinion Biotechnology (2014) 27 134-141.

Koch C, Müller S, Harms H, Harnisch F
Microbiomes in bioenergy production: From analysis to management
Current Opinion Biotechnology (2014) 27, 65-72.

Koch C, Fetzer I, Schmidt T, Harms H, Müller S
Monitoring functions in managed microbial systems by cytometric bar coding
Environmental Science and Technology (2013) 47, 1753-1760

Jahn M, Seifert J, von Bergen M, Schmid A, Bühler B, Müller S
Subpopulation-proteomics in prokaryotic populations
Current Opinion Biotechnology (2013) 24, 79-87.

Koch C, Günther S, Desta AF, Hübschmann T, Müller S
Cytometric fingerprinting for analysing microbial intra-community structure variation and identifying sub-community function
Nature Protocols (2013) 8/1, 190-202.

Günther S, Koch C, Hübschmann T, Röske I, Müller RA, Bley T, Harms H, Müller S
Correlation of community dynamics and process parameters as a tool for the prediction of the stability of wastewater treatment.
Environmental Science and Technology (2012) 46(1), 84-92.

Harnisch F, Koch C, Patil SA, Hübschmann T, Müller S, Schröder U
Revealing the electrochemically driven selection in natural community derived microbial biofilms using flow–cytometry
Energy & Environmental Science (2011) 4 (4) 1265 – 1267.

Müller S and Nebe-von-Caron G
Functional single-cell analyses – flow cytometry and cell sorting of microbial populations and communities.
FEMS Microbiol Rev (2010) 34, 554–587.

Müller, S.
Modes of cytometric bacterial DNA pattern – A tool for pursuing growth
Cell Proliferation (2007) 40, 621-635. 

Achilles J., Stahl F., Harms H., Müller S.
Isolation of intact RNA from cytometrically sorted S. cerevisiae for the analysis of intra-population diversity of gene expression
Nature Protocols (2007) 2/9, 2203-2211.




Inhalt:

2020 (1)
2019 (8)
2018 (7)
2017 (4)
2016 (4)
2015 (9)
2014 (9)
2013 (13)
2012 (2)
2011 (7)
2010 (7)

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