Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.copbio.2010.01.002
Title (Primary) Origin and analysis of microbial population heterogeneity in bioprocesses
Author Müller, S.; Harms, H.; Bley, T.
Source Titel Current Opinion in Biotechnology
Year 2010
Department UMB
Volume 21
Issue 1
Page From 100
Page To 113
Language englisch
Abstract Heterogeneity of industrial production cultures is accepted to a certain degree; however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies. Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle. Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.
Persistent UFZ Identifier
Müller, S., Harms, H., Bley, T. (2010):
Origin and analysis of microbial population heterogeneity in bioprocesses
Curr. Opin. Biotechnol. 21 (1), 100 - 113 10.1016/j.copbio.2010.01.002