Multiple Stressor Ecology - mStress
We address the combined effects of chemical & non-chemical stressors in complex ecosystems (‘the lab to field gap’). This includes the following challenges:
· evaluation of different types of chemical mixtures in the environment
· combined effects with other stressors such as climate-change or plastic pollution
· diversity of species sensitivities towards chemicals, particles and non-chemical stressors
· address natural community complexity (the ecotoxicology of macrozoobenthos and microphytobenthos) and species interactions (intra-/interspecific competition, trophic interactions)
To address these gaps and scientific challenges we focus on the following vision and mission:
Vision:
Protecting aquatic communities from
chemical threats by understanding of chemical/non-chemical stressor effects
and interactions in complex field conditions under climate change
Mission:
Provide a Multiple Line of Evidence (MLoE) approach and mechanistic
understanding to evidence chemical effects in ecologically relevant systems
(such as communities and ecosystems) across biological scales.
Approach:
We use the Multiple Lines of Evidence approach which
combines effect-based and community-based strategies. Resting upon the
monitoring strategies of the Water Framework Directive (WFD) we combine a
‘green BQE’ (microphytobenthos) and a ‘red BQE’ (macrozoobenthos) and address
the linkage of the two BQEs from an ecological/mechanistic perspective. We
focus on the trophic transfer and indirect effects by top-down and bottom-up
control between the primary producers and the next trophic level(s). These
community-level approaches are rooted in an effect-based screening strategy
using single-species as model organisms for the both BQEs (in vivo-testing
using daphnia, snails and algae). This simplification guarantees
high-throughput screening of chemicals and hazard assessment of environmental
mixtures.
mStress Group
mStress Group Leader
Dr. Mechthild Schmitt- Jansen
Phone: +49 341 6025 1523
E-Mail
mStress Group Members
Dr. Dana Kühnel
Scientist
Phone: +49 341 6025 1515
E-Mail
Dr. Stefan Lips
Scientist
Phone: +49 341 6025 2858
E-Mail
Dr. Mbuyiselwa Moloi
Guest scientist (Project funded)
Phone: +49 341 6025 4172
E-Mail
Silke Aulhorn
Technician
Phone: +49 341 6025 1520
E-Mail
Carlotta Becker
Technician
Phone: +49 341 6025 2105
E-Mail
Louis Susset
ITN PhD student
Phone: +49 341 6025 4962
E-Mail
Alumni
Rene Willenberg, master student (2024), current working place: Wasserstraßen- und Schifffahrtsamt Weser in Verden
Lisa Gollot, master student (2022)
Maximilian Pataki, master student (2020), current working place: Synlab
Bastian Herbert Polst, PhD student (2018-2020), current working place: Uni Wageningen
Afolarin Ogungbemi, PhD student (2018-2021), current working place: Currenta.de
Christoph Rummel, (PhD student, co- supervision - 2021), current working place: UBA
Floriane Larras, (2016- 2021), PostDoc, current working place: KREATiS.eu
Publications
Index:
You could use our publication index for further requests.
2025 (2)
- Eze, O.O., Ogbuene, E.B., Ibraheem, O., Küster, E., Eze, T.C. (2025):
Novel flame retardants (NFRs) in e-waste: Environmental burdens, health implications, and recommendations for safety assessment and sustainable management
Toxicology 511 , art. 154037 10.1016/j.tox.2024.154037 - Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2025):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Environ. Sci. Technol. 59 (9), 4304 - 4317 10.1021/acs.est.4c11757
2024 (11)
- Escher, B.I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J.K., Dann, J.P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., Scholz, S., Schulze, T., Spahr, S., Ulrich, N., Weitere, M., Varga, E. (2024):
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nat. Water 2 (9), 889 - 898 10.1038/s44221-024-00297-4 - Jemec Kokalj, A., Drobne, D., Novak, S., Kühnel, D. (2024):
Engineered nanomaterials
In: Vighi, M. (ed.)
General principles of ecological risk assessment: Protecting ecosystems in the third millennium
Cambridge Scholars Publishing, Cambridge, p. 382 - 393 - Kühnel, D., Krug, H.F., Steinbach, C., Nau, K. (2024):
The DaNa projects: public communication of (nano)material safety data - from conspiracy theories to study quality
Front. Toxicol. 6 , art. 1382458 10.3389/ftox.2024.1382458 - Lips, S., Schmitt-Jansen, M., Borchert, E. (2024):
Metagenomic analyses of the plastisphere reveals a common functional potential across oceans
bioRxiv 10.1101/2024.08.29.610283 - Menger, F., Römerscheid, M., Lips, S., Klein, O., Nabi, D., Gandrass, J., Joerss, H., Wendt-Potthoff, K., Bedulina, D., Zimmermann, T., Schmitt-Jansen, M., Huber, C., Böhme, A., Ulrich, N., Beck, A.J., Pröfrock, D., Achterberg, E.P., Jahnke, A., Hildebrandt, L. (2024):
Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions
J. Hazard. Mater. 477 , art. 135256 10.1016/j.jhazmat.2024.135256 - Pastor-López, E.J., Escolà, M., Kisielius, V., Arias, C.A., Carvalho, P.N., Gorito, A.M., Ramos, S., Freitas, V., Guimarães, L., Almeida, C.M.R., Müller, J.A., Küster, E., Kilian, R.M., Diawara, A., Ba, S., Matamoros, V. (2024):
Potential of nature-based solutions to reduce antibiotics, antimicrobial resistance, and pathogens in aquatic ecosystems. a critical review
Sci. Total Environ. 946 , art. 174273 10.1016/j.scitotenv.2024.174273 - Scales, B.S., Hassenrück, C., Moldaenke, L., Hassa, J., Rückert-Reed, C., Rummel, C., Völkner, C., Rynek, R., Busche, T., Kalinowski, J., Jahnke, A., Schmitt-Jansen, M., Wendt-Potthoff, K., Oberbeckmann, S. (2024):
Hunting for pigments in bacterial settlers of the Great Pacific Garbage Patch
Environ. Microbiol. 26 (6), e16639 10.1111/1462-2920.16639 - Schmidt, C., Kühnel, D., Materić, D., Stubenrauch, J., Schubert, K., Luo, A., Wendt-Potthoff, K., Jahnke, A. (2024):
Supporting data of the Short communication: A multidisciplinary perspective on the role of plastic pollution in the triple planetary crisis [Dataset]
Zenodo 10.5281/zenodo.12794921 - Schmidt, C., Kühnel, D., Materić, D., Stubenrauch, J., Schubert, K., Luo, A., Wendt-Potthoff, K., Jahnke, A. (2024):
A multidisciplinary perspective on the role of plastic pollution in the triple planetary crisis
Environ. Int. 193 , art. 109059 10.1016/j.envint.2024.109059 - Steska, T., Wagner, S., Reemtsma, T., Kühnel, D. (2024):
Influence of silver fiber morphology on dose-response relationship and enrichment in Daphnia magna studied by elemental imaging with LA-ICP-TOF-MS
Chem. Res. Toxicol. 37 (2), 292 - 301 10.1021/acs.chemrestox.3c00293 - Zidar, P., Kühnel, D., Sever Škapin, A., Skalar, T., Drobne, D., Škrlep, L., Mušič, B., Jemec Kokalj, A. (2024):
Comparing the effects of pristine and UV–VIS aged microplastics: Behavioural response of model terrestrial and freshwater crustaceans
Ecotox. Environ. Safe. 285 , art. 117020 10.1016/j.ecoenv.2024.117020
2023 (15)
- Jemec, A., Kuehnel, D., Drobne, D., Zidar, P. (2023):
Behavioural response to microplastics: case study with woodlice and daphnids
Toxicol. Lett. 384 (Suppl. 1), S209 - S209 10.1016/S0378-4274(23)00758-0 - Jemec Kokalj, A., Heinlaan, M., Novak, S., Drobne, D., Kühnel, D. (2023):
Defining quality criteria for nanoplastic hazard evaluation: The case of polystyrene nanoplastics and aquatic invertebrate Daphnia spp.
Nanomaterials 13 (3), art. 536 10.3390/nano13030536 - Kuehnel, D. (2023):
Micro-and nano-plastics in our environment: presence and potential impact
Toxicol. Lett. 384 (Suppl. 1), S44 10.1016/S0378-4274(23)00376-4 - Kuehnel, D., Heinlaan, M., Novak, S., Drobne, D., Kokalj, A.J. (2023):
Study quality criteria for nanoplastics: a case study on polystyrene nanoplastics and the aquatic invertebrate Daphnia spp.
Toxicol. Lett. 384 (Suppl. 1), S208 - S208 10.1016/S0378-4274(23)00756-7 - Kühnel, D., Krug, H.F., Mattern, A., Jemec Kokalj, A. (2023):
Human and environmental hazard of nanomaterials used in textiles
In: Cornier, J., Pursche, F. (eds.)
Particle technology and textiles: Review of applications
De Gruyter STEM
De Gruyter, Berlin ; Boston, p. 343 - 372 10.1515/9783110670776-018 - Kühnel, D., Steska, T., Schlich, K., Wolf, C., Wohlleben, W., Hund-Rinke, K. (2023):
Polymers of low concern? Assessment of microplastic particles used in 3D printing regarding their toxicity on Raphidocelis subcapitata and Daphnia magna
Microplastics and Nanoplastics 3 , art. 29 10.1186/s43591-023-00078-y - Küster, E., Addo, G.G., Aulhorn, S., Kühnel, D. (2023):
Miniaturisation of the Daphnia magna immobilisation assay for the reliabletesting of low volume samples
UCL Open Environment Preprint 10.14324/111.444/000219.v1 - López Moreira Mazacotte, G.A., Polst, B., Gross, E.M., Schmitt-Jansen, M., Hölker, F., Hilt, S. (2023):
Microcosm experiments combined with process based-modeling reveal differential response and adaptation of aquatic primary producers to warming and agricultural run-off
Front. Plant Sci. 14 , art. 1120441 10.3389/fpls.2023.1120441 - Massei, R., Brack, W., Seidensticker, S., Hollert, H., Muz, M., Schulze, T., Krauss, M., Küster, E. (2023):
Neurotoxicity in complex environmental mixtures—a case-study at River Danube in Novi Sad (Serbia) using zebrafish embryos
Environ. Sci. Pollut. Res. 30 (42), 96138 - 96146 10.1007/s11356-023-29186-1 - Mullins, M., Himly, M., Rodríguez Llopis, I., Furxhi, I., Hofer, S., Hofstätter, N., Wick, P., Romeo, D., Kühnel, D., Siivola, K., Catalán, J., Hund-Rinke, K., Xiarchos, I., Linehan, S., Schuurbiers, D., García Bilbao, A., Barruetabeña, L., Drobne, D. (2023):
(Re)Conceptualizing decision-making tools in a risk governance framework for emerging technologies—the case of nanomaterials
Environ. Syst. Decis. 43 (1), 3 - 15 10.1007/s10669-022-09870-2 - Nau, K., Espinoza, S., Krug, H.F., Marquardt, C., Mattern, A., Möller, N., Steinbach, C., Kühnel, D. (2023):
Knowledge Base Materials sustainable science communication on advanced materials
In: Scholz, S.G., Howlett, R.J., Setchi, R. (eds.)
Sustainable design and manufacturing. Proceedings of the 9th International Conference on Sustainable Design and Manufacturing (SDM 2022)
Smart Innovation, Systems and Technologies 338
Springer Nature, Singapore, p. 33 - 42 10.1007/978-981-19-9205-6_4 - Polst, B.H. (2023):
Exposure pathways matter: Aquatic phototrophic communities respond differently to agricultural run-off exposed via sediment or water
Open Science Framework (OSF) 10.17605/OSF.IO/8ZGS5 - Polst, B.H., Allen, J., Hölker, F., Hilt, S., Stibor, H., Gross, E.M., Schmitt-Jansen, M. (2023):
Exposure pathways matter: Aquatic phototrophic communities respond differently to agricultural run-off exposed via sediment or water
J. Appl. Ecol. 60 (9), 1868 - 1880 10.1111/1365-2664.14478 - Ramsperger, A.F.R.M., Bergamaschi, E., Panizzolo, M., Fenoglio, I., Barbero, F., Peters, R., Undas, A., Purker, S., Giese, B., Lalyer, C.R., Tamargo, A., Moreno-Arribas, M.V., Grossart, H.-P., Kühnel, D., Dietrich, J., Paulsen, F., Afanou, A.K., Zienolddiny-Narui, S., Eriksen Hammer, S., Kringlen Ervik, T., Graff, P., Brinchmann, B.C., Nordby, K.-C., Wallin, H., Nassi, M., Benetti, F., Zanella, M., Brehm, J., Kress, H., Löder, M.G.J., Laforsch, C. (2023):
Nano- and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans
NanoImpact 29 , art. 100441 10.1016/j.impact.2022.100441 - Tora, D., Hentschel, U., Lips, S., Schmitt-Jansen, M., Borchert, E. (2023):
16S rRNA gene sequence analysis of the microbial community on microplastic samples from the North Atlantic and Great Pacific Garbage Patches
Afr. J. Microbiol. Res. 17 (5), 123 - 138 10.5897/AJMR2022.9682
2022 (12)
- Cébron, A., Karpouzas, D.G., Martin-Laurent, F., Morin, S., Palacios, C., Schmitt-Jansen, M. (2022):
Editorial: Microbial ecotoxicology advances to improve environmental and human health under global change
Front. Microbiol. 13 , art. 870404 10.3389/fmicb.2022.870404 - Dunker, S., Boyd, M., Durka, W., Erler, S., Harpole, W.S., Henning, S., Herzschuh, U., Hornick, T., Knight, T., Lips, S., Mäder, P., Motivans Švara, E., Mozarowski, S., Rakosy, D., Römermann, C., Schmitt-Jansen, M., Stoof-Leichsenring, K., Stratmann, F., Treudler, R., Virtanen, R., Wendt-Potthoff, K., Wilhelm, C. (2022):
The potential of multispectral imaging flow cytometry for environmental monitoring
Cytom. Part A 101 (9), 782 - 799 10.1002/cyto.a.24658 - Guasch, H., Bernal, S., Bruno, D., Carney Almroth, B., Cochero, J., Corcoll, N., Cornejo, D., Gacia, E., Kroll, A., Lavoie, I., Ledesma, J.L.J., Lupon, A., Margenat, H., Morin, S., Navarro, E., Ribot, M., Riis, T., Schmitt-Jansen, M., Tlili, A., Martí, E. (2022):
Interactions between microplastics and benthic biofilms in fluvial ecosystems: Knowledge gaps and future trends
Freshw. Sci. 41 (3), 442 - 458 10.1086/721472 - Hund-Rinke, K., Broßell, D., Eilebrecht, S., Schlich, K., Schlinkert, R., Steska, T., Wolf, C., Kühnel, D. (2022):
Prioritising nano- and microparticles: identification of physicochemical properties relevant for toxicity to Raphidocelis subcapitata and Daphnia magna
Environ. Sci. Eur. 34 , art. 116 10.1186/s12302-022-00695-z - Liess, M., Liebmann, L., Lück, M., Vormeier, P., Weisner, O., Foit, K., Knillmann, S., Schäfer, R.B., Schulze, T., Krauss, M., Brack, W., Reemtsma, T., Halbach, K., Link, M., Schreiner, V.C., Schneeweiss, A., Möder, M., Weitere, M., Kaske, O., von Tümpling, W., Gunold, R., Ulrich, N., Paschke, A., Schüürmann, G., Schmitt-Jansen, M., Küster, E., Borchardt, D. (2022):
Umsetzung des Nationalen Aktionsplans zur nachhaltigen Anwendung von Pflanzenschutzmitteln (NAP) – Pilotstudie zur Ermittlung der Belastung von Kleingewässern in der Agrarlandschaft mit Pflanzenschutzmittel-Rückständen. Abschlussbericht, Forschungskennzahl 3717 63 403 0
Texte Umweltbundesamt 07/2022
Umweltbundesamt, Dessau-Roßlau, 319 S. - Lips, S., Larras, F., Schmitt-Jansen, M. (2022):
Community metabolomics provides insights into mechanisms of pollution-induced community tolerance of periphyton
Sci. Total Environ. 824 , art. 153777 10.1016/j.scitotenv.2022.153777 - Polst, B.H., Hilt, S., Stibor, H., Hölker, F., Allen, J., Vijayaraj, V., Kipferler, N., Leflaive, J., Gross, E.M., Schmitt-Jansen, M. (2022):
Warming lowers critical thresholds for multiple stressor–induced shifts between aquatic primary producers
Sci. Total Environ. 838, Part 4 , art. 156511 10.1016/j.scitotenv.2022.156511 - Rummel, C.D., Schäfer, H., Jahnke, A., Arp, H.P.H., Schmitt-Jansen, M. (2022):
Effects of leachates from UV-weathered microplastic on the microalgae Scenedesmus vacuolatus
Anal. Bioanal. Chem. 414 (4), 1469 - 1479 10.1007/s00216-021-03798-3 - Schmitt-Jansen, M., Lips, S., Schäfer, H., Rummel, C. (2022):
Microplastic: A new habitat for biofilm communities
In: Rocha-Santos, T., Costa, M.F., Mouneyrac, C. (eds.)
Handbook of microplastics in the environment
Springer, Cham, p. 1049 - 1068 10.1007/978-3-030-39041-9_22 - van Broekhuizen, P., Säämänen, A., Schuurbiers, D., Isigonis, P., Jensen, K.A., Kühnel, D., Le Blansch, K. (2022):
Tyre wear nanoparticles as test for a nano risk governance framework
Front. Environ. Sci. 10 , art. 1045246 10.3389/fenvs.2022.1045246 - Vijayaraj, V., Kipferler, N., Stibor, H., Allen, J., Hölker, F., Laviale, M., Leflaive, J., López Moreira Mazacotte, G.A., Polst, B.H., Schmitt-Jansen, M., Hilt, S., Gross, E.M. (2022):
Evaluating multiple stressor effects on benthic–pelagic freshwater communities in systems of different complexities: Challenges in upscaling
Water 14 (4), art. 581 10.3390/w14040581 - Vijayaraj, V., Laviale, M., Allen, J., Amoussou, N., Hilt, S., Hölker, F., Kipferler, N., Leflaive, J., López Moreira M., G.A., Polst, B., Schmitt-Jansen, M., Stibor, H., Gross, E.M. (2022):
Multiple-stressor exposure of aquatic food webs: nitrate and warming modulate the effect of pesticides
Water Res. 216 , art. 118325 10.1016/j.watres.2022.118325
2021 (9)
- Allen, J., Gross, E.M., Courcoul, C., Bouletreau, S., Compin, A., Elger, A., Ferriol, J., Hilt, S., Jassey, V.E.J., Laviale, M., Polst, B.H., Schmitt-Jansen, M., Stibor, H., Vijayaraj, V., Leflaive, J. (2021):
Disentangling the direct and indirect effects of agricultural runoffon freshwater ecosystems subject to global warming: A microcosm study
Water Res. 190 , art. 116713 10.1016/j.watres.2020.116713 - Arp, H.P.H., Kühnel, D., Rummel, C., MacLeod, M., Potthoff, A., Reichelt, S., Rojo-Nieto, E., Schmitt-Jansen, M., Sonnenberg, J., Toorman, E., Jahnke, A. (2021):
Weathering plastics as a planetary boundary threat: Exposure, fate, and hazards
Environ. Sci. Technol. 55 (11), 7246 - 7255 10.1021/acs.est.1c01512 - Jemec Kokalj, A., Hartmann, N.B., Drobne, D., Potthoff, A., Kühnel, D. (2021):
Quality of nanoplastics and microplastics ecotoxicity studies: Refining quality criteria for nanomaterial studies
J. Hazard. Mater. 415 , art. 125751 10.1016/j.jhazmat.2021.125751 - Liess, M., Liebmann, L., Vormeier, P., Weisner, O., Altenburger, R., Borchardt, D., Brack, W., Chatzinotas, A., Escher, B., Foit, K., Gunold, R., Henz, S., Hitzfeld, K.L., Schmitt-Jansen, M., Kamjunke, N., Kaske, O., Knillmann, S., Krauss, M., Küster, E., Link, M., Lück, M., Möder, M., Müller, A., Paschke, A., Schäfer, R.B., Schneeweiss, A., Schreiner, V.C., Schulze, T., Schüürmann, G., von Tümpling, W., Weitere, M., Wogram, J., Reemtsma, T. (2021):
Pesticides are the dominant stressors for vulnerable insects in lowland streams
Water Res. 201 , art. 117262 10.1016/j.watres.2021.117262 - Ogungbemi, A.O., Massei, R., Altenburger, R., Scholz, S., Küster, E. (2021):
Assessing combined effects for mixtures of similar and dissimilar acting neuroactive substances on zebrafish embryo movement
Toxics 9 (5), art. 104 10.3390/toxics9050104 - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2021):
Automated measurement of the spontaneous tail coiling of zebrafish embryos as a sensitive behavior endpoint using a workflow in KNIME
MethodsX 8 , art. 101330 10.1016/j.mex.2021.101330 - Rummel, C.D., Lechtenfeld, O.J., Kallies, R., Benke, A., Herzsprung, P., Rynek, R., Wagner, S., Potthoff, A., Jahnke, A., Schmitt-Jansen, M. (2021):
Conditioning film and early biofilm succession on plastic surfaces
Environ. Sci. Technol. 55 (16), 11006 - 11018 10.1021/acs.est.0c07875 - Teixidó, E., Klüver, N., Ogungbemi, A.O., Küster, E., Scholz, S. (2021):
Evaluation of neurotoxic effects in zebrafish embryos by automatic measurement of early motor behaviors
In: Llorens, J., Barenys, M. (eds.)
Experimental neurotoxicology methods
Neuromethods 172
Springer Nature, p. 381 - 397 10.1007/978-1-0716-1637-6_17 - Weitere, M., Altenburger, R., Anlanger, C., Baborowski, M., Bärlund, I., Beckers, L.-M., Borchardt, D., Brack, W., Brase, L., Busch, W., Chatzinotas, A., Deutschmann, B., Eligehausen, J., Frank, K., Graeber, D., Griebler, C., Hagemann, J., Herzsprung, P., Hollert, H., Inostroza, P.A., Jäger, C.G., Kallies, R., Kamjunke, N., Karrasch, B., Kaschuba, S., Kaus, A., Klauer, B., Knöller, K., Koschorreck, M., Krauss, M., Kunz, J.V., Kurz, M.J., Liess, M., Mages, M., Müller, C., Muschket, M., Musolff, A., Norf, H., Pöhlein, F., Reiber, L., Risse-Buhl, U., Schramm, K.-W., Schmitt-Jansen, M., Schmitz, M., Strachauer, U., von Tümpling, W., Weber, N., Wild, R., Wolf, C., Brauns, M. (2021):
Disentangling multiple chemical and non-chemical stressors in a lotic ecosystem using a longitudinal approach
Sci. Total Environ. 769 , art. 144324 10.1016/j.scitotenv.2020.144324
2020 (7)
- Fink, P., Norf, H., Anlanger, C., Brauns, M., Kamjunke, N., Risse-Buhl, U., Schmitt-Jansen, M., Weitere, M., Borchardt, D. (2020):
Streamside mobile mesocosms (MOBICOS): A new modular research infrastructure for hydro-ecological process studies across catchment-scale gradients
Int. Rev. Hydrobiol. 105 (3-4), 63 - 73 10.1002/iroh.201902009 - Gawel, A., Seiwert, B., Sühnholz, S., Schmitt-Jansen, M., Mackenzie, K. (2020):
In-situ treatment of herbicide-contaminated groundwater–Feasibility study for the cases atrazine and bromacil using two novel nanoremediation-type materials
J. Hazard. Mater. 393 , art. 122470 10.1016/j.jhazmat.2020.122470 - Hund-Rinke, K., Sinram, T., Schlich, K., Nickel, C., Dickehut, H.P., Schmidt, M., Kühnel, D. (2020):
Attachment efficiency of nanomaterials to algae as an important criterion for ecotoxicity and grouping
Nanomaterials 10 (6), art. 1021 10.3390/nano10061021 - Larras, F., Billoir, E., Scholz, S., Tarkka, M., Wubet, T., Delignette-Muller, M.-L., Schmitt-Jansen, M. (2020):
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus
J. Hazard. Mater. 397 , art. 122727 10.1016/j.jhazmat.2020.122727 - Mohaupt, V., Völker, J., Altenburger, R., Birk, S., Kirst, I., Kühnel, D., Küster, E., Semeradova, S., Šubelj, G. (2020):
Pesticides in European rivers, lakes and groundwaters – Data assessment
ETC/ICM Technical Report 1/2020
European Topic Centre on Inland, Coastal and Marine Waters, Helmholtz Centre for Environmental Research GmbH – UFZ, Magdeburg, 86 pp. - Ogungbemi, A.O., Teixido, E., Massei, R., Scholz, S., Küster, E. (2020):
Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
Neurotoxicol. Teratol. 81 , art. 106918 10.1016/j.ntt.2020.106918 - Weise, H., Auge, H., Baessler, C., Bärlund, I., Bennett, E.M., Berger, U., Bohn, F., Bonn, A., Borchardt, D., Brand, F., Chatzinotas, A., Corstanje, R., De Laender, F., Dietrich, P., Dunker, S., Durka, W., Fazey, I., Groeneveld, J., Guilbaud, C.S.E., Harms, H., Harpole, S., Harris, J., Jax, K., Jeltsch, F., Johst, K., Joshi, J., Klotz, S., Kühn, I., Kuhlicke, C., Müller, B., Radchuk, V., Reuter, H., Rinke, K., Schmitt-Jansen, M., Seppelt, R., Singer, A., Standish, R.J., Thulke, H.-H., Tietjen, B., Weitere, M., Wirth, C., Wolf, C., Grimm, V. (2020):
Resilience trinity: safeguarding ecosystem functioning and services across three different time horizons and decision contexts
Oikos 129 (4), 445 - 456 10.1111/oik.07213
2019 (9)
- Jemec Kokalj, A., Kuehnel, D., Puntar, B., Žgajnar Gotvajn, A., Kalčikova, G. (2019):
An exploratory ecotoxicity study of primary microplastics versus aged in natural waters and wastewaters
Environ. Pollut. 254 , art. 112980 10.1016/j.envpol.2019.112980 - Kühnel, D., Nickel, C., Hellack, B., van der Zalm, E., Kussatz, C., Herrchen, M., Meisterjahn, B., Hund-Rinke, K. (2019):
Closing gaps for environmental risk screening of engineered nanomaterials
NanoImpact 15 , art. 100173 10.1016/j.impact.2019.100173 - Küster, E., Kalkhof, S., Aulhorn, S., von Bergen, M., Gündel, U. (2019):
Effects of five substances with different modes of action on cathepsin H, C and L activities in zebrafish embryos
Int. J. Environ. Res. Public Health 16 (20), art. 3956 10.3390/ijerph16203956 - Massei, R., Hollert, H., Krauss, M., von Tümpling, W., Weidauer, C., Haglund, P., Küster, E., Gallampois, C., Tysklind, M., Brack, W. (2019):
Toxicity and neurotoxicity profiling of contaminated sediments from Gulf of Bothnia (Sweden): a multi‑endpoint assay with zebrafish embryos
Environ. Sci. Eur. 31 , art. 8 10.1186/s12302-019-0188-y - Moreno Osorio, J.H., Benettoni, P., Schmidt, M., Stryhanyuk, H., Schmitt-Jansen, M., Pinto, G., Pollio, A., Frunzo, L., Lens, P.N.L., Richnow, H.H., Esposito, G., Musat, N. (2019):
Investigation of architecture development and phosphate distribution in Chlorella biofilm by complementary microscopy techniques
FEMS Microbiol. Ecol. 95 (4), fiz029 10.1093/femsec/fiz029 - Ogungbemi, A., Leuthold, D., Scholz, S., Küster, E. (2019):
Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
Environ. Sci. Eur. 31 , art. 88 10.1186/s12302-019-0270-5 - Schmidt, S., Altenburger, R., Kühnel, D. (2019):
From the air to the water phase: implication for toxicity testing of combustion-derived particles
Biomass Convers. Biorefinery 9 (1), 213 - 225 10.1007/s13399-017-0295-1 - Weil, M., Mackenzie, K., Foit, K., Kühnel, D., Busch, W., Bundschuh, M., Schulz, R., Duis, K. (2019):
Environmental risk or benefit? Comprehensive risk assessment of groundwater treated with nano Fe0-based Carbo-Iron®
Sci. Total Environ. 677 , 156 - 166 10.1016/j.scitotenv.2019.04.360 - Wohlleben, W., Hellack, B., Nickel, C., Herrchen, M., Hund-Rinke, K., Kettler, K., Riebeling, C., Haase, A., Funk, B., Kühnel, D., Göhler, D., Stintz, M., Schumacher, C., Wiemann, M., Keller, J., Landsiedel, R., Broßell, D., Pitzko, S., Kuhlbusch, T.A.J. (2019):
The nanoGRAVUR framework to group (nano)materials for their occupational, consumer, environmental risks based on a harmonized set of material properties, applied to 34 case studies
Nanoscale 11 (38), 17637 - 17654 10.1039/c9nr03306h
2018 (8)
- Brack, W., Escher, B.I., Müller, E., Schmitt-Jansen, M., Schulze, T., Slobodnik, J., Hollert, H. (2018):
Towards a holistic and solution-oriented monitoring of chemical status of European water bodies: how to support the EU strategy for a non-toxic environment?
Environ. Sci. Eur. 30 , art. 33 10.1186/s12302-018-0161-1 - Hund-Rinke, K., Schlich, K., Kühnel, D., Hellack, B., Kaminski, H., Nickel, C. (2018):
Grouping concept for metal and metal oxide nanomaterials with regard to their ecotoxicological effects on algae, daphnids and fish embryos
NanoImpact 9 , 52 - 60 10.1016/j.impact.2017.10.003 - Krug, H.F., Bohmer, N., Kühnel, D., Marquardt, C., Nau, K., Steinbach, C. (2018):
The DaNa2.0 Knowledge Base Nanomaterials—An important measure accompanying nanomaterials development
Nanomaterials 8 (4), art. 204 10.3390/nano8040204 - Kühnel, D. (2018):
Progress towards risk assessment for engineered nanomaterials
In: Dhawan, A., Anderson, D., Shanker, R. (eds.)
Nanotoxicology: Experimental and computational perspectives
Issues in Toxicology 35
Royal Society of Chemistry (RSC), Cambridge, p. 232 - 247 10.1039/9781782623922-00232 - Kühnel, D., Krug, H.F., Jemec Kokalj, A. (2018):
Environmental impacts of engineered nanomaterials—imbalances in the safety assessment of selected nanomaterials
Materials 11 (8), art. 1444 10.3390/ma11081444 - Larras, F., Billoir, E., Baillard, V., Siberchicot, A., Scholz, S., Wubet, T., Tarkka, M., Schmitt-Jansen, M., Delignette-Muller, M.-L. (2018):
DRomics: A turnkey tool to support the use of the dose–response framework for omics data in ecological risk assessment
Environ. Sci. Technol. 52 (24), 14461 - 14468 10.1021/acs.est.8b04752 - Naasz, S., Altenburger, R., Kühnel, D. (2018):
Environmental mixtures of nanomaterials and chemicals: The Trojan-horse phenomenon and its relevance for ecotoxicity
Sci. Total Environ. 635 , 1170 - 1181 10.1016/j.scitotenv.2018.04.180 - Polst, B.H., Anlanger, C., Risse-Buhl, U., Larras, F., Hein, T., Weitere, M., Schmitt-Jansen, M. (2018):
Hydrodynamics alter the tolerance of autotrophic biofilm communities toward herbicides
Front. Microbiol. 9 , art. 2884 10.3389/fmicb.2018.02884
2017 (10)
- Böhme, S., Baccaro, M., Schmidt, M., Potthoff, A., Stärk, H.-J., Reemtsma, T., Kühnel, D. (2017):
Metal uptake and distribution in the zebrafish (Danio rerio) embryo: differences between nanoparticles and metal ions
Environ. Sci.-Nano 4 (5), 1005 - 1015 10.1039/c6en00440g - Jahnke, A., Arp, H.P.H., Escher, B.I., Gewert, B., Gorokhova, E., Kühnel, D., Ogonowski, M., Potthoff, A., Rummel, C., Schmitt-Jansen, M., Toorman, E., MacLeod, M. (2017):
Reducing uncertainty and confronting ignorance about the possible impacts of weathering plastic in the marine environment
Environ. Sci. Technol. Lett. 4 (3), 85 - 90 10.1021/acs.estlett.7b00008 - Kühnel, D., Marquardt, C., Nau, K., Krug, H.F., Paul, F., Steinbach, C. (2017):
Environmental benefits and concerns on safety: communicating latest results on nanotechnology safety research—the project DaNa2.0
Environ. Sci. Pollut. Res. 24 (12), 11120 - 11125 10.1007/s11356-016-6217-0 - Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W. (2017):
Biotransformation in the zebrafish embryo – temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene
Environ. Pollut. 230 , 1 - 11 10.1016/j.envpol.2017.04.083 - Kurth, D., Lips, S., Massei, R., Krauss, M., Luckenbach, T., Schulze, T., Brack, W. (2017):
The impact of chemosensitisation on bioaccumulation and sediment toxicity
Chemosphere 186 , 652 - 659 10.1016/j.chemosphere.2017.08.019 - Potthoff, A., Oelschlägel, K., Schmitt-Jansen, M., Rummel, C.D., Kühnel, D. (2017):
From the sea to the laboratory: Characterization of microplastic as prerequisite for the assessment of ecotoxicological impact
Integr. Environ. Assess. Manag. 13 (3), 500 - 504 10.1002/ieam.1902 - Ribeiro, A.R., Leite, P.E., Falagan-Lotsch, P., Benetti, F., Micheletti, C., Budtz, H.C., Jacobsen, N.R., Lisboa-Filho, P.N., Rocha, R.A., Kühnel, D., Hristozov, D., Granjeiro, J.M. (2017):
Challenges on the toxicological predictions of engineered nanoparticles
NanoImpact 8 , 59 - 72 10.1016/j.impact.2017.07.006 - Rummel, C.D., Jahnke, A., Gorokhova, E., Kühnel, D., Schmitt-Jansen, M. (2017):
Impacts of biofilm formation on the fate and potential effects of microplastic in the aquatic environment
Environ. Sci. Technol. Lett. 4 (7), 258 - 267 10.1021/acs.estlett.7b00164 - Steinbach, C., Bohmer, N., Krug, H.F., Kühnel, D., Nau, K., Paul, F., Reithel, S., Marquardt, C. (2017):
DaNa 2.0 – verlässliche Informationen zur Sicherheit von marktüblichen Nanomaterialien. DaNa 2.0 – reliable information on the safety of commercially available nanomaterials
Chem. Ing. Tech. 89 (3), 232 - 238 10.1002/cite.201600074 - Välitalo, P., Massei, R., Heiskanen, I., Behnisch, P., Brack, W., Tindall, A.J., Du Pasquier, D., Küster, E., Mikola, A., Schulze, T., Sillanpää, M. (2017):
Effect-based assessment of toxicity removal during wastewater treatment
Water Res. 126 , 153 - 163 10.1016/j.watres.2017.09.014
2016 (9)
- Brox, S., Seiwert, B., Haase, N., Küster, E., Reemtsma, T. (2016):
Metabolism of clofibric acid in zebrafish embryos (Danio rerio) as determined by liquid chromatography–high resolution–mass spectrometry
Comp. Biochem. Physiol. C-Toxicol. Pharmacol. 185–186 , 20 - 28 10.1016/j.cbpc.2016.02.007 - Brox, S., Seiwert, B., Küster, E., Reemtsma, T. (2016):
Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): Influence of physicochemical properties and of niological processes
Environ. Sci. Technol. 50 (18), 10264 - 10272 10.1021/acs.est.6b04325 - Heinlaan, M., Muna, M., Knöbel, M., Kistler, D., Odzak, N., Kühnel, D., Müller, J., Gupta, G.S., Kumar, A., Shanker, R., Sigg, L. (2016):
Natural water as the test medium for Ag and CuO nanoparticle hazard evaluation: An interlaboratory case study
Environ. Pollut. 216 , 689 - 699 10.1016/j.envpol.2016.06.033 - Jemec, A., Kahru, A., Potthoff, A., Drobne, D., Heinlaan, M., Böhme, S., Geppert, M., Novak, S., Schirmer, K., Rekulapally, R., Singh, S., Aruoja, V., Sihtmäe, M., Juganson, K., Käkinen, A., Kühnel, D. (2016):
An interlaboratory comparison of nanosilver characterisation and hazard identification: Harmonising techniques for high quality data
Environ. Int. 87 , 20 - 32 10.1016/j.envint.2015.10.014 - Kos, M., Kahru, A., Drobne, D., Singh, S., Kalčíková, G., Kühnel, D., Rohit, R., Žgajnar Gotvajn, A., Jemec, A. (2016):
A case study to optimise and validate the brine shrimp Artemia franciscana immobilisation assay with silver nanoparticles: The role of harmonisation
Environ. Pollut. 213 , 173 - 183 10.1016/j.envpol.2016.02.015 - Nau, K., Bohmer, N., Kühnel, D., Marquardt, C., Paul, F., Steinbach, C., Krug, H.F. (2016):
The DaNa2.0 knowledge base on nanomaterials – Communicating current nanosafety research based on evaluated literature data
J. Mat. Educ. 38 (3-4), 93 - 108 - Schmidt, S., Busch, W., Altenburger, R., Küster, E. (2016):
Mixture toxicity of water contaminants-effect analysis using the zebrafish embryo assay (Danio rerio)
Chemosphere 152 , 503 - 512 10.1016/j.chemosphere.2016.03.006 - Schmitt-Jansen, M., Bley, L.-M., Krumbiegel, M.L., Rotter, S. (2016):
Induced community tolerance of periphyton towards combined salt and toxic stress
Freshw. Biol. 61 (12), 2152 - 2161 10.1111/fwb.12799 - Tlili, A., Berard, A., Blanck, H., Bouchez, A., Cássio, F., Eriksson, K.M., Morin, S., Montuelle, B., Navarro, E., Pascoal, C., Pesce, S., Schmitt-Jansen, M., Behra, R. (2016):
Pollution-induced community tolerance (PICT): towards an ecologically relevant risk assessment of hemicals in aquatic systems
Freshw. Biol. 61 (12), 2141 - 2151 10.1111/fwb.12558
2015 (10)
- Böhme, S., Kühnel, D., Stärk, H.-J., Reemtsma, T. (2015):
New developments in the field of the visualization of nanoparticle uptake by environmental organisms with LA-ICP-MS
In: Daus, B., Bings, N., Leopold, K., Otto, M., Panne, U., Welz, U., Wennrich, R. (eds.)
Canas ’15. Colloquium Analytische Atomspektroskopie, 8.–11. März 2015, Helmholtz-Zentrum für Umweltforschung – UFZ Leipzig. Colloquium Analytical Atomic Spectroscopy, 8–11 March, 2015, Helmholtz Centre for Environmental Research – UFZ Leipzig
Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig, 61 - 62 - Böhme, S., Stärk, H.-J., Kühnel, D., Reemtsma, T. (2015):
Exploring LA-ICP-MS as a quantitative imaging technique to study nanoparticle uptake in Daphnia magna and zebrafish (Danio rerio) embryos
Anal. Bioanal. Chem. 407 (18), 5477 - 5485 10.1007/s00216-015-8720-4 - Böhme, S., Stärk, H.-J., Reemtsma, T., Kühnel, D. (2015):
Effect propagation after silver nanoparticle exposure in zebrafish (Danio rerio) embryos: a correlation to internal concentration and distribution patterns
Environ. Sci.-Nano 2 (6), 603 - 614 10.1039/c5en00118h - Hachicho, N., Reithel, S., Miltner, A., Heipieper, H.J., Küster, E., Luckenbach, T. (2015):
Body mass parameters, lipid profiles and protein contents of zebrafish embryos and effects of 2,4-dinitrophenol exposure
PLOS One 10 (8), e0134755 10.1371/journal.pone.0134755 - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54 10.1016/j.toxlet.2015.08.151 - Potthoff, A., Weil, M., Meißner, T., Kühnel, D. (2015):
Towards sensible toxicity testing for nanomaterials: proposal for the specification of test design
Sci. Technol. Adv. Mater. 16 (6), art. 065006 10.1088/1468-6996/16/6/065006 - Riedl, J., Schreiber, R., Otto, M., Heilmeier, H., Altenburger, R., Schmitt-Jansen, M. (2015):
Metabolic effect level index links multivariate metabolic fingerprints to ecotoxicological effect assessment
Environ. Sci. Technol. 49 (13), 8096 - 8104 10.1021/acs.est.5b01386 - Rotter, S., Gunold, R., Mothes, S., Paschke, A., Brack, W., Altenburger, R., Schmitt-Jansen, M. (2015):
Pollution-induced community tolerance to diagnose hazardous chemicals in multiple contaminated aquatic systems
Environ. Sci. Technol. 49 (16), 10048 - 10056 10.1021/acs.est.5b01297 - Vogs, C., Kühnert, A., Hug, C., Küster, E., Altenburger, R. (2015):
A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus
Environ. Toxicol. Chem. 34 (1), 100 - 111 10.1002/etc.2764 - Weil, M., Meißner, T., Busch, W., Springer, A., Kühnel, D., Schulz, R., Duis, K. (2015):
The oxidized state of the nanocomposite Carbo-Iron® causes no adverse effects on growth, survival and differential gene expression in zebrafish
Sci. Total Environ. 530-531 , 198 - 208 10.1016/j.scitotenv.2015.05.087