iTox – integrative toxicology

In iTox we aim to integrate data and knowledge from different fields of toxicology to investigate molecular toxicological events and their relation to adverse outcomes at different scales. The integration of own data with knowledge and data from databases and other sources is key in our research that aims at understanding general and specific toxicological processes relevant for human and environmental health with a particular focus on chemical mixtures. 

Chemical mixture risk assessment 

We collect, investigate and apply mode of action knowledge and effect data of chemicals for environmental mixture risk assessment, predict mixture effects at different scales and investigate and identify mixture risk drivers with a main focus on the aquatic environment.

“Something from nothing” or combined hazards of environmental pollutants

combined hazards iTOX
A) Mixture toxicity observed in zebrafish embryo with 12 chemicals that cause no effect in individual compound exposures (Jakobs et al. 2020), B) Mixture risks of pollutants from waste water treatment plant effluents in comparison to a novel designed reference mixture (Beckers et al. 2023, Kramer et al. 2024)

Patterns and mechanisms of toxicological responses

We work on the investigation, modelling and visualisation of toxicogenomic and morphological effects and study time and concentration dependencies as well as mixture and recovery effects, mainly using the zebrafish embryo model organism but also data from other test systems.

Predicted and observed whole transcriptome responses after mixture exposures

Biotox 6
A) predicted and B) observed whole transcriptome effect patterns in the zebrafish embryo after mixture exposure (Schüttler et al. 2021, Smax=Sensitivity, sum(CI)=measure for significance)

Tools and software

We develop tools for data management, integration, and visualization, as well as respective workflows for producing and providing FAIR data in toxicology.

tfp browser

The tfp-browser

  • a R Shiny tool for exploration and visualization of whole transcriptome toxicogenomic data obtained with the zebrafish embryo model for more than 70 chemicals (Schüttler et al. 2019)

       Link
 

intob logo

The INTOB Software

  • an integrated software and database for effect observations on organism scale (Michaelis et al. 2024)

       Link
 

Group members

itox group Nov 2024

If you are interested in joining the group please contact Wibke Busch

Dr. Wibke Busch
Group Leader
Phone: +49 341 6025 1581
E-Mail

Paul Michaelis
Bioinformatican
Phone: +49 341 6025 1823
E-Mail

Dr. Riccardo Massei
PostDoc
Phone: +49 341 6025 1512
E-Mail

Dr. Nils Klüver
Scientist
Phone +49 341 6025 1558
E-Mail

Janet Krüger
Technican
Phone: +49 341 6025 1480
E-Mail

Berfin Erdogan
Scientist
+49 341 6025 1306
E-Mail 

Samuel Türken
PhD Student
E-Mail

Jasmin Stockhause
Student assistant
E-Mail

Najlae El Haidi
Master student
E-Mail 

iTox Alumni

Lena Knödler, Bachelor Student and Student Assistant 2024,Georg-August University Göttingen

Lukas Nerlich, Bachelor Student and Student Assistant 2022-2024, University Bayreuth, next position: PhD student University Tübingen

Bente Nissen, Master Student and Scientist 2023-2024, University Copenhagen, Denmark, next position: PhD student at EAWAG, Switzerland

Lena Kramer, Student Assistant 2021-2023, University Tübingen

Bernhard Kodritsch, PhD Student 2020-2023, next position: Scientist at German Environmental Agency (UBA)

Konstantinos Gkrintzalis, Visiting Fellow (Alexander von Humboldt Foundation) 2021-2023, Assistant Professor Dublin City University, Ireland

Gianina Jakobs, PhD Student 2019-2022, next position: Sustainability Manager at Edelrid

Marco Rump, Master Student 2022, next position: PhD student at Alfred-Wegner Institute (AWI)

Paula Klein, Student Assistant 2022, Technical University Dresden

Maria Franz, Student Assistant 2021, Technical University Munich

David Leuthold, PhD Student 2017-2020, next position: PostDoc at UFZ

Sophie Scholz, Student Assistant 2020, University Potsdam

Andreas Schüttler, PhD Student and PostDoc 2016-2019, next position: Group Leader at German Federal Institute of Hydrology

Joseline Alt, Student Assistent 2019, FU Berlin

Jona Schulze, Master Student 2019, next position: Scientist at German Environmental Agency (UBA)

Marie Miotke, Master Student 2019, next position: GENEWIZ Germany GmbH

Stefan Krämer, Master Student 2018, next position: PhD student at UFZ

Marcella Bader-Blukott, Student Assistant 2018, University Leipzig

Jelena Fix, Master Student 2018, next position: GENEWIZ Germany GmbH
 

Publications

Index:

You could use our publication index for further requests.

2025 (5)

to index

2024 (8)

to index

2023 (6)

to index

2022 (11)

to index

2021 (4)

to index

2020 (6)

to index

2019 (9)

to index

2018 (8)

to index

2017 (8)

to index

2016 (6)

to index

2015 (5)

to index