Publication Details

Reference Category Journals
DOI / URL link
Title (Primary) The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice
Author Zimmermann, J.; Durek, P.; Kühl, A.A.; Schattenberg, F.; Maschmeyer, P.; Siracusa, F.; Lehmann, K.; Westendorf, K.; Weber, M.; Riedel, R.; Müller, S.; Radbruch, A.; Chang, H.-D.;
Journal European Journal of Immunology
Year 2018
Department UMB;
Volume 48
Issue 1
Language englisch;
POF III (all) R31;
Supplements https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Feji.201747100&attachmentId=2200466254
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Feji.201747100&attachmentId=2200466255
Keywords Inflammatory bowel disease; Microbiota; T cell transfer colitis; T helper cells; T-bet
UFZ wide themes RU4;
Abstract Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag−/− mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag−/− recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.
ID 19845
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19845
Zimmermann, J., Durek, P., Kühl, A.A., Schattenberg, F., Maschmeyer, P., Siracusa, F., Lehmann, K., Westendorf, K., Weber, M., Riedel, R., Müller, S., Radbruch, A., Chang, H.-D. (2018):
The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice
Eur. J. Immunol. 48 (1), 161 - 167