iTox – integrative toxicology
In iTox we aim to integrate data and knowledge from different fields of toxicology to investigate molecular toxicological events and their relation to adverse outcomes at different scales. The integration of own data with knowledge and data from databases and other sources is key in our research that aims at understanding general and specific toxicological processes relevant for human and environmental health with a particular focus on chemical mixtures.
Chemical mixture risk assessment
We collect, investigate and apply mode of action knowledge and effect data of chemicals for environmental mixture risk assessment, predict mixture effects at different scales and investigate and identify mixture risk drivers with a main focus on the aquatic environment.
“Something from nothing” or combined hazards of environmental pollutants
Patterns and mechanisms of toxicological responses
We work on the investigation, modelling and visualisation of toxicogenomic and morphological effects and study time and concentration dependencies as well as mixture and recovery effects, mainly using the zebrafish embryo model organism but also data from other test systems.
Predicted and observed whole transcriptome responses after mixture exposures
Tools and software
We develop tools for data management, integration, and visualization, as well as respective workflows for producing and providing FAIR data in toxicology.
The tfp-browser
- a R Shiny tool for exploration and visualization of whole transcriptome toxicogenomic data obtained with the zebrafish embryo model for more than 70 chemicals (Schüttler et al. 2019)
The INTOB Software
- an integrated software and database for effect observations on organism scale (Michaelis et al. 2024)
Group members
If you are interested in joining the group please contact Wibke Busch
Dr. Wibke Busch
Group Leader
Phone: +49 341 6025 1581
E-Mail
Paul Michaelis
Bioinformatican
Phone: +49 341 6025 1823
E-Mail
Najlae El Haidi
Master student
E-Mail
iTox Alumni
Lena Knödler, Bachelor Student and Student Assistant 2024,Georg-August University Göttingen
Lukas Nerlich, Bachelor Student and Student Assistant 2022-2024, University Bayreuth, next position: PhD student University Tübingen
Bente Nissen, Master Student and Scientist 2023-2024, University Copenhagen, Denmark, next position: PhD student at EAWAG, Switzerland
Lena Kramer, Student Assistant 2021-2023, University Tübingen
Bernhard Kodritsch, PhD Student 2020-2023, next position: Scientist at German Environmental Agency (UBA)
Konstantinos Gkrintzalis, Visiting Fellow (Alexander von Humboldt Foundation) 2021-2023, Assistant Professor Dublin City University, Ireland
Gianina Jakobs, PhD Student 2019-2022, next position: Sustainability Manager at Edelrid
Marco Rump, Master Student 2022, next position: PhD student at Alfred-Wegner Institute (AWI)
Paula Klein, Student Assistant 2022, Technical University Dresden
Maria Franz, Student Assistant 2021, Technical University Munich
David Leuthold, PhD Student 2017-2020, next position: PostDoc at UFZ
Sophie Scholz, Student Assistant 2020, University Potsdam
Andreas Schüttler, PhD Student and PostDoc 2016-2019, next position: Group Leader at German Federal Institute of Hydrology
Joseline Alt, Student Assistent 2019, FU Berlin
Jona Schulze, Master Student 2019, next position: Scientist at German Environmental Agency (UBA)
Marie Miotke, Master Student 2019, next position: GENEWIZ Germany GmbH
Stefan Krämer, Master Student 2018, next position: PhD student at UFZ
Marcella Bader-Blukott, Student Assistant 2018, University Leipzig
Jelena Fix, Master Student 2018, next position: GENEWIZ Germany GmbH
Publications
Index:
You could use our publication index for further requests.
2025 (8)
- Bertram, M.G., Ågerstrand, M., Thoré, E.S.J., Allen, J., Balshine, S., Brand, J.A., Brooks, B.W., Dang, Z., Duquesne, S., Ford, A.T., Hoffmann, F., Hollert, H., Jacob, S., Kloas, W., Klüver, N., Lazorchak, J., Ledesma, M., Maack, G., Macartney, E.L., Martin, J.M., Melvin, S.D., Michelangeli, M., Mohr, S., Padilla, S., Pyle, G., Saaristo, M., Sahm, R., Smit, E., Steevens, J.A., van den Berg, S., Vossen, L.E., Wlodkowic, D., Wong, B.B.M., Ziegler, M., Brodin, T. (2025):
EthoCRED: a framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity studies
Biol. Rev. 100 (2), 556 - 585 10.1111/brv.13154 - Canzler, S., Lehmann, J., Schor, J., Busch, W., Hackermüller, J. (2025):
From toxicogenomics data to cumulative assessment groups: A mechanistic framework for chemical grouping
bioRxiv 10.1101/2025.01.24.634648 - Massei, R., Busch, W., Serrano-Solano, B., Bernt, M., Scholz, S., Nicolay, E.K., Bohring, H., Bumberger, J. (2025):
High-content screening (HCS) workflows for FAIR image data management with OMERO
Sci. Rep. 15 , art. 16236 10.1038/s41598-025-00720-0 - Michaelis, P., Klüver, N., Aulhorn, S., Bohring, H., Bumberger, J., Haase, K., Kuhnert, T., Küster, E., Krüger, J., Luckenbach, T., Massei, R., Nerlich, L., Petruschke, S., Schnicke, T., Schnurpel, A., Scholz, S., Schweiger, N., Sielaff, D., Busch, W. (2025):
Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Environ. Sci. Technol. 59 (9), 4304 - 4317 10.1021/acs.est.4c11757 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Correction to: Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1579 10.1007/s00204-025-03998-1 - Nöth, J., Michaelis, P., Schüler, L., Scholz, S., Krüger, J., Haake, V., Busch, W. (2025):
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Arch. Toxicol. 99 (4), 1561 - 1578 10.1007/s00204-024-03944-7 - Schor, J., Mutlu, İ., Busch, W., Bumberger, J., Schulze, T., Ulrich, N., Hassan, K.N., Krauss, M., Brack, W., Doan, T., Bingert, S., Hackermüller, J. (2025):
Neo4j Container Link for the Curated Dataset in ChEOS Project [Data set]
Zenodo 10.5281/zenodo.14616124 - Schunck, F., Busch, W., Focks, A. (2025):
Hierarchical approaches for integrating sparse, multivariate toxicological effect data in whole organism molecular dynamics models
bioRxiv 10.1101/2025.05.09.652942
2024 (9)
- Dichgans, F., Schulze, T., Büttner, O., Busch, W., Schulz, C., Sachse, D., Schmidt, C. (2024):
Dataset of River Water Quality for Saxony, Germany, 1985-2023 [dataset]
PANGAEA 10.1594/PANGAEA.969111 - Escher, B.I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J.K., Dann, J.P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., Scholz, S., Schulze, T., Spahr, S., Ulrich, N., Weitere, M., Varga, E. (2024):
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Nat. Water 2 (9), 889 - 898 10.1038/s44221-024-00297-4 - Gutsfeld, S., Wehmas, L., Omoyeni, I.E., Schweiger, N., Leuthold, D., Michaelis, P., Howey, X.M., Gaballah, S., Herold, N., Vogs, C., Wood, C., Bertotto, L., Wu, G.-M., Klüver, N., Busch, W., Scholz, S., Schor, J., Tal, T. (2024):
Investigation of peroxisome proliferator-activated receptor genes as requirements for visual startle response hyperactivity in larval zebrafish exposed to structurally similar per- and polyfluoroalkyl substances (PFAS)
Environ. Health Perspect. 132 (7), art. 077007 10.1289/EHP13667 - Kodritsch, B., Schunck, F., Krauss, M., Focks, A., Busch, W. (2024):
Survival, nrf2, internal concentration, and external concentration timeseries of zebrafish embryos exposed to Diuron, Diclofenac or Naproxen used in TKTD modelling
GIN 10.12751/g-node.l6jqgf - Kramer, L., Schulze, T., Klüver, N., Altenburger, R., Hackermüller, J., Krauss, M., Busch, W. (2024):
Curated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment
Sci. Data 11 , art. 60 10.1038/s41597-023-02904-7 - Michaelis, P., Klüver, N., Busch, W. (2024):
Integrated Effect Database for Toxicological Observations (INTOB) [Data set]
Zenodo 10.5281/zenodo.11030299 - Nöth, J., Busch, W., Tal, T., Lai, C., Ambekar, A., Kießling, T.R., Scholz, S. (2024):
Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Arch. Toxicol. 98 (2), 537 - 549 10.1007/s00204-023-03633-x - Schunck, F., Kodritsch, B., Krauss, M., Busch, W., Focks, A. (2024):
Integrating time-resolved nrf2 gene-expression data into a full GUTS model as a proxy for toxicodynamic damage in zebrafish embryo
Environ. Sci. Technol. 58 (50), 21942 - 21953 10.1021/acs.est.4c06267 - Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P.J., Escher, B.I., Dirven, H., Hellsten, K., Dolva, K., Hessel, E., Heusinkveld, H.J., Hadzhiev, Y., Hurem, S., Jagiello, K., Judzinska, B., Klüver, N., Knoll-Gellida, A., Kühne, B.A., Leist, M., Lislien, M., Lyche, J.L., Müller, F., Colbourne, J.K., Neuhaus, W., Pallocca, G., Seeger, B., Scharkin, I., Scholz, S., Spjuth, O., Torres-Ruiz, M., Bartmann, K. (2024):
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
Front. Toxicol. 6 , art. 1359507 10.3389/ftox.2024.1359507
2023 (6)
- Bashirova, N., Poppitz, D., Klüver, N., Scholz, S., Matysik, J., Alia, A. (2023):
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Sci. Rep. 13 , art. 1891 10.1038/s41598-023-28712-y - Beckers, L.-M., Altenburger, R., Brack, W., Escher, B.I., Hackermüller, J., Hassold, E., Illing, G., Krauss, M., Krüger, J., Michaelis, P., Schüttler, A., Stevens, S., Busch, W. (2023):
A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment
Environ. Int. 179 , art. 108155 10.1016/j.envint.2023.108155 - Kramer, L., Schulze, T., Klüver, N., Altenburger, R., Hackermüller, J., Krauss, M., Busch, W. (2023):
Curated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment [Data set] v2
Zenodo 10.5281/zenodo.10071824 - Sanz, C.M., Schiavone, V., Ibarra, J., Di Donato, V., Truong, L., Tanguay, R., Hsieh, J.-H., Ryan, K., Ellis, L., Molina Martinez, B., Del Pozo, A., Alzualde, A., Muriana, A., Klüver, N., Behl, M., Woodland, C., Sachana, M., Hessel, E. (2023):
Towards developing a harmonized experimental protocol of embryonic zebrafish light/dark transition behavior test for Organisation for Economic Co-operation and Development (OECD) Developmental Neurotoxicity (DNT) In-Vitro Testing Battery
Toxicol. Lett. 384 (Suppl. 1), S249 - S249 10.1016/S0378-4274(23)00847-0 - Schmeisser, S., Miccoli, A., von Bergen, M., Berggren, E., Braeuning, A., Busch, W., Desaintes, C., Gourmelon, A., Grafström, R., Harrill, J., Hartung, T., Herzler, M., Kass, G.E.N., Kleinstreuer, N., Leist, M., Luijten, M., Marx-Stoelting, P., Poetz, O., van Ravenzwaay, B., Roggeband, R., Rogiers, V., Roth, A., Sanders, P., Thomas, R.S., Vinggaard, A.M., Vinken, M., van de Water, B., Luch, A., Tralau, T. (2023):
New approach methodologies in human regulatory toxicology – Not if, but how and when!
Environ. Int. 178 , art. 108082 10.1016/j.envint.2023.108082 - Wilhelmi, P., Giri, V., Zickgraf, F.M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R., Funk-Weyer, D. (2023):
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
Chem.-Biol. Interact. 382 , art. 110565 10.1016/j.cbi.2023.110565
2022 (11)
- Alzualde, A., Hsieh, J.-H., Ellis, L., Schiavone, V., Truong, L., Legradi, J., Rubbini, D., Woodland, C., Klüver, N., Ryan, K., Behl, M., Terriente, J., Muriana, A., Tanguay, R., Sachana, M., Hill, B., Padilla, S., Shafer, T., Hessel, E. (2022):
An inter-laboratory case study to harmonize zebrafish light-dark transition test to predict developmental neurotoxicity for the OECD guidance document
Int. J. Toxicol. 41 (1), 55 - 56 10.1177/10915818211061894 - Finckh, S., Beckers, L.-M., Busch, W., Carmona, E., Dulio, V., Kramer, L., Krauss, M., Posthuma, L., Schulze, T., Slootweg, J., von der Ohe, P.C., Brack, W. (2022):
Concentrations of 366 emerging chemicals in 56 European wastewater treatment plant effluents by LC-HRMS target screening
PANGAEA 10.1594/PANGAEA.940755 - Finckh, S., Beckers, L.-M., Busch, W., Carmona, E., Dulio, V., Kramer, L., Krauss, M., Posthuma, L., Schulze, T., Slootweg, J., von der Ohe, P.C., Brack, W. (2022):
A risk based assessment approach for chemical mixtures from wastewater treatment plant effluents
Environ. Int. 164 , art. 107234 10.1016/j.envint.2022.107234 - Henneberger, L., Mühlenbrink, M., Klüver, N., Escher, B. (2022):
Trout and human plasma protein binding of selected pharmaceuticals informs the fish plasma model
Environ. Toxicol. Chem. 41 (3), 559 - 568 10.1002/etc.4934 - Nöth, J., Michaelis, P., Busch, W., Scholz, S. (2022):
Analysis vascular disruptors in zebrafish embryos as an endpoint to predict developmental toxicity
Toxicol. Lett. 368 (Suppl.), S34 - S35 10.1016/j.toxlet.2022.07.111 - Padilla, S., Hill, B.N., Legradi, J., Klüver, N. (2022):
Using zebrafish to assess developmental neurotoxicity
In: Gupta, R.C. (ed.)
Reproductive and developmental toxicology. Third edition
Academic Press / Elsevier, London, p. 239 - 251 10.1016/B978-0-323-89773-0.00013-8 - Sanz, C.M., Ibarra, J., Rubbini, D., Hsieh, J.-H., Ellis, L., Alzualde, A., Truong, L., Klüver, N., Muriana, A., Ryan, K., Behl, M., Molina, B., Legradi, J., Padilla, S., Woodland, C., Tanguay, R., Hill, B., Shafer, T., Sachana, M., Terriente, J., Di Donato, V., Schiavone, V., Hessel, E. (2022):
Zebrafish, a novel key player for human risk assessment: latest advances on developmental neurotoxicity from an international consortium
Toxicol. Lett. 368 (Suppl.), S235 - S236 10.1016/j.toxlet.2022.07.632 - Schor, J., Scheibe, P., Bernt, M., Busch, W., Lai, C., Hackermüller, J. (2022):
AI for predicting chemical-effect associations at the chemical universe level — deepFPlearn
Brief. Bioinform. 23 (5), bbac257 10.1093/bib/bbac257 - Teixidó, E., Kieβling, T.R., Klüver, N., Scholz, S. (2022):
Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test
Arch. Toxicol. 96 (5), 1353 - 1369 10.1007/s00204-022-03253-x - Thessen, A.E., Marvel, S., Achenbach, J.C., Fischer, S., Haendel, M.A., Hayward, K., Klüver, N., Könemann, S., Legradi, J., Lein, P., Leong, C., Mylroie, J.E., Padilla, S., Perone, D., Planchart, A., Miñana Prieto, R., Muriana, A., Quevedo, C., Reif, D., Ryan, K., Stinckens, E., Truong, L., Vergauwen, L., Vom Berg, C., Wilbanks, M., Yaghoobi, B., Hamm, J. (2022):
Implementation of zebrafish ontologies for toxicology screening
Front. Toxicol. 4 , art. 817999 10.3389/ftox.2022.817999 - Wilhelmi, P., Giri, V., Henkes, S., Walk, T., Haake, V., Scholz, S., Busch, W., Barenys, M., Zickgraf, F., Landsiedel, R., Funk-Weyer, D., Birk, B., Flick, B. (2022):
A targeted metabolomics approach for unraveling different modes of embryotoxicity in zebrafish
Toxicol. Lett. 368 (Suppl.), S252 - S252 10.1016/j.toxlet.2022.07.671
2021 (4)
- Ford, A.T., Ågerstrand, M., Brooks, B.W., Allen, J., Bertram, M.G., Brodin, T., Dang, Z., Duquesne, S., Sahm, R., Hoffmann, F., Hollert, H., Jacob, S., Klüver, N., Lazorchak, J.M., Ledesma, M., Melvin, S.D., Mohr, S., Padilla, S., Pyle, G.G., Scholz, S., Saaristo, M., Smit, E., Steevens, J.A., van den Berg, S., Kloas, W., Wong, B.B.M., Ziegler, M., Maack, G. (2021):
The role of behavioral ecotoxicology in environmental protection
Environ. Sci. Technol. 55 (9), 5620 - 5628 10.1021/acs.est.0c06493 - Schüttler, A., Jakobs, G., Fix, J.M., Krauss, M., Krüger, J., Leuthold, D., Altenburger, R., Busch, W. (2021):
Transcriptome-wide prediction and measurement of combined effects induced by chemical mixture exposure in zebrafish embryos
Environ. Health Perspect. 129 (4), art. 047006 10.1289/EHP7773 - Teixidó, E., Klüver, N., Ogungbemi, A.O., Küster, E., Scholz, S. (2021):
Evaluation of neurotoxic effects in zebrafish embryos by automatic measurement of early motor behaviors
In: Llorens, J., Barenys, M. (eds.)
Experimental neurotoxicology methods
Neuromethods 172
Springer Nature, p. 381 - 397 10.1007/978-1-0716-1637-6_17 - Weitere, M., Altenburger, R., Anlanger, C., Baborowski, M., Bärlund, I., Beckers, L.-M., Borchardt, D., Brack, W., Brase, L., Busch, W., Chatzinotas, A., Deutschmann, B., Eligehausen, J., Frank, K., Graeber, D., Griebler, C., Hagemann, J., Herzsprung, P., Hollert, H., Inostroza, P.A., Jäger, C.G., Kallies, R., Kamjunke, N., Karrasch, B., Kaschuba, S., Kaus, A., Klauer, B., Knöller, K., Koschorreck, M., Krauss, M., Kunz, J.V., Kurz, M.J., Liess, M., Mages, M., Müller, C., Muschket, M., Musolff, A., Norf, H., Pöhlein, F., Reiber, L., Risse-Buhl, U., Schramm, K.-W., Schmitt-Jansen, M., Schmitz, M., Strachauer, U., von Tümpling, W., Weber, N., Wild, R., Wolf, C., Brauns, M. (2021):
Disentangling multiple chemical and non-chemical stressors in a lotic ecosystem using a longitudinal approach
Sci. Total Environ. 769 , art. 144324 10.1016/j.scitotenv.2020.144324
2020 (6)
- Canzler, S., Schor, J., Busch, W., Schubert, K., Rolle-Kampczyk, U.E., Seitz, H., Kamp, H., von Bergen, M., Buesen, R., Hackermüller, J. (2020):
Prospects and challenges of multi‑omics data integration in toxicology
Arch. Toxicol. 94 (2), 371 - 388 10.1007/s00204-020-02656-y - Escher, B.I., Abagyan, R., Embry, M., Klüver, N., Redman, A.D., Zarfl, C., Parkerton, T.F. (2020):
Recommendations for improving methods and models for aquatic hazard assessment of ionizable organic chemicals
Environ. Toxicol. Chem. 39 (2), 269 - 286 10.1002/etc.4602 - Fischer, F.C., Abele, C., Henneberger, L., Klüver, N., König, M., Mühlenbrink, M., Schlichting, R., Escher, B.I. (2020):
Cellular metabolism in high-throughput in vitro reporter gene assays and implications for the quantitative in vitro-in vivo extrapolation
Chem. Res. Toxicol. 33 (7), 1770 - 1779 10.1021/acs.chemrestox.0c00037 - Jakobs, G., Krüger, J., Schüttler, A., Altenburger, R., Busch, W. (2020):
Mixture toxicity analysis in zebrafish embryo a time and concentration resolved study on mixture effect predictivity
Environ. Sci. Eur. 32 , art. 143 10.1186/s12302-020-00409-3 - Krämer, S., Busch, W., Schüttler, A. (2020):
A self-organizing map of the fathead minnow liver transcriptome to identify consistent toxicogenomic patterns across chemical fingerprints
Environ. Toxicol. Chem. 39 (3), 526 - 537 10.1002/etc.4646 - Shatilina, Z., Drozdova, P., Bedulina, D., Rivarola-Duarte, L., Schreiber, S., Otto, C., Jühling, F., Aulhorn, S., Busch, W., Lubyaga, Y., Kondrateva, E., Pobezhimova, T., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Pörtner, H.-O., Stadler, P.F., Luckenbach, T., Timofeyev, M. (2020):
Transcriptome-level effects of the model organic pollutant phenanthrene and its solvent acetone in three amphipod species
Comp. Biochem. Physiol. D-Genomics Proteomics 33 , art. 100630 10.1016/j.cbd.2019.100630
2019 (9)
- Altenburger, R., Brack, W., Burgess, R.M., Busch, W., Escher, B.I., Focks, A., Hewitt, L.M., Jacobsen, B.N., López de Alda, M., Ait-Aissa, S., Backhaus, T., Ginebreda, A., Hilscherová, K., Hollender, J., Hollert, H., Neale, P.A., Schulze, T., Schymanski, E.L., Teodorovic, I., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Zonja, B., Krauss, M. (2019):
Future water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures
Environ. Sci. Eur. 31 , art. 12 10.1186/s12302-019-0193-1 - Bittner, L., Klüver, N., Henneberger, L., Mühlenbrink, M., Zarfl, C., Escher, B.I. (2019):
Combined ion-trapping and mass balance models to describe the pH-dependent uptake and toxicity of acidic and basic pharmaceuticals in zebrafish embryos (Danio rerio)
Environ. Sci. Technol. 53 (13), 7877 - 7886 10.1021/acs.est.9b02563 - Bittner, L., Teixidó, E., Keddi, I., Escher, B.I., Klüver, N. (2019):
pH‐Dependent uptake and sublethal effects of antihistamines in zebrafish (Danio rerio) embryos
Environ. Toxicol. Chem. 38 (5), 1012 - 1022 10.1002/etc.4395 - Drozdova, P., Rivarola-Duarte, L., Bedulina, D., Axenov-Gribanov, D., Schreiber, S., Gurkov, A., Shatilina, Z., Vereshchagina, K., Lubyaga, Y., Madyarova, E., Otto, C., Jühling, F., Busch, W., Jakob, L., Lucassen, M., Sartoris, F.J., Hackermüller, J., Hoffmann, S., Pörtner, H.-O., Luckenbach, T., Timofeyev, M., Stadler, P.F. (2019):
Comparison between transcriptomic responses to short-term stress exposures of a common Holarctic and endemic Lake Baikal amphipods
BMC Genomics 20 , art. 712 10.1186/s12864-019-6024-3 - Klüver, N., Bittermann, K., Escher, B.I. (2019):
QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test
Aquat. Toxicol. 207 , 110 - 119 10.1016/j.aquatox.2018.12.003 - Leuthold, D., Klüver, N., Altenburger, R., Busch, W. (2019):
Can environmentally relevant neuroactive chemicals specifically be detected with the locomotor response test in zebrafish embryos?
Environ. Sci. Technol. 53 (1), 482 - 493 10.1021/acs.est.8b04327 - Schüttler, A., Altenburger, R., Ammar, M., Bader-Blukott, M., Jakobs, G., Knapp, J., Krüger, J., Reiche, K., Wu, G.-M., Busch, W. (2019):
Map and model—moving from observation to prediction in toxicogenomics
GigaScience 8 (6), giz057 10.1093/gigascience/giz057 - Serra, H., Scholze, M., Altenburger, R., Busch, W., Budzinski, H., Brion, F., Aït-Aïssa, S. (2019):
Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays
Chemosphere 227 , 334 - 344 10.1016/j.chemosphere.2019.04.060 - Weil, M., Mackenzie, K., Foit, K., Kühnel, D., Busch, W., Bundschuh, M., Schulz, R., Duis, K. (2019):
Environmental risk or benefit? Comprehensive risk assessment of groundwater treated with nano Fe0-based Carbo-Iron®
Sci. Total Environ. 677 , 156 - 166 10.1016/j.scitotenv.2019.04.360
2018 (8)
- Altenburger, R., Scholze, M., Busch, W., Escher, B.I., Jakobs, G., Krauss, M., Krüger, J., Neale, P.A., Ait-Aissa, S., Almeida, A.C., Seiler, T.-B., Brion, F., Hilscherová, K., Hollert, H., Novák, J., Schlichting, R., Serra, H., Shao, Y., Tindall, A., Tolefsen, K.-E., Umbuzeiro, G., Williams, T.D., Kortenkamp, A. (2018):
Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays
Environ. Int. 114 , 95 - 106 10.1016/j.envint.2018.02.013 - Beckers, L.-M., Busch, W., Krauss, M., Schulze, T., Brack, W. (2018):
Characterization and risk assessment of seasonal and weather dynamics in organic pollutant mixtures from discharge of a separate sewer system
Water Res. 135 , 122 - 133 10.1016/j.watres.2018.02.002 - Bittner, L., Teixido, E., Seiwert, B., Escher, B.I., Klüver, N. (2018):
Influence of pH on the uptake and toxicity of β-blockers in embryos of zebrafish, Danio rerio
Aquat. Toxicol. 201 , 129 - 137 10.1016/j.aquatox.2018.05.020 - Legradi, J.B., Di Paolo, C., Kraak, M.H.S., van der Geest, H.G., Schymanski, E.L., Williams, A.J., Dingemans, M.M.L., Massei, R., Brack, W., Cousin, X., Begout, M.-L., van der Oost, R., Carion, A., Suarez‑Ulloa, V., Silvestre, F., Escher, B.I., Engwall, M., Nilén, G., Keiter, S.H., Pollet, D., Waldmann, P., Kienle, C., Werner, I., Haigis, A.-C., Knapen, D., Vergauwen, L., Spehr, M., Schulz, W., Busch, W., Leuthold, D., Scholz, S., vom Berg, C.M., Basu, N., Murphy, C.A., Lampert, A., Kuckelkorn, J., Grummt, T., Hollert, H. (2018):
An ecotoxicological view on neurotoxicity assessment
Environ. Sci. Eur. 30 , art. 46 10.1186/s12302-018-0173-x - Massei, R., Busch, W., Wolschke, H., Schinkel, L., Bitsch, M., Schulze, T., Krauss, M., Brack, W. (2018):
Screening of pesticide and biocide patterns as risk drivers in sediments of major European river mouths: ubiquitous or river basin-specific contamination?
Environ. Sci. Technol. 52 (4), 2251 - 2260 10.1021/acs.est.7b04355 - Neale, P.A., Brack, W., Ait-Aissa, S., Busch, W., Hollender, J., Krauss, M., Maillot-Maréchal, E., Munz, N.A., Schlichting, R., Schulze, T., Vogler, B., Escher, B.I. (2018):
Solid-phase extraction as sample preparation of water samples for cell-based and other in vitro bioassays
Environ. Sci.-Process Impacts 20 (3), 493 - 504 10.1039/C7EM00555E - Sobanska, M., Scholz, S., Nyman, A.-M., Cesnaitis, R., Gutierrez Alonso, S., Klüver, N., Kühne, R., Tyle, H., de Knecht, J., Dang, Z., Lundbergh, I., Carlon, C., De Coen, W. (2018):
Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
Environ. Toxicol. Chem. 37 (3), 657 - 670 10.1002/etc.4055 - Whalley, C., Mohaupt, V., Busch, W., van den Roovaart, J., van Dujnhoven, N., Kirst, I., Schmedtje, U., Altenburger, R., Sommer, L. (2018):
Chemicals in European waters - Knowledge developments
EEA Report 18/2018
Office for Official Publications of the European Communities, Luxembourg, 76 pp. 10.2800/265080
2017 (8)
- Baumer, A., Bittermann, K., Klüver, N., Escher, B.I. (2017):
Baseline toxicity and ion-trapping models to describe the pH-dependence of bacterial toxicity of pharmaceuticals
Environ. Sci.-Process Impacts 19 (7), 901 - 916 10.1039/c7em00099e - Escher, B.I., Baumer, A., Bittermann, K., Henneberger, L., König, M., Kühnert, C., Klüver, N. (2017):
General baseline toxicity QSAR for nonpolar, polar and ionisable chemicals and their mixtures in the bioluminescence inhibition assay with Aliivibrio fischeri
Environ. Sci.-Process Impacts 19 (3), 414 - 428 10.1039/c6em00692b - Escher, B.I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S.K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J.J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J., Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G.W., Müller, A., Phillips, D.H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y.-M., Trump, S., Walter-Rohde, S., Wambaugh, J.F. (2017):
From the exposome to mechanistic understanding of chemical-induced adverse effects
Environ. Int. 99 , 97 - 106 10.1016/j.envint.2016.11.029 - Kühnert, A., Vogs, C., Seiwert, B., Aulhorn, S., Altenburger, R., Hollert, H., Küster, E., Busch, W. (2017):
Biotransformation in the zebrafish embryo – temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding xenobiotic benz[a]anthracene
Environ. Pollut. 230 , 1 - 11 10.1016/j.envpol.2017.04.083 - Neale, P.A., Altenburger, R., Aït-Aïssa, S., Brion, F., Busch, W., De Aragão Umbuzeiro, G., Denison, M.S., Du Pasquier, D., Hilscherová, K., Hollert, H., Morales, D.A., Novák, J., Schlichting, R., Seiler, T.-B., Serra, H., Shao, Y., Tindall, A.J., Tollefsen, K.E., Williams, T.D., Escher, B.I. (2017):
Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water
Water Res. 123 , 734 - 750 10.1016/j.watres.2017.07.016 - Neale, P.A., Munz, N.A., Aїt-Aїssa, S., Altenburger, R., Brion, F., Busch, W., Escher, B.I., Hilscherová, K., Kienle, C., Novák, J., Seiler, T.-B., Shao, Y., Stamm, C., Hollender, J. (2017):
Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams
Sci. Total Environ. 576 , 785 - 795 10.1016/j.scitotenv.2016.10.141 - Schmidt, S., Busch, W., Altenburger, R. (2017):
Biotestverfahren zur Abschätzung von Wirkpotenzialen in der aquatischen Umwelt : Vorschlag einer modularen Biotestbatterie für das aquatische Umweltmonitoring als Ergebnis einer systematischen Literaturrecherche und Bewertung
LUBW Landesanstalt für Umwelt Baden-Württemberg, Karlsruhe, 98 S. - Schüttler, A., Reiche, K., Altenburger, R., Busch, W. (2017):
The transcriptome of the zebrafish embryo after chemical exposure: a meta-analysis
Toxicol. Sci. 157 (2), 291 - 304 10.1093/toxsci/kfx045
2016 (6)
- Brack, W., Ait-Aissa, S., Burgess, R.M., Busch, W., Creusot, N., Di Paolo, C., Escher, B.I., Hewitt, L.M., Hilscherova, K., Hollender, J., Hollert, H., Jonker, W., Kool, J., Lamoree, M., Muschket, M., Neumann, S., Rostkowski, P., Ruttkies, C., Schollee, J., Schymanski, E.L., Schulze, T., Seiler, T.-B., Tindall, A.J., De Aragão Umbuzeiro, G., Vrana, B., Krauss, M. (2016):
Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview
Sci. Total Environ. 544 , 1073 - 1118 10.1016/j.scitotenv.2015.11.102 - Busch, W., Schmidt, S., Kühne, R., Schulze, T., Krauss, M., Altenburger, R. (2016):
Micropollutants in European rivers: A mode of action survey to support the development of effect-based tools for water monitoring
Environ. Toxicol. Chem. 35 (8), 1887 - 1899 10.1002/etc.3460 - Klüver, N., Vogs, C., Altenburger, R., Escher, B.I., Scholz, S. (2016):
Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test
Chemosphere 164 , 164 - 173 10.1016/j.chemosphere.2016.08.079 - Schmidt, S., Busch, W., Altenburger, R., Küster, E. (2016):
Mixture toxicity of water contaminants-effect analysis using the zebrafish embryo assay (Danio rerio)
Chemosphere 152 , 503 - 512 10.1016/j.chemosphere.2016.03.006 - Scholz, S., Klüver, N., Kühne, R. (2016):
Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. Report ECHA-UFZ contract ECHA/2014/341
Helmholtz Centre for Environmental Research - UFZ, Leipzig, 104 pp. - Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016):
Zebrafish biosensor for toxicant induced muscle hyperactivity
Sci. Rep. 6 , art. 23768 10.1038/srep23768
2015 (5)
- Altenburger, R., Ait-Aissa, S., Antczak, P., Backhaus, T., Barceló, D., Seiler, T.-B., Brion, F., Busch, W., Chipman, K., López de Alda, M., De Aragão Umbuzeiro, G., Escher, B.I., Falciani, F., Faust, M., Focks, A., Hilscherova, K., Hollender, J., Hollert, H., Jäger, F., Jahnke, A., Kortenkamp, A., Krauss, M., Lemkine, G.F., Munthe, J., Neumann, S., Schymanski, E.L., Scrimshaw, M., Segner, H., Slobodnik, J., Smedes, F., Kughathas, S., Teodorovic, I., Tindall, A.J., Tollefsen, K.E., Walz, K.-H., Williams, T.D., van den Brink, P.J., van Gils, J., Vrana, B., Zhang, X., Brack, W. (2015):
Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management
Sci. Total Environ. 512-513 , 540 - 551 10.1016/j.scitotenv.2014.12.057 - Klüver, N., König, M., Ortmann, J., Massei, R., Paschke, A., Kühne, R., Scholz, S. (2015):
Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic compounds
Environ. Sci. Technol. 49 (11), 7002 - 7011 10.1021/acs.est.5b01910 - Luckenbach, T., Küster, E., Busch, W., Scholz, S., Altenburger, R. (2015):
What determines chemical uptake by the zebrafish embryo model?
Toxicol. Lett. 238 (2, Suppl.), S54 10.1016/j.toxlet.2015.08.151 - Smetanová, S., Riedl, J., Zitzkat, D.P., Altenburger, R., Busch, W. (2015):
High-throughput concentration–response analysis for omics datasets
Environ. Toxicol. Chem. 34 (9), 2167 - 2180 10.1002/etc.3025 - Weil, M., Meißner, T., Busch, W., Springer, A., Kühnel, D., Schulz, R., Duis, K. (2015):
The oxidized state of the nanocomposite Carbo-Iron® causes no adverse effects on growth, survival and differential gene expression in zebrafish
Sci. Total Environ. 530-531 , 198 - 208 10.1016/j.scitotenv.2015.05.087