Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.copbio.2010.01.002
Titel (primär) Origin and analysis of microbial population heterogeneity in bioprocesses
Autor Müller, S.; Harms, H.; Bley, T.
Quelle Current Opinion in Biotechnology
Erscheinungsjahr 2010
Department UMB
Band/Volume 21
Heft 1
Seite von 100
Seite bis 113
Sprache englisch
Abstract Heterogeneity of industrial production cultures is accepted to a certain degree; however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies. Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle. Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.
dauerhafte UFZ-Verlinkung
Müller, S., Harms, H., Bley, T. (2010):
Origin and analysis of microbial population heterogeneity in bioprocesses
Curr. Opin. Biotechnol. 21 (1), 100 - 113 10.1016/j.copbio.2010.01.002