Details zur Publikation

Referenztyp Zeitschriften
DOI / URL Link
Titel (primär) Origin and analysis of microbial population heterogeneity in bioprocesses
Autor Müller, S.; Harms, H.; Bley, T.;
Journal / Serie Current Opinion in Biotechnology
Erscheinungsjahr 2010
Department UMB;
Band/Volume 21
Heft 1
Sprache englisch;
Abstract Heterogeneity of industrial production cultures is accepted to a certain degree; however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies. Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle. Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.
ID 10343
dauerhafte UFZ-Verlinkung http://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=10343
Müller, S., Harms, H., Bley, T. (2010):
Origin and analysis of microbial population heterogeneity in bioprocesses
Curr. Opin. Biotechnol. 21 (1), 100 - 113