Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1002/eji.201747100 |
| Title (Primary) | The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice |
| Author | Zimmermann, J.; Durek, P.; Kühl, A.A.; Schattenberg, F.; Maschmeyer, P.; Siracusa, F.; Lehmann, K.; Westendorf, K.; Weber, M.; Riedel, R.; Müller, S.; Radbruch, A.; Chang, H.-D. |
| Source Titel | European Journal of Immunology |
| Year | 2018 |
| Department | UMB |
| Volume | 48 |
| Issue | 1 |
| Page From | 161 |
| Page To | 167 |
| Language | englisch |
| Supplements | Supplement 1 Supplement 2 |
| Keywords | Inflammatory bowel disease; Microbiota; T cell transfer colitis; T helper cells; T-bet |
| UFZ wide themes | RU4; |
| Abstract | Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag−/− mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag−/− recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation. |
| Zimmermann, J., Durek, P., Kühl, A.A., Schattenberg, F., Maschmeyer, P., Siracusa, F., Lehmann, K., Westendorf, K., Weber, M., Riedel, R., Müller, S., Radbruch, A., Chang, H.-D. (2018): The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice Eur. J. Immunol. 48 (1), 161 - 167 10.1002/eji.201747100 |
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