Prof. Dr. Susann Müller
Contact
Prof. Dr. Susann Müller
Group Leader Flow Cytometry
Department of Environmental Microbiology
Working Group Flow Cytometry
Helmholtz Centre for
Environmental Research - UFZ
Permoserstr. 15, 04318 Leipzig, Germany
Phone +49 341 235-1318
susann.mueller@ufz.de
Web of Science ResearcherID K-1293-2013: https://publons.com/researcher/2607767/susann-muller/publications/
ORCID: https://orcid.org/0000-0003-2060-6256
CV / Scientific Career
1985
Diploma in Biochemistry, Martin-Luther-University Halle-Wittenberg
1985-1991
Scientific assistant at the Institute of Biotechnology of the Academy of Science of the GDR, Leipzig
1992
PhD, University of Halle-Wittenberg, subject: 'Population dynamics of S. cerevisiae'
1992-1993
Scientific assistant in the Scientist Integration Programme of the Coordination and Development Initiative for institutes of the former Academy of Sciences of the GDR
1994-1997
Scientific assistant at the University of Leipzig; Faculty of Biosciences, Pharmacy and Psychology; Department Biotechnology
1997-2000
Grant for habilitation of the Saxon Ministry of Science and Art (SMWK), Dresden
since 2001
Senior scientist at the Department of Environmental Microbiology, UFZ Centre for Environmental Research Leipzig-Halle
2003
Habilitation at the Technical University Dresden, Faculty of Natural Science and Mathematics; subject: 'Multiparametric Cytometry'
2011
apl. Professor for Microbiology at the Leipzig University, Faculty of Life Sciences
Research interests
The process control of bioreactor grown microbial communities must handle a niche with certain boundaries and also with fast growth and assembly dynamics of the community members. In order to probe, monitor, and eventually control artificial or natural communities in managed systems, rapid detection and evaluation methods are required. We apply microbial community flow cytometry, which provides single cell-based high-dimensional data. To interpret the resulting time series data, we draw inspiration from macroecology, in which a rich set of concepts has been developed for describing population dynamics. We focused, for example, on stability concepts and developed a workflow to monitor and compute the stability properties resistance, resilience, displacement speed, and elasticity. In addition, metacommunity paradigms are studied on the single cell level. We use various diversity indices and interaction profiles to describe community assembly strategies and functional dependencies of community members.
In addition, we are working in projects connected to a future bio-based circular economy. The carboxylate platform is one of these proposals and a promising technology for substituting fossil resources for the provision of platform chemicals and liquid fuels. We also aim to develop a biological system for phosphate recovery from wastewater thus using waste streams as raw materials.
Current research
Deutsche Forschungsgemeinschaft (DFG)
Aktenzeichen: GZ: MU 1089/10-1, AOBJ: 687645
Projektnummer: 503905203
Schwerpunktprogramms (SPP) "Emergente Funktionen der bakteriellen Multizellularität"
Analyse der lokalen Struktur und Funktion von bakteriellen Kolonien und Biofilmen auf Einzelzellebene mittels Durchflusszytometrie, Zellsortierung, Multi-omics und Datenwissenschaft -
Z-PROJECT“
1.11.2022-31.10.2025
Total: 556.550 €
Zentrales Innovationsprogramm Mittelstand (ZIM) des BMWi – Kooperationsnetzwerke
Aktenzeichen: 16KN043226, INAR - BioPRec
BioP-Rec - Die Entwicklung eines automatisierten, rein biologischen, chemiefreien Phosphorrückgewinnungsverfahrens (im Zuge einer klassischen Abwasserreinigungsanlage) zur Herstellung eines hocheffizienten schwermetallfreien, organischen Phosphordüngers'
Responsible: Susann Müller
01.03.2019 – 31.08.2022
Total: 187.919 €
Zentrales Innovationsprogramm Mittelstand (ZIM) des BMWi – Kooperationsnetzwerke
Aktenzeichen: 16KN074623 INET - BitCa
Entwicklung einer Bioinformatischen Community Analyse zur Regelung von komplexen mikrobiellen biotechnischen Prozessen – BitCA
Responsible: Susann Müller
01.07.2019 – 30.10.2022
Total: 181.071 €
Chinese Scholarship Council (CSC)
China, Ministery of Education
‘Harnessing microbial community assembly and plasticity for resiliencing heterogeneous cell systems’
(responsible: Susann Müller)
01.03.2019-30.2.2023
Total: Scholarship
Gordon and Betty Moore Foundation
Grant Number: GBMF9730
Resolving archaeal contributions to the first eukaryotic common ancestor: Developing new tools for accessing the genomes of uncultivated archaea.
In cooperation with the University of California, Santa Barbara Earth Research Institute
13.08.2020-01.09.2023
23 K€
EU- H2020- Horizon 2020 Societal Challenge 2
Aktenzeichen: Proposal 101000733 – PROMICON
PROMICON - FNR-12-2020 - Industrial microbiomes – learning from nature
Harnessing the power of nature through productive microbial consortia in biotechnology – Measure, Model & Master (PROMICON)
01.06.2021-31.12.2024
Total: 200 k€ UFZ, AG Flow Cytometry
Chinese Scholarship Council (CSC)
China, Ministery of Education
‘Construction of functionally active artificial communities based on individual cell analyses and ecological theory’
01.10.2021-31.09.2025
Total: Scholarship
Current classes
Modul: Structure, Function and Ecology of Microbial Communities 11-BIO-204
Master of Science Integrative Biology, Focus Biodiversity, Ecology, and Evolution (BEE)
Vorlesung (2SWS), Seminar (2SWS), Praktikum (5SWS)
Zusammenarbeit mit Prof. Dr. Chatzinotas
Masterstudiengang Biologie, 1. Semester
Modul: Quantitative Biologie und Biotechnologie 11-BCH-0822
Mitarbeit im Rahmen der Vorlesung
Masterstudiengang Biochemie, 1. Semester
Modul: Mikrobielle Ökologie und Umweltbiotechnologie 11-BCH-0707
Mitarbeit im Rahmen des Seminars und Praktikums
Masterstudiengang Biochemie, 1. Semester
Modul: Interaktionen in aquatischen und terrestrischen Ökosystemen 11-BIO-205
Mitarbeit im Rahmen der Vorlesung
Masterstudiengang Biologie, 1. Semester
Other Professional Activities
- President of the German Society of Cytometry (DGfZ, 2008 -2010)
- Associate Editor for Microbiology for CYTOMETRY Part A
- Member of the Educational Committee of ISAC (2011 - 2012)
- Board member of ISAC Scholars Program Committee (ISPC, 2013-2015)
Selected Publications
Jurburg SD, Eisenhauer N, Buscot F, Chatzinotas A, Chaudhari NM, Heintz-Buschart A, Kallies R, Küsel K, Litchman E, Macdonald CA, Müller S, Reuben RC, da Rocha UN, Panagiotou G, Rillig MC, Singh BK.
Potential of microbiome-based solutions for agrifood systems
Nature Food (2022) DOI - 10.1038/s43016-022-00576-x
Li S, Abdulkadir N, Schattenberg F, Rocha UN, Grimm V, Müller S, Liu Z
Stabilising microbial communities by looped mass transfer
Proceedings of the National Academy of Sciences (PNAS) (2022) 119/17, e2117814119
Cohen Y, Pasternak Z, Müller S, Hübschmann T, Schattenberg F, Sivakala KK, Abed-Rabbo A,
Chatzinotas A & Jurkevitch E
Community and single cell analyses reveal complex predatory interactions between bacteria in high-diversity systems.
Nature Communications (2021) 12, 5481.
Vučič V, Süring C, Harms H, Müller S, Günther S.
A framework for P-cycle assessment in wastewater treatment plants.
Science of the Total Environment (2021) 760C, 143392.
Cichocki N, Hübschmann T, Schattenberg F, Kerckhof FM, Overmann J, Müller S.
Bacterial mock communities as standards for reproducible cytometric microbiome analysis.
Nature Protocols (2020) 15, 2788-2812. DOI: 10.1038/s41596-020-0362-0
Hübschmann T, Müller S, Wissenbach DK, Kang K, Buettner C, Panagiotou G, Noll M, Rolle-Kampczyk U, Fenske W, von Bergen M.
Gastric bypass surgery alters the community structure and functional composition of
the intestinal microbiota independently of weight loss.
Microbiomes (2020) 8/13
Krause JL, Schaepe SS, Fritz-Wallace K, Engelmann B, Rolle-Kampczyk U, Kleinsteuber S, Schattenberg F, Liu Z, Mueller S, Jehmlich N,Von Bergen M, and Herberth G.
Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use.
Gut Microbes (2020) doi.org/10.1080/19490976.2019.1702431
Liu Z, Müller S.
Bacterial community diversity dynamics highlight degrees of nestedness and turnover patterns.
Cytometry Part A (2020) doi.org/10.1002/cyto.a.23965
Lambrecht J, Cichocki N, Schattenberg F, Kleinsteuber S, Harms H, Müller S, Sträuber, H
Key sub-community dynamics of medium-cain carboxylate production
Microbial Cell Factory (2019) 18:92.
Ludwig J, Höner zu Siederdissen C, Liu Z, Stadler PF, Müller S
flowEMMi: An automated model-based clustering tool for microbial cytometric data.
BMC Bioinformatics (2019), 20:643
Liu Z, Cichocki N, Hübschmann T, Süring C, Ofiţeru ID, Sloan WT, Grimm V, Müller S
Neutral mechanisms and niche differentiation in steady-state insular microbial communities revealed by single cell analysis.
Environmental Microbiology (2019), 21/1, 164-181.
Liu Z, Cichocki N, Bonk F, Günther S, Schattenberg F, Harms H, Centler F, Müller S. Ecological stability properties of microbial communities assessed by flow cytometry.
mSphere (2018), 3/1, e00564-17
Koch C, Müller S. Personalized microbiome dynamics – Cytometric fingerprints for routine
diagnostics.
Molecular Aspects of Medicine (2018), 59, 123-134
Günther S, Faust K, Schumann, J, Harms H, Raes, J, Müller S.
Species-sorting and mass-transfer paradigms control managed natural metacommunities.
Environmental Microbiology (2016); 18(12):4862-4877.
Zimmermann J, Hübschmann T, Schattenberg F, Schumann J, Durek P, Riedel R, Friedrich M, Glauben R, Siegmund B, Radbruch A, Müller S, Dong HD
High-resolution Microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition.
European Journal of Immunology (2016) 46, 1300-1303
Jahn M, Günther S, Müller S
Non-random distribution of macromolecules as driving forces for phenotypic variation
Current Opinion Microbiology (2015) 25, 49-55.
Koch C, Harnisch F, Schröder U and Müller S
Cytometric fingerprints: evaluation of new tools for analyzing microbial community dynamics
Frontiers in Microbiology Section Systems Microbiology 2014, Vol. 5 Article 273, 1-11.
Jahn M, Vorpahl C, Türkowsky D, Lindmeyer M, Bühler B, Harms H, Müller S
Accurate Determination of Plasmid Copy Number of Flow-Sorted Cells using Droplet Digital PCR
Analytical Chemistry (2014) 86 5969-5976.
Koch C, Harms H, Müller S
Dynamics in the microbial cytome – single cell analytics in natural systems
Current Opinion Biotechnology (2014) 27 134-141.
Koch C, Müller S, Harms H, Harnisch F
Microbiomes in bioenergy production: From analysis to management
Current Opinion Biotechnology (2014) 27, 65-72.
Koch C, Fetzer I, Schmidt T, Harms H, Müller S
Monitoring functions in managed microbial systems by cytometric bar coding
Environmental Science and Technology (2013) 47, 1753-1760
Jahn M, Seifert J, von Bergen M, Schmid A, Bühler B, Müller S
Subpopulation-proteomics in prokaryotic populations
Current Opinion Biotechnology (2013) 24, 79-87.
Koch C, Günther S, Desta AF, Hübschmann T, Müller S
Cytometric fingerprinting for analysing microbial intra-community structure variation and identifying sub-community function
Nature Protocols (2013) 8/1, 190-202.
Günther S, Koch C, Hübschmann T, Röske I, Müller RA, Bley T, Harms H, Müller S
Correlation of community dynamics and process parameters as a tool for the prediction of the stability of wastewater treatment.
Environmental Science and Technology (2012) 46(1), 84-92.
Harnisch F, Koch C, Patil SA, Hübschmann T, Müller S, Schröder U
Revealing the electrochemically driven selection in natural community derived microbial biofilms using flow–cytometry
Energy & Environmental Science (2011) 4 (4) 1265 – 1267.
Müller S and Nebe-von-Caron G
Functional single-cell analyses – flow cytometry and cell sorting of microbial populations and communities.
FEMS Microbiol Rev (2010) 34, 554–587.
Müller, S.
Modes of cytometric bacterial DNA pattern – A tool for pursuing growth
Cell Proliferation (2007) 40, 621-635.
Achilles J., Stahl F., Harms H., Müller S.
Isolation of intact RNA from cytometrically sorted S. cerevisiae for the analysis of intra-population diversity of gene expression
Nature Protocols (2007) 2/9, 2203-2211.
Index:
You could use our publication index for further requests.
2021 (5)
- Cohen, Y., Pasternak, Z., Müller, S., Hübschmann, T., Schattenberg, F., Sivakala, K.K., Abed-Rabbo, A., Chatzinotas, A., Jurkevitch, E. (2021):
Community and single cell analyses reveal complex predatory interactions between bacteria in high diversity systems
Nat. Commun. 12 , art. 5481
full text (doi) - Heyse, J., Schattenberg, F., Rubbens, P., Müller, S., Waegeman, W., Boon, N., Props, R. (2021):
Predicting the presence and abundance of bacterial taxa in environmental communities through flow cytometric fingerprinting
mSystems 6 (5), e00551-21
full text (doi) - Qin, W., Stärk, H.-J., Müller, S., Reemtsma, T., Wagner, S. (2021):
Determination of elemental distribution and evaluation of elemental concentration in single Saccharomyces cerevisiae cells using single cell-inductively coupled plasma mass spectrometry
Metallomics 13 (6), mfab032
full text (doi) - Vučić, V., Müller, S. (2021):
New developments in biological phosphorus accessibility and recovery approaches from soil and waste streams
Eng. Life Sci. 21 (3-4), 77 - 86
full text (doi) - Vučić, V., Süring, C., Harms, H., Müller, S., Günther, S. (2021):
A framework for P-cycle assessment in wastewater treatment plants
Sci. Total Environ. 760 , art. 143392
full text (doi)
2020 (8)
- Alvarez Esquivel, D.Y., Guo, Y., Brown, R.K., Müller, S., Schröder, U., Harnisch, F. (2020):
Investigating community dynamics and performance during microbial electrochemical degradation of whey
ChemElectroChem 7 (4), 989 - 997
full text (doi) - Cichocki, N., Hübschmann, T., Schattenberg, F., Kerckhof, F.M., Overmann, J., Müller, S. (2020):
Bacterial mock communities as standards for reproducible cytometric microbiome analysis
Nat. Protoc. 15 , 2788 - 2812
full text (doi) - Guo, Y., Rosa, L.F.M., Müller, S., Harnisch, F. (2020):
Monitoring stratification of anode biofilms in bioelectrochemical laminar flow reactors using flow cytometry
Environ. Sci. Ecotechnol. 4 , art. 10062
full text (doi) - Haange, S.-B., Jehmlich, N., Krügel, U., Hintschich, C., Wehrmann, D., Hankir, M., Seyfried, F., Froment, J., Hübschmann, T., Müller, S., Wissenbach, D.K., Kang, K.H., Buettner, C., Panagiotou, G., Noll, M., Rolle-Kampczyk, U., Fenske, W., von Bergen, M. (2020):
Gastric bypass surgery in a rat model alters the community structure and functional composition of the intestinal microbiota independently of weight loss
Microbiome 8 , art. 13
full text (doi) - Krause, J.L., Schaepe, S.S., Fritz-Wallace, K., Engelmann, B., Rolle-Kampczyk, U., Kleinsteuber, S., Schattenberg, F., Liu, Z., Müller, S., Jehmlich, N., von Bergen, M., Herberth, G. (2020):
Following the community development of SIHUMIx – a new intestinal in vitro model for bioreactor use
Gut Microbes 11 (4), 1116 - 1129
full text (doi) - Krause, J.L., Schäpe, S.S., Schattenberg, F., Müller, S., Ackermann, G., Rolle-Kampczyk, U.E., Jehmlich, N., Pierzchalski, A., von Bergen, M., Herberth, G. (2020):
The activation of mucosal-associated invariant T (MAIT) cells is affected by microbial diversity and riboflavin utilization in vitro
Front. Microbiol. 11 , art. 755
full text (doi) - Liu, Z., Müller, S. (2020):
Bacterial community diversity dynamics highlight degrees of nestedness and turnover patterns
Cytom. Part A 97 (7), 742 - 748
full text (doi) - Müller, S., Chang, H.-D. (2020):
Microorganisms and their activities within microbial communities
Cytom. Part A 97 (7), 681 - 682
full text (doi)
2019 (10)
- Calabrese, F., Voloshynovska, I., Musat, F., Thullner, M., Schlömann, M., Richnow, H.H., Lambrecht, J., Müller, S., Wick, L.Y., Musat, N., Stryhanyuk, H. (2019):
Quantitation and comparison of phenotypic heterogeneity among single cells of monoclonal microbial populations
Front. Microbiol. 10 , art. 2814
full text (doi) - Cossarizza, A., Chang, H.-D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Müller, S., Agace, W.W., et al. (2019):
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Eur. J. Immunol. 49 (10), 1457 - 1973
full text (doi) - Czechowska, K., Lannigan, J., Wang, L., Arcidiacono, J., Ashhurst, T.M., Barnard, R.M., Bauer, S., Bispo, C., Bonilla, D.L., Brinkman, R.R., Cabanski, M., Chang, H.-D., Chakrabarti, L., Chojnowski, G., Cotleur, B., Degheidy, H., Dela Cruz, G.V., Eck, S., Elliott, J., Errington, R., Filby, A., Gagnon, D., Gardner, R., Green, C., Gregory, M., Groves, C.J., Hall, C., Hammes, F., Hedrick, M., Hoffman, R., Icha, J., Ivaska, J., Jenner, D.C., Jones, D., Kerckhof, F.M., Kukat, C., Lanham, D., Leavesley, S., Lee, M., Lin‐Gibson, S., Litwin, V., Liu, Y., Molloy, J., Moore, J.S., Müller, S., Nedbal, J., Niesner, R., Nitta, N., Ohlsson‐Wilhelm, B., Paul, N.E., Perfetto, S., Portat, Z., Props, R., Radtke, S., Rayanki, R., Rieger, A., Rogers, S., Rubbens, P., Salomon, R., Schiemann, M., Sharpe, J., Sonder, S.U., Stewart, J.J., Sun, Y., Ulrich, H., Van Isterdael, G., Vitaliti, A., van Vreden, C., Weber, M., Zimmermann, J., Vacca, G., Wallace, P., Tárnok, A. (2019):
Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops
Cytom. Part A 95 (6), 598 - 644
full text (doi) - Donnenberg, V.S., Müller, S., Houston, J.P., Holden, E. (2019):
Cytometry score: 23 to 4
Cytom. Part A 95 (3), 259 - 260
full text (doi) - Engel, C., Schattenberg, F., Dohnt, K., Schröder, U., Müller, S., Krull, R. (2019):
Long-term behavior of defined mixed cultures of Geobacter sulfurreducens and Shewanella oneidensis in bioelectrochemical systems
Front. Bioeng. Biotechnol. 7 , art. 60
full text (doi) - Guo, Y., Cichocki, N., Schattenberg, F., Geffers, R., Harms, H., Müller, S. (2019):
AgNPs change microbial community structures of wastewater
Front. Microbiol. 9 , art. 3211
full text (doi) - Lambrecht, J., Cichocki, N., Schattenberg, F., Kleinsteuber, S., Harms, H., Müller, S., Sträuber, H. (2019):
Key sub‑community dynamics of medium‑chain carboxylate production
Microb. Cell. Fact. 18 , art. 92
full text (doi) - Liu, Z., Cichocki, N., Hübschmann, T., Süring, C., Ofiţeru, I.D., Sloan, W.T., Grimm, V., Müller, S. (2019):
Neutral mechanisms and niche differentiation in steady-state insular microbial communities revealed by single cell analysis
Environ. Microbiol. 21 (1), 164 - 181
full text (doi) - Ludwig, J., Höner zu Siederdissen, C., Liu, Z., Stadler, P.F., Müller, S. (2019):
flowEMMi: an automated model-based clustering tool for microbial cytometric data
BMC Bioinformatics 20 , art. 643
full text (doi) - Schäpe, S.S., Krause, J.L., Engelmann, B., Fritz-Wallace, K., Schattenberg, F., Liu, Z., Müller, S., Jehmlich, N., Rolle-Kampczyk, U., Herberth, G., von Bergen, M. (2019):
The simplified human intestinal microbiota (SIHUMIx) shows high structural and functional resistance against changing transit times in in vitro bioreactors
Microorganisms 7 (12), art. 641
full text (doi)
2018 (7)
- Günther, S., Becker, D., Hübschmann, T., Reinert, S., Kleinsteuber, S., Müller, S., Wilhelm, C. (2018):
Long-term biogas production from glycolate by diverse and highly dynamic communities
Microorganisms 6 (4), art. 130
full text (doi) - Günther, S., Grunert, M., Müller, S. (2018):
Overview of recent advances in phosphorus recovery for fertilizer production
Eng. Life Sci. 18 (7), 434 - 439
full text (doi) - Koch, C., Müller, S. (2018):
Personalized microbiome dynamics – Cytometric fingerprints for routine diagnostics
Mol. Asp. Med. 59 , 123 - 134
full text (doi) - Lambrecht, J., Schattenberg, F., Harms, H., Müller, S. (2018):
Characterizing microbiome dynamics – flow cytometry based workflows from pure cultures to natural communities
J. Vis. Exp. (137), e58033
full text (doi) - Liu, Z., Cichocki, N., Bonk, F., Günther, S., Schattenberg, F., Harms, H., Centler, F., Müller, S. (2018):
Ecological stability properties of microbial communities assessed by flow cytometry
mSphere 3 (1), e00564-17
full text (doi) - van Gelder, S., Röhrig, N., Schattenberg, F., Cichocki, N., Schumann, J., Schmalz, G., Haak, R., Ziebolz, D., Müller, S. (2018):
A cytometric approach to follow variation and dynamics of the salivary microbiota
Methods 134–135 , 67 - 79
full text (doi) - Zimmermann, J., Durek, P., Kühl, A.A., Schattenberg, F., Maschmeyer, P., Siracusa, F., Lehmann, K., Westendorf, K., Weber, M., Riedel, R., Müller, S., Radbruch, A., Chang, H.-D. (2018):
The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice
Eur. J. Immunol. 48 (1), 161 - 167
full text (doi)
2017 (4)
- Cossarizza, A., Chang, H.-D., Radbruch, A., Akdis, M., Andrä, I., Annunziato, F., Bacher, P., Barnaba, V., Battistini, L., Bauer, W.M., Baumgart, S., Becher, B., Beisker, W., Berek, C., Blanco, A., Borsellino, G., Boulais, P.E., Brinkman, R.R., Büscher, M., Busch, D.H., Bushnell, T.P., Cao, X., Cavani, A., Chattopadhyay, P.K., Cheng, Q., Chow, S., Clerici, M., Cooke, A., Cosma, A., Cosmi, L., Cumano, A., Dang, V.D., Davies, D., De Biasi, S., Del Zotto, G., Müller, S., Müller, W., et al. (2017):
Guidelines for the use of flow cytometry and cell sorting in immunological studies
Eur. J. Immunol. 47 (10), 1584 - 1797
full text (doi) - Guo, Y., Baumgart, S., Stärk, H.-J., Harms, H., Müller, S. (2017):
Mass cytometry for detection of silver at the bacterial single cell level
Front. Microbiol. 8 , art. 1326
full text (doi) - Guo, Y., Stärk, H.J., Hause, G., Schmidt, M., Harms, H., Wick, L.Y., Müller, S. (2017):
Heterogenic response of prokaryotes toward silver nanoparticles and ions is facilitated by phenotypes and attachment of silver aggregates to cell surfaces
Cytom. Part A 91 (8), 775 - 784
full text (doi) - Lambrecht, J., Cichocki, N., Hübschmann, T., Koch, C., Harms, H., Müller, S. (2017):
Flow cytometric quantification, sorting and sequencing of methanogenic archaea based on F420 autofluorescence
Microb. Cell. Fact. 16 , art. 180
full text (doi)
2016 (4)
- Günther, S., Faust, K., Schumann, J., Harms, H., Raes, J., Müller, S. (2016):
Species-sorting and mass-transfer paradigms control managed natural metacommunities
Environ. Microbiol. 18 (12), 4862 - 4877
full text (doi) - Jahn, M., Vorpahl, C., Hübschmann, T., Harms, H., Müller, S. (2016):
Copy number variability of expression plasmids determined by cell sorting and Droplet Digital PCR
Microb. Cell. Fact. 15 , art. 211
full text (doi) - Lieder, S., Jahn, M., Koepff, J., Müller, S., Takors, R. (2016):
Environmental stress speeds up DNA replication in Pseudomonas putida in chemostat cultivations
Biotechnol. J. 11 (1), 155 - 163
full text (doi) - Zimmermann, J., Hübschmann, T., Schattenberg, F., Schumann, J., Durek, P., Riedel, R., Friedrich, M., Glauben, R., Siegmund, B., Radbruch, A., Müller, S., Chang, H.-D. (2016):
High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition
Eur. J. Immunol. 46 (5), 1300 - 1303
full text (doi)
2015 (9)
- Günther, S., Müller, S. (2015):
Facilitated gate setting by sequential dot plot scanning
Cytom. Part A 87 (7), 661 - 664
full text (doi) - Jahn, M., Günther, S., Müller, S. (2015):
Non-random distribution of macromolecules as driving forces for phenotypic variation
Curr. Opin. Microbiol. 25 , 49 - 55
full text (doi) - King, N., Müller, S. (2015):
Environmental microbiology: Revisiting the physiology of microorganisms on the single cell scale. Editorial overview
Curr. Opin. Microbiol. 25 , v - vi
full text (doi) - Koch, C., Kuchenbuch, A., Kretzschmar, J., Wedwitschka, H., Liebetrau, J., Müller, S., Harnisch, F. (2015):
Coupling electric energy and biogas production in anaerobic digesters – impacts on the microbiome
RSC Advances 5 (40), 31329 - 31340
full text (doi) - Lindmeyer, M., Jahn, M., Vorpahl, C., Müller, S., Schmid, A., Bühler, B. (2015):
Variability in subpopulation formation propagates into biocatalytic variability of engineered Pseudomonas putida strains
Front. Microbiol. 6 , art. 1042
full text (doi) - Melzer, S., Winter, G., Jäger, K., Hübschmann, T., Hause, G., Syrowatka, F., Harms, H., Tárnok, A., Müller, S. (2015):
Cytometric patterns reveal growth states of Shewanella putrefaciens
Microb. Biotechnol. 8 (3), 379 - 391
full text (doi) - Müller, S., Schleinitz, K. (2015):
Flow cytometry and microbial community fingerprinting
In: Wilkinson, M.G. (ed.)
Flow cytometry in microbiology: Technology and applications
Caister Academic Press, Norfolk, p. 77 - 89 - Pous, N., Koch, C., Vilà-Rovira, A., Balaguer, M.D., Colprim, J., Mühlenberg, J., Müller, S., Harnisch, F., Puig, S. (2015):
Monitoring and engineering reactor microbiomes of denitrifying bioelectrochemical systems
RSC Advances 5 (84), 68326 - 68333
full text (doi) - Zimmermann, M., Escrig, S., Hübschmann, T., Kirf, M.K., Brand, A., Inglis, R.F., Musat, N., Müller, S., Meibom, A., Ackermann, M., Schreiber, F. (2015):
Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS
Front. Microbiol. 6 , art. 243
full text (doi)
2014 (9)
- Bühligen, F., Lindner, P., Fetzer, I., Stahl, F., Scheper, T., Harms, H., Müller, S. (2014):
Analysis of aging in lager brewing yeast during serial repitching
J. Biotechnol. 187 , 60 - 70
full text (doi) - Jahn, M., Vorpahl, C., Türkowsky, D., Lindmeyer, M., Bühler, B., Harms, H., Müller, S. (2014):
Accurate determination of plasmid copy number of flow-sorted cells using droplet digital PCR
Anal. Chem. 86 (12), 5969 - 5976
full text (doi) - Jahn, M., Vorpahl, C., Türkowsky, D., Lindmeyer, M., Bühler, B., Harms, H., Müller, S. (2014):
Population heterogeneity in Pseudomonas putida analyzed on the single cell level using proteomics and digital PCR
New Biotech. 31 (Suppl.), S58 - S59
full text (doi) - Koch, C., Harms, H., Müller, S. (2014):
Dynamics in the microbial cytome — single cell analytics in natural systems
Curr. Opin. Biotechnol. 27 , 134 - 141
full text (doi) - Koch, C., Harnisch, F., Schröder, U., Müller, S. (2014):
Cytometric fingerprints: evaluation of new tools for analyzing microbial community dynamics
Front. Microbiol. 5 , art. 273
full text (doi) - Koch, C., Müller, S., Harms, H., Harnisch, F. (2014):
Microbiomes in bioenergy production: From analysis to management
Curr. Opin. Biotechnol. 27 , 65 - 72
full text (doi) - Lieder, S., Jahn, M., Seifert, J., von Bergen, M., Müller, S., Takors, R. (2014):
Subpopulation-proteomics reveal growth rate, but not cell cycling, as a major impact on protein composition in Pseudomonas putida KT2440
AMB Express 4 , art. 71
full text (doi) - Schumann, J., Koch, C., Günther, S., Fetzer, I., Müller, S. (2014):
flowCHIC: Analyze flow cytometric data using histogram information
R package version 1.0.0
http://www.bioconductor.org/packages/release/bioc/html/flowCHIC.html
October 2014: 5 downloads (distinct IPs: ~500)
full text (url) - Schumann, J., Koch, C., Günther, S., Fetzer, I., Müller, S. (2014):
flowCyBar: Analyze flow cytometric data using gate information
R package version 1.2.0
http://www.bioconductor.org/packages/release/bioc/html/flowCyBar.html
October 2014: 1491 downloads (distinct IPs: December 2014: ~2000)
full text (url)
2013 (13)
- Bühligen, F., Rüdinger, P., Fetzer, I., Stahl, F., Scheper, T., Harms, H., Müller, S. (2013):
Sustainability of industrial yeast serial repitching practice studied by gene expression and correlation analysis
J. Biotechnol. 168 (4), 718 - 728
full text (doi) - Jahn, M., Seifert, J., Hübschmann, T., von Bergen, M., Harms, H., Müller, S. (2013):
Comparison of preservation methods for bacterial cells in cytomics and proteomics
Journal of Integrated OMICS 3 (1), 25 - 33
full text (doi) - Jahn, M., Seifert, J., von Bergen, M., Schmid, A., Bühler, B., Müller, S. (2013):
Subpopulation-proteomics in prokaryotic populations
Curr. Opin. Biotechnol. 24 (1), 79 - 87
full text (doi) - Koch, C., Brumme, B., Müller, S. (2013):
Mikrobielle Gemeinschaften im Visier der Durchflusszytometrie : Aktivitätsanalyse per Barcode
Biospektrum 19 (4), 396 - 400
full text (doi) - Koch, C., Fetzer, I., Harms, H., Müller, S. (2013):
CHIC—an automated approach for the detection of dynamic variations in complex microbial communities
Cytom. Part A 83 (6), 561 - 567
full text (doi) - Koch, C., Fetzer, I., Schmidt, T., Harms, H., Müller, S. (2013):
Monitoring functions in managed microbial systems by cytometric bar coding
Environ. Sci. Technol. 47 (3), 1753 - 1760
full text (doi) - Koch, C., Günther, S., Desta, A.F., Hübschmann, T., Müller, S. (2013):
Cytometric fingerprinting for analyzing microbial intracommunity structure variation and identifying subcommunity function
Nat. Protoc. 8 (1), 190 - 202
full text (doi) - Lentendu, G., Hübschmann, T., Müller, S., Dunker, S., Buscot, F., Wilhelm, C. (2013):
Recovery of soil unicellular eukaryotes: an efficiency and activity analysis on the single cell level
J. Microbiol. Methods 95 (3), 463 - 469
full text (doi) - Mehlig, L., Petzold, M., Heder, C., Günther, S., Müller, S., Eschenhagen, M., Röske, I., Röske, K. (2013):
Biodiversity of polyphosphate accumulating bacteria in eight WWTPs with different modes of operation
J. Environ. Eng.-ASCE 139 (8), 1089 - 1098
full text (doi) - Müller, S., Hiller, K. (2013):
From multi-omics to basic structures of biological systems
Curr. Opin. Biotechnol. 24 (1), 1 - 3
full text (doi) - Neumeyer, A., Hübschmann, T., Müller, S., Frunzke, J. (2013):
Monitoring of population dynamics of Corynebacterium glutamicum by multiparameter flow cytometry
Microb. Biotechnol. 6 (2), 157 - 167
full text (doi) - Rohwerder, T., Müller, R.H., Weichler, M.T., Schuster, J., Hübschmann, T., Müller, S., Harms, H. (2013):
Cultivation of Aquincola tertiaricarbonis L108 on the fuel oxygenate intermediate tert-butyl alcohol induces aerobic anoxygenic photosynthesis at extremely low feeding rates
Microbiology-(UK) 159 (10), 2180 - 2190
full text (doi) - Vogt, J., Stahl, F., Scheper, T., Müller, S. (2013):
Isolation of intact RNA from sorted S. cerevisiae cells for differential gene expression analysis
In: Gupta, V.K., Tuohy, M., Ayyachamy, M., Turner, K.M., O’Donovan, A. (eds.)
Laboratory protocols in fungal biology : current methods in fungal biology
Fungal Biology
Springer, New York, p. 265 - 277
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2012 (2)
- Günther, S., Koch, C., Hübschmann, T., Röske, I., Müller, R., Bley, T., Harms, H., Müller, S. (2012):
Correlation of community dynamics and process parameters as a tool for the prediction of the stability of wastewater treatment
Environ. Sci. Technol. 46 (1), 84 - 92
full text (doi) - Müller, S., Hübschmann, T., Kleinsteuber, S., Vogt, C. (2012):
High resolution single cell analytics to follow microbial community dynamics in anaerobic ecosystems
Methods 57 (3), 338 - 349
full text (doi)
2011 (7)
- Bombach, P., Hübschmann, T., Fetzer, I., Kleinsteuber, S., Geyer, R., Harms, H., Müller, S. (2011):
Resolution of natural microbial community dynamics by community fingerprinting, flow cytometry, and trend interpretation analysis
In: Müller, S., Bley, T. (eds.)
High resolution microbial single cell analytics
Adv. Biochem. Eng. Biotechnol. 124
Springer, Berlin, Heidelberg, p. 151 - 181
full text (doi) - Harnisch, F., Koch, C., Patil, S.A., Hübschmann, T., Müller, S., Schröder, U. (2011):
Revealing the electrochemically driven selection in natural community derived microbial biofilms using flow-cytometry
Energy Environ. Sci. (4), 1265 - 1267
full text (doi) - Müller, S., Bley, T. (eds., 2011):
High resolution microbial single cell analytics
Adv. Biochem. Eng. Biotechnol. 124
Springer, Berlin, Heidelberg, 233 pp.
full text (doi) - Müller, S., Johnson, D.R. (2011):
Application of cytomics to separate natural microbial communities by their physiological properties
In: de Bruijn, F.J. (ed.)
Handbook of molecular microbial ecology I : metagenomics and complementary approaches
Wiley-Blackwell, Hoboken, NJ, p. 727 - 734 - Patil, S.A., Harnisch, F., Koch, C., Hübschmann, T., Fetzer, I., Carmona-Martínez, A.A., Müller, S., Schröder, U. (2011):
Electroactive mixed culture derived biofilms in microbial bioelectrochemical systems: the role of pH on biofilm formation, performance and composition
Bioresour. Technol. 102 (20), 9683 - 9690
full text (doi) - Trutnau, M., Petzold, M., Mehlig, L., Eschenhagen, M., Geipel, K., Müller, S., Bley, T., Röske, I. (2011):
Using a carbon-based ASM3 EAWAG Bio-P for modelling the enhanced biological phosphorus removal in anaerobic/aerobic activated sludge systems
Bioprocess. Biosyst. Eng. 34 (3), 287 - 295
full text (doi) - Valet, G., Endl, E., Müller, S. (2011):
20 years of the German Society for Cytometry: past and future concepts
Cytom. Part A 79A (11), 891 - 893
full text (doi)
2010 (7)
- Jehmlich, N., Hübschmann, T., Gesell Salazar, M., Völker, U., Benndorf, D., Müller, S., von Bergen, M., Schmidt, F. (2010):
Advanced tool for characterization of microbial cultures by combining cytomics and proteomics
Appl. Microbiol. Biotechnol. 88 (2), 575 - 584
full text (doi) - Müller, S., Bley, T. (2010):
Flow cytometry
In: Flickinger, M.C. (ed.)
Encyclopedia of industrial biotechnology: bioprocess, bioseparation, and cell technology, Vol. 4
Wiley, Oxford, p. 2451 - 2467
full text (doi) - Müller, S., Harms, H., Bley, T. (2010):
Origin and analysis of microbial population heterogeneity in bioprocesses
Curr. Opin. Biotechnol. 21 (1), 100 - 113
full text (doi) - Müller, S., Nebe-von-Caron, G. (2010):
Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities
FEMS Microbiol. Rev. 34 (4), 544 - 587
full text (doi) - Müller, S. (2010):
Functional flow cytometry in environmental microbiology
In: Timmis, K.N., McGenity, T., van der Meer, J.R., de Lorenzo, V. (eds.)
Experimental protocols and appendices
Handbook of Hydrocarbon and Lipid Microbiology Vol. 5, Part 3
Springer International Publishing, Cham, p. 4103 - 4112
full text (doi) - Sträuber, H., Hübschmann, T., Jehmlich, N., Schmidt, F., von Bergen, M., Harms, H., Müller, S. (2010):
NBDT (3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene) - A novel fluorescent dye for studying mechanisms of toluene uptake into vital bacteria
Cytom. Part A 77A (2), 113 - 120
full text (doi) - Sträuber, H., Müller, S. (2010):
Viability states of bacteria - specific mechanisms of selected probes
Cytom. Part A 77A (7), 623 - 634
full text (doi)